Gene Gene information from NCBI Gene database.
Entrez ID 6629
Gene name Small nuclear ribonucleoprotein polypeptide B2
Gene symbol SNRPB2
Synonyms (NCBI Gene)
Msl1U2B''
Chromosome 20
Chromosome location 20p12.1
Summary The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A`. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythema
miRNA miRNA information provided by mirtarbase database.
614
miRTarBase ID miRNA Experiments Reference
MIRT030365 hsa-miR-24-3p Microarray 19748357
MIRT031432 hsa-miR-16-5p Proteomics 18668040
MIRT044882 hsa-miR-193a-3p CLASH 23622248
MIRT201474 hsa-miR-5692a PAR-CLIP 20371350
MIRT201466 hsa-miR-1277-5p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
GO ID Ontology Definition Evidence Reference
GO:0000398 Process MRNA splicing, via spliceosome IBA
GO:0000398 Process MRNA splicing, via spliceosome IC 2951739, 9731529, 11991638
GO:0000398 Process MRNA splicing, via spliceosome IDA 28076346, 28781166, 32494006, 36797247
GO:0000398 Process MRNA splicing, via spliceosome NAS 31744343
GO:0001650 Component Fibrillar center IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603520 11155 ENSG00000125870
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P08579
Protein name U2 small nuclear ribonucleoprotein B'' (U2 snRNP B'')
Protein function Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA (PubM
PDB 1A9N , 5MQF , 5O9Z , 5XJC , 5YZG , 5Z56 , 5Z57 , 5Z58 , 6AH0 , 6AHD , 6FF7 , 6ICZ , 6ID0 , 6ID1 , 6QDV , 6QX9 , 6Y53 , 6Y5Q , 7A5P , 7ABG , 7ABI , 7EVO , 7VPX , 7W59 , 7W5A , 7W5B , 8C6J , 8CH6 , 8H6E , 8H6J , 8H6K , 8H6L , 8HK1 , 8I0P , 8I0R , 8I0S , 8I0T , 8I0U , 8I0V , 8I0W , 8QO9 , 8QXD , 8QZS , 8R08 , 8R09 , 8R0A , 8R0B , 8RM5 , 9FMD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00076 RRM_1 9 80 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
PF00076 RRM_1 153 219 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
Sequence
Sequence length 225
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Spliceosome   mRNA Splicing - Major Pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CHRONIC KIDNEY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CONNECTIVE TISSUE DISEASES Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
KIDNEY FAILURE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations