Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
665
Gene name Gene Name - the full gene name approved by the HGNC.
BCL2 interacting protein 3 like
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BNIP3L
Synonyms (NCBI Gene) Gene synonyms aliases
BNIP3a, NIP3L, NIX
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p21.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003359 hsa-miR-221-3p Reporter assay;Western blot;qRT-PCR;Microarray 20018759
MIRT052472 hsa-let-7a-5p CLASH 23622248
MIRT052099 hsa-let-7b-5p CLASH 23622248
MIRT054568 hsa-miR-137 Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 24573672
MIRT054568 hsa-miR-137 Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 24573672
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 9973195, 10381623, 16189514, 19060904, 20200478, 21264221, 21516116, 22645275, 24316735, 24981860, 25416956, 25910212, 27107012, 28514442, 31515488, 32296183, 33961781, 34845370
GO:0005521 Function Lamin binding IDA 10381623
GO:0005521 Function Lamin binding IPI 10381623
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605368 1085 ENSG00000104765
Protein
UniProt ID O60238
Protein name BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L)
Protein function Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitoc
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06553 BNIP3 17 218 BNIP3 Family
Sequence
Sequence length 219
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Mitophagy - animal   TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Metabolic Syndrome Metabolic syndrome N/A N/A GWAS
Schizophrenia Schizophrenia N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Brain Ischemia Stimulate 34389795
Breast Neoplasms Associate 37610095
Colorectal Neoplasms Associate 26517689
Fibrosis Associate 35796776
Glioblastoma Associate 22984526
Glioma Associate 18670645, 22984526
Hypoxia Stimulate 12663450, 18670645, 33496385
Hypoxia Associate 22984526
Hypoxia Brain Associate 18670645
Intestinal Neoplasms Associate 35796776