Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	65993
Gene name Gene Name - the full gene name approved by the HGNC.	Mitochondrial ribosomal protein S34
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MRPS34
Synonyms (NCBI Gene) Gene synonyms aliases	COXPD32, MRP-S12, MRP-S34, MRPS12, mS34
Disease Acronyms (UniProt) Disease acronyms from UniProt database	COXPD32
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020816	hsa-miR-155-5p	Proteomics	18668040
MIRT029599	hsa-miR-26b-5p	Microarray	19088304
MIRT050407	hsa-miR-23a-3p	CLASH	23622248
MIRT1160391	hsa-miR-1275	CLIP-seq
MIRT1160392	hsa-miR-2355-5p	CLIP-seq
MIRT1160393	hsa-miR-296-5p	CLIP-seq
MIRT1160394	hsa-miR-3153	CLIP-seq
MIRT1160395	hsa-miR-3166	CLIP-seq
MIRT1160396	hsa-miR-3670	CLIP-seq
MIRT1160397	hsa-miR-3679-3p	CLIP-seq
MIRT1160398	hsa-miR-4315	CLIP-seq
MIRT1160399	hsa-miR-4426	CLIP-seq
MIRT1160400	hsa-miR-4506	CLIP-seq
MIRT1160401	hsa-miR-4525	CLIP-seq
MIRT1160402	hsa-miR-4647	CLIP-seq
MIRT1160403	hsa-miR-4662b	CLIP-seq
MIRT1160404	hsa-miR-4665-5p	CLIP-seq
MIRT1160405	hsa-miR-4723-5p	CLIP-seq
MIRT1160406	hsa-miR-4771	CLIP-seq
MIRT1160407	hsa-miR-4792	CLIP-seq
MIRT1160408	hsa-miR-625	CLIP-seq
MIRT2046086	hsa-miR-103b	CLIP-seq
MIRT2046087	hsa-miR-1256	CLIP-seq
MIRT2046088	hsa-miR-1262	CLIP-seq
MIRT2046089	hsa-miR-1827	CLIP-seq
MIRT2046090	hsa-miR-214	CLIP-seq
MIRT2046091	hsa-miR-3128	CLIP-seq
MIRT2046092	hsa-miR-3151	CLIP-seq
MIRT2046093	hsa-miR-3619-5p	CLIP-seq
MIRT1160396	hsa-miR-3670	CLIP-seq
MIRT2046094	hsa-miR-376a	CLIP-seq
MIRT2046095	hsa-miR-376b	CLIP-seq
MIRT2046096	hsa-miR-3974	CLIP-seq
MIRT2046097	hsa-miR-4259	CLIP-seq
MIRT2046098	hsa-miR-4286	CLIP-seq
MIRT2046099	hsa-miR-4447	CLIP-seq
MIRT2046100	hsa-miR-4455	CLIP-seq
MIRT2046101	hsa-miR-4472	CLIP-seq
MIRT2046102	hsa-miR-4488	CLIP-seq
MIRT2046103	hsa-miR-4697-5p	CLIP-seq
MIRT2046104	hsa-miR-4701-3p	CLIP-seq
MIRT2046105	hsa-miR-4717-5p	CLIP-seq
MIRT2046106	hsa-miR-4720-5p	CLIP-seq
MIRT2046107	hsa-miR-4753-5p	CLIP-seq
MIRT1160406	hsa-miR-4771	CLIP-seq
MIRT1160407	hsa-miR-4792	CLIP-seq
MIRT2046108	hsa-miR-4799-3p	CLIP-seq
MIRT2046109	hsa-miR-486-3p	CLIP-seq
MIRT2046110	hsa-miR-491-5p	CLIP-seq
MIRT2046111	hsa-miR-571	CLIP-seq
MIRT2046112	hsa-miR-609	CLIP-seq
MIRT2046113	hsa-miR-761	CLIP-seq
MIRT1160391	hsa-miR-1275	CLIP-seq
MIRT1160394	hsa-miR-3153	CLIP-seq
MIRT2046100	hsa-miR-4455	CLIP-seq
MIRT1160400	hsa-miR-4506	CLIP-seq
MIRT1160401	hsa-miR-4525	CLIP-seq
MIRT1160404	hsa-miR-4665-5p	CLIP-seq
MIRT1160405	hsa-miR-4723-5p	CLIP-seq
MIRT1160408	hsa-miR-625	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003735	Function	Structural constituent of ribosome	IBA	21873635
GO:0003735	Function	Structural constituent of ribosome	IMP	28777931
GO:0005739	Component	Mitochondrion	IDA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005763	Component	Mitochondrial small ribosomal subunit	IBA	21873635
GO:0005763	Component	Mitochondrial small ribosomal subunit	ISS
GO:0032543	Process	Mitochondrial translation	IBA	21873635
GO:0032543	Process	Mitochondrial translation	IMP	28777931
GO:0032543	Process	Mitochondrial translation	ISS
GO:0070125	Process	Mitochondrial translational elongation	TAS
GO:0070126	Process	Mitochondrial translational termination	TAS

MIM	HGNC	e!Ensembl
611994	16618	ENSG00000074071

Protein

UniProt ID

P82930

Protein name

Small ribosomal subunit protein mS34 (28S ribosomal protein S34, mitochondrial) (MRP-S34) (S34mt)

Protein function

Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation.

PDB

3J9M , 6NU2 , 6RW4 , 6RW5 , 6VLZ , 6VMI , 6ZM5 , 6ZM6 , 6ZS9 , 6ZSA , 6ZSB , 6ZSC , 6ZSD , 6ZSE , 6ZSG , 7A5F , 7A5G , 7A5I , 7A5K , 7L08 , 7OG4 , 7P2E , 7PNX , 7PNY , 7PNZ , 7PO0 , 7PO1 , 7PO2 , 7PO3 , 7QI4 , 7QI5 , 7QI6 , 8ANY , 8CSP , 8CSQ , 8CSR , 8CSS , 8CST , 8CSU , 8K2A , 8OIR , 8OIS , 8QRK , 8QRL , 8QRM , 8QRN , 8RRI , 8XT0 , 8XT2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16053	MRP-S34	61 → 187	Mitochondrial 28S ribosomal protein S34	Family

Sequence

MARKKVRPRLIAELARRVRALREQLNRPRDSQLYAVDYETLTRPFSGRRLPVRAWADVRR
ESRLLQLLGRLPLFGLGRLVTRKSWLWQHDEPCYWRLTRVRPDYTAQNLDHGKAWGILTF
KGKTESEAREIEHVMYHDWRLVPKHEEEAFTAFTPAPEDSLASVPYPPLLRAMIIAERQK
NGDTSTEEPMLNVQRIRMEPWDYPAKQEDKGRAKGTPV

Sequence length

218

Interactions

View interactions

	Reactome
			Mitochondrial translation elongation Mitochondrial translation termination

Show/Hide Causal Diseases (6)

Disease term	Disease name	dbSNP ID	References
Causal
Combined oxidative phosphorylation deficiency	COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 32	rs587776508, rs576462794, rs118203917, rs387906327, rs139430866, rs387906962, rs138119149, rs387907061, rs1562800908, rs397515421, rs397514598, rs397514610, rs397514611, rs397514612, rs201431517 View all (155 more)	28777931
Developmental delay	Global developmental delay	rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291 View all (32 more)
Developmental regression	Developmental regression	rs1224421127
Leigh syndrome	Leigh Disease	rs267606829, rs137852863, rs121908577, rs1445075330, rs121908985, rs104893898, rs28939679, rs104894705, rs1568985256, rs199476144, rs199474672, rs118192098, rs118192100, rs199476133, rs199476135 View all (107 more)	2877793
Nystagmus	Nystagmus	rs137852207, rs137852208, rs1928435502, rs137852209, rs137852210, rs1929191668, rs137852211, rs137852212, rs2124209414, rs387906720, rs387906721, rs1602791884, rs786205896
Optic atrophy	Optic Atrophy	rs121434508, rs267607017, rs80356524, rs80356525, rs879255560, rs104893753, rs80356529, rs397515360, rs104893620, rs199476104, rs199476112, rs199476118, rs398124298, rs770066665, rs398124299 View all (37 more)

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Ptosis	Blepharoptosis, Ptosis	ClinVar
Leigh Syndrome	Leigh syndrome	GenCC

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining
Cholangiocarcinoma	Associate	35841118
Leigh Disease	Associate	28777931
Mitochondrial Diseases	Associate	28777931

MRPS34 (mitochondrial ribosomal protein S34)