Gene Gene information from NCBI Gene database.
Entrez ID 6722
Gene name Serum response factor
Gene symbol SRF
Synonyms (NCBI Gene)
MCM1
Chromosome 6
Chromosome location 6p21.1
Summary This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response e
miRNA miRNA information provided by mirtarbase database.
477
miRTarBase ID miRNA Experiments Reference
MIRT000365 hsa-miR-122-5p Luciferase reporter assayqRT-PCRWestern blot 19726678
MIRT000365 hsa-miR-122-5p Luciferase reporter assayqRT-PCRWestern blot 19726678
MIRT006153 hsa-miR-483-5p Luciferase reporter assayqRT-PCRWestern blot 21893058
MIRT006153 hsa-miR-483-5p Luciferase reporter assayqRT-PCRWestern blot 21893058
MIRT006153 hsa-miR-483-5p Luciferase reporter assayqRT-PCRWestern blot 21893058
Transcription factors Transcription factors information provided by TRRUST V2 database.
5
Transcription factor Regulation Reference
ATF6 Unknown 9271374
ELK1 Unknown 15531578
MKL1 Unknown 14565952
NR3C1 Repression 17016446
TEAD1 Unknown 24344135
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
135
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin IEA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 1509260
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600589 11291 ENSG00000112658
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P11831
Protein name Serum response factor (SRF)
Protein function SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coact
PDB 1HBX , 1K6O , 1SRS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00319 SRF-TF 150 197 SRF-type transcription factor (DNA-binding and dimerisation domain) Domain
Sequence
MLPTQAGAAAALGRGSALGGSLNRTPTGRPGGGGGTRGANGGRVPGNGAGLGPGRLEREA
AAAAATTPAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEMEIGMVVGGPEASAAA
TGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTG
TQVLLLVASETGHVYTF
ATRKLQPMITSETGKALIQTCLNSPDSPPRSDPTTDQRMSATG
FEETDLTYQVSESDSSGETKDTLKPAFTVTNLPGTTSTIQTAPSTSTTMQVSSGPSFPIT
NYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQLPTSFTLMPGGAVAQQVPVQAI
QVHQAPQQASPSRDSSTDLTQTSSSGTVTLPATIMTSSVPTTVGGHMMYPSPHAVMYAPT
SGLGDGSLTVLNAFSQAPSTMQVSHSQVQEPGGVPQVFLTASSGTVQIPVSAVQLHQMAV
IGQQAGSSSNLTELQVVNLDTAHSTKSE
Sequence length 508
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  MAPK signaling pathway
cGMP-PKG signaling pathway
Human T-cell leukemia virus 1 infection
Viral carcinogenesis
  RHO GTPases Activate Formins
NGF-stimulated transcription
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CARDIOMYOPATHIES Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CONGENITAL HEART DISEASE ClinGen, Disgenet, GWAS catalog
ClinGen, Disgenet, GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HIV INFECTIONS CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PRIMARY CARDIOMYOPATHY Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Acidosis Associate 40217316
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of Lung Associate 31323040
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Associate 34185408
★☆☆☆☆
Found in Text Mining only
Atrial Fibrillation Associate 25523945
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 17934210, 21670154, 26179713, 26885614, 31894257
★☆☆☆☆
Found in Text Mining only
Calcinosis Cutis Associate 36509758
★☆☆☆☆
Found in Text Mining only
Cap Myopathy Associate 23576568
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 36421692
★☆☆☆☆
Found in Text Mining only
Carcinoma Associate 34067464
★☆☆☆☆
Found in Text Mining only
Cardiomyopathies Associate 25338953
★★☆☆☆
Found in Text Mining + Unknown/Other Associations