SRD5A1 (steroid 5 alpha-reductase 1)

Gene

• Entrez ID: 6715
• Gene name: Steroid 5 alpha-reductase 1
• Gene symbol: SRD5A1
• Synonyms (NCBI Gene): S5AR 1
• Chromosome: 5
• Chromosome location: 5p15.31
• Summary: Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024451	hsa-miR-215-5p	Microarray	19074876
MIRT026876	hsa-miR-192-5p	Microarray	19074876
MIRT711475	hsa-miR-148a-5p	HITS-CLIP	19536157
MIRT711474	hsa-miR-28-5p	HITS-CLIP	19536157
MIRT711473	hsa-miR-3139	HITS-CLIP	19536157
MIRT711472	hsa-miR-708-5p	HITS-CLIP	19536157
MIRT711471	hsa-miR-6793-3p	HITS-CLIP	19536157
MIRT711470	hsa-miR-5193	HITS-CLIP	19536157
MIRT711469	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT711468	hsa-miR-516a-3p	HITS-CLIP	19536157
MIRT711467	hsa-miR-516b-3p	HITS-CLIP	19536157
MIRT711466	hsa-miR-7162-5p	HITS-CLIP	19536157
MIRT711465	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT711464	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT711463	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT695818	hsa-miR-3929	HITS-CLIP	23313552
MIRT695817	hsa-miR-4419b	HITS-CLIP	23313552
MIRT695816	hsa-miR-4478	HITS-CLIP	23313552
MIRT695815	hsa-miR-5690	HITS-CLIP	23313552
MIRT695814	hsa-miR-665	HITS-CLIP	23313552
MIRT695813	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT695812	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT695811	hsa-miR-219a-2-3p	HITS-CLIP	23313552
MIRT695810	hsa-miR-1827	HITS-CLIP	23313552
MIRT695809	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT695808	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT695807	hsa-miR-298	HITS-CLIP	23313552
MIRT695806	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT695805	hsa-miR-7977	HITS-CLIP	23313552
MIRT695804	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT649129	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT649127	hsa-miR-6729-3p	HITS-CLIP	23824327
MIRT649128	hsa-miR-1470	HITS-CLIP	23824327
MIRT649126	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT649125	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT649124	hsa-miR-1266-3p	HITS-CLIP	23824327
MIRT649123	hsa-miR-205-5p	HITS-CLIP	23824327
MIRT649122	hsa-miR-4287	HITS-CLIP	23824327
MIRT649121	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT649120	hsa-miR-26b-3p	HITS-CLIP	23824327
MIRT649119	hsa-miR-1206	HITS-CLIP	23824327
MIRT649118	hsa-miR-6853-3p	HITS-CLIP	23824327
MIRT649117	hsa-miR-2116-5p	HITS-CLIP	23824327
MIRT649116	hsa-miR-22-5p	HITS-CLIP	23824327
MIRT649115	hsa-miR-4677-5p	HITS-CLIP	23824327
MIRT531560	hsa-miR-4797-5p	PAR-CLIP	22012620
MIRT531559	hsa-miR-759	PAR-CLIP	22012620
MIRT531558	hsa-miR-412-3p	PAR-CLIP	22012620
MIRT531557	hsa-miR-6754-3p	PAR-CLIP	22012620
MIRT531556	hsa-miR-6837-3p	PAR-CLIP	22012620
MIRT531554	hsa-miR-4481	PAR-CLIP	22012620
MIRT531555	hsa-miR-4745-5p	PAR-CLIP	22012620
MIRT531553	hsa-miR-6878-5p	PAR-CLIP	22012620
MIRT531552	hsa-miR-6731-5p	PAR-CLIP	22012620
MIRT531551	hsa-miR-8085	PAR-CLIP	22012620
MIRT531550	hsa-miR-1233-5p	PAR-CLIP	22012620
MIRT531549	hsa-miR-6778-5p	PAR-CLIP	22012620
MIRT531548	hsa-miR-30c-1-3p	PAR-CLIP	22012620
MIRT531547	hsa-miR-30c-2-3p	PAR-CLIP	22012620
MIRT531546	hsa-miR-6788-5p	PAR-CLIP	22012620
MIRT711475	hsa-miR-148a-5p	HITS-CLIP	19536157
MIRT711474	hsa-miR-28-5p	HITS-CLIP	19536157
MIRT711473	hsa-miR-3139	HITS-CLIP	19536157
MIRT711472	hsa-miR-708-5p	HITS-CLIP	19536157
MIRT711471	hsa-miR-6793-3p	HITS-CLIP	19536157
MIRT711470	hsa-miR-5193	HITS-CLIP	19536157
MIRT711469	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT711468	hsa-miR-516a-3p	HITS-CLIP	19536157
MIRT711467	hsa-miR-516b-3p	HITS-CLIP	19536157
MIRT711466	hsa-miR-7162-5p	HITS-CLIP	19536157
MIRT711465	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT711464	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT711463	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT695818	hsa-miR-3929	HITS-CLIP	23313552
MIRT695817	hsa-miR-4419b	HITS-CLIP	23313552
MIRT695816	hsa-miR-4478	HITS-CLIP	23313552
MIRT695815	hsa-miR-5690	HITS-CLIP	23313552
MIRT695814	hsa-miR-665	HITS-CLIP	23313552
MIRT695813	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT695812	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT695811	hsa-miR-219a-2-3p	HITS-CLIP	23313552
MIRT695810	hsa-miR-1827	HITS-CLIP	23313552
MIRT695809	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT695808	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT695807	hsa-miR-298	HITS-CLIP	23313552
MIRT695806	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT695805	hsa-miR-7977	HITS-CLIP	23313552
MIRT695804	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT649129	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT649127	hsa-miR-6729-3p	HITS-CLIP	23824327
MIRT649128	hsa-miR-1470	HITS-CLIP	23824327
MIRT649126	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT649125	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT649124	hsa-miR-1266-3p	HITS-CLIP	23824327
MIRT649123	hsa-miR-205-5p	HITS-CLIP	23824327
MIRT649122	hsa-miR-4287	HITS-CLIP	23824327
MIRT649121	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT649120	hsa-miR-26b-3p	HITS-CLIP	23824327
MIRT649119	hsa-miR-1206	HITS-CLIP	23824327
MIRT649118	hsa-miR-6853-3p	HITS-CLIP	23824327
MIRT649117	hsa-miR-2116-5p	HITS-CLIP	23824327
MIRT649116	hsa-miR-22-5p	HITS-CLIP	23824327
MIRT649115	hsa-miR-4677-5p	HITS-CLIP	23824327
MIRT531560	hsa-miR-4797-5p	PAR-CLIP	22012620
MIRT531559	hsa-miR-759	PAR-CLIP	22012620
MIRT531558	hsa-miR-412-3p	PAR-CLIP	22012620
MIRT531557	hsa-miR-6754-3p	PAR-CLIP	22012620
MIRT531556	hsa-miR-6837-3p	PAR-CLIP	22012620
MIRT531554	hsa-miR-4481	PAR-CLIP	22012620
MIRT531555	hsa-miR-4745-5p	PAR-CLIP	22012620
MIRT531553	hsa-miR-6878-5p	PAR-CLIP	22012620
MIRT531552	hsa-miR-6731-5p	PAR-CLIP	22012620
MIRT531551	hsa-miR-8085	PAR-CLIP	22012620
MIRT531550	hsa-miR-1233-5p	PAR-CLIP	22012620
MIRT531549	hsa-miR-6778-5p	PAR-CLIP	22012620
MIRT531548	hsa-miR-30c-1-3p	PAR-CLIP	22012620
MIRT531547	hsa-miR-30c-2-3p	PAR-CLIP	22012620
MIRT531546	hsa-miR-6788-5p	PAR-CLIP	22012620
MIRT1387825	hsa-miR-103b	CLIP-seq
MIRT1387826	hsa-miR-1245	CLIP-seq
MIRT1387827	hsa-miR-136	CLIP-seq
MIRT1387828	hsa-miR-182	CLIP-seq
MIRT1387829	hsa-miR-196a	CLIP-seq
MIRT1387830	hsa-miR-196b	CLIP-seq
MIRT1387831	hsa-miR-203	CLIP-seq
MIRT1387832	hsa-miR-2110	CLIP-seq
MIRT1387833	hsa-miR-216b	CLIP-seq
MIRT1387834	hsa-miR-27a	CLIP-seq
MIRT1387835	hsa-miR-27b	CLIP-seq
MIRT1387836	hsa-miR-3065-5p	CLIP-seq
MIRT1387837	hsa-miR-31	CLIP-seq
MIRT1387838	hsa-miR-3120-3p	CLIP-seq
MIRT1387839	hsa-miR-3133	CLIP-seq
MIRT1387840	hsa-miR-3153	CLIP-seq
MIRT1387841	hsa-miR-3184	CLIP-seq
MIRT1387842	hsa-miR-329	CLIP-seq
MIRT1387843	hsa-miR-330-3p	CLIP-seq
MIRT1387844	hsa-miR-331-5p	CLIP-seq
MIRT1387845	hsa-miR-342-3p	CLIP-seq
MIRT1387846	hsa-miR-3545-5p	CLIP-seq
MIRT1387847	hsa-miR-3609	CLIP-seq
MIRT1387848	hsa-miR-3613-3p	CLIP-seq
MIRT1387849	hsa-miR-3614-5p	CLIP-seq
MIRT1387850	hsa-miR-3617	CLIP-seq
MIRT1387851	hsa-miR-362-3p	CLIP-seq
MIRT1387852	hsa-miR-3675-3p	CLIP-seq
MIRT1387853	hsa-miR-377	CLIP-seq
MIRT1387854	hsa-miR-3927	CLIP-seq
MIRT1387855	hsa-miR-3941	CLIP-seq
MIRT1387856	hsa-miR-423-5p	CLIP-seq
MIRT1387857	hsa-miR-4271	CLIP-seq
MIRT1387858	hsa-miR-4305	CLIP-seq
MIRT1387859	hsa-miR-4307	CLIP-seq
MIRT1387860	hsa-miR-4311	CLIP-seq
MIRT1387861	hsa-miR-4438	CLIP-seq
MIRT1387862	hsa-miR-4474-5p	CLIP-seq
MIRT1387863	hsa-miR-450b-5p	CLIP-seq
MIRT1387864	hsa-miR-4514	CLIP-seq
MIRT1387865	hsa-miR-4662a-5p	CLIP-seq
MIRT1387866	hsa-miR-4684-5p	CLIP-seq
MIRT1387867	hsa-miR-4692	CLIP-seq
MIRT1387868	hsa-miR-4696	CLIP-seq
MIRT1387869	hsa-miR-4705	CLIP-seq
MIRT1387870	hsa-miR-4725-3p	CLIP-seq
MIRT1387871	hsa-miR-4796-3p	CLIP-seq
MIRT1387872	hsa-miR-485-3p	CLIP-seq
MIRT1387873	hsa-miR-491-5p	CLIP-seq
MIRT1387874	hsa-miR-495	CLIP-seq
MIRT1387875	hsa-miR-5095	CLIP-seq
MIRT1387876	hsa-miR-513a-3p	CLIP-seq
MIRT1387877	hsa-miR-513a-5p	CLIP-seq
MIRT1387878	hsa-miR-518a-5p	CLIP-seq
MIRT1387879	hsa-miR-527	CLIP-seq
MIRT1387880	hsa-miR-539	CLIP-seq
MIRT1387881	hsa-miR-545	CLIP-seq
MIRT1387882	hsa-miR-548ae	CLIP-seq
MIRT1387883	hsa-miR-548ah	CLIP-seq
MIRT1387884	hsa-miR-548aj	CLIP-seq
MIRT1387885	hsa-miR-548am	CLIP-seq
MIRT1387886	hsa-miR-548p	CLIP-seq
MIRT1387887	hsa-miR-548t	CLIP-seq
MIRT1387888	hsa-miR-548x	CLIP-seq
MIRT1387889	hsa-miR-554	CLIP-seq
MIRT1387890	hsa-miR-583	CLIP-seq
MIRT1387891	hsa-miR-601	CLIP-seq
MIRT1387892	hsa-miR-603	CLIP-seq
MIRT1387893	hsa-miR-641	CLIP-seq
MIRT2116180	hsa-miR-1183	CLIP-seq
MIRT2116181	hsa-miR-1208	CLIP-seq
MIRT1387827	hsa-miR-136	CLIP-seq
MIRT1387828	hsa-miR-182	CLIP-seq
MIRT1387829	hsa-miR-196a	CLIP-seq
MIRT1387830	hsa-miR-196b	CLIP-seq
MIRT1387833	hsa-miR-216b	CLIP-seq
MIRT1387834	hsa-miR-27a	CLIP-seq
MIRT1387835	hsa-miR-27b	CLIP-seq
MIRT1387837	hsa-miR-31	CLIP-seq
MIRT2116182	hsa-miR-3154	CLIP-seq
MIRT2116183	hsa-miR-3161	CLIP-seq
MIRT2116184	hsa-miR-3202	CLIP-seq
MIRT1387842	hsa-miR-329	CLIP-seq
MIRT1387844	hsa-miR-331-5p	CLIP-seq
MIRT2116185	hsa-miR-361-3p	CLIP-seq
MIRT1387851	hsa-miR-362-3p	CLIP-seq
MIRT1387852	hsa-miR-3675-3p	CLIP-seq
MIRT2116186	hsa-miR-3679-3p	CLIP-seq
MIRT1387854	hsa-miR-3927	CLIP-seq
MIRT1387855	hsa-miR-3941	CLIP-seq
MIRT2116187	hsa-miR-4272	CLIP-seq
MIRT2116188	hsa-miR-4278	CLIP-seq
MIRT1387858	hsa-miR-4305	CLIP-seq
MIRT2116189	hsa-miR-4462	CLIP-seq
MIRT2116190	hsa-miR-4489	CLIP-seq
MIRT2116191	hsa-miR-4533	CLIP-seq
MIRT2116192	hsa-miR-4640-3p	CLIP-seq
MIRT2116193	hsa-miR-466	CLIP-seq
MIRT2116194	hsa-miR-4672	CLIP-seq
MIRT1387866	hsa-miR-4684-5p	CLIP-seq
MIRT2116195	hsa-miR-4714-3p	CLIP-seq
MIRT2116196	hsa-miR-4716-3p	CLIP-seq
MIRT2116197	hsa-miR-4721	CLIP-seq
MIRT2116198	hsa-miR-4757-5p	CLIP-seq
MIRT1387876	hsa-miR-513a-3p	CLIP-seq
MIRT1387877	hsa-miR-513a-5p	CLIP-seq
MIRT1387878	hsa-miR-518a-5p	CLIP-seq
MIRT1387879	hsa-miR-527	CLIP-seq
MIRT1387880	hsa-miR-539	CLIP-seq
MIRT1387892	hsa-miR-603	CLIP-seq
MIRT2116199	hsa-miR-663b	CLIP-seq
MIRT2338712	hsa-miR-1179	CLIP-seq
MIRT2338713	hsa-miR-1245b-3p	CLIP-seq
MIRT2338714	hsa-miR-1273f	CLIP-seq
MIRT2338715	hsa-miR-1297	CLIP-seq
MIRT1387827	hsa-miR-136	CLIP-seq
MIRT2338716	hsa-miR-143	CLIP-seq
MIRT1387831	hsa-miR-203	CLIP-seq
MIRT2338717	hsa-miR-26a	CLIP-seq
MIRT2338718	hsa-miR-26b	CLIP-seq
MIRT1387840	hsa-miR-3153	CLIP-seq
MIRT2116183	hsa-miR-3161	CLIP-seq
MIRT1387841	hsa-miR-3184	CLIP-seq
MIRT1387843	hsa-miR-330-3p	CLIP-seq
MIRT1387844	hsa-miR-331-5p	CLIP-seq
MIRT2338719	hsa-miR-3682-3p	CLIP-seq
MIRT1387856	hsa-miR-423-5p	CLIP-seq
MIRT2116187	hsa-miR-4272	CLIP-seq
MIRT1387861	hsa-miR-4438	CLIP-seq
MIRT2338720	hsa-miR-4465	CLIP-seq
MIRT1387863	hsa-miR-450b-5p	CLIP-seq
MIRT2338721	hsa-miR-4699-5p	CLIP-seq
MIRT2338722	hsa-miR-4708-5p	CLIP-seq
MIRT2116195	hsa-miR-4714-3p	CLIP-seq
MIRT2338723	hsa-miR-4770	CLIP-seq
MIRT2338724	hsa-miR-508-5p	CLIP-seq
MIRT1387875	hsa-miR-5095	CLIP-seq
MIRT1387876	hsa-miR-513a-3p	CLIP-seq
MIRT1387878	hsa-miR-518a-5p	CLIP-seq
MIRT1387879	hsa-miR-527	CLIP-seq
MIRT2338725	hsa-miR-548ac	CLIP-seq
MIRT1387882	hsa-miR-548ae	CLIP-seq
MIRT1387884	hsa-miR-548aj	CLIP-seq
MIRT1387885	hsa-miR-548am	CLIP-seq
MIRT2338726	hsa-miR-548d-3p	CLIP-seq
MIRT1387888	hsa-miR-548x	CLIP-seq
MIRT2338727	hsa-miR-548z	CLIP-seq
MIRT2632141	hsa-miR-1226	CLIP-seq
MIRT2632142	hsa-miR-1296	CLIP-seq
MIRT2632143	hsa-miR-1587	CLIP-seq
MIRT2632144	hsa-miR-18a	CLIP-seq
MIRT2632145	hsa-miR-18b	CLIP-seq
MIRT2632146	hsa-miR-2278	CLIP-seq
MIRT2632147	hsa-miR-2909	CLIP-seq
MIRT2632148	hsa-miR-2964a-5p	CLIP-seq
MIRT2632149	hsa-miR-3065-3p	CLIP-seq
MIRT1387845	hsa-miR-342-3p	CLIP-seq
MIRT1387853	hsa-miR-377	CLIP-seq
MIRT2632150	hsa-miR-4417	CLIP-seq
MIRT2632151	hsa-miR-4492	CLIP-seq
MIRT2632152	hsa-miR-4498	CLIP-seq
MIRT2632153	hsa-miR-4505	CLIP-seq
MIRT2632154	hsa-miR-4509	CLIP-seq
MIRT2632155	hsa-miR-4512	CLIP-seq
MIRT1387864	hsa-miR-4514	CLIP-seq
MIRT2632156	hsa-miR-4656	CLIP-seq
MIRT2632157	hsa-miR-4675	CLIP-seq
MIRT1387867	hsa-miR-4692	CLIP-seq
MIRT2632158	hsa-miR-4735-3p	CLIP-seq
MIRT2632159	hsa-miR-4741	CLIP-seq
MIRT2632160	hsa-miR-4783-3p	CLIP-seq
MIRT2632161	hsa-miR-541	CLIP-seq
MIRT2632162	hsa-miR-548m	CLIP-seq
MIRT2632163	hsa-miR-550a	CLIP-seq
MIRT2632164	hsa-miR-550b	CLIP-seq
MIRT2632165	hsa-miR-634	CLIP-seq
MIRT2632166	hsa-miR-646	CLIP-seq
MIRT2632167	hsa-miR-654-5p	CLIP-seq
MIRT2632168	hsa-miR-762	CLIP-seq
MIRT1387853	hsa-miR-377	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001655	Process	Urogenital system development	IEA
GO:0001889	Process	Liver development	IEA
GO:0003865	Function	3-oxo-5-alpha-steroid 4-dehydrogenase activity	IBA
GO:0003865	Function	3-oxo-5-alpha-steroid 4-dehydrogenase activity	IDA	17986282
GO:0003865	Function	3-oxo-5-alpha-steroid 4-dehydrogenase activity	IEA
GO:0003865	Function	3-oxo-5-alpha-steroid 4-dehydrogenase activity	TAS
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006694	Process	Steroid biosynthetic process	IEA
GO:0006702	Process	Androgen biosynthetic process	IBA
GO:0006702	Process	Androgen biosynthetic process	IEA
GO:0006702	Process	Androgen biosynthetic process	TAS
GO:0006710	Process	Androgen catabolic process	IEA
GO:0007530	Process	Sex determination	NAS	1686016
GO:0007548	Process	Sex differentiation	IEA
GO:0008202	Process	Steroid metabolic process	IEA
GO:0008209	Process	Androgen metabolic process	IEA
GO:0008584	Process	Male gonad development	IBA
GO:0008584	Process	Male gonad development	IEA
GO:0009055	Function	Electron transfer activity	TAS	1686016
GO:0009267	Process	Cellular response to starvation	IEA
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0014850	Process	Response to muscle activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016101	Process	Diterpenoid metabolic process	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016627	Function	Oxidoreductase activity, acting on the CH-CH group of donors	IEA
GO:0021510	Process	Spinal cord development	IEA
GO:0021766	Process	Hippocampus development	IEA
GO:0021794	Process	Thalamus development	IEA
GO:0021854	Process	Hypothalamus development	IEA
GO:0021983	Process	Pituitary gland development	IEA
GO:0021987	Process	Cerebral cortex development	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030539	Process	Male genitalia development	IEA
GO:0030540	Process	Female genitalia development	IEA
GO:0032354	Process	Response to follicle-stimulating hormone	IEA
GO:0032355	Process	Response to estradiol	IEA
GO:0032869	Process	Cellular response to insulin stimulus	IEA
GO:0033218	Function	Amide binding	IEA
GO:0033574	Process	Response to testosterone	IEA
GO:0042428	Process	Serotonin metabolic process	IEA
GO:0042448	Process	Progesterone metabolic process	IEA
GO:0043025	Component	Neuronal cell body	IBA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043627	Process	Response to estrogen	IEA
GO:0047751	Function	3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0060348	Process	Bone development	IEA
GO:0060416	Process	Response to growth hormone	IEA
GO:0060992	Process	Response to fungicide	IEA
GO:0070402	Function	NADPH binding	IEA
GO:0070852	Component	Cell body fiber	IEA
GO:0071320	Process	Cellular response to cAMP	IEA
GO:0071363	Process	Cellular response to growth factor stimulus	IEA
GO:0071392	Process	Cellular response to estradiol stimulus	IEA
GO:0071394	Process	Cellular response to testosterone stimulus	IEA
GO:0071549	Process	Cellular response to dexamethasone stimulus	IEA
GO:0071872	Process	Cellular response to epinephrine stimulus	IEA
GO:1904015	Process	Cellular response to serotonin	IEA

Other IDs

• MIM: 184753
• HGNC: 11284
• e!Ensembl: ENSG00000145545

Protein

• UniProt ID: P18405
• Protein name: 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC 1.3.1.22) (SR type 1) (Steroid 5-alpha-reductase 1) (S5AR 1)
• Protein function: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02544	Steroid_dh	110 → 259	3-oxo-5-alpha-steroid 4-dehydrogenase	Family

• Tissue specificity: TISSUE SPECIFICITY: Liver and prostate (at a low level).
• Sequence:

  MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
  LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
  IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
  TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
  LRKFEEYPKFRKIIIPFLF

• Sequence length: 259

Pathways

KEGG:

Steroid hormone biosynthesis
Metabolic pathways

Reactome:

Androgen biosynthesis

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Ovarian serous cystadenocarcinoma	Uncertain significance	rs201816903	RCV005927166

Associations from Text Mining
Disease Name	Relationship Type	References
Alcoholism	Associate	21323680
Alopecia	Associate	36460729
Breast Neoplasms	Associate	15212687
Calcinosis Cutis	Stimulate	22971343
Cardiac Output Low	Associate	34788622
Disorders of Sex Development	Associate	35432193
Hirsutism	Associate	21676395
Hyperandrogenism	Associate	16100771
Metabolic Syndrome	Associate	29084161
Neoplasm Metastasis	Associate	24244276
Neoplasms	Associate	25371445, 30538099, 34788622
Polycystic Ovary Syndrome	Associate	38537477
Prostatic Hyperplasia	Associate	29084161
Prostatic Neoplasms	Associate	23258647, 25371445, 27164191, 30538099
Stomach Neoplasms	Associate	27893427
Triple Negative Breast Neoplasms	Associate	25356777
Urinary Bladder Neoplasms	Associate	21323680