Gene Gene information from NCBI Gene database.
Entrez ID 6613
Gene name Small ubiquitin like modifier 2
Gene symbol SUMO2
Synonyms (NCBI Gene)
HSMT3SMT3BSMT3H2SUMO3Smt3A
Chromosome 17
Chromosome location 17q25.1
Summary This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unl
miRNA miRNA information provided by mirtarbase database.
354
miRTarBase ID miRNA Experiments Reference
MIRT051926 hsa-let-7b-5p CLASH 23622248
MIRT045212 hsa-miR-186-5p CLASH 23622248
MIRT045212 hsa-miR-186-5p CLASH 23622248
MIRT698721 hsa-miR-619-3p HITS-CLIP 23313552
MIRT698720 hsa-miR-1228-3p HITS-CLIP 23313552
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
MTA1 Activation 21965678
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22681889
GO:0005515 Function Protein binding IPI 15383276, 16169070, 16626738, 17099698, 17099700, 17491593, 20016594, 20016603, 20802522, 21212807, 21252943, 21326211, 21900206, 21965678, 21988832, 22878415, 25416956, 27068747, 28514442, 30914427, 32296183, 33961781
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 21965678
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603042 11125 ENSG00000188612
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61956
Protein name Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B)
Protein function Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the
PDB 1WM2 , 1WM3 , 1WZ0 , 2AWT , 2CKH , 2D07 , 2IO0 , 2IO3 , 2IYD , 2N1W , 2N9E , 2RPQ , 3UIN , 3UIO , 3ZO5 , 4BKG , 4NPN , 5D2M , 5ELU , 5EQL , 5GHB , 5GHC , 6JXW , 6JXX , 7ZJV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF11976 Rad60-SLD 18 88 Ubiquitin-2 like Rad60 SUMO-like Family
Tissue specificity TISSUE SPECIFICITY: Broadly expressed. {ECO:0000269|PubMed:9556629}.
Sequence
Sequence length 95
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Nucleocytoplasmic transport
Fluid shear stress and atherosclerosis
  Vitamin D (calciferol) metabolism
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Acute Disease Associate 24335474
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Associate 27084229
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Associate 24971881
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 17127214, 19236054
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 26458400, 28665748
★☆☆☆☆
Found in Text Mining only
Ectrodactyly Associate 28539665
★☆☆☆☆
Found in Text Mining only
Fever Stimulate 22890844
★☆☆☆☆
Found in Text Mining only
Fragile X Tremor Ataxia Syndrome Associate 37830578
★☆☆☆☆
Found in Text Mining only
Glioblastoma Associate 23078246
★☆☆☆☆
Found in Text Mining only
Herpes Simplex Associate 26200910
★☆☆☆☆
Found in Text Mining only