Gene Gene information from NCBI Gene database.
Entrez ID 6723
Gene name Spermidine synthase
Gene symbol SRM
Synonyms (NCBI Gene)
PAPTSPDSYSPS1SRML1
Chromosome 1
Chromosome location 1p36.22
Summary The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine bio
miRNA miRNA information provided by mirtarbase database.
513
miRTarBase ID miRNA Experiments Reference
MIRT025815 hsa-miR-7-5p Microarray 19073608
MIRT044635 hsa-miR-320a CLASH 23622248
MIRT038148 hsa-miR-423-5p CLASH 23622248
MIRT037815 hsa-miR-455-3p CLASH 23622248
MIRT037588 hsa-miR-744-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
GO ID Ontology Definition Evidence Reference
GO:0003824 Function Catalytic activity IEA
GO:0004766 Function Spermidine synthase activity IBA
GO:0004766 Function Spermidine synthase activity IDA 17585781
GO:0004766 Function Spermidine synthase activity IEA
GO:0004766 Function Spermidine synthase activity TAS 2069720
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
182891 11296 ENSG00000116649
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P19623
Protein name Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase)
Protein function Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards
PDB 2O05 , 2O06 , 2O07 , 2O0L , 3RW9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF17284 Spermine_synt_N 19 73 Spermidine synthase tetramerisation domain Domain
PF01564 Spermine_synth 76 261 Domain
Sequence
Sequence length 302
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cysteine and methionine metabolism
Arginine and proline metabolism
Glutathione metabolism
Metabolic pathways
  Metabolism of polyamines