SPP1 (secreted phosphoprotein 1)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6696
Gene name Gene Name - the full gene name approved by the HGNC.
Secreted phosphoprotein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SPP1
Synonyms (NCBI Gene) Gene synonyms aliases
BNSP, BSPI, ETA-1, OPN
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane an
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT004565 hsa-miR-299-5p immunoblot 19538464
MIRT004565 hsa-miR-299-5p qRT-PCR 19538464
MIRT004565 hsa-miR-299-5p Luciferase reporter assay 19538464
MIRT004565 hsa-miR-299-5p Luciferase reporter assay 19538464
MIRT004565 hsa-miR-299-5p immunoblot, Luciferase reporter assay, Microarray, qRT-PCR 19538464
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(12)
Transcription factor Regulation Reference
CEBPA Activation 14712233
ERG Activation 21669963
FOXD3 Activation 11891324
HDAC1 Repression 20609221;22422937
HTATIP2 Repression 18537194;19349353
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001503 Process Ossification IEA
GO:0001649 Process Osteoblast differentiation IBA
GO:0001649 Process Osteoblast differentiation IEA
GO:0005125 Function Cytokine activity IEA
GO:0005178 Function Integrin binding IPI 25839998
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
166490 11255 ENSG00000118785
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P10451
Protein name Osteopontin (Bone sialoprotein 1) (Nephropontin) (Secreted phosphoprotein 1) (SPP-1) (Urinary stone protein) (Uropontin)
Protein function Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. ; Acts as a cytokine inv
PDB 3CXD , 3DSF , 9EOU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00865 Osteopontin 21 → 314 Osteopontin Family
Tissue specificity TISSUE SPECIFICITY: Detected in cerebrospinal fluid and urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717). Bone. Found in plasma. {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313, ECO:0000269|PubMed:37453717}.
Sequence
Sequence length 314
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  PI3K-Akt signaling pathway
Apelin signaling pathway
Focal adhesion
ECM-receptor interaction
Toll-like receptor signaling pathway
GnRH secretion
Human papillomavirus infection 		  Degradation of the extracellular matrix
Signaling by PDGF
Integrin cell surface interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
RUNX3 Regulates Immune Response and Cell Migration
Post-translational protein phosphorylation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (3)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Gout Gout N/A N/A GWAS
Otosclerosis Otosclerosis N/A N/A GWAS
Systemic lupus erythematosus systemic lupus erythematosus N/A N/A GenCC
Show/Hide Text Mining Associations (482)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
3C syndrome Associate 18442196
Acidemia isovaleric Associate 26491674
Acro Osteolysis Stimulate 19369175
Acrogeria gottron type Associate 22456539
Acute Coronary Syndrome Stimulate 22711477
Acute Coronary Syndrome Associate 31530226
Acute Kidney Injury Stimulate 30582197
Acute On Chronic Liver Failure Associate 37257271
Adamantinoma Associate 21983933
Adenocarcinoma Associate 15136764, 20349162, 24299561, 26068949, 26081616