Gene Gene information from NCBI Gene database.
Entrez ID 6624
Gene name Fascin actin-bundling protein 1
Gene symbol FSCN1
Synonyms (NCBI Gene)
FAN1HSNSNLp55
Chromosome 7
Chromosome location 7p22.1
Summary This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell mi
miRNA miRNA information provided by mirtarbase database.
437
miRTarBase ID miRNA Experiments Reference
MIRT003543 hsa-miR-145-5p Luciferase reporter assayqRT-PCRWestern blot 20160723
MIRT003543 hsa-miR-145-5p Luciferase reporter assayqRT-PCRWestern blot 20160723
MIRT003542 hsa-miR-133a-3p Luciferase reporter assayqRT-PCRWestern blot 20160723
MIRT003543 hsa-miR-145-5p Western blot 21218087
MIRT003543 hsa-miR-145-5p Western blot 21218087
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
72
GO ID Ontology Definition Evidence Reference
GO:0001725 Component Stress fiber IDA 3525578
GO:0001725 Component Stress fiber IEA
GO:0001726 Component Ruffle IBA
GO:0001726 Component Ruffle IDA 3525578
GO:0002102 Component Podosome IDA 20137952
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602689 11148 ENSG00000075618
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q16658
Protein name Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55)
Protein function Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin
PDB 1DFC , 3LLP , 3P53 , 4GOV , 4GOY , 4GP0 , 4GP3 , 6B0T , 6I0Z , 6I10 , 6I11 , 6I12 , 6I13 , 6I14 , 6I15 , 6I16 , 6I17 , 6I18 , 7ZAU , 8VO5 , 8VO6 , 8VO7 , 8VO8 , 8VO9 , 8VOA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06268 Fascin 20 134 Fascin domain Domain
PF06268 Fascin 142 256 Fascin domain Domain
PF06268 Fascin 268 378 Fascin domain Domain
PF06268 Fascin 391 493 Fascin domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
Sequence length 493
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  MicroRNAs in cancer   Interleukin-4 and Interleukin-13 signaling
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, BASAL CELL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma Associate 12592367, 17029629, 37832352
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of Lung Associate 34477172, 36311801
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of Lung Stimulate 35149175
★☆☆☆☆
Found in Text Mining only
Adenoma Associate 17029629, 19738613
★☆☆☆☆
Found in Text Mining only
Adrenal Cortex Neoplasms Associate 30476173
★☆☆☆☆
Found in Text Mining only
Adrenocortical Carcinoma Associate 30476173, 31783819, 34536950
★☆☆☆☆
Found in Text Mining only
Aicardi Syndrome Associate 30476173, 31783819
★☆☆☆☆
Found in Text Mining only
Ameloblastoma Associate 29926463
★☆☆☆☆
Found in Text Mining only
Anophthalmia with pulmonary hypoplasia Associate 37832352
★☆☆☆☆
Found in Text Mining only
Arthropathy progressive pseudorheumatoid of childhood Associate 31213128
★☆☆☆☆
Found in Text Mining only