Gene Gene information from NCBI Gene database.
Entrez ID 6693
Gene name Sialophorin
Gene symbol SPN
Synonyms (NCBI Gene)
CD43GALGPGPL115LEU-22LSN
Chromosome 16
Chromosome location 16p11.2
Summary This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular
miRNA miRNA information provided by mirtarbase database.
1071
miRTarBase ID miRNA Experiments Reference
MIRT052328 hsa-let-7b-5p CLASH 23622248
MIRT051630 hsa-let-7e-5p CLASH 23622248
MIRT710297 hsa-miR-590-3p HITS-CLIP 19536157
MIRT710296 hsa-miR-6765-3p HITS-CLIP 19536157
MIRT710295 hsa-miR-1279 HITS-CLIP 19536157
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
SP1 Activation 8055899
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
59
GO ID Ontology Definition Evidence Reference
GO:0001562 Process Response to protozoan IEA
GO:0001808 Process Negative regulation of type IV hypersensitivity IEA
GO:0001931 Component Uropod IEA
GO:0001931 Component Uropod ISS
GO:0002296 Process T-helper 1 cell lineage commitment IDA 18036228
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
182160 11249 ENSG00000197471
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P16150
Protein name Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)]
Protein function Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its
Family and domains
Tissue specificity TISSUE SPECIFICITY: Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
Sequence
MATLLLLLGVLVVSPDALGSTTAVQTPTSGEPLVSTSEPLSSKMYTTSITSDPKADSTGD
QTSALPPSTSINEGSPLWTSIGASTGSPLPEPTTYQEVSIKMSSVPQETPHATSHPAVPI
TANSLGSHTVTGGTITTNSPETSSRTSGAPVTTAASSLETSRGTSGPPLTMATVSLETSK
GTSGPPVTMATDSLETSTGTTGPPVTMTTGSLEPSSGASGPQVSSVKLSTMMSPTTSTNA
STVPFRNPDENSRGMLPVAVLVALLAVIVLVALLLLWRRRQKRRTGALVLSRGGKRNGVV
DAWAGPAQVPEEGAVTVTVGGSGGDKGSGFPDGEGSSRRPTLTTFFGRRKSRQGSLAMEE
LKSGSGPSLKGEEEPLVASEDGAVDAPAPDEPEGGDGAAP
Sequence length 400
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cell adhesion molecules   Cell surface interactions at the vascular wall
Basigin interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
9
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
SPN-related disorder Benign; Likely benign rs1050881, rs1555489927, rs11574556, rs139180392, rs377094142, rs368227662, rs2229654, rs2229653, rs75737897 RCV003974587
RCV003942102
RCV003919416
RCV003941729
RCV003949490
RCV003934645
RCV003972953
RCV003975614
RCV003920547
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Anemia Diamond Blackfan Associate 31157955
Anemia Refractory with Excess of Blasts Associate 10602163
Arthritis Rheumatoid Inhibit 7621589
Arthritis Rheumatoid Associate 9665944
Burkitt Lymphoma Associate 25612555
Burkitt Lymphoma Stimulate 28509416
Carcinogenesis Associate 21372249
Carcinoma Adenoid Cystic Associate 26191305
Chromosome 12 12p trisomy Inhibit 18061951
Chromosome 12 12p trisomy Associate 28187524