Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6650
Gene name	Calpain 15
Gene symbol	CAPN15
Synonyms (NCBI Gene)	OGINSOLH
Chromosome	16
Chromosome location	16p13.3
Summary	This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during visual system development. [prov

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miRTarBase ID	miRNA	Experiments	Reference
MIRT115781	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT115779	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT115778	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT115786	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT115784	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT115782	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT115787	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT115788	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT494386	hsa-miR-3609	PAR-CLIP	23592263
MIRT494385	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT494384	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT115783	hsa-miR-142-5p	PAR-CLIP	23592263
MIRT115798	hsa-miR-5590-3p	PAR-CLIP	23592263
MIRT115793	hsa-miR-4469	PAR-CLIP	23592263
MIRT494383	hsa-miR-7113-3p	PAR-CLIP	23592263
MIRT494382	hsa-miR-4287	PAR-CLIP	23592263
MIRT494380	hsa-miR-4685-3p	PAR-CLIP	23592263
MIRT494381	hsa-miR-6835-5p	PAR-CLIP	23592263
MIRT115800	hsa-miR-6752-5p	PAR-CLIP	23592263
MIRT115807	hsa-miR-6842-5p	PAR-CLIP	23592263
MIRT115812	hsa-miR-7110-5p	PAR-CLIP	23592263
MIRT115795	hsa-miR-4651	PAR-CLIP	23592263
MIRT115789	hsa-miR-608	PAR-CLIP	23592263
MIRT115801	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT115802	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT115780	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT494379	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT494378	hsa-miR-3151-5p	PAR-CLIP	23592263
MIRT115792	hsa-miR-4447	PAR-CLIP	23592263
MIRT115794	hsa-miR-4472	PAR-CLIP	23592263
MIRT494377	hsa-miR-6742-5p	PAR-CLIP	23592263
MIRT115808	hsa-miR-6867-3p	PAR-CLIP	23592263
MIRT115799	hsa-miR-6751-5p	PAR-CLIP	23592263
MIRT115805	hsa-miR-6803-5p	PAR-CLIP	23592263
MIRT115804	hsa-miR-6796-5p	PAR-CLIP	23592263
MIRT284424	hsa-miR-1321	PAR-CLIP	23592263
MIRT284431	hsa-miR-4739	PAR-CLIP	23592263
MIRT284433	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT494376	hsa-miR-4688	PAR-CLIP	23592263
MIRT494375	hsa-miR-6743-5p	PAR-CLIP	23592263
MIRT284426	hsa-miR-4270	PAR-CLIP	23592263
MIRT284428	hsa-miR-4441	PAR-CLIP	23592263
MIRT284435	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT494374	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT494372	hsa-miR-3176	PAR-CLIP	23592263
MIRT494373	hsa-miR-3922-3p	PAR-CLIP	23592263
MIRT494371	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT494370	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT494369	hsa-miR-4757-5p	PAR-CLIP	23592263
MIRT494368	hsa-miR-6744-3p	PAR-CLIP	23592263
MIRT494367	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT494366	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT494365	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT494363	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT494364	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT494362	hsa-miR-6878-3p	PAR-CLIP	23592263
MIRT115781	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT115779	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT115778	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT115786	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT115784	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT115782	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT115787	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT115788	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT754885	hsa-miR-3609	PAR-CLIP	23592263
MIRT754886	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT754887	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT115783	hsa-miR-142-5p	PAR-CLIP	23592263
MIRT115798	hsa-miR-5590-3p	PAR-CLIP	23592263
MIRT115793	hsa-miR-4469	PAR-CLIP	23592263
MIRT754888	hsa-miR-7113-3p	PAR-CLIP	23592263
MIRT754889	hsa-miR-4287	PAR-CLIP	23592263
MIRT754890	hsa-miR-4685-3p	PAR-CLIP	23592263
MIRT754891	hsa-miR-6835-5p	PAR-CLIP	23592263
MIRT115800	hsa-miR-6752-5p	PAR-CLIP	23592263
MIRT115807	hsa-miR-6842-5p	PAR-CLIP	23592263
MIRT115812	hsa-miR-7110-5p	PAR-CLIP	23592263
MIRT115795	hsa-miR-4651	PAR-CLIP	23592263
MIRT115789	hsa-miR-608	PAR-CLIP	23592263
MIRT115801	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT115802	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT115780	hsa-miR-92a-2-5p	PAR-CLIP	23592263
MIRT754892	hsa-miR-491-5p	PAR-CLIP	23592263
MIRT754893	hsa-miR-3151-5p	PAR-CLIP	23592263
MIRT115792	hsa-miR-4447	PAR-CLIP	23592263
MIRT115794	hsa-miR-4472	PAR-CLIP	23592263
MIRT754894	hsa-miR-6742-5p	PAR-CLIP	23592263
MIRT115808	hsa-miR-6867-3p	PAR-CLIP	23592263
MIRT115799	hsa-miR-6751-5p	PAR-CLIP	23592263
MIRT115805	hsa-miR-6803-5p	PAR-CLIP	23592263
MIRT115804	hsa-miR-6796-5p	PAR-CLIP	23592263
MIRT284424	hsa-miR-1321	PAR-CLIP	23592263
MIRT284431	hsa-miR-4739	PAR-CLIP	23592263
MIRT284433	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT754895	hsa-miR-4688	PAR-CLIP	23592263
MIRT754896	hsa-miR-6743-5p	PAR-CLIP	23592263
MIRT284426	hsa-miR-4270	PAR-CLIP	23592263
MIRT284428	hsa-miR-4441	PAR-CLIP	23592263
MIRT284435	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT754897	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT754898	hsa-miR-3176	PAR-CLIP	23592263
MIRT754899	hsa-miR-3922-3p	PAR-CLIP	23592263
MIRT754900	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT754901	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT754902	hsa-miR-4757-5p	PAR-CLIP	23592263
MIRT754903	hsa-miR-6744-3p	PAR-CLIP	23592263
MIRT754904	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT754905	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT754906	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT754907	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT754908	hsa-miR-486-3p	PAR-CLIP	23592263
MIRT754909	hsa-miR-6878-3p	PAR-CLIP	23592263

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IBA
GO:0004198	Function	Calcium-dependent cysteine-type endopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005737	Component	Cytoplasm	IBA
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008234	Function	Cysteine-type peptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
603267	11182	ENSG00000103326

O75808

Protein name

Calpain-15 (EC 3.4.22.-) (Small optic lobes homolog)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00641	zf-RanBP	4 → 32	Zn-finger in Ran binding protein and others	Domain
PF00641	zf-RanBP	143 → 172	Zn-finger in Ran binding protein and others	Domain
PF00641	zf-RanBP	412 → 441	Zn-finger in Ran binding protein and others	Domain
PF00648	Peptidase_C2	488 → 791	Calpain family cysteine protease	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with higher expression in brain. {ECO:0000269|PubMed:9722942}.

Sequence

MATVGEWSCVRCTFLNPAGQRQCSICEAPRHKPDLNHILRLSVEEQKWPCARCTFRNFLG
KEACEVCGFTPEPAPGAAFLPVLNGVLPKPPAILGEPKGSCQEEAGPVRTAGLVATEPAR
GQCEDKDEEEKEEQEEEEGAAEPRGGWACPRCTLHNTPVASSCSVCGGPRRLSLPRIPPE
ALVVPEVVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSSTLQ
NNPVPRSRREVPPQLQPPVPEAAQPSPSAGCRGAPQGSGWAGASRLAELLSGKRLSVLEE
EATEGGTSRVEAGSSTSGSDIIDLAGDTVRYTPASPSSPDFTTWSCAKCTLRNPTVAPRC
SACGCSKLHGFQEHGEPPTHCPDCGADKPSPCGRSCGRVSSAQKAARVLPERPGQWACPA
CTLLNALRAKHCAACHTPQLLVAQRRGAAPLRRRESMHVEQRRQTDEGEAKALWENIVAF
CRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHTLR
PSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAEGAYQVRLCKDGTWTTVLVDD
MLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCESLA
LQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRPRHAYS
ILDVRDVQGTRLLRLRNPWGRFSWNGSWSDEWPHWPGHLRGELMPHGSSEGVFWMEYGDF
VRYFDSVDICKVHSDWQEARVQGCFPSSASAPVGVTALTVLERASLEFALFQEGSRRSDA
VDSHLLDLCILVFRATFGSGGHLSLGRLLAHSKRAVKKFVSCDVMLEPGEYAVVCCAFNH
WGPPLPGTPAPQASSPSAGVPRASPEPPGHVLAVYSSRLVMVEPVEAQPTTLADAIILLT
ESRGERHEGREGMTCYYLTHGWAGLIVVVENRHPKAYLHVQCDCTDSFNVVSTRGSLRTQ
DSVPPLHRQVLVILSQLEGNAGFSITHRLAHRKAAQAFLSDWTASKGTHSPPLTPEVAGL
HGPRPL

Sequence length

1086

Interactions

View interactions

	Reactome
			Degradation of the extracellular matrix

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Oculogastrointestinal-neurodevelopmental syndrome	Pathogenic	rs2142085042, rs2142072159, rs762523863, rs2142086271, rs2142084042	RCV001387527 RCV001387528 RCV001387530 RCV001387531 RCV001387533

Show/Hide Unknown Diseases (13)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Likely benign	rs146637756	RCV005927303
Adrenocortical carcinoma, hereditary	Conflicting classifications of pathogenicity	rs1441582052	RCV005871162
CAPN15-related disorder	Uncertain significance; Likely benign; Benign; Conflicting classifications of pathogenicity	rs144209708, rs773799955, rs763566668, rs145595428, rs146637756, rs2505842019, rs141227716, rs572003179, rs141612773, rs149502771, rs145916590, rs142810996, rs147299088, rs371731942, rs373834069 View all (34 more)	RCV003933697 RCV003936647 RCV003928923 RCV003984354 RCV003973779 RCV003412437 RCV003938929 RCV003929062 RCV003938930 RCV003938931 RCV003938932 RCV003938933 RCV003966363 RCV003919123 RCV003929063 RCV003919124 RCV003929064 RCV003966364 RCV003949092 RCV003956644 RCV003909487 RCV003924155 RCV003929597 RCV003906860 RCV003984678 RCV003903883 RCV003899459 RCV003941945 RCV003944561 RCV003944599 RCV003954935 RCV003927139 RCV003939718 RCV003914357 RCV003924741 RCV003969267 RCV003922156 RCV003922243 RCV003922283 RCV003924681 RCV003934336 RCV003956808 RCV003971748 RCV003971499 RCV003971545 RCV003967164 RCV003969422 RCV004753749 RCV003935911
Cervical cancer	Likely benign	rs144075530	RCV005938834
Colon adenocarcinoma	Likely benign	rs201572166	RCV005929389
Colorectal cancer	Likely benign	rs201572166	RCV005929391
Familial cancer of breast	Likely benign	rs144075530	RCV005938833
Gastric cancer	Likely benign	rs144075530	RCV005938836
Hepatocellular carcinoma	Likely benign	rs201572166	RCV005929390
Lung cancer	Likely benign	rs201572166, rs144075530	RCV005929393 RCV005938837
Malignant tumor of urinary bladder	Likely benign	rs202055221	RCV005938726
Sarcoma	Likely benign	rs201572166, rs144075530	RCV005929392 RCV005938835
Thymoma	Likely benign	rs374456445	RCV005933494

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Dehydrated Hereditary Stomatocytosis Pseudohyperkalemia and Perinatal Edema	Associate	29221444
Leiomyosarcoma	Associate	22419440
Plaque Atherosclerotic	Associate	29221444

CAPN15 (calpain 15)