SPRR2A (small proline rich protein 2A)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6700
Gene name Gene Name - the full gene name approved by the HGNC.
Small proline rich protein 2A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SPRR2A
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q21.3
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
miRTarBase ID miRNA Experiments Reference
MIRT2338135 hsa-miR-3121-5p CLIP-seq
MIRT2338136 hsa-miR-4690-3p CLIP-seq
MIRT2338137 hsa-miR-617 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
Transcription factor Regulation Reference
ELF3 Activation 10773884
POU2F3 Unknown 8816448
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001533 Component Cornified envelope IEA
GO:0001533 Component Cornified envelope TAS
GO:0005515 Function Protein binding IPI 18155796
GO:0005576 Component Extracellular region IDA 34735226
GO:0005576 Component Extracellular region IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
182267 11261 ENSG00000241794
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P35326
Protein name Small proline-rich protein 2A (SPR-2A) (2-1)
Protein function Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bea
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14820 SPRR2 2 → 69 Small proline-rich 2 Family
Tissue specificity TISSUE SPECIFICITY: Expressed in intestine; selectively expressed in goblet cells. {ECO:0000269|PubMed:34735226}.
Sequence
Sequence length 72
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Formation of the cornified envelope
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Glioblastoma Glioblastoma N/A N/A GWAS
Show/Hide Text Mining Associations (27)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Allergic Fungal Sinusitis Stimulate 28859701
Aortic Aneurysm Abdominal Inhibit 26771601
Autoimmune Diseases Associate 22933251
Autoimmune Pancreatitis Associate 32147308
Calcinosis Cutis Inhibit 30108165
Colitis Lymphocytic Associate 25232259
Colitis Ulcerative Associate 25232259
Diabetes Mellitus Type 1 Associate 6440310
Diabetic Retinopathy Associate 35304162
Disease Associate 30108165