Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6611
Gene name	Spermine synthase
Gene symbol	SMS
Synonyms (NCBI Gene)	MRSRMRXSSRSPMSYSRSSpS
Chromosome	X
Chromosome location	Xp22.11
Summary	This gene encodes a protein belonging to the spermidine/spermin synthase family and catalyzes the production of spermine from spermidine. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene cause an X-linked intellect

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SNP ID	Visualize variation	Clinical significance	Consequence
rs121434610	G>A	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs150564614	G>A	Conflicting-interpretations-of-pathogenicity, likely-benign	Synonymous variant, coding sequence variant
rs267607076	T>G	Pathogenic	Missense variant, coding sequence variant
rs371972467	C>G,T	Conflicting-interpretations-of-pathogenicity	Intron variant
rs397515381	G>A	Pathogenic	Intron variant
rs397515549	T>A,C	Pathogenic	Synonymous variant, missense variant, intron variant, coding sequence variant
rs397515550	G>A	Pathogenic	Missense variant, intron variant, coding sequence variant
rs397515551	A>G	Pathogenic	Missense variant, coding sequence variant
rs397515552	T>C	Pathogenic	Missense variant, coding sequence variant
rs397515553	A>C,G	Pathogenic	Missense variant, coding sequence variant
rs1064794901	G>T	Likely-pathogenic	Missense variant, coding sequence variant
rs1556001304	A>T	Likely-pathogenic, not-provided	Missense variant, coding sequence variant
rs1602210346	C>T	Pathogenic	Coding sequence variant, missense variant
rs1602220706	TGAA>-	Pathogenic	Coding sequence variant, frameshift variant

468

Show/Hide all (468)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030218	hsa-miR-26b-5p	Microarray	19088304
MIRT045576	hsa-miR-149-5p	CLASH	23622248
MIRT042888	hsa-miR-324-3p	CLASH	23622248
MIRT038683	hsa-miR-7-1-3p	CLASH	23622248
MIRT682162	hsa-miR-490-3p	HITS-CLIP	23706177
MIRT682161	hsa-miR-7851-3p	HITS-CLIP	23706177
MIRT682160	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT682159	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT682158	hsa-miR-4756-3p	HITS-CLIP	23706177
MIRT682157	hsa-miR-4257	HITS-CLIP	23706177
MIRT682156	hsa-miR-3192-5p	HITS-CLIP	23706177
MIRT682155	hsa-miR-5186	HITS-CLIP	23706177
MIRT682154	hsa-miR-4468	HITS-CLIP	23706177
MIRT682153	hsa-miR-1827	HITS-CLIP	23706177
MIRT682152	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT682151	hsa-miR-6086	HITS-CLIP	23706177
MIRT682150	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT682149	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT682148	hsa-miR-3612	HITS-CLIP	23706177
MIRT682147	hsa-miR-650	HITS-CLIP	23706177
MIRT682146	hsa-miR-7106-5p	HITS-CLIP	23706177
MIRT682145	hsa-miR-149-3p	HITS-CLIP	23706177
MIRT682144	hsa-miR-4728-5p	HITS-CLIP	23706177
MIRT682143	hsa-miR-6785-5p	HITS-CLIP	23706177
MIRT682142	hsa-miR-6883-5p	HITS-CLIP	23706177
MIRT682141	hsa-miR-6799-5p	HITS-CLIP	23706177
MIRT682140	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT682139	hsa-miR-1273h-5p	HITS-CLIP	23706177
MIRT682138	hsa-miR-30b-3p	HITS-CLIP	23706177
MIRT682137	hsa-miR-3689a-3p	HITS-CLIP	23706177
MIRT682136	hsa-miR-3689b-3p	HITS-CLIP	23706177
MIRT682135	hsa-miR-3689c	HITS-CLIP	23706177
MIRT682134	hsa-miR-6779-5p	HITS-CLIP	23706177
MIRT682133	hsa-miR-6780a-5p	HITS-CLIP	23706177
MIRT682132	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT609901	hsa-miR-4282	HITS-CLIP	23824327
MIRT609899	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT609898	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT609897	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT609896	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT609895	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT609901	hsa-miR-4282	HITS-CLIP	23824327
MIRT609901	hsa-miR-4282	HITS-CLIP	23824327
MIRT609900	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT618165	hsa-miR-626	HITS-CLIP	23824327
MIRT618164	hsa-miR-6876-3p	HITS-CLIP	23824327
MIRT609901	hsa-miR-4282	HITS-CLIP	23824327
MIRT609900	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT609899	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT609898	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT609897	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT609896	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT609895	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT618165	hsa-miR-626	HITS-CLIP	23824327
MIRT618164	hsa-miR-6876-3p	HITS-CLIP	23824327
MIRT609901	hsa-miR-4282	HITS-CLIP	23824327
MIRT609900	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT609899	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT609898	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT609897	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT609896	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT609895	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT609901	hsa-miR-4282	HITS-CLIP	23824327
MIRT609900	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT609899	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT609898	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT609897	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT609896	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT609895	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT682139	hsa-miR-1273h-5p	PAR-CLIP	26701625
MIRT682139	hsa-miR-1273h-5p	PAR-CLIP	26701625
MIRT682139	hsa-miR-1273h-5p	PAR-CLIP	26701625
MIRT682145	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT682145	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT682145	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT682153	hsa-miR-1827	PAR-CLIP	26701625
MIRT682153	hsa-miR-1827	PAR-CLIP	26701625
MIRT682153	hsa-miR-1827	PAR-CLIP	26701625
MIRT682160	hsa-miR-1910-3p	PAR-CLIP	26701625
MIRT682160	hsa-miR-1910-3p	PAR-CLIP	26701625
MIRT682160	hsa-miR-1910-3p	PAR-CLIP	26701625
MIRT682150	hsa-miR-2467-3p	PAR-CLIP	26701625
MIRT682150	hsa-miR-2467-3p	PAR-CLIP	26701625
MIRT682150	hsa-miR-2467-3p	PAR-CLIP	26701625
MIRT682138	hsa-miR-30b-3p	PAR-CLIP	26701625
MIRT682138	hsa-miR-30b-3p	PAR-CLIP	26701625
MIRT682138	hsa-miR-30b-3p	PAR-CLIP	26701625
MIRT682156	hsa-miR-3192-5p	PAR-CLIP	26701625
MIRT682156	hsa-miR-3192-5p	PAR-CLIP	26701625
MIRT682156	hsa-miR-3192-5p	PAR-CLIP	26701625
MIRT682148	hsa-miR-3612	PAR-CLIP	26701625
MIRT682148	hsa-miR-3612	PAR-CLIP	26701625
MIRT682148	hsa-miR-3612	PAR-CLIP	26701625
MIRT682137	hsa-miR-3689a-3p	PAR-CLIP	26701625
MIRT682137	hsa-miR-3689a-3p	PAR-CLIP	26701625
MIRT682137	hsa-miR-3689a-3p	PAR-CLIP	26701625
MIRT682136	hsa-miR-3689b-3p	PAR-CLIP	26701625
MIRT682136	hsa-miR-3689b-3p	PAR-CLIP	26701625
MIRT682136	hsa-miR-3689b-3p	PAR-CLIP	26701625
MIRT682135	hsa-miR-3689c	PAR-CLIP	26701625
MIRT682135	hsa-miR-3689c	PAR-CLIP	26701625
MIRT682135	hsa-miR-3689c	PAR-CLIP	26701625
MIRT682152	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT682152	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT682152	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT682157	hsa-miR-4257	PAR-CLIP	26701625
MIRT682157	hsa-miR-4257	PAR-CLIP	26701625
MIRT682157	hsa-miR-4257	PAR-CLIP	26701625
MIRT682154	hsa-miR-4468	PAR-CLIP	26701625
MIRT682154	hsa-miR-4468	PAR-CLIP	26701625
MIRT682154	hsa-miR-4468	PAR-CLIP	26701625
MIRT682140	hsa-miR-455-3p	PAR-CLIP	26701625
MIRT682140	hsa-miR-455-3p	PAR-CLIP	26701625
MIRT682140	hsa-miR-455-3p	PAR-CLIP	26701625
MIRT682144	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT682144	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT682144	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT682158	hsa-miR-4756-3p	PAR-CLIP	26701625
MIRT682158	hsa-miR-4756-3p	PAR-CLIP	26701625
MIRT682158	hsa-miR-4756-3p	PAR-CLIP	26701625
MIRT682162	hsa-miR-490-3p	PAR-CLIP	26701625
MIRT682162	hsa-miR-490-3p	PAR-CLIP	26701625
MIRT682162	hsa-miR-490-3p	PAR-CLIP	26701625
MIRT682155	hsa-miR-5186	PAR-CLIP	26701625
MIRT682155	hsa-miR-5186	PAR-CLIP	26701625
MIRT682155	hsa-miR-5186	PAR-CLIP	26701625
MIRT682151	hsa-miR-6086	PAR-CLIP	26701625
MIRT682151	hsa-miR-6086	PAR-CLIP	26701625
MIRT682151	hsa-miR-6086	PAR-CLIP	26701625
MIRT682149	hsa-miR-6499-3p	PAR-CLIP	26701625
MIRT682149	hsa-miR-6499-3p	PAR-CLIP	26701625
MIRT682149	hsa-miR-6499-3p	PAR-CLIP	26701625
MIRT682147	hsa-miR-650	PAR-CLIP	26701625
MIRT682147	hsa-miR-650	PAR-CLIP	26701625
MIRT682147	hsa-miR-650	PAR-CLIP	26701625
MIRT682159	hsa-miR-6511a-5p	PAR-CLIP	26701625
MIRT682159	hsa-miR-6511a-5p	PAR-CLIP	26701625
MIRT682159	hsa-miR-6511a-5p	PAR-CLIP	26701625
MIRT682132	hsa-miR-6516-5p	PAR-CLIP	26701625
MIRT682132	hsa-miR-6516-5p	PAR-CLIP	26701625
MIRT682132	hsa-miR-6516-5p	PAR-CLIP	26701625
MIRT682134	hsa-miR-6779-5p	PAR-CLIP	26701625
MIRT682134	hsa-miR-6779-5p	PAR-CLIP	26701625
MIRT682134	hsa-miR-6779-5p	PAR-CLIP	26701625
MIRT682133	hsa-miR-6780a-5p	PAR-CLIP	26701625
MIRT682133	hsa-miR-6780a-5p	PAR-CLIP	26701625
MIRT682133	hsa-miR-6780a-5p	PAR-CLIP	26701625
MIRT682143	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT682143	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT682143	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT682141	hsa-miR-6799-5p	PAR-CLIP	26701625
MIRT682141	hsa-miR-6799-5p	PAR-CLIP	26701625
MIRT682141	hsa-miR-6799-5p	PAR-CLIP	26701625
MIRT682142	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT682142	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT682142	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT682146	hsa-miR-7106-5p	PAR-CLIP	26701625
MIRT682146	hsa-miR-7106-5p	PAR-CLIP	26701625
MIRT682146	hsa-miR-7106-5p	PAR-CLIP	26701625
MIRT682161	hsa-miR-7851-3p	PAR-CLIP	26701625
MIRT682161	hsa-miR-7851-3p	PAR-CLIP	26701625
MIRT682161	hsa-miR-7851-3p	PAR-CLIP	26701625
MIRT682139	hsa-miR-1273h-5p	PAR-CLIP	27292025
MIRT682139	hsa-miR-1273h-5p	PAR-CLIP	27292025
MIRT682145	hsa-miR-149-3p	PAR-CLIP	27292025
MIRT682145	hsa-miR-149-3p	PAR-CLIP	27292025
MIRT682153	hsa-miR-1827	PAR-CLIP	27292025
MIRT682153	hsa-miR-1827	PAR-CLIP	27292025
MIRT682160	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT682160	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT682150	hsa-miR-2467-3p	PAR-CLIP	27292025
MIRT682150	hsa-miR-2467-3p	PAR-CLIP	27292025
MIRT682138	hsa-miR-30b-3p	PAR-CLIP	27292025
MIRT682138	hsa-miR-30b-3p	PAR-CLIP	27292025
MIRT682156	hsa-miR-3192-5p	PAR-CLIP	27292025
MIRT682156	hsa-miR-3192-5p	PAR-CLIP	27292025
MIRT682148	hsa-miR-3612	PAR-CLIP	27292025
MIRT682148	hsa-miR-3612	PAR-CLIP	27292025
MIRT682137	hsa-miR-3689a-3p	PAR-CLIP	27292025
MIRT682137	hsa-miR-3689a-3p	PAR-CLIP	27292025
MIRT682136	hsa-miR-3689b-3p	PAR-CLIP	27292025
MIRT682136	hsa-miR-3689b-3p	PAR-CLIP	27292025
MIRT682135	hsa-miR-3689c	PAR-CLIP	27292025
MIRT682135	hsa-miR-3689c	PAR-CLIP	27292025
MIRT682152	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT682152	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT682157	hsa-miR-4257	PAR-CLIP	27292025
MIRT682157	hsa-miR-4257	PAR-CLIP	27292025
MIRT682154	hsa-miR-4468	PAR-CLIP	27292025
MIRT682154	hsa-miR-4468	PAR-CLIP	27292025
MIRT682140	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT682140	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT682144	hsa-miR-4728-5p	PAR-CLIP	27292025
MIRT682144	hsa-miR-4728-5p	PAR-CLIP	27292025
MIRT682158	hsa-miR-4756-3p	PAR-CLIP	27292025
MIRT682158	hsa-miR-4756-3p	PAR-CLIP	27292025
MIRT682162	hsa-miR-490-3p	PAR-CLIP	27292025
MIRT682162	hsa-miR-490-3p	PAR-CLIP	27292025
MIRT682155	hsa-miR-5186	PAR-CLIP	27292025
MIRT682155	hsa-miR-5186	PAR-CLIP	27292025
MIRT682151	hsa-miR-6086	PAR-CLIP	27292025
MIRT682151	hsa-miR-6086	PAR-CLIP	27292025
MIRT682149	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT682149	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT682147	hsa-miR-650	PAR-CLIP	27292025
MIRT682147	hsa-miR-650	PAR-CLIP	27292025
MIRT682159	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT682159	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT682132	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT682132	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT682134	hsa-miR-6779-5p	PAR-CLIP	27292025
MIRT682134	hsa-miR-6779-5p	PAR-CLIP	27292025
MIRT682133	hsa-miR-6780a-5p	PAR-CLIP	27292025
MIRT682133	hsa-miR-6780a-5p	PAR-CLIP	27292025
MIRT682143	hsa-miR-6785-5p	PAR-CLIP	27292025
MIRT682143	hsa-miR-6785-5p	PAR-CLIP	27292025
MIRT682141	hsa-miR-6799-5p	PAR-CLIP	27292025
MIRT682141	hsa-miR-6799-5p	PAR-CLIP	27292025
MIRT682142	hsa-miR-6883-5p	PAR-CLIP	27292025
MIRT682142	hsa-miR-6883-5p	PAR-CLIP	27292025
MIRT682146	hsa-miR-7106-5p	PAR-CLIP	27292025
MIRT682146	hsa-miR-7106-5p	PAR-CLIP	27292025
MIRT682161	hsa-miR-7851-3p	PAR-CLIP	27292025
MIRT682161	hsa-miR-7851-3p	PAR-CLIP	27292025
MIRT682162	hsa-miR-490-3p	HITS-CLIP	23706177
MIRT682161	hsa-miR-7851-3p	HITS-CLIP	23706177
MIRT682160	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT682159	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT682158	hsa-miR-4756-3p	HITS-CLIP	23706177
MIRT682157	hsa-miR-4257	HITS-CLIP	23706177
MIRT682156	hsa-miR-3192-5p	HITS-CLIP	23706177
MIRT682155	hsa-miR-5186	HITS-CLIP	23706177
MIRT682154	hsa-miR-4468	HITS-CLIP	23706177
MIRT682153	hsa-miR-1827	HITS-CLIP	23706177
MIRT682152	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT682151	hsa-miR-6086	HITS-CLIP	23706177
MIRT682150	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT682149	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT682148	hsa-miR-3612	HITS-CLIP	23706177
MIRT682147	hsa-miR-650	HITS-CLIP	23706177
MIRT682146	hsa-miR-7106-5p	HITS-CLIP	23706177
MIRT682145	hsa-miR-149-3p	HITS-CLIP	23706177
MIRT682144	hsa-miR-4728-5p	HITS-CLIP	23706177
MIRT682143	hsa-miR-6785-5p	HITS-CLIP	23706177
MIRT682142	hsa-miR-6883-5p	HITS-CLIP	23706177
MIRT682141	hsa-miR-6799-5p	HITS-CLIP	23706177
MIRT682140	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT682139	hsa-miR-1273h-5p	HITS-CLIP	23706177
MIRT682138	hsa-miR-30b-3p	HITS-CLIP	23706177
MIRT682137	hsa-miR-3689a-3p	HITS-CLIP	23706177
MIRT682136	hsa-miR-3689b-3p	HITS-CLIP	23706177
MIRT682135	hsa-miR-3689c	HITS-CLIP	23706177
MIRT682134	hsa-miR-6779-5p	HITS-CLIP	23706177
MIRT682133	hsa-miR-6780a-5p	HITS-CLIP	23706177
MIRT682132	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT609901	hsa-miR-4282	HITS-CLIP	23824327
MIRT609899	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT609898	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT609897	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT609896	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT609895	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT609901	hsa-miR-4282	HITS-CLIP	23824327
MIRT609901	hsa-miR-4282	HITS-CLIP	23824327
MIRT609900	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT618165	hsa-miR-626	HITS-CLIP	23824327
MIRT618164	hsa-miR-6876-3p	HITS-CLIP	23824327
MIRT609901	hsa-miR-4282	HITS-CLIP	23824327
MIRT609900	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT609899	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT609898	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT609897	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT609896	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT609895	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT618165	hsa-miR-626	HITS-CLIP	23824327
MIRT618164	hsa-miR-6876-3p	HITS-CLIP	23824327
MIRT609901	hsa-miR-4282	HITS-CLIP	23824327
MIRT609900	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT609899	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT609898	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT609897	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT609896	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT609895	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT609901	hsa-miR-4282	HITS-CLIP	23824327
MIRT609900	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT609899	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT609898	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT609897	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT609896	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT609895	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT1373922	hsa-miR-103a	CLIP-seq
MIRT1373923	hsa-miR-107	CLIP-seq
MIRT1373924	hsa-miR-127-5p	CLIP-seq
MIRT1373925	hsa-miR-1301	CLIP-seq
MIRT1373926	hsa-miR-1470	CLIP-seq
MIRT1373927	hsa-miR-148a	CLIP-seq
MIRT1373928	hsa-miR-148b	CLIP-seq
MIRT1373929	hsa-miR-152	CLIP-seq
MIRT1373930	hsa-miR-2054	CLIP-seq
MIRT1373931	hsa-miR-23a	CLIP-seq
MIRT1373932	hsa-miR-23b	CLIP-seq
MIRT1373933	hsa-miR-23c	CLIP-seq
MIRT1373934	hsa-miR-2964a-5p	CLIP-seq
MIRT1373935	hsa-miR-29a	CLIP-seq
MIRT1373936	hsa-miR-29b	CLIP-seq
MIRT1373937	hsa-miR-29c	CLIP-seq
MIRT1373938	hsa-miR-3120-3p	CLIP-seq
MIRT1373939	hsa-miR-3156-5p	CLIP-seq
MIRT1373940	hsa-miR-338-3p	CLIP-seq
MIRT1373941	hsa-miR-3607-5p	CLIP-seq
MIRT1373942	hsa-miR-3689d	CLIP-seq
MIRT1373943	hsa-miR-3919	CLIP-seq
MIRT1373944	hsa-miR-4274	CLIP-seq
MIRT1373945	hsa-miR-4278	CLIP-seq
MIRT1373946	hsa-miR-4476	CLIP-seq
MIRT1373947	hsa-miR-4489	CLIP-seq
MIRT1373948	hsa-miR-4506	CLIP-seq
MIRT1373949	hsa-miR-4519	CLIP-seq
MIRT1373950	hsa-miR-4524	CLIP-seq
MIRT1373951	hsa-miR-4530	CLIP-seq
MIRT1373952	hsa-miR-4667-3p	CLIP-seq
MIRT1373953	hsa-miR-4688	CLIP-seq
MIRT1373954	hsa-miR-4691-5p	CLIP-seq
MIRT1373955	hsa-miR-4697-3p	CLIP-seq
MIRT1373956	hsa-miR-4753-3p	CLIP-seq
MIRT1373957	hsa-miR-4775	CLIP-seq
MIRT1373958	hsa-miR-4802-5p	CLIP-seq
MIRT1373959	hsa-miR-483-3p	CLIP-seq
MIRT1373960	hsa-miR-5047	CLIP-seq
MIRT1373961	hsa-miR-539	CLIP-seq
MIRT1373962	hsa-miR-545	CLIP-seq
MIRT1373963	hsa-miR-548c-3p	CLIP-seq
MIRT1373964	hsa-miR-548p	CLIP-seq
MIRT1373965	hsa-miR-576-5p	CLIP-seq
MIRT1373966	hsa-miR-590-3p	CLIP-seq
MIRT1373967	hsa-miR-593	CLIP-seq
MIRT1373968	hsa-miR-639	CLIP-seq
MIRT1373969	hsa-miR-642a	CLIP-seq
MIRT1373970	hsa-miR-766	CLIP-seq
MIRT1373971	hsa-miR-873	CLIP-seq
MIRT1373972	hsa-miR-889	CLIP-seq
MIRT1373922	hsa-miR-103a	CLIP-seq
MIRT1373923	hsa-miR-107	CLIP-seq
MIRT1373925	hsa-miR-1301	CLIP-seq
MIRT1373926	hsa-miR-1470	CLIP-seq
MIRT1373927	hsa-miR-148a	CLIP-seq
MIRT1373928	hsa-miR-148b	CLIP-seq
MIRT1373929	hsa-miR-152	CLIP-seq
MIRT2111377	hsa-miR-2110	CLIP-seq
MIRT1373931	hsa-miR-23a	CLIP-seq
MIRT1373932	hsa-miR-23b	CLIP-seq
MIRT1373933	hsa-miR-23c	CLIP-seq
MIRT1373934	hsa-miR-2964a-5p	CLIP-seq
MIRT1373938	hsa-miR-3120-3p	CLIP-seq
MIRT2111378	hsa-miR-3150a-3p	CLIP-seq
MIRT2111379	hsa-miR-3153	CLIP-seq
MIRT1373939	hsa-miR-3156-5p	CLIP-seq
MIRT1373940	hsa-miR-338-3p	CLIP-seq
MIRT2111380	hsa-miR-345	CLIP-seq
MIRT2111381	hsa-miR-3591-3p	CLIP-seq
MIRT1373941	hsa-miR-3607-5p	CLIP-seq
MIRT2111382	hsa-miR-4260	CLIP-seq
MIRT2111383	hsa-miR-4271	CLIP-seq
MIRT1373944	hsa-miR-4274	CLIP-seq
MIRT1373948	hsa-miR-4506	CLIP-seq
MIRT1373949	hsa-miR-4519	CLIP-seq
MIRT1373950	hsa-miR-4524	CLIP-seq
MIRT1373951	hsa-miR-4530	CLIP-seq
MIRT1373952	hsa-miR-4667-3p	CLIP-seq
MIRT1373955	hsa-miR-4697-3p	CLIP-seq
MIRT2111384	hsa-miR-4725-3p	CLIP-seq
MIRT1373960	hsa-miR-5047	CLIP-seq
MIRT2111385	hsa-miR-513b	CLIP-seq
MIRT1373962	hsa-miR-545	CLIP-seq
MIRT1373963	hsa-miR-548c-3p	CLIP-seq
MIRT1373964	hsa-miR-548p	CLIP-seq
MIRT1373965	hsa-miR-576-5p	CLIP-seq
MIRT1373968	hsa-miR-639	CLIP-seq
MIRT1373969	hsa-miR-642a	CLIP-seq
MIRT1373970	hsa-miR-766	CLIP-seq
MIRT1373922	hsa-miR-103a	CLIP-seq
MIRT1373923	hsa-miR-107	CLIP-seq
MIRT2334468	hsa-miR-1207-3p	CLIP-seq
MIRT1373925	hsa-miR-1301	CLIP-seq
MIRT1373926	hsa-miR-1470	CLIP-seq
MIRT1373927	hsa-miR-148a	CLIP-seq
MIRT1373928	hsa-miR-148b	CLIP-seq
MIRT1373929	hsa-miR-152	CLIP-seq
MIRT2334469	hsa-miR-205	CLIP-seq
MIRT2334470	hsa-miR-224	CLIP-seq
MIRT1373931	hsa-miR-23a	CLIP-seq
MIRT1373932	hsa-miR-23b	CLIP-seq
MIRT1373933	hsa-miR-23c	CLIP-seq
MIRT1373934	hsa-miR-2964a-5p	CLIP-seq
MIRT1373935	hsa-miR-29a	CLIP-seq
MIRT1373936	hsa-miR-29b	CLIP-seq
MIRT1373937	hsa-miR-29c	CLIP-seq
MIRT1373938	hsa-miR-3120-3p	CLIP-seq
MIRT1373939	hsa-miR-3156-5p	CLIP-seq
MIRT1373940	hsa-miR-338-3p	CLIP-seq
MIRT2111380	hsa-miR-345	CLIP-seq
MIRT2111381	hsa-miR-3591-3p	CLIP-seq
MIRT1373941	hsa-miR-3607-5p	CLIP-seq
MIRT1373942	hsa-miR-3689d	CLIP-seq
MIRT1373944	hsa-miR-4274	CLIP-seq
MIRT1373945	hsa-miR-4278	CLIP-seq
MIRT1373946	hsa-miR-4476	CLIP-seq
MIRT2334471	hsa-miR-4477b	CLIP-seq
MIRT1373947	hsa-miR-4489	CLIP-seq
MIRT1373948	hsa-miR-4506	CLIP-seq
MIRT1373949	hsa-miR-4519	CLIP-seq
MIRT1373950	hsa-miR-4524	CLIP-seq
MIRT1373951	hsa-miR-4530	CLIP-seq
MIRT1373952	hsa-miR-4667-3p	CLIP-seq
MIRT1373953	hsa-miR-4688	CLIP-seq
MIRT1373954	hsa-miR-4691-5p	CLIP-seq
MIRT1373955	hsa-miR-4697-3p	CLIP-seq
MIRT2334472	hsa-miR-4698	CLIP-seq
MIRT2334473	hsa-miR-4764-3p	CLIP-seq
MIRT1373958	hsa-miR-4802-5p	CLIP-seq
MIRT1373959	hsa-miR-483-3p	CLIP-seq
MIRT1373960	hsa-miR-5047	CLIP-seq
MIRT2111385	hsa-miR-513b	CLIP-seq
MIRT1373962	hsa-miR-545	CLIP-seq
MIRT1373963	hsa-miR-548c-3p	CLIP-seq
MIRT1373964	hsa-miR-548p	CLIP-seq
MIRT1373965	hsa-miR-576-5p	CLIP-seq
MIRT1373966	hsa-miR-590-3p	CLIP-seq
MIRT2334474	hsa-miR-607	CLIP-seq
MIRT2334475	hsa-miR-618	CLIP-seq
MIRT1373968	hsa-miR-639	CLIP-seq
MIRT1373969	hsa-miR-642a	CLIP-seq
MIRT1373970	hsa-miR-766	CLIP-seq
MIRT1373971	hsa-miR-873	CLIP-seq
MIRT1373972	hsa-miR-889	CLIP-seq
MIRT1373927	hsa-miR-148a	CLIP-seq
MIRT1373928	hsa-miR-148b	CLIP-seq
MIRT1373929	hsa-miR-152	CLIP-seq
MIRT1373931	hsa-miR-23a	CLIP-seq
MIRT1373932	hsa-miR-23b	CLIP-seq
MIRT1373933	hsa-miR-23c	CLIP-seq
MIRT1373944	hsa-miR-4274	CLIP-seq
MIRT1373948	hsa-miR-4506	CLIP-seq
MIRT1373949	hsa-miR-4519	CLIP-seq
MIRT1373950	hsa-miR-4524	CLIP-seq
MIRT1373955	hsa-miR-4697-3p	CLIP-seq
MIRT1373963	hsa-miR-548c-3p	CLIP-seq
MIRT1373965	hsa-miR-576-5p	CLIP-seq
MIRT1373968	hsa-miR-639	CLIP-seq
MIRT1373922	hsa-miR-103a	CLIP-seq
MIRT1373923	hsa-miR-107	CLIP-seq
MIRT1373925	hsa-miR-1301	CLIP-seq
MIRT1373934	hsa-miR-2964a-5p	CLIP-seq
MIRT1373938	hsa-miR-3120-3p	CLIP-seq
MIRT1373941	hsa-miR-3607-5p	CLIP-seq
MIRT1373942	hsa-miR-3689d	CLIP-seq
MIRT1373945	hsa-miR-4278	CLIP-seq
MIRT1373946	hsa-miR-4476	CLIP-seq
MIRT1373947	hsa-miR-4489	CLIP-seq
MIRT1373953	hsa-miR-4688	CLIP-seq
MIRT1373958	hsa-miR-4802-5p	CLIP-seq
MIRT1373960	hsa-miR-5047	CLIP-seq
MIRT1373971	hsa-miR-873	CLIP-seq
MIRT1373934	hsa-miR-2964a-5p	CLIP-seq
MIRT1373938	hsa-miR-3120-3p	CLIP-seq
MIRT1373942	hsa-miR-3689d	CLIP-seq
MIRT1373946	hsa-miR-4476	CLIP-seq
MIRT1373958	hsa-miR-4802-5p	CLIP-seq
MIRT1373971	hsa-miR-873	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005829	Component	Cytosol	TAS
GO:0006555	Process	Methionine metabolic process	TAS	7546290
GO:0006595	Process	Polyamine metabolic process	IEA
GO:0006595	Process	Polyamine metabolic process	TAS	9299240
GO:0006596	Process	Polyamine biosynthetic process	IEA
GO:0006597	Process	Spermine biosynthetic process	IBA
GO:0006597	Process	Spermine biosynthetic process	IEA
GO:0008215	Process	Spermine metabolic process	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016768	Function	Spermine synthase activity	IBA
GO:0016768	Function	Spermine synthase activity	IEA
GO:0016768	Function	Spermine synthase activity	TAS
GO:0070062	Component	Extracellular exosome	HDA	23533145

MIM	HGNC	e!Ensembl
300105	11123	ENSG00000102172

P52788

Protein name

Spermine synthase (SPMSY) (EC 2.5.1.22) (Spermidine aminopropyltransferase)

Protein function

Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).

PDB

3C6K , 3C6M

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17950	SpmSyn_N	21 → 117	S-adenosylmethionine decarboxylase N -terminal	Domain
PF17284	Spermine_synt_N	123 → 172	Spermidine synthase tetramerisation domain	Domain
PF01564	Spermine_synth	174 → 366		Domain

Sequence

MAAARHSTLDFMLGAKADGETILKGLQSIFQEQGMAESVHTWQDHGYLATYTNKNGSFAN
LRIYPHGLVLLDLQSYDGDAQGKEEIDSILNKVEERMKELSQDSTGRVKRLPPIVRGGAI
DRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVNLAESDLAYTRA
IMGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMVEIDQMVIDGCKKYMRKTCGDV
LDNLKGDCYQVLIEDCIPVLKRYAKEGREFDYVINDLTAVPISTSPEEDSTWEFLRLILD
LSMKVLKQDGKYFTQGNCVNLTEALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTV
WKKAKP

Sequence length

366

Interactions

View interactions

	KEGG		Reactome
	Cysteine and methionine metabolism Arginine and proline metabolism Glutathione metabolism Metabolic pathways		Metabolism of polyamines

Show/Hide Causal Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Intellectual disability	Pathogenic	rs1925241775	RCV001249470
Nonpapillary renal cell carcinoma	Likely pathogenic	rs1924581492, rs1924586809	RCV005911007 RCV005908881
Smith-Magenis syndrome	Likely pathogenic	rs1569351529	RCV000760247
SMS-related disorder	Likely pathogenic	rs397515550, rs113689961, rs1556001304	RCV004527931 RCV004544192 RCV000509103
Syndromic X-linked intellectual disability Snyder type	Likely pathogenic; Pathogenic	rs2146953457, rs2519671183, rs2147517480, rs2519671108, rs397515381, rs121434610, rs267607076, rs1602220706, rs397515550, rs397515551, rs1602210346, rs1924650670, rs1924586809, rs397515553, rs1924243873, rs1924648986 View all (1 more)	RCV002052168 RCV003333236 RCV003153129 RCV003225648 RCV000012389 RCV000012390 RCV000012391 RCV000853623 RCV000055903 RCV000055905 RCV001007564 RCV001255181 RCV001171510 RCV000074415 RCV001250132 RCV001310252
Thyroid cancer, nonmedullary, 1	Likely pathogenic	rs1924581492	RCV005911008

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs2239674	RCV005915909
Cholangiocarcinoma	Benign	rs2239674	RCV005915910
Developmental disorder	Uncertain significance	rs746297985	RCV001843773
Familial cancer of breast	Benign	rs12013805	RCV005915946
Gastric cancer	Benign	rs12013805	RCV005915947
History of neurodevelopmental disorder	Uncertain significance	rs751807035	RCV000720966
Lung cancer	Benign	rs2239674	RCV005915911
Squamous cell lung carcinoma	Uncertain significance	rs746297985	RCV005922774
Uterine carcinosarcoma	Benign	rs12013805	RCV005915948

Show/Hide Text Mining Associations (18)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	37334367, 37709932
Anxiety	Associate	21152090
Anxiety Disorders	Associate	21152090
Breast Neoplasms	Associate	30733278
Carcinoma Hepatocellular	Stimulate	36544774
Carcinoma Hepatocellular	Associate	38097948
Cartilage Diseases	Associate	18205922
Colorectal Neoplasms	Associate	27433286
Hypoxia	Associate	38097948
Intellectual Disability	Associate	28720891, 32838743
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	23160178
Mental Retardation X Linked	Associate	19206178
Neoplasms	Associate	11877759, 33494814
Prostatic Neoplasms	Associate	11877759
Seizures	Associate	32838743
Smith Magenis Syndrome	Associate	34667072
Snyder Robinson syndrome	Associate	19206178, 19277733, 20556796, 21647366, 23408511, 25340632, 25888122, 26174906, 26761001, 32838743, 34667072, 37712293
Stiff Person Syndrome	Associate	8245784

SMS (spermine synthase)