Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6648
Gene name Gene Name - the full gene name approved by the HGNC.
Superoxide dismutase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SOD2
Synonyms (NCBI Gene) Gene synonyms aliases
GC1, GClnc1, IPO-B, IPOB, MNSOD, MVCD6, Mn-SOD, lncRNA-GC1
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q25.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs4880 A>G Drug-response, risk-factor, benign Coding sequence variant, 5 prime UTR variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000993 hsa-miR-377-3p Luciferase reporter assay, Western blot 18716028
MIRT000135 hsa-miR-222-3p Flow, Luciferase reporter assay, Microarray, qRT-PCR, Western blot 19487542
MIRT005745 hsa-miR-17-3p Luciferase reporter assay, Quantitative proteomic approach, Western blot 21203553
MIRT028409 hsa-miR-30a-5p Proteomics 18668040
MIRT043729 hsa-miR-342-3p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
DDB2 Repression 18431487
FOXO4 Activation 21536589
JUN Unknown 15330761
NFE2L2 Activation 22493435
NFKB1 Activation 11880364;14515147;19507253
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000302 Process Response to reactive oxygen species IEA
GO:0000303 Process Response to superoxide IEA
GO:0000303 Process Response to superoxide IMP 16179351
GO:0001666 Process Response to hypoxia IEA
GO:0001836 Process Release of cytochrome c from mitochondria IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
147460 11180 ENSG00000291237
Protein
UniProt ID P04179
Protein name Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1)
Protein function Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
PDB 1AP5 , 1AP6 , 1EM1 , 1JA8 , 1LUV , 1LUW , 1MSD , 1N0J , 1N0N , 1PL4 , 1PM9 , 1QNM , 1SZX , 1VAR , 1XDC , 1XIL , 1ZSP , 1ZTE , 1ZUQ , 2ADP , 2ADQ , 2GDS , 2P4K , 2QKA , 2QKC , 3C3S , 3C3T , 5GXO , 5T30 , 5VF9 , 7KKS , 7KKU , 7KKW , 7KLB , 8SKS , 8VHW , 8VHY , 8VJ0 , 8VJ4 , 8VJ5 , 8VJ8 , 9BVY , 9BW2 , 9BWM , 9BWQ , 9BWR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00081 Sod_Fe_N 25 106 Iron/manganese superoxide dismutases, alpha-hairpin domain Domain
PF02777 Sod_Fe_C 113 216 Iron/manganese superoxide dismutases, C-terminal domain Domain
Sequence
Sequence length 222
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  FoxO signaling pathway
Peroxisome
Longevity regulating pathway
Longevity regulating pathway - multiple species
Huntington disease
Chemical carcinogenesis - reactive oxygen species
Lipid and atherosclerosis
  Transcriptional activation of mitochondrial biogenesis
Detoxification of Reactive Oxygen Species
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Lung Cancer Non-Small Cell Lung Cancer SOD2 inhibition increases ?-Lapachone sensitivity in NSCLC 35794066 CBGDA
Myopathy cardiomyopathy N/A N/A GenCC
Prostate cancer Prostate cancer N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
3 Hydroxy 3 Methylglutaryl CoA Lyase Deficiency Associate 28377796
Abortion Habitual Inhibit 26821085
Abortion Spontaneous Associate 25140979
Achalasia Addisonianism Alacrimia syndrome Associate 34777635
Acromegaly Associate 29046499
Acute Kidney Injury Associate 26787049
Adenocarcinoma Associate 15534883, 20638682
Adenocarcinoma of Lung Inhibit 20690800
Adenocarcinoma of Lung Associate 23271813
Adenoma Associate 10363564