Gene Gene information from NCBI Gene database.
Entrez ID 6678
Gene name Secreted protein acidic and cysteine rich
Gene symbol SPARC
Synonyms (NCBI Gene)
BM-40OI17ONONT
Chromosome 5
Chromosome location 5q33.1
Summary This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene produc
SNPs SNP information provided by dbSNP.
2
SNP ID Visualize variation Clinical significance Consequence
rs1057517662 C>T Pathogenic Missense variant, coding sequence variant
rs1057517663 C>T Pathogenic Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
1255
miRTarBase ID miRNA Experiments Reference
MIRT001922 hsa-miR-29c-3p Luciferase reporter assay 18390668
MIRT001922 hsa-miR-29c-3p Luciferase reporter assay 18390668
MIRT004126 hsa-miR-192-5p Microarray 16822819
MIRT001922 hsa-miR-29c-3p ImmunohistochemistryqRT-PCR 21125666
MIRT006175 hsa-miR-29a-3p Luciferase reporter assayMicroarrayNorthern blotqRT-PCRWestern blot 21880628
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
SATB1 Activation 17343824
VHL Activation 15824735
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34
GO ID Ontology Definition Evidence Reference
GO:0001937 Process Negative regulation of endothelial cell proliferation IDA 12867428
GO:0005201 Function Extracellular matrix structural constituent RCA 28327460
GO:0005509 Function Calcium ion binding IBA
GO:0005509 Function Calcium ion binding IDA 7034958
GO:0005509 Function Calcium ion binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
182120 11219 ENSG00000113140
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P09486
Protein name SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine)
Protein function Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acid
PDB 1BMO , 1NUB , 1SRA , 2V53
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09289 FOLN 72 93 Follistatin/Osteonectin-like EGF domain Domain
PF00050 Kazal_1 95 149 Kazal-type serine protease inhibitor domain Domain
PF10591 SPARC_Ca_bdg 152 289 Secreted protein acidic and rich in cysteine Ca binding region Domain
Sequence
Sequence length 303
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Platelet degranulation
Nuclear signaling by ERBB4
ECM proteoglycans
Scavenging by Class H Receptors
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
48
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Osteogenesis imperfecta type 17 Pathogenic rs112382148, rs1057517662, rs1057517663 RCV003988721
RCV000412625
RCV000412523
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Clear cell carcinoma of kidney Benign rs6874468 RCV005925317
Colon adenocarcinoma Benign rs6874468 RCV005925316
Colorectal cancer Benign rs6874468 RCV005925318
Familial cancer of breast Conflicting classifications of pathogenicity rs199932910 RCV005907493
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Coronary Syndrome Inhibit 20976234
Adenocarcinoma Stimulate 14562024
Adenocarcinoma Associate 39938232
Adenocarcinoma of Lung Associate 15756262, 31296175
Adenoma Associate 30175151
Agricultural Workers' Diseases Associate 25126876
Alzheimer Disease Associate 30883351
Androgen Insensitivity Syndrome Associate 34867780
Anthracosis Associate 25126876
Aortic Valve Disease Associate 32089075