Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6723
Gene name Gene Name - the full gene name approved by the HGNC.
Spermidine synthase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SRM
Synonyms (NCBI Gene) Gene synonyms aliases
PAPT, SPDSY, SPS1, SRML1
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p36.22
Summary Summary of gene provided in NCBI Entrez Gene.
The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine bio
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025815 hsa-miR-7-5p Microarray 19073608
MIRT044635 hsa-miR-320a CLASH 23622248
MIRT038148 hsa-miR-423-5p CLASH 23622248
MIRT037815 hsa-miR-455-3p CLASH 23622248
MIRT037588 hsa-miR-744-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004766 Function Spermidine synthase activity IBA 21873635
GO:0004766 Function Spermidine synthase activity IDA 17585781
GO:0004766 Function Spermidine synthase activity TAS
GO:0005515 Function Protein binding IPI 21044950
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
182891 11296 ENSG00000116649
Protein
UniProt ID P19623
Protein name Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase)
Protein function Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards
PDB 2O05 , 2O06 , 2O07 , 2O0L , 3RW9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF17284 Spermine_synt_N 19 73 Spermidine synthase tetramerisation domain Domain
PF01564 Spermine_synth 76 261 Domain
Sequence
Sequence length 302
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cysteine and methionine metabolism
Arginine and proline metabolism
Glutathione metabolism
Metabolic pathways
  Metabolism of polyamines
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370
View all (5 more)
27602772
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 9020892
Colitis Ulcerative Associate 39596612
Colorectal Neoplasms Associate 27433286
Lymphoma B Cell Associate 36384092
Multiple Myeloma Associate 7774716
Neoplasms Associate 26581548, 32108042
Prostatic Neoplasms Associate 32108042, 32558033
Stomach Neoplasms Associate 35036435