Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6628
Gene name	Small nuclear ribonucleoprotein polypeptides B and B1
Gene symbol	SNRPB
Synonyms (NCBI Gene)	CCMS, COD, SNRPB1, Sm-B/B', SmB/B', SmB/SmB', snRNP-B
Chromosome	20
Chromosome location	20p13
Summary	The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a ro

Show/Hide all(4)

SNP ID	Visualize variation	Clinical significance	Consequence
rs786201019	C>A,G,T	Pathogenic	Intron variant
rs786201020	C>A,G	Pathogenic	Intron variant
rs786201021	G>T	Pathogenic	Intron variant
rs786201022	G>T	Pathogenic	5 prime UTR variant

Show/Hide all(203)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022383	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT045972	hsa-miR-125b-5p	CLASH	23622248
MIRT044720	hsa-miR-320a	CLASH	23622248
MIRT041541	hsa-miR-193b-3p	CLASH	23622248
MIRT508961	hsa-miR-4428	PAR-CLIP	20371350
MIRT508960	hsa-miR-6856-3p	PAR-CLIP	20371350
MIRT508959	hsa-miR-4681	PAR-CLIP	20371350
MIRT508958	hsa-miR-577	PAR-CLIP	20371350
MIRT508957	hsa-miR-4759	PAR-CLIP	20371350
MIRT508956	hsa-miR-6888-5p	PAR-CLIP	20371350
MIRT508955	hsa-miR-4717-5p	PAR-CLIP	20371350
MIRT508954	hsa-miR-15a-3p	PAR-CLIP	20371350
MIRT508953	hsa-miR-1295b-3p	PAR-CLIP	20371350
MIRT508952	hsa-miR-4457	PAR-CLIP	20371350
MIRT508950	hsa-miR-5704	PAR-CLIP	20371350
MIRT508951	hsa-miR-376a-3p	PAR-CLIP	20371350
MIRT508949	hsa-miR-376b-3p	PAR-CLIP	20371350
MIRT083200	hsa-let-7a-2-3p	PAR-CLIP	20371350
MIRT083202	hsa-let-7g-3p	PAR-CLIP	20371350
MIRT508961	hsa-miR-4428	PAR-CLIP	20371350
MIRT508960	hsa-miR-6856-3p	PAR-CLIP	20371350
MIRT508959	hsa-miR-4681	PAR-CLIP	20371350
MIRT508958	hsa-miR-577	PAR-CLIP	20371350
MIRT508957	hsa-miR-4759	PAR-CLIP	20371350
MIRT508956	hsa-miR-6888-5p	PAR-CLIP	20371350
MIRT508955	hsa-miR-4717-5p	PAR-CLIP	20371350
MIRT508954	hsa-miR-15a-3p	PAR-CLIP	20371350
MIRT508953	hsa-miR-1295b-3p	PAR-CLIP	20371350
MIRT508952	hsa-miR-4457	PAR-CLIP	20371350
MIRT508950	hsa-miR-5704	PAR-CLIP	20371350
MIRT508951	hsa-miR-376a-3p	PAR-CLIP	20371350
MIRT508949	hsa-miR-376b-3p	PAR-CLIP	20371350
MIRT083200	hsa-let-7a-2-3p	PAR-CLIP	20371350
MIRT083202	hsa-let-7g-3p	PAR-CLIP	20371350
MIRT508961	hsa-miR-4428	PAR-CLIP	23446348
MIRT508960	hsa-miR-6856-3p	PAR-CLIP	23446348
MIRT508959	hsa-miR-4681	PAR-CLIP	23446348
MIRT508958	hsa-miR-577	PAR-CLIP	23446348
MIRT508957	hsa-miR-4759	PAR-CLIP	23446348
MIRT508956	hsa-miR-6888-5p	PAR-CLIP	23446348
MIRT508955	hsa-miR-4717-5p	PAR-CLIP	23446348
MIRT508954	hsa-miR-15a-3p	PAR-CLIP	23446348
MIRT508953	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT508952	hsa-miR-4457	PAR-CLIP	23446348
MIRT508950	hsa-miR-5704	PAR-CLIP	23446348
MIRT508951	hsa-miR-376a-3p	PAR-CLIP	23446348
MIRT508949	hsa-miR-376b-3p	PAR-CLIP	23446348
MIRT083200	hsa-let-7a-2-3p	PAR-CLIP	23446348
MIRT083202	hsa-let-7g-3p	PAR-CLIP	23446348
MIRT508961	hsa-miR-4428	PAR-CLIP	20371350
MIRT508960	hsa-miR-6856-3p	PAR-CLIP	20371350
MIRT508959	hsa-miR-4681	PAR-CLIP	20371350
MIRT508958	hsa-miR-577	PAR-CLIP	20371350
MIRT508957	hsa-miR-4759	PAR-CLIP	20371350
MIRT508956	hsa-miR-6888-5p	PAR-CLIP	20371350
MIRT508955	hsa-miR-4717-5p	PAR-CLIP	20371350
MIRT508954	hsa-miR-15a-3p	PAR-CLIP	20371350
MIRT508953	hsa-miR-1295b-3p	PAR-CLIP	20371350
MIRT508952	hsa-miR-4457	PAR-CLIP	20371350
MIRT508950	hsa-miR-5704	PAR-CLIP	20371350
MIRT508951	hsa-miR-376a-3p	PAR-CLIP	20371350
MIRT508949	hsa-miR-376b-3p	PAR-CLIP	20371350
MIRT083200	hsa-let-7a-2-3p	PAR-CLIP	20371350
MIRT083202	hsa-let-7g-3p	PAR-CLIP	20371350
MIRT508961	hsa-miR-4428	PAR-CLIP	20371350
MIRT508960	hsa-miR-6856-3p	PAR-CLIP	20371350
MIRT508959	hsa-miR-4681	PAR-CLIP	20371350
MIRT508958	hsa-miR-577	PAR-CLIP	20371350
MIRT508957	hsa-miR-4759	PAR-CLIP	20371350
MIRT508956	hsa-miR-6888-5p	PAR-CLIP	20371350
MIRT508955	hsa-miR-4717-5p	PAR-CLIP	20371350
MIRT508954	hsa-miR-15a-3p	PAR-CLIP	20371350
MIRT508953	hsa-miR-1295b-3p	PAR-CLIP	20371350
MIRT508952	hsa-miR-4457	PAR-CLIP	20371350
MIRT508950	hsa-miR-5704	PAR-CLIP	20371350
MIRT508951	hsa-miR-376a-3p	PAR-CLIP	20371350
MIRT508949	hsa-miR-376b-3p	PAR-CLIP	20371350
MIRT083200	hsa-let-7a-2-3p	PAR-CLIP	20371350
MIRT083202	hsa-let-7g-3p	PAR-CLIP	20371350
MIRT508961	hsa-miR-4428	PAR-CLIP	23446348
MIRT508960	hsa-miR-6856-3p	PAR-CLIP	23446348
MIRT508959	hsa-miR-4681	PAR-CLIP	23446348
MIRT508958	hsa-miR-577	PAR-CLIP	23446348
MIRT508957	hsa-miR-4759	PAR-CLIP	23446348
MIRT508956	hsa-miR-6888-5p	PAR-CLIP	23446348
MIRT508955	hsa-miR-4717-5p	PAR-CLIP	23446348
MIRT508954	hsa-miR-15a-3p	PAR-CLIP	23446348
MIRT508953	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT508952	hsa-miR-4457	PAR-CLIP	23446348
MIRT508950	hsa-miR-5704	PAR-CLIP	23446348
MIRT508951	hsa-miR-376a-3p	PAR-CLIP	23446348
MIRT508949	hsa-miR-376b-3p	PAR-CLIP	23446348
MIRT083200	hsa-let-7a-2-3p	PAR-CLIP	23446348
MIRT083202	hsa-let-7g-3p	PAR-CLIP	23446348
MIRT1376104	hsa-miR-1207-5p	CLIP-seq
MIRT1376105	hsa-miR-3150b-3p	CLIP-seq
MIRT1376106	hsa-miR-3160-3p	CLIP-seq
MIRT1376107	hsa-miR-3672	CLIP-seq
MIRT1376108	hsa-miR-4261	CLIP-seq
MIRT1376109	hsa-miR-4270	CLIP-seq
MIRT1376110	hsa-miR-4300	CLIP-seq
MIRT1376111	hsa-miR-4441	CLIP-seq
MIRT1376112	hsa-miR-4514	CLIP-seq
MIRT1376113	hsa-miR-4689	CLIP-seq
MIRT1376114	hsa-miR-4692	CLIP-seq
MIRT1376115	hsa-miR-4763-3p	CLIP-seq
MIRT1376116	hsa-miR-4779	CLIP-seq
MIRT1376117	hsa-miR-4784	CLIP-seq
MIRT1376118	hsa-miR-495	CLIP-seq
MIRT1376119	hsa-miR-920	CLIP-seq
MIRT1376120	hsa-miR-940	CLIP-seq
MIRT1376104	hsa-miR-1207-5p	CLIP-seq
MIRT1376105	hsa-miR-3150b-3p	CLIP-seq
MIRT1376106	hsa-miR-3160-3p	CLIP-seq
MIRT1376121	hsa-miR-340	CLIP-seq
MIRT1376122	hsa-miR-376a	CLIP-seq
MIRT1376123	hsa-miR-376b	CLIP-seq
MIRT1376108	hsa-miR-4261	CLIP-seq
MIRT1376109	hsa-miR-4270	CLIP-seq
MIRT1376110	hsa-miR-4300	CLIP-seq
MIRT1376111	hsa-miR-4441	CLIP-seq
MIRT1376112	hsa-miR-4514	CLIP-seq
MIRT1376113	hsa-miR-4689	CLIP-seq
MIRT1376114	hsa-miR-4692	CLIP-seq
MIRT1376115	hsa-miR-4763-3p	CLIP-seq
MIRT1376117	hsa-miR-4784	CLIP-seq
MIRT1376124	hsa-miR-4795-3p	CLIP-seq
MIRT1376119	hsa-miR-920	CLIP-seq
MIRT1376120	hsa-miR-940	CLIP-seq
MIRT1376118	hsa-miR-495	CLIP-seq
MIRT1376104	hsa-miR-1207-5p	CLIP-seq
MIRT1376105	hsa-miR-3150b-3p	CLIP-seq
MIRT1376106	hsa-miR-3160-3p	CLIP-seq
MIRT1376108	hsa-miR-4261	CLIP-seq
MIRT1376109	hsa-miR-4270	CLIP-seq
MIRT1376110	hsa-miR-4300	CLIP-seq
MIRT1376111	hsa-miR-4441	CLIP-seq
MIRT1376112	hsa-miR-4514	CLIP-seq
MIRT2111840	hsa-miR-4536	CLIP-seq
MIRT1376113	hsa-miR-4689	CLIP-seq
MIRT1376114	hsa-miR-4692	CLIP-seq
MIRT1376115	hsa-miR-4763-3p	CLIP-seq
MIRT1376116	hsa-miR-4779	CLIP-seq
MIRT1376117	hsa-miR-4784	CLIP-seq
MIRT1376118	hsa-miR-495	CLIP-seq
MIRT1376119	hsa-miR-920	CLIP-seq
MIRT1376120	hsa-miR-940	CLIP-seq
MIRT1376104	hsa-miR-1207-5p	CLIP-seq
MIRT1376105	hsa-miR-3150b-3p	CLIP-seq
MIRT1376106	hsa-miR-3160-3p	CLIP-seq
MIRT1376107	hsa-miR-3672	CLIP-seq
MIRT1376108	hsa-miR-4261	CLIP-seq
MIRT1376109	hsa-miR-4270	CLIP-seq
MIRT1376110	hsa-miR-4300	CLIP-seq
MIRT1376111	hsa-miR-4441	CLIP-seq
MIRT1376112	hsa-miR-4514	CLIP-seq
MIRT2111840	hsa-miR-4536	CLIP-seq
MIRT1376113	hsa-miR-4689	CLIP-seq
MIRT1376114	hsa-miR-4692	CLIP-seq
MIRT1376115	hsa-miR-4763-3p	CLIP-seq
MIRT1376116	hsa-miR-4779	CLIP-seq
MIRT1376117	hsa-miR-4784	CLIP-seq
MIRT1376118	hsa-miR-495	CLIP-seq
MIRT1376119	hsa-miR-920	CLIP-seq
MIRT1376120	hsa-miR-940	CLIP-seq
MIRT2629151	hsa-miR-1204	CLIP-seq
MIRT2629152	hsa-miR-125a-5p	CLIP-seq
MIRT2629153	hsa-miR-125b	CLIP-seq
MIRT2629154	hsa-miR-1291	CLIP-seq
MIRT2629155	hsa-miR-328	CLIP-seq
MIRT2629156	hsa-miR-3664-5p	CLIP-seq
MIRT1376107	hsa-miR-3672	CLIP-seq
MIRT2629157	hsa-miR-3915	CLIP-seq
MIRT2629158	hsa-miR-3928	CLIP-seq
MIRT2629159	hsa-miR-4319	CLIP-seq
MIRT2111840	hsa-miR-4536	CLIP-seq
MIRT2629160	hsa-miR-4633-3p	CLIP-seq
MIRT2629161	hsa-miR-4714-5p	CLIP-seq
MIRT2629162	hsa-miR-4734	CLIP-seq
MIRT1376118	hsa-miR-495	CLIP-seq
MIRT2629163	hsa-miR-544b	CLIP-seq
MIRT2629164	hsa-miR-587	CLIP-seq
MIRT2629165	hsa-miR-658	CLIP-seq
MIRT2629166	hsa-miR-663b	CLIP-seq
MIRT2629151	hsa-miR-1204	CLIP-seq
MIRT2629152	hsa-miR-125a-5p	CLIP-seq
MIRT2629153	hsa-miR-125b	CLIP-seq
MIRT2629154	hsa-miR-1291	CLIP-seq
MIRT2629155	hsa-miR-328	CLIP-seq
MIRT2629156	hsa-miR-3664-5p	CLIP-seq
MIRT1376107	hsa-miR-3672	CLIP-seq
MIRT2629157	hsa-miR-3915	CLIP-seq
MIRT2629158	hsa-miR-3928	CLIP-seq
MIRT2629159	hsa-miR-4319	CLIP-seq
MIRT2111840	hsa-miR-4536	CLIP-seq
MIRT2629160	hsa-miR-4633-3p	CLIP-seq
MIRT2629161	hsa-miR-4714-5p	CLIP-seq
MIRT2629162	hsa-miR-4734	CLIP-seq
MIRT1376118	hsa-miR-495	CLIP-seq
MIRT2629163	hsa-miR-544b	CLIP-seq
MIRT2629164	hsa-miR-587	CLIP-seq
MIRT2629165	hsa-miR-658	CLIP-seq
MIRT2629166	hsa-miR-663b	CLIP-seq

Show/Hide all(64)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000387	Process	Spliceosomal snRNP assembly	IDA	18984161
GO:0000398	Process	MRNA splicing, via spliceosome	IBA
GO:0000398	Process	MRNA splicing, via spliceosome	IC	11991638
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	28076346, 28781166, 32494006, 36797247
GO:0000398	Process	MRNA splicing, via spliceosome	NAS	15564372, 30975767, 31744343, 33677607
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	IPI	18082603
GO:0005515	Function	Protein binding	IPI	8076607, 10500148, 11714716, 11748230, 12065586, 12975319, 15105431, 15494309, 15848170, 16000308, 16087681, 17332742, 18951082, 18984161, 19325628, 21070772, 22365833, 25416956, 28514442, 31515488, 32296183, 32814053, 33961781, 35271311, 37248947, 38225382
GO:0005634	Component	Nucleus	IDA	28076346, 28781166
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	21113136, 30975767, 31744343
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005681	Component	Spliceosomal complex	IPI	30975767, 33677607
GO:0005681	Component	Spliceosomal complex	NAS	31744343
GO:0005681	Component	Spliceosomal complex	TAS	2531083
GO:0005682	Component	U5 snRNP	IBA
GO:0005682	Component	U5 snRNP	NAS	15564372
GO:0005683	Component	U7 snRNP	IDA	11574479
GO:0005684	Component	U2-type spliceosomal complex	IDA	32494006, 36797247
GO:0005685	Component	U1 snRNP	IBA
GO:0005685	Component	U1 snRNP	IDA	21113136, 25555158
GO:0005685	Component	U1 snRNP	IEA
GO:0005685	Component	U1 snRNP	IPI	33677607
GO:0005685	Component	U1 snRNP	NAS	15564372
GO:0005686	Component	U2 snRNP	IBA
GO:0005686	Component	U2 snRNP	IEA
GO:0005686	Component	U2 snRNP	NAS	15564372, 31744343
GO:0005687	Component	U4 snRNP	IBA
GO:0005687	Component	U4 snRNP	IDA	21516107
GO:0005687	Component	U4 snRNP	NAS	15564372
GO:0005689	Component	U12-type spliceosomal complex	IDA	15146077
GO:0005697	Component	Telomerase holoenzyme complex	IDA	18082603
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	18984161
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006397	Process	MRNA processing	IEA
GO:0006479	Process	Protein methylation	IDA	18495660
GO:0008380	Process	RNA splicing	IEA
GO:0008380	Process	RNA splicing	TAS	2531083
GO:0030532	Component	Small nuclear ribonucleoprotein complex	TAS	2531083
GO:0034709	Component	Methylosome	IDA	18984161
GO:0034719	Component	SMN-Sm protein complex	IDA	18984161
GO:0036261	Process	7-methylguanosine cap hypermethylation	NAS	15564372
GO:0046540	Component	U4/U6 x U5 tri-snRNP complex	IBA
GO:0046540	Component	U4/U6 x U5 tri-snRNP complex	IDA	26912367
GO:0046540	Component	U4/U6 x U5 tri-snRNP complex	IPI	30975767
GO:0070034	Function	Telomerase RNA binding	IPI	18082603
GO:0070990	Function	SnRNP binding	IBA
GO:0071004	Component	U2-type prespliceosome	IBA
GO:0071005	Component	U2-type precatalytic spliceosome	IDA	28781166
GO:0071007	Component	U2-type catalytic step 2 spliceosome	IDA	28076346
GO:0071013	Component	Catalytic step 2 spliceosome	IBA
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638
GO:0071204	Component	Histone pre-mRNA 3'end processing complex	IEA
GO:0071208	Function	Histone pre-mRNA DCP binding	IEA
GO:1903241	Process	U2-type prespliceosome assembly	NAS	31744343
GO:1990446	Function	U1 snRNP binding	IEA
GO:1990447	Function	U2 snRNP binding	IEA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
182282	11153	ENSG00000125835

P14678

Protein name

Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) (Sm protein B/B') (Sm-B/B') (SmB/B')

Protein function

Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:25555158, Pu

PDB

1D3B , 3CW1 , 3JCR , 3PGW , 4PJO , 4WZJ , 5MQF , 5O9Z , 5XJC , 5YZG , 5Z56 , 5Z57 , 5Z58 , 6AH0 , 6FF7 , 6ICZ , 6ID0 , 6ID1 , 6QDV , 6QW6 , 6QX9 , 6V4X , 6Y53 , 6Y5Q , 7A5P , 7ABG , 7ABI , 7DVQ , 7EVO , 7QTT , 7VPX , 7W59 , 7W5A , 7W5B , 8C6J , 8CH6 , 8H6E , 8H6J , 8H6K , 8H6L , 8HK1 , 8I0P , 8I0R , 8I0S , 8I0T , 8I0U , 8I0V , 8I0W , 8Q7Q , 8Q7V , 8Q7W

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01423	LSM	7 → 82	LSM domain	Domain

Sequence

MTVGKSSKMLQHIDYRMRCILQDGRIFIGTFKAFDKHMNLILCDCDEFRKIKPKNSKQAE
REEKRVLGLVLLRGENLVSMTVEGPPPKDTGIARVPLAGAAGGPGIGRAAGRGIPAGVPM
PQAPAGLAGPVRGVGGPSQQVMTPQGRGTVAAAAAAATASIAGAPTQYPPGRGGPPPPMG
RGAPPPGMMGPPPGMRPPMGPPMGIPPGRGTPMGMPPPGMRPPPPGMRGPPPPGMRPPRP

Sequence length

240

Interactions

View interactions

	KEGG		Reactome
	Spliceosome Systemic lupus erythematosus		SLBP independent Processing of Histone Pre-mRNAs snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Show/Hide Causal Diseases (1)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Cerebrocostomandibular Syndrome	Cerebro-costo-mandibular syndrome	rs786201021, rs786201022, rs786201019, rs786201020	N/A

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown ClinVar non-pathogenic, GenCC, GWAS & CBGDA associations
Hepatocellular Carcinoma	Hepatocellular carcinoma	Overlapping CRISPR screens and HCC expression microarray data, we found 13 clinically relevant targets that are essential for HCC tumor cell growth and were significantly up-regulated in HCC tumors	31022357	CBGDA

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Associate	22876301
Breast Neoplasms	Associate	20418484
Carcinoma Hepatocellular	Associate	33289700, 38189879
Carcinoma Renal Cell	Associate	35617983
Cardiomyopathies	Associate	32631246
Esophageal Neoplasms	Associate	39287291
Glioblastoma	Associate	27287018
Lung Neoplasms	Associate	22876301
Mandibular Injuries	Associate	25047197
Muscular Atrophy Spinal	Associate	11720283
Neoplasms	Associate	33289700, 38189879

SNRPB (small nuclear ribonucleoprotein polypeptides B and B1)