SPRR2A (small proline rich protein 2A)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID 6700
Gene name Small proline rich protein 2A
Gene symbol SPRR2A
Synonyms (NCBI Gene)
-
Chromosome 1
Chromosome location 1q21.3
miRNA miRNA information provided by mirtarbase database.
3
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
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miRTarBase ID miRNA Experiments Reference
MIRT2338135 hsa-miR-3121-5p CLIP-seq
MIRT2338136 hsa-miR-4690-3p CLIP-seq
MIRT2338137 hsa-miR-617 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
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Transcription factor Regulation Reference
ELF3 Activation 10773884
POU2F3 Unknown 8816448
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
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GO ID Ontology Definition Evidence Reference
GO:0001533 Component Cornified envelope IEA
GO:0001533 Component Cornified envelope TAS
GO:0005515 Function Protein binding IPI 18155796
GO:0005576 Component Extracellular region IDA 34735226
GO:0005576 Component Extracellular region IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
182267 11261 ENSG00000241794
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P35326
Protein name Small proline-rich protein 2A (SPR-2A) (2-1)
Protein function Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bea
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14820 SPRR2 2 → 69 Small proline-rich 2 Family
Tissue specificity TISSUE SPECIFICITY: Expressed in intestine; selectively expressed in goblet cells. {ECO:0000269|PubMed:34735226}.
Sequence
Sequence length 72
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
  Reactome
    Formation of the cornified envelope