Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6646
Gene name	Sterol O-acyltransferase 1
Gene symbol	SOAT1
Synonyms (NCBI Gene)	ACACTACATACAT-1ACAT1SOATSTAT
Chromosome	1
Chromosome location	1q25.2
Summary	The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atheroscle

239

Show/Hide all (239)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016592	hsa-miR-193b-3p	Microarray	20304954
MIRT024321	hsa-miR-215-5p	Microarray	19074876
MIRT026807	hsa-miR-192-5p	Microarray	19074876
MIRT027734	hsa-miR-98-5p	Microarray	19088304
MIRT045139	hsa-miR-186-5p	CLASH	23622248
MIRT041152	hsa-miR-500a-3p	CLASH	23622248
MIRT035871	hsa-miR-1303	CLASH	23622248
MIRT699056	hsa-miR-512-5p	HITS-CLIP	23313552
MIRT699055	hsa-miR-510-5p	HITS-CLIP	23313552
MIRT699054	hsa-miR-4453	HITS-CLIP	23313552
MIRT699053	hsa-miR-4538	HITS-CLIP	23313552
MIRT699052	hsa-miR-4695-5p	HITS-CLIP	23313552
MIRT699051	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT699050	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT699049	hsa-miR-940	HITS-CLIP	23313552
MIRT699048	hsa-miR-3929	HITS-CLIP	23313552
MIRT699047	hsa-miR-4419b	HITS-CLIP	23313552
MIRT699046	hsa-miR-4478	HITS-CLIP	23313552
MIRT699045	hsa-miR-5690	HITS-CLIP	23313552
MIRT699044	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT699043	hsa-miR-4459	HITS-CLIP	23313552
MIRT699042	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT699041	hsa-miR-665	HITS-CLIP	23313552
MIRT699040	hsa-miR-3664-3p	HITS-CLIP	23313552
MIRT699039	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT699038	hsa-miR-1827	HITS-CLIP	23313552
MIRT699037	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT699036	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT699035	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT699034	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT699033	hsa-miR-548ac	HITS-CLIP	23313552
MIRT699032	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT699031	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT699030	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT699029	hsa-miR-548z	HITS-CLIP	23313552
MIRT699028	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT699027	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT699026	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT699025	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT699024	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT699023	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT699022	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT699021	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT699020	hsa-miR-2681-3p	HITS-CLIP	23313552
MIRT699019	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT699018	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT699056	hsa-miR-512-5p	HITS-CLIP	23313552
MIRT699055	hsa-miR-510-5p	HITS-CLIP	23313552
MIRT699054	hsa-miR-4453	HITS-CLIP	23313552
MIRT699053	hsa-miR-4538	HITS-CLIP	23313552
MIRT699052	hsa-miR-4695-5p	HITS-CLIP	23313552
MIRT699051	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT699050	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT699049	hsa-miR-940	HITS-CLIP	23313552
MIRT699048	hsa-miR-3929	HITS-CLIP	23313552
MIRT699047	hsa-miR-4419b	HITS-CLIP	23313552
MIRT699046	hsa-miR-4478	HITS-CLIP	23313552
MIRT699045	hsa-miR-5690	HITS-CLIP	23313552
MIRT699044	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT699043	hsa-miR-4459	HITS-CLIP	23313552
MIRT699042	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT699041	hsa-miR-665	HITS-CLIP	23313552
MIRT699040	hsa-miR-3664-3p	HITS-CLIP	23313552
MIRT699039	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT699038	hsa-miR-1827	HITS-CLIP	23313552
MIRT699037	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT699036	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT699035	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT699034	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT699033	hsa-miR-548ac	HITS-CLIP	23313552
MIRT699032	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT699031	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT699030	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT699029	hsa-miR-548z	HITS-CLIP	23313552
MIRT699028	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT699027	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT699026	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT699025	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT699024	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT699023	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT699022	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT699021	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT699020	hsa-miR-2681-3p	HITS-CLIP	23313552
MIRT699019	hsa-miR-3675-3p	HITS-CLIP	23313552
MIRT699018	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT1378436	hsa-miR-1297	CLIP-seq
MIRT1378437	hsa-miR-1299	CLIP-seq
MIRT1378438	hsa-miR-1825	CLIP-seq
MIRT1378439	hsa-miR-192	CLIP-seq
MIRT1378440	hsa-miR-199a-5p	CLIP-seq
MIRT1378441	hsa-miR-199b-5p	CLIP-seq
MIRT1378442	hsa-miR-202	CLIP-seq
MIRT1378443	hsa-miR-215	CLIP-seq
MIRT1378444	hsa-miR-26a	CLIP-seq
MIRT1378445	hsa-miR-26b	CLIP-seq
MIRT1378446	hsa-miR-3925-3p	CLIP-seq
MIRT1378447	hsa-miR-4257	CLIP-seq
MIRT1378448	hsa-miR-4320	CLIP-seq
MIRT1378449	hsa-miR-4465	CLIP-seq
MIRT1378450	hsa-miR-4659a-3p	CLIP-seq
MIRT1378451	hsa-miR-4659b-3p	CLIP-seq
MIRT1378452	hsa-miR-4678	CLIP-seq
MIRT1378453	hsa-miR-4705	CLIP-seq
MIRT1378454	hsa-miR-4709-5p	CLIP-seq
MIRT1378455	hsa-miR-4775	CLIP-seq
MIRT1378456	hsa-miR-4782-5p	CLIP-seq
MIRT1378457	hsa-miR-502-5p	CLIP-seq
MIRT1378458	hsa-miR-516b	CLIP-seq
MIRT1553912	hsa-miR-190	CLIP-seq
MIRT1553913	hsa-miR-190b	CLIP-seq
MIRT1553914	hsa-miR-320a	CLIP-seq
MIRT1553915	hsa-miR-320b	CLIP-seq
MIRT1553916	hsa-miR-320c	CLIP-seq
MIRT1553917	hsa-miR-320d	CLIP-seq
MIRT1553918	hsa-miR-4429	CLIP-seq
MIRT2112912	hsa-miR-3682-5p	CLIP-seq
MIRT2112913	hsa-miR-520d-5p	CLIP-seq
MIRT2112914	hsa-miR-524-5p	CLIP-seq
MIRT2394945	hsa-miR-1238	CLIP-seq
MIRT2394946	hsa-miR-338-5p	CLIP-seq
MIRT2394947	hsa-miR-4307	CLIP-seq
MIRT2460240	hsa-miR-3978	CLIP-seq
MIRT2460241	hsa-miR-4481	CLIP-seq
MIRT2460242	hsa-miR-4658	CLIP-seq
MIRT2460243	hsa-miR-4745-5p	CLIP-seq
MIRT2460244	hsa-miR-4758-5p	CLIP-seq
MIRT2460245	hsa-miR-550b	CLIP-seq
MIRT2630059	hsa-miR-1207-3p	CLIP-seq
MIRT2394945	hsa-miR-1238	CLIP-seq
MIRT2630060	hsa-miR-1283	CLIP-seq
MIRT2630061	hsa-miR-181a	CLIP-seq
MIRT2630062	hsa-miR-181b	CLIP-seq
MIRT2630063	hsa-miR-181c	CLIP-seq
MIRT2630064	hsa-miR-181d	CLIP-seq
MIRT2630065	hsa-miR-200b	CLIP-seq
MIRT2630066	hsa-miR-200c	CLIP-seq
MIRT1378442	hsa-miR-202	CLIP-seq
MIRT2630067	hsa-miR-2276	CLIP-seq
MIRT2630068	hsa-miR-2355-5p	CLIP-seq
MIRT2630069	hsa-miR-28-3p	CLIP-seq
MIRT2630070	hsa-miR-3125	CLIP-seq
MIRT2630071	hsa-miR-3127-3p	CLIP-seq
MIRT2630072	hsa-miR-3163	CLIP-seq
MIRT2630073	hsa-miR-329	CLIP-seq
MIRT2630074	hsa-miR-335	CLIP-seq
MIRT2630075	hsa-miR-340	CLIP-seq
MIRT2630076	hsa-miR-362-3p	CLIP-seq
MIRT2630077	hsa-miR-3662	CLIP-seq
MIRT2630078	hsa-miR-3667-3p	CLIP-seq
MIRT2630079	hsa-miR-3680	CLIP-seq
MIRT2112912	hsa-miR-3682-5p	CLIP-seq
MIRT2630080	hsa-miR-3685	CLIP-seq
MIRT2630081	hsa-miR-3916	CLIP-seq
MIRT2630082	hsa-miR-3941	CLIP-seq
MIRT2630083	hsa-miR-3945	CLIP-seq
MIRT2630084	hsa-miR-4253	CLIP-seq
MIRT1378447	hsa-miR-4257	CLIP-seq
MIRT2630085	hsa-miR-4262	CLIP-seq
MIRT2630086	hsa-miR-4263	CLIP-seq
MIRT2630087	hsa-miR-4275	CLIP-seq
MIRT2630088	hsa-miR-4282	CLIP-seq
MIRT2630089	hsa-miR-429	CLIP-seq
MIRT2630090	hsa-miR-4302	CLIP-seq
MIRT2394947	hsa-miR-4307	CLIP-seq
MIRT2630091	hsa-miR-4522	CLIP-seq
MIRT1378450	hsa-miR-4659a-3p	CLIP-seq
MIRT1378451	hsa-miR-4659b-3p	CLIP-seq
MIRT2630092	hsa-miR-4670-3p	CLIP-seq
MIRT1378452	hsa-miR-4678	CLIP-seq
MIRT2630093	hsa-miR-4694-3p	CLIP-seq
MIRT1378454	hsa-miR-4709-5p	CLIP-seq
MIRT2630094	hsa-miR-4713-5p	CLIP-seq
MIRT2630095	hsa-miR-4760-3p	CLIP-seq
MIRT2630096	hsa-miR-4762-3p	CLIP-seq
MIRT2630097	hsa-miR-4762-5p	CLIP-seq
MIRT2630098	hsa-miR-4772-3p	CLIP-seq
MIRT2630099	hsa-miR-4777-3p	CLIP-seq
MIRT2630100	hsa-miR-485-3p	CLIP-seq
MIRT2630101	hsa-miR-487a	CLIP-seq
MIRT2630102	hsa-miR-513a-3p	CLIP-seq
MIRT2112913	hsa-miR-520d-5p	CLIP-seq
MIRT2112914	hsa-miR-524-5p	CLIP-seq
MIRT2630103	hsa-miR-548c-3p	CLIP-seq
MIRT2630104	hsa-miR-548p	CLIP-seq
MIRT2630105	hsa-miR-576-5p	CLIP-seq
MIRT2630106	hsa-miR-584	CLIP-seq
MIRT2630107	hsa-miR-603	CLIP-seq
MIRT2630108	hsa-miR-616	CLIP-seq
MIRT2630109	hsa-miR-648	CLIP-seq
MIRT2630110	hsa-miR-875-5p	CLIP-seq
MIRT2630111	hsa-miR-942	CLIP-seq
MIRT2630059	hsa-miR-1207-3p	CLIP-seq
MIRT2630060	hsa-miR-1283	CLIP-seq
MIRT2630061	hsa-miR-181a	CLIP-seq
MIRT2630062	hsa-miR-181b	CLIP-seq
MIRT2630063	hsa-miR-181c	CLIP-seq
MIRT2630064	hsa-miR-181d	CLIP-seq
MIRT2630065	hsa-miR-200b	CLIP-seq
MIRT2630066	hsa-miR-200c	CLIP-seq
MIRT2630067	hsa-miR-2276	CLIP-seq
MIRT2630068	hsa-miR-2355-5p	CLIP-seq
MIRT2630069	hsa-miR-28-3p	CLIP-seq
MIRT2630071	hsa-miR-3127-3p	CLIP-seq
MIRT2630073	hsa-miR-329	CLIP-seq
MIRT2630076	hsa-miR-362-3p	CLIP-seq
MIRT2630079	hsa-miR-3680	CLIP-seq
MIRT2112912	hsa-miR-3682-5p	CLIP-seq
MIRT2630080	hsa-miR-3685	CLIP-seq
MIRT2630082	hsa-miR-3941	CLIP-seq
MIRT2630083	hsa-miR-3945	CLIP-seq
MIRT2630084	hsa-miR-4253	CLIP-seq
MIRT2630085	hsa-miR-4262	CLIP-seq
MIRT2630086	hsa-miR-4263	CLIP-seq
MIRT2630087	hsa-miR-4275	CLIP-seq
MIRT2630088	hsa-miR-4282	CLIP-seq
MIRT2630089	hsa-miR-429	CLIP-seq
MIRT2630090	hsa-miR-4302	CLIP-seq
MIRT2630091	hsa-miR-4522	CLIP-seq
MIRT1378450	hsa-miR-4659a-3p	CLIP-seq
MIRT1378451	hsa-miR-4659b-3p	CLIP-seq
MIRT2630092	hsa-miR-4670-3p	CLIP-seq
MIRT1378454	hsa-miR-4709-5p	CLIP-seq
MIRT2630095	hsa-miR-4760-3p	CLIP-seq
MIRT2630097	hsa-miR-4762-5p	CLIP-seq
MIRT2630098	hsa-miR-4772-3p	CLIP-seq
MIRT2630099	hsa-miR-4777-3p	CLIP-seq
MIRT2630100	hsa-miR-485-3p	CLIP-seq
MIRT2630101	hsa-miR-487a	CLIP-seq
MIRT2630102	hsa-miR-513a-3p	CLIP-seq
MIRT2112913	hsa-miR-520d-5p	CLIP-seq
MIRT2112914	hsa-miR-524-5p	CLIP-seq
MIRT2630103	hsa-miR-548c-3p	CLIP-seq
MIRT2630104	hsa-miR-548p	CLIP-seq
MIRT2630105	hsa-miR-576-5p	CLIP-seq
MIRT2630106	hsa-miR-584	CLIP-seq
MIRT2630107	hsa-miR-603	CLIP-seq
MIRT2630108	hsa-miR-616	CLIP-seq
MIRT2630109	hsa-miR-648	CLIP-seq
MIRT2630110	hsa-miR-875-5p	CLIP-seq

Show/Hide all (45)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000062	Function	Fatty-acyl-CoA binding	IBA
GO:0000062	Function	Fatty-acyl-CoA binding	IDA	16647063
GO:0004772	Function	Sterol O-acyltransferase activity	IDA	9756919
GO:0004772	Function	Sterol O-acyltransferase activity	IEA
GO:0004772	Function	Sterol O-acyltransferase activity	IMP	8407899, 9020103
GO:0005515	Function	Protein binding	IPI	21044950, 23169578, 28514442, 33961781
GO:0005783	Component	Endoplasmic reticulum	IDA	10623671
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	17412327
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0008202	Process	Steroid metabolic process	IEA
GO:0008203	Process	Cholesterol metabolic process	IBA
GO:0008203	Process	Cholesterol metabolic process	IDA	9756919
GO:0008203	Process	Cholesterol metabolic process	IDA	16647063, 18971559
GO:0008203	Process	Cholesterol metabolic process	IEA
GO:0008203	Process	Cholesterol metabolic process	IEA
GO:0008203	Process	Cholesterol metabolic process	IMP	8407899
GO:0008203	Process	Cholesterol metabolic process	TAS	24608080
GO:0008374	Function	O-acyltransferase activity	IEA
GO:0010742	Process	Macrophage derived foam cell differentiation	IMP	8407899, 15353128
GO:0010742	Process	Macrophage derived foam cell differentiation	NAS	18971559
GO:0010878	Process	Cholesterol storage	IMP	8407899
GO:0015485	Function	Cholesterol binding	IBA
GO:0015485	Function	Cholesterol binding	IDA	16647063, 32433613, 32433614
GO:0016020	Component	Membrane	IDA	9756919
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0033344	Process	Cholesterol efflux	IBA
GO:0033344	Process	Cholesterol efflux	IMP	15308631
GO:0034379	Process	Very-low-density lipoprotein particle assembly	IMP	15308631
GO:0034383	Process	Low-density lipoprotein particle clearance	TAS
GO:0034736	Function	Cholesterol O-acyltransferase activity	IBA
GO:0034736	Function	Cholesterol O-acyltransferase activity	IDA	16647063, 32433613, 32433614
GO:0034736	Function	Cholesterol O-acyltransferase activity	IEA
GO:0034736	Function	Cholesterol O-acyltransferase activity	IMP	8407899
GO:0034736	Function	Cholesterol O-acyltransferase activity	TAS	24608080
GO:0042632	Process	Cholesterol homeostasis	IDA	32433614
GO:0042632	Process	Cholesterol homeostasis	IEA
GO:0042632	Process	Cholesterol homeostasis	TAS	11401500
GO:0042802	Function	Identical protein binding	IPI	32433613, 32433614
GO:0042986	Process	Positive regulation of amyloid precursor protein biosynthetic process	IMP	17412327

MIM	HGNC	e!Ensembl
102642	11177	ENSG00000057252

P35610

Protein name

Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1)

Protein function

Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:32433613, PubMed:32433614, PubMed:32944968, PubMed:9020103). Plays a role in lipoprotein ass

PDB

6L47 , 6L48 , 6P2J , 6P2P , 6VUM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03062	MBOAT	171 → 520	MBOAT, membrane-bound O-acyltransferase family	Family

Sequence

MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEE
LKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGK
IFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGK
FPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPT
YVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYF
LFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSAR
VLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTW
NVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFM
FFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVR
PRSWTCRYVF

Sequence length

550

Interactions

View interactions

	KEGG		Reactome
	Steroid biosynthesis Cholesterol metabolism		LDL clearance

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Familial cancer of breast	Uncertain significance	rs143353203	RCV005932166

Show/Hide Text Mining Associations (23)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
2 Hydroxyglutaricaciduria	Associate	35409086
Adrenal Insufficiency	Associate	21239516
Adrenocortical Carcinoma	Associate	32449514, 35409086
Allergic Fungal Sinusitis	Stimulate	25196914
Astrocytoma	Associate	35409086
Atherosclerosis	Associate	23305686
Carcinoma Hepatocellular	Associate	34039309
Carcinoma Renal Cell	Associate	24028971, 35633317
Cerebral Infarction	Associate	24577316
Colorectal Neoplasms	Associate	39940954
Corneal Dystrophy Crystalline of Schnyder	Associate	23169578
Coronary Artery Disease	Associate	24577316
Coronary Disease	Associate	31684966
Glioblastoma	Associate	35409086
Glioma	Associate	37980334
Hypertension	Associate	36626481
Leprosy	Associate	38273053
Lung Neoplasms	Associate	38149558
Neoplasms	Associate	28595267, 32449514, 34039309, 34326474, 35409086
Neoplasms	Stimulate	37304239
Neuroinflammatory Diseases	Associate	35409086
Prostatic Neoplasms	Associate	28595267, 34326474
Psoriasis	Associate	38273053

SOAT1 (sterol O-acyltransferase 1)