Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	65985
Gene name	Acetoacetyl-CoA synthetase
Gene symbol	AACS
Synonyms (NCBI Gene)	ACSF1SUR-5
Chromosome	12
Chromosome location	12q24.31

223

Show/Hide all (223)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003093	hsa-miR-122-5p	Luciferase reporter assayqRT-PCR	19296470
MIRT045810	hsa-miR-191-5p	CLASH	23622248
MIRT037034	hsa-miR-877-3p	CLASH	23622248
MIRT531947	hsa-miR-3614-5p	PAR-CLIP	22012620
MIRT531946	hsa-miR-589-3p	PAR-CLIP	22012620
MIRT531945	hsa-miR-6793-3p	PAR-CLIP	22012620
MIRT531944	hsa-miR-1470	PAR-CLIP	22012620
MIRT531943	hsa-miR-4667-3p	PAR-CLIP	22012620
MIRT531942	hsa-miR-4466	PAR-CLIP	22012620
MIRT531941	hsa-miR-675-5p	PAR-CLIP	22012620
MIRT531947	hsa-miR-3614-5p	PAR-CLIP	22012620
MIRT531946	hsa-miR-589-3p	PAR-CLIP	22012620
MIRT531945	hsa-miR-6793-3p	PAR-CLIP	22012620
MIRT531944	hsa-miR-1470	PAR-CLIP	22012620
MIRT531943	hsa-miR-4667-3p	PAR-CLIP	22012620
MIRT531942	hsa-miR-4466	PAR-CLIP	22012620
MIRT531941	hsa-miR-675-5p	PAR-CLIP	22012620
MIRT756646	hsa-miR-1243	CLIP-seq
MIRT756647	hsa-miR-125a-5p	CLIP-seq
MIRT756648	hsa-miR-125b	CLIP-seq
MIRT756649	hsa-miR-1276	CLIP-seq
MIRT756650	hsa-miR-137	CLIP-seq
MIRT756651	hsa-miR-153	CLIP-seq
MIRT756652	hsa-miR-19a	CLIP-seq
MIRT756653	hsa-miR-19b	CLIP-seq
MIRT756654	hsa-miR-25	CLIP-seq
MIRT756655	hsa-miR-3126-5p	CLIP-seq
MIRT756656	hsa-miR-3163	CLIP-seq
MIRT756657	hsa-miR-32	CLIP-seq
MIRT756658	hsa-miR-320a	CLIP-seq
MIRT756659	hsa-miR-320b	CLIP-seq
MIRT756660	hsa-miR-320c	CLIP-seq
MIRT756661	hsa-miR-320d	CLIP-seq
MIRT756662	hsa-miR-342-5p	CLIP-seq
MIRT756663	hsa-miR-363	CLIP-seq
MIRT756664	hsa-miR-3654	CLIP-seq
MIRT756665	hsa-miR-367	CLIP-seq
MIRT756666	hsa-miR-3910	CLIP-seq
MIRT756667	hsa-miR-4278	CLIP-seq
MIRT756668	hsa-miR-4282	CLIP-seq
MIRT756669	hsa-miR-4311	CLIP-seq
MIRT756670	hsa-miR-4319	CLIP-seq
MIRT756671	hsa-miR-4419a	CLIP-seq
MIRT756672	hsa-miR-4429	CLIP-seq
MIRT756673	hsa-miR-448	CLIP-seq
MIRT756674	hsa-miR-4495	CLIP-seq
MIRT756675	hsa-miR-4502	CLIP-seq
MIRT756676	hsa-miR-4510	CLIP-seq
MIRT756677	hsa-miR-4664-5p	CLIP-seq
MIRT756678	hsa-miR-4668-5p	CLIP-seq
MIRT756679	hsa-miR-4695-3p	CLIP-seq
MIRT756680	hsa-miR-4725-5p	CLIP-seq
MIRT756681	hsa-miR-4729	CLIP-seq
MIRT756682	hsa-miR-4760-3p	CLIP-seq
MIRT756683	hsa-miR-4768-3p	CLIP-seq
MIRT756684	hsa-miR-486-5p	CLIP-seq
MIRT756685	hsa-miR-494	CLIP-seq
MIRT756686	hsa-miR-504	CLIP-seq
MIRT756687	hsa-miR-544b	CLIP-seq
MIRT756688	hsa-miR-548an	CLIP-seq
MIRT756689	hsa-miR-570	CLIP-seq
MIRT756690	hsa-miR-583	CLIP-seq
MIRT756691	hsa-miR-622	CLIP-seq
MIRT756692	hsa-miR-711	CLIP-seq
MIRT756693	hsa-miR-92a	CLIP-seq
MIRT756694	hsa-miR-92b	CLIP-seq
MIRT1921846	hsa-miR-1229	CLIP-seq
MIRT1921847	hsa-miR-128	CLIP-seq
MIRT1921848	hsa-miR-140-3p	CLIP-seq
MIRT1921849	hsa-miR-197	CLIP-seq
MIRT1921850	hsa-miR-4639-3p	CLIP-seq
MIRT1921851	hsa-miR-603	CLIP-seq
MIRT1923137	hsa-miR-1302	CLIP-seq
MIRT1923138	hsa-miR-15a	CLIP-seq
MIRT1923139	hsa-miR-15b	CLIP-seq
MIRT1923140	hsa-miR-16	CLIP-seq
MIRT1923141	hsa-miR-195	CLIP-seq
MIRT756658	hsa-miR-320a	CLIP-seq
MIRT756659	hsa-miR-320b	CLIP-seq
MIRT756660	hsa-miR-320c	CLIP-seq
MIRT756661	hsa-miR-320d	CLIP-seq
MIRT1923142	hsa-miR-374a	CLIP-seq
MIRT1923143	hsa-miR-374b	CLIP-seq
MIRT1923144	hsa-miR-424	CLIP-seq
MIRT1923145	hsa-miR-4298	CLIP-seq
MIRT756672	hsa-miR-4429	CLIP-seq
MIRT1923146	hsa-miR-4524	CLIP-seq
MIRT1923147	hsa-miR-4698	CLIP-seq
MIRT1923148	hsa-miR-497	CLIP-seq
MIRT1923149	hsa-miR-503	CLIP-seq
MIRT1923150	hsa-miR-548p	CLIP-seq
MIRT1923151	hsa-miR-646	CLIP-seq
MIRT1923137	hsa-miR-1302	CLIP-seq
MIRT1923138	hsa-miR-15a	CLIP-seq
MIRT1923139	hsa-miR-15b	CLIP-seq
MIRT1923140	hsa-miR-16	CLIP-seq
MIRT1923141	hsa-miR-195	CLIP-seq
MIRT756658	hsa-miR-320a	CLIP-seq
MIRT756659	hsa-miR-320b	CLIP-seq
MIRT756660	hsa-miR-320c	CLIP-seq
MIRT756661	hsa-miR-320d	CLIP-seq
MIRT2164669	hsa-miR-3612	CLIP-seq
MIRT2164670	hsa-miR-3663-3p	CLIP-seq
MIRT1923144	hsa-miR-424	CLIP-seq
MIRT1923145	hsa-miR-4298	CLIP-seq
MIRT756672	hsa-miR-4429	CLIP-seq
MIRT2164671	hsa-miR-4443	CLIP-seq
MIRT1923146	hsa-miR-4524	CLIP-seq
MIRT1923148	hsa-miR-497	CLIP-seq
MIRT1923149	hsa-miR-503	CLIP-seq
MIRT2164672	hsa-miR-526b	CLIP-seq
MIRT2164673	hsa-miR-578	CLIP-seq
MIRT1923151	hsa-miR-646	CLIP-seq
MIRT2164674	hsa-miR-650	CLIP-seq
MIRT756646	hsa-miR-1243	CLIP-seq
MIRT2466438	hsa-miR-125a-3p	CLIP-seq
MIRT2466439	hsa-miR-1266	CLIP-seq
MIRT756649	hsa-miR-1276	CLIP-seq
MIRT1923138	hsa-miR-15a	CLIP-seq
MIRT1923139	hsa-miR-15b	CLIP-seq
MIRT1923140	hsa-miR-16	CLIP-seq
MIRT2466440	hsa-miR-1827	CLIP-seq
MIRT1923141	hsa-miR-195	CLIP-seq
MIRT756652	hsa-miR-19a	CLIP-seq
MIRT756653	hsa-miR-19b	CLIP-seq
MIRT2466441	hsa-miR-224	CLIP-seq
MIRT2466442	hsa-miR-23a	CLIP-seq
MIRT2466443	hsa-miR-23b	CLIP-seq
MIRT2466444	hsa-miR-23c	CLIP-seq
MIRT2466445	hsa-miR-3138	CLIP-seq
MIRT2466446	hsa-miR-3189-3p	CLIP-seq
MIRT756658	hsa-miR-320a	CLIP-seq
MIRT756659	hsa-miR-320b	CLIP-seq
MIRT756660	hsa-miR-320c	CLIP-seq
MIRT756661	hsa-miR-320d	CLIP-seq
MIRT2164669	hsa-miR-3612	CLIP-seq
MIRT756664	hsa-miR-3654	CLIP-seq
MIRT2466447	hsa-miR-3664-3p	CLIP-seq
MIRT756666	hsa-miR-3910	CLIP-seq
MIRT2466448	hsa-miR-3934	CLIP-seq
MIRT2466449	hsa-miR-3977	CLIP-seq
MIRT1923144	hsa-miR-424	CLIP-seq
MIRT2466450	hsa-miR-4263	CLIP-seq
MIRT756669	hsa-miR-4311	CLIP-seq
MIRT2466451	hsa-miR-432	CLIP-seq
MIRT756672	hsa-miR-4429	CLIP-seq
MIRT2164671	hsa-miR-4443	CLIP-seq
MIRT2466452	hsa-miR-4462	CLIP-seq
MIRT756674	hsa-miR-4495	CLIP-seq
MIRT2466453	hsa-miR-4518	CLIP-seq
MIRT1923146	hsa-miR-4524	CLIP-seq
MIRT2466454	hsa-miR-4640-3p	CLIP-seq
MIRT756679	hsa-miR-4695-3p	CLIP-seq
MIRT2466455	hsa-miR-4707-3p	CLIP-seq
MIRT2466456	hsa-miR-4717-3p	CLIP-seq
MIRT756682	hsa-miR-4760-3p	CLIP-seq
MIRT2466457	hsa-miR-4787-5p	CLIP-seq
MIRT756684	hsa-miR-486-5p	CLIP-seq
MIRT756685	hsa-miR-494	CLIP-seq
MIRT1923148	hsa-miR-497	CLIP-seq
MIRT2466458	hsa-miR-502-5p	CLIP-seq
MIRT1923149	hsa-miR-503	CLIP-seq
MIRT756688	hsa-miR-548an	CLIP-seq
MIRT2466459	hsa-miR-548b-3p	CLIP-seq
MIRT2466460	hsa-miR-576-5p	CLIP-seq
MIRT756690	hsa-miR-583	CLIP-seq
MIRT2466461	hsa-miR-592	CLIP-seq
MIRT2466462	hsa-miR-597	CLIP-seq
MIRT2466463	hsa-miR-602	CLIP-seq
MIRT756691	hsa-miR-622	CLIP-seq
MIRT1923151	hsa-miR-646	CLIP-seq
MIRT2164674	hsa-miR-650	CLIP-seq
MIRT756692	hsa-miR-711	CLIP-seq
MIRT2466464	hsa-miR-764	CLIP-seq
MIRT2466438	hsa-miR-125a-3p	CLIP-seq
MIRT2466439	hsa-miR-1266	CLIP-seq
MIRT756649	hsa-miR-1276	CLIP-seq
MIRT1923138	hsa-miR-15a	CLIP-seq
MIRT1923139	hsa-miR-15b	CLIP-seq
MIRT1923140	hsa-miR-16	CLIP-seq
MIRT2466440	hsa-miR-1827	CLIP-seq
MIRT1923141	hsa-miR-195	CLIP-seq
MIRT756652	hsa-miR-19a	CLIP-seq
MIRT756653	hsa-miR-19b	CLIP-seq
MIRT2466441	hsa-miR-224	CLIP-seq
MIRT2466442	hsa-miR-23a	CLIP-seq
MIRT2466443	hsa-miR-23b	CLIP-seq
MIRT2466444	hsa-miR-23c	CLIP-seq
MIRT2466445	hsa-miR-3138	CLIP-seq
MIRT756658	hsa-miR-320a	CLIP-seq
MIRT756659	hsa-miR-320b	CLIP-seq
MIRT756660	hsa-miR-320c	CLIP-seq
MIRT756661	hsa-miR-320d	CLIP-seq
MIRT2164669	hsa-miR-3612	CLIP-seq
MIRT2466447	hsa-miR-3664-3p	CLIP-seq
MIRT2466448	hsa-miR-3934	CLIP-seq
MIRT2466449	hsa-miR-3977	CLIP-seq
MIRT1923144	hsa-miR-424	CLIP-seq
MIRT756669	hsa-miR-4311	CLIP-seq
MIRT756672	hsa-miR-4429	CLIP-seq
MIRT2164671	hsa-miR-4443	CLIP-seq
MIRT2466452	hsa-miR-4462	CLIP-seq
MIRT756674	hsa-miR-4495	CLIP-seq
MIRT2466453	hsa-miR-4518	CLIP-seq
MIRT1923146	hsa-miR-4524	CLIP-seq
MIRT2466454	hsa-miR-4640-3p	CLIP-seq
MIRT756679	hsa-miR-4695-3p	CLIP-seq
MIRT2466455	hsa-miR-4707-3p	CLIP-seq
MIRT2466456	hsa-miR-4717-3p	CLIP-seq
MIRT756682	hsa-miR-4760-3p	CLIP-seq
MIRT2466457	hsa-miR-4787-5p	CLIP-seq
MIRT756685	hsa-miR-494	CLIP-seq
MIRT1923148	hsa-miR-497	CLIP-seq
MIRT1923149	hsa-miR-503	CLIP-seq
MIRT2466459	hsa-miR-548b-3p	CLIP-seq
MIRT756690	hsa-miR-583	CLIP-seq
MIRT2466461	hsa-miR-592	CLIP-seq
MIRT2466462	hsa-miR-597	CLIP-seq
MIRT2466463	hsa-miR-602	CLIP-seq
MIRT756691	hsa-miR-622	CLIP-seq
MIRT1923151	hsa-miR-646	CLIP-seq
MIRT2164674	hsa-miR-650	CLIP-seq
MIRT2466464	hsa-miR-764	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0016874	Function	Ligase activity	IEA
GO:0030729	Function	Acetoacetate-CoA ligase activity	IBA
GO:0030729	Function	Acetoacetate-CoA ligase activity	IEA
GO:0030729	Function	Acetoacetate-CoA ligase activity	TAS
GO:0032024	Process	Positive regulation of insulin secretion	IBA
GO:0046951	Process	Ketone body biosynthetic process	TAS

MIM	HGNC	e!Ensembl
614364	21298	ENSG00000081760

Q86V21

Protein name

Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog)

Protein function

Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16177	ACAS_N	47 → 105	Acetyl-coenzyme A synthetase N-terminus	Family
PF00501	AMP-binding	103 → 546	AMP-binding enzyme	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in kidney, heart and brain, but low in liver. {ECO:0000269|PubMed:12623130}.

Sequence

MSKEERPGREEILECQVMWEPDSKKNTQMDRFRAAVGAACGLALESYDDLYHWSVESYSD
FWAEFWKFSGIVFSRVYDEVVDTSKGIADVPEWFKGSRLNYAENLLRHKENDRVALYIAR
EGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGDRVVGYLPNSEHAVEAMLAAASIGAIW
SSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHNHMEKLQQVVKGLPDLKKVVVIP
YVSSRENIDLSKIPNSVFLDDFLATGTSEQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCM
VHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVGWMMWNWMVSLLATGAAMVLYDGSPLV
PTPNVLWDLVDRIGITVLVTGAKWLSVLEEKAMKPVETHSLQMLHTILSTGSPLKAQSYE
YVYRCIKSSILLGSISGGTDIISCFMGHNFSLPVYKGEIQARNLGMAVEAWNEEGKAVWG
ESGELVCTKPIPCQPTHFWNDENGNKYRKAYFSKFPGIWAHGDYCRINPKTGGIVMLGRS
DGTLNPNGVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERVILFLKMASGHAFQPDLV
KRIRDAIRMGLSARHVPSLILETKGIPYTLNGKKVEVAVKQIIAGKAVEQGGAFSNPETL
DLYRDIPELQGF

Sequence length

672

Interactions

View interactions

	KEGG		Reactome
	Valine, leucine and isoleucine degradation Butanoate metabolism Metabolic pathways		Synthesis of Ketone Bodies

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs77320648	RCV005904583
Cervical cancer	Benign	rs77320648	RCV005904585
Clear cell carcinoma of kidney	Benign	rs77320648	RCV005904586
Colon adenocarcinoma	Benign	rs77320648	RCV005904582
Colorectal cancer	Uncertain significance	rs140472203	RCV005927136
Gastric cancer	Benign	rs77320648	RCV005904587
Hepatocellular carcinoma	Benign	rs77320648	RCV005904584
Lung cancer	Benign	rs77320648	RCV005904590
Thyroid cancer, nonmedullary, 1	Benign	rs77320648	RCV005904589
Uterine carcinosarcoma	Benign	rs77320648	RCV005904588
Uterine corpus endometrial carcinoma	Benign	rs77320648	RCV005904591

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Carcinoma Hepatocellular	Associate	24452951
Carcinoma Hepatocellular	Stimulate	36205594
Colorectal Neoplasms	Associate	35924107
Insulin Resistance	Associate	30913280
Metabolic Syndrome	Associate	30913280

AACS (acetoacetyl-CoA synthetase)