BMX (BMX non-receptor tyrosine kinase)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
660
Gene name Gene Name - the full gene name approved by the HGNC.
BMX non-receptor tyrosine kinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BMX
Synonyms (NCBI Gene) Gene synonyms aliases
ETK, PSCTK2, PSCTK3
Chromosome Chromosome number
X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xp22.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyro
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(6)
miRTarBase ID miRNA Experiments Reference
MIRT735520 hsa-miR-218-5p Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), Immunohistochemistry (IHC), Immunofluorescence, qRT-PCR, In situ hybridization 31477834
MIRT1943410 hsa-miR-1298 CLIP-seq
MIRT1943411 hsa-miR-361-5p CLIP-seq
MIRT1943412 hsa-miR-4775 CLIP-seq
MIRT1943413 hsa-miR-590-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(23)
GO ID Ontology Definition Evidence Reference
GO:0002250 Process Adaptive immune response IBA 21873635
GO:0004713 Function Protein tyrosine kinase activity IBA 21873635
GO:0004713 Function Protein tyrosine kinase activity TAS 7970727
GO:0004715 Function Non-membrane spanning protein tyrosine kinase activity IBA 21873635
GO:0004715 Function Non-membrane spanning protein tyrosine kinase activity IDA 10688651, 11331870
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
300101 1079 ENSG00000102010
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P51813
Protein name Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38)
Protein function Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Partic
PDB 2EKX , 2YS2 , 3SXR , 3SXS , 6I99 , 8X2A
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00169 PH 5 → 111 PH domain Domain
PF00779 BTK 119 → 148 BTK motif Motif
PF00017 SH2 296 → 377 SH2 domain Domain
PF07714 PK_Tyr_Ser-Thr 417 → 666 Protein tyrosine and serine/threonine kinase Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines.
Sequence
Sequence length 675
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Apoptotic cleavage of cellular proteins
Synthesis of PIPs at the plasma membrane
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Lung carcinoma Large cell carcinoma of lung rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
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Show/Hide Text Mining Associations (28)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 28422715
Adenoma Stimulate 35221332
Alzheimer Disease Associate 24731980
Anxiety Associate 24860816
Biliary Atresia Associate 34962102
Brain Concussion Associate 24860816
Brain Injuries Traumatic Associate 24860816
Breast Neoplasms Stimulate 25649765
Carcinoma Associate 17823122
Carcinoma Renal Cell Associate 24606948