Gene Gene information from NCBI Gene database.
Entrez ID 665
Gene name BCL2 interacting protein 3 like
Gene symbol BNIP3L
Synonyms (NCBI Gene)
BNIP3aNIP3LNIX
Chromosome 8
Chromosome location 8p21.2
Summary This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including
miRNA miRNA information provided by mirtarbase database.
552
miRTarBase ID miRNA Experiments Reference
MIRT003359 hsa-miR-221-3p Reporter assay;Western blot;qRT-PCR;Microarray 20018759
MIRT052472 hsa-let-7a-5p CLASH 23622248
MIRT052099 hsa-let-7b-5p CLASH 23622248
MIRT054568 hsa-miR-137 ImmunofluorescenceImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 24573672
MIRT054568 hsa-miR-137 ImmunofluorescenceImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 24573672
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
42
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 9973195, 10381623, 16189514, 19060904, 20200478, 21264221, 21516116, 22645275, 24316735, 24981860, 25416956, 25910212, 27107012, 28514442, 31515488, 32296183, 33961781, 34845370
GO:0005521 Function Lamin binding IDA 10381623
GO:0005521 Function Lamin binding IPI 10381623
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605368 1085 ENSG00000104765
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O60238
Protein name BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L)
Protein function Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitoc
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06553 BNIP3 17 218 BNIP3 Family
Sequence
Sequence length 219
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Mitophagy - animal   TP53 Regulates Transcription of Genes Involved in Cytochrome C Release