SPRR1A (small proline rich protein 1A)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6698
Gene name Gene Name - the full gene name approved by the HGNC.
Small proline rich protein 1A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SPRR1A
Synonyms (NCBI Gene) Gene synonyms aliases
SPRK
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q21.3
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
miRTarBase ID miRNA Experiments Reference
MIRT029568 hsa-miR-26b-5p Microarray 19088304
MIRT1385954 hsa-miR-2355-5p CLIP-seq
MIRT1385955 hsa-miR-3614-5p CLIP-seq
MIRT1385956 hsa-miR-3667-3p CLIP-seq
MIRT1385957 hsa-miR-640 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
ELF3 Unknown 9733767
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001533 Component Cornified envelope IDA 7543090, 10908733
GO:0001533 Component Cornified envelope TAS
GO:0005198 Function Structural molecule activity TAS 8325635
GO:0005515 Function Protein binding IPI 10066784, 32296183
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
182265 11259 ENSG00000169474
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P35321
Protein name Cornifin-A (19 kDa pancornulin) (SPRK) (Small proline-rich protein IA) (SPR-IA)
Protein function Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02389 Cornifin 17 → 73 Disordered
PF02389 Cornifin 59 → 87 Disordered
Sequence
Sequence length 89
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Formation of the cornified envelope
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Carcinoma Squamous cell carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 8617999
Show/Hide Text Mining Associations (18)
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 25424702
Carcinoma Pancreatic Ductal Associate 35617311
Carcinoma Squamous Cell Associate 25424702
Carcinoma Squamous Cell Stimulate 9008234
Dermatitis Atopic Associate 27304082, 32213830
Esophageal Squamous Cell Carcinoma Inhibit 25424702
Gingivitis Associate 29779262
Keratoconus Associate 36240204
Kimura Disease Stimulate 9008234
Lymphoma Large B Cell Diffuse Associate 24886019