SLIT3 (slit guidance ligand 3)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 6586
Gene name Slit guidance ligand 3
Gene symbol SLIT3
Synonyms (NCBI Gene)
MEGF5SLIL2SLIT1Slit-3slit2
Chromosome 5
Chromosome location 5q34-q35.1
Summary The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
miRNA miRNA information provided by mirtarbase database.
19
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (19)
miRTarBase ID miRNA Experiments Reference
MIRT053057 hsa-miR-218-2-3p ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 23720784
MIRT2109754 hsa-miR-362-5p CLIP-seq
MIRT2109755 hsa-miR-500b CLIP-seq
MIRT2109756 hsa-miR-501-5p CLIP-seq
MIRT2333092 hsa-miR-3667-3p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
42
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (42)
GO ID Ontology Definition Evidence Reference
GO:0003180 Process Aortic valve morphogenesis IEA
GO:0003180 Process Aortic valve morphogenesis ISS
GO:0003181 Process Atrioventricular valve morphogenesis IEA
GO:0003181 Process Atrioventricular valve morphogenesis ISS
GO:0005509 Function Calcium ion binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603745 11087 ENSG00000184347
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75094
Protein name Slit homolog 3 protein (Slit-3) (Multiple epidermal growth factor-like domains protein 5) (Multiple EGF-like domains protein 5)
Protein function May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01462 LRRNT 33 → 60 Leucine rich repeat N-terminal domain Family
PF13855 LRR_8 61 → 121 Leucine rich repeat Repeat
PF13855 LRR_8 109 → 169 Leucine rich repeat Repeat
PF13855 LRR_8 157 → 217 Leucine rich repeat Repeat
PF01463 LRRCT 239 → 264 Leucine rich repeat C-terminal domain Family
PF01462 LRRNT 279 → 306 Leucine rich repeat N-terminal domain Family
PF13855 LRR_8 307 → 367 Leucine rich repeat Repeat
PF13855 LRR_8 331 → 391 Leucine rich repeat Repeat
PF01463 LRRCT 461 → 486 Leucine rich repeat C-terminal domain Family
PF13855 LRR_8 532 → 593 Leucine rich repeat Repeat
PF13855 LRR_8 581 → 641 Leucine rich repeat Repeat
PF13855 LRR_8 605 → 665 Leucine rich repeat Repeat
PF01463 LRRCT 687 → 712 Leucine rich repeat C-terminal domain Family
PF01462 LRRNT 724 → 751 Leucine rich repeat N-terminal domain Family
PF13855 LRR_8 752 → 811 Leucine rich repeat Repeat
PF13855 LRR_8 799 → 859 Leucine rich repeat Repeat
PF01463 LRRCT 881 → 906 Leucine rich repeat C-terminal domain Family
PF12661 hEGF 925 → 944 Human growth factor-like EGF Domain
PF00008 EGF 959 → 992 EGF-like domain Domain
PF00008 EGF 1000 → 1030 EGF-like domain Domain
PF00008 EGF 1038 → 1070 EGF-like domain Domain
PF00008 EGF 1078 → 1108 EGF-like domain Domain
PF00008 EGF 1123 → 1153 EGF-like domain Domain
PF02210 Laminin_G_2 1186 → 1314 Laminin G domain Domain
PF00008 EGF 1371 → 1401 EGF-like domain Domain
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in thyroid. {ECO:0000269|PubMed:9813312}.
Sequence 
MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIP
RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNK
LQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRAL
RDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFT
LCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLME
IPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSL
VLYGNKITEIVKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISK
GLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKS
KKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLN
DNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRV
FRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINL
LSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQ
LSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLI
DLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPE
GSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT
HRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCI
QNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVC
ICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVA
HKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQE
PTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGD
NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPK
SLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKA
LPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG
KCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSG
EHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQ
CTDGSSFVEEVERHLECGCLACS
Sequence length 1523
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Axon guidance   Signaling by ROBO receptors
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
23
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Familial congenital diaphragmatic hernia Likely pathogenic rs926590189 RCV001281695
Show/Hide Unknown Diseases (2)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
SLIT3-related anomalies of the kidney and urinary tract Uncertain significance rs77214174, rs149709542, rs138307962, rs750504474, rs746097776 RCV003148089
RCV003148182
RCV003148207
RCV003333269
RCV003333343
SLIT3-related disorder Uncertain significance; Likely benign; Benign rs372876846, rs768418458, rs1761053731, rs143047334, rs149659886, rs72839508, rs140499772, rs147560182, rs1454938390, rs144594798, rs35568421, rs143425660, rs577752594, rs577365804, rs145745913
View all (2 more)		 RCV003420404
RCV003429078
RCV003410445
RCV003901071
RCV003908953
RCV004756516
RCV003939008
RCV003939257
RCV003896402
RCV003903949
RCV003927127
RCV003951669
RCV003949680
RCV003949499
RCV003978918
RCV003910432
RCV003922954
Show/Hide Text Mining Associations (36)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Inhibit 36752296
Adenoma Associate 24516561, 27896617
Arthritis Rheumatoid Associate 20298552
Bicuspid Aortic Valve Disease Associate 36071494
Bipolar Disorder Associate 27112568
Breast Neoplasms Associate 15534609, 36361532, 37178414
Carcinoma Hepatocellular Associate 19114000
Carcinoma Non Small Cell Lung Associate 26632718
Carcinoma Squamous Cell Associate 29568882, 36451444
Colonic Neoplasms Inhibit 35034539