Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6678
Gene name Gene Name - the full gene name approved by the HGNC.
Secreted protein acidic and cysteine rich
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SPARC
Synonyms (NCBI Gene) Gene synonyms aliases
BM-40, OI17, ON, ONT
Disease Acronyms (UniProt) Disease acronyms from UniProt database
OI17
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q33.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene produc
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs1057517662 C>T Pathogenic Missense variant, coding sequence variant
rs1057517663 C>T Pathogenic Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001922 hsa-miR-29c-3p Luciferase reporter assay 18390668
MIRT001922 hsa-miR-29c-3p Luciferase reporter assay 18390668
MIRT004126 hsa-miR-192-5p Microarray 16822819
MIRT001922 hsa-miR-29c-3p Immunohistochemistry, qRT-PCR 21125666
MIRT006175 hsa-miR-29a-3p Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot 21880628
Transcription factors
Transcription factor Regulation Reference
SATB1 Activation 17343824
VHL Activation 15824735
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001503 Process Ossification IEA
GO:0001937 Process Negative regulation of endothelial cell proliferation IDA 12867428
GO:0002576 Process Platelet degranulation TAS
GO:0005201 Function Extracellular matrix structural constituent RCA 28327460
GO:0005509 Function Calcium ion binding IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
182120 11219 ENSG00000113140
Protein
UniProt ID P09486
Protein name SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine)
Protein function Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acid
PDB 1BMO , 1NUB , 1SRA , 2V53
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09289 FOLN 72 93 Follistatin/Osteonectin-like EGF domain Domain
PF00050 Kazal_1 95 149 Kazal-type serine protease inhibitor domain Domain
PF10591 SPARC_Ca_bdg 152 289 Secreted protein acidic and rich in cysteine Ca binding region Domain
Sequence
Sequence length 303
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Platelet degranulation
Nuclear signaling by ERBB4
ECM proteoglycans
Scavenging by Class H Receptors
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Adrenocortical carcinoma Adrenocortical carcinoma rs121912656, rs28934874, rs121912662, rs786202525, rs121912664, rs397516435, rs121913343, rs587780070, rs121912666, rs55832599, rs587782144, rs587782272, rs587782529, rs587782620, rs587782664
View all (30 more)
22156929
Colonic neoplasms Malignant tumor of colon, Colonic Neoplasms rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 17397030
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
18458674
Colorectal neoplasms Colorectal Neoplasms rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
18458674
Unknown
Disease term Disease name Evidence References Source
Osteogenesis Imperfecta osteogenesis imperfecta type 4 GenCC
Ischemic Stroke Ischemic Stroke GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acute Coronary Syndrome Inhibit 20976234
Adenocarcinoma Stimulate 14562024
Adenocarcinoma Associate 39938232
Adenocarcinoma of Lung Associate 15756262, 31296175
Adenoma Associate 30175151
Agricultural Workers' Diseases Associate 25126876
Alzheimer Disease Associate 30883351
Androgen Insensitivity Syndrome Associate 34867780
Anthracosis Associate 25126876
Aortic Valve Disease Associate 32089075