Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6585
Gene name	Slit guidance ligand 1
Gene symbol	SLIT1
Synonyms (NCBI Gene)	MEGF4SLIL1SLIT-1SLIT3
Chromosome	10
Chromosome location	10q24.1

160

Show/Hide all (160)

miRTarBase ID	miRNA	Experiments	Reference
MIRT039395	hsa-miR-421	CLASH	23622248
MIRT653389	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT636220	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT653388	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT639917	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT641914	hsa-miR-1324	HITS-CLIP	23824327
MIRT639916	hsa-miR-5193	HITS-CLIP	23824327
MIRT639915	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT639914	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT639913	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT639912	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT639911	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT639910	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT639909	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT639908	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT639917	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT639916	hsa-miR-5193	HITS-CLIP	23824327
MIRT639915	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT639914	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT639913	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT639912	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT639911	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT639910	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT639909	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT639908	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT636220	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT513362	hsa-miR-4695-5p	PAR-CLIP	23446348
MIRT513361	hsa-miR-4779	PAR-CLIP	23446348
MIRT513360	hsa-miR-5008-3p	PAR-CLIP	23446348
MIRT513359	hsa-miR-6737-3p	PAR-CLIP	23446348
MIRT513358	hsa-miR-7157-3p	PAR-CLIP	23446348
MIRT513357	hsa-miR-485-5p	PAR-CLIP	23446348
MIRT513356	hsa-miR-6884-5p	PAR-CLIP	23446348
MIRT513355	hsa-miR-4505	PAR-CLIP	23446348
MIRT513354	hsa-miR-5787	PAR-CLIP	23446348
MIRT513353	hsa-miR-4640-5p	PAR-CLIP	23446348
MIRT513352	hsa-miR-4726-5p	PAR-CLIP	23446348
MIRT513350	hsa-miR-6508-3p	PAR-CLIP	23446348
MIRT513351	hsa-miR-541-3p	PAR-CLIP	23446348
MIRT513349	hsa-miR-654-5p	PAR-CLIP	23446348
MIRT513348	hsa-miR-92a-2-5p	PAR-CLIP	23446348
MIRT513346	hsa-miR-6769a-5p	PAR-CLIP	23446348
MIRT513347	hsa-miR-6769b-5p	PAR-CLIP	23446348
MIRT513345	hsa-miR-4266	PAR-CLIP	23446348
MIRT653389	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT636220	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT653388	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT639917	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT641914	hsa-miR-1324	HITS-CLIP	23824327
MIRT639916	hsa-miR-5193	HITS-CLIP	23824327
MIRT639915	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT639914	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT639913	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT639912	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT639911	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT639910	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT639909	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT639908	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT639917	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT639916	hsa-miR-5193	HITS-CLIP	23824327
MIRT639915	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT639914	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT639913	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT639912	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT639911	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT639910	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT639909	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT639908	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT636220	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT513362	hsa-miR-4695-5p	PAR-CLIP	23446348
MIRT513361	hsa-miR-4779	PAR-CLIP	23446348
MIRT513360	hsa-miR-5008-3p	PAR-CLIP	23446348
MIRT513359	hsa-miR-6737-3p	PAR-CLIP	23446348
MIRT513358	hsa-miR-7157-3p	PAR-CLIP	23446348
MIRT513357	hsa-miR-485-5p	PAR-CLIP	23446348
MIRT513356	hsa-miR-6884-5p	PAR-CLIP	23446348
MIRT513355	hsa-miR-4505	PAR-CLIP	23446348
MIRT513354	hsa-miR-5787	PAR-CLIP	23446348
MIRT513353	hsa-miR-4640-5p	PAR-CLIP	23446348
MIRT513352	hsa-miR-4726-5p	PAR-CLIP	23446348
MIRT513350	hsa-miR-6508-3p	PAR-CLIP	23446348
MIRT513351	hsa-miR-541-3p	PAR-CLIP	23446348
MIRT513349	hsa-miR-654-5p	PAR-CLIP	23446348
MIRT513348	hsa-miR-92a-2-5p	PAR-CLIP	23446348
MIRT513346	hsa-miR-6769a-5p	PAR-CLIP	23446348
MIRT513347	hsa-miR-6769b-5p	PAR-CLIP	23446348
MIRT513345	hsa-miR-4266	PAR-CLIP	23446348
MIRT1369702	hsa-miR-1208	CLIP-seq
MIRT1369703	hsa-miR-1266	CLIP-seq
MIRT1369704	hsa-miR-1295	CLIP-seq
MIRT1369705	hsa-miR-2355-5p	CLIP-seq
MIRT1369706	hsa-miR-296-3p	CLIP-seq
MIRT1369707	hsa-miR-3130-3p	CLIP-seq
MIRT1369708	hsa-miR-3664-3p	CLIP-seq
MIRT1369709	hsa-miR-3668	CLIP-seq
MIRT1369710	hsa-miR-3935	CLIP-seq
MIRT1369711	hsa-miR-4294	CLIP-seq
MIRT1369712	hsa-miR-4326	CLIP-seq
MIRT1369713	hsa-miR-4474-3p	CLIP-seq
MIRT1369714	hsa-miR-4518	CLIP-seq
MIRT1369715	hsa-miR-4710	CLIP-seq
MIRT1369716	hsa-miR-4717-5p	CLIP-seq
MIRT1369717	hsa-miR-4792	CLIP-seq
MIRT1369718	hsa-miR-4793-3p	CLIP-seq
MIRT1369702	hsa-miR-1208	CLIP-seq
MIRT1369707	hsa-miR-3130-3p	CLIP-seq
MIRT2109744	hsa-miR-346	CLIP-seq
MIRT2109745	hsa-miR-3591-5p	CLIP-seq
MIRT2109746	hsa-miR-4290	CLIP-seq
MIRT1369711	hsa-miR-4294	CLIP-seq
MIRT1369712	hsa-miR-4326	CLIP-seq
MIRT2109747	hsa-miR-4460	CLIP-seq
MIRT2109748	hsa-miR-4527	CLIP-seq
MIRT2109749	hsa-miR-4715-3p	CLIP-seq
MIRT2109750	hsa-miR-4727-3p	CLIP-seq
MIRT2109751	hsa-miR-4727-5p	CLIP-seq
MIRT2109752	hsa-miR-4769-3p	CLIP-seq
MIRT1369718	hsa-miR-4793-3p	CLIP-seq
MIRT2109753	hsa-miR-615-5p	CLIP-seq
MIRT2333081	hsa-miR-140-3p	CLIP-seq
MIRT2333082	hsa-miR-150	CLIP-seq
MIRT1369705	hsa-miR-2355-5p	CLIP-seq
MIRT2333083	hsa-miR-3176	CLIP-seq
MIRT2109744	hsa-miR-346	CLIP-seq
MIRT2109745	hsa-miR-3591-5p	CLIP-seq
MIRT2333084	hsa-miR-3922-3p	CLIP-seq
MIRT2109746	hsa-miR-4290	CLIP-seq
MIRT2109747	hsa-miR-4460	CLIP-seq
MIRT2109748	hsa-miR-4527	CLIP-seq
MIRT2333085	hsa-miR-4659a-3p	CLIP-seq
MIRT2333086	hsa-miR-4659b-3p	CLIP-seq
MIRT2333087	hsa-miR-4685-5p	CLIP-seq
MIRT2109749	hsa-miR-4715-3p	CLIP-seq
MIRT2109750	hsa-miR-4727-3p	CLIP-seq
MIRT2109751	hsa-miR-4727-5p	CLIP-seq
MIRT2333088	hsa-miR-4757-5p	CLIP-seq
MIRT2109752	hsa-miR-4769-3p	CLIP-seq
MIRT2109753	hsa-miR-615-5p	CLIP-seq
MIRT2459951	hsa-miR-2861	CLIP-seq
MIRT2459952	hsa-miR-3189-5p	CLIP-seq
MIRT2459953	hsa-miR-3192	CLIP-seq
MIRT2459954	hsa-miR-4323	CLIP-seq
MIRT2459955	hsa-miR-4434	CLIP-seq
MIRT2459956	hsa-miR-4516	CLIP-seq
MIRT2459957	hsa-miR-661	CLIP-seq
MIRT2459951	hsa-miR-2861	CLIP-seq
MIRT2459952	hsa-miR-3189-5p	CLIP-seq
MIRT2459953	hsa-miR-3192	CLIP-seq
MIRT2459954	hsa-miR-4323	CLIP-seq
MIRT2459955	hsa-miR-4434	CLIP-seq
MIRT2459956	hsa-miR-4516	CLIP-seq
MIRT2459957	hsa-miR-661	CLIP-seq
MIRT2333083	hsa-miR-3176	CLIP-seq
MIRT2333084	hsa-miR-3922-3p	CLIP-seq
MIRT2627400	hsa-miR-520a-5p	CLIP-seq
MIRT2627401	hsa-miR-525-5p	CLIP-seq
MIRT2333083	hsa-miR-3176	CLIP-seq
MIRT2333084	hsa-miR-3922-3p	CLIP-seq
MIRT2627400	hsa-miR-520a-5p	CLIP-seq
MIRT2627401	hsa-miR-525-5p	CLIP-seq

Show/Hide all (38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005509	Function	Calcium ion binding	NAS	9813312
GO:0005515	Function	Protein binding	IPI	21653829, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	NAS	9813312
GO:0007097	Process	Nuclear migration	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0007409	Process	Axonogenesis	IEA
GO:0007411	Process	Axon guidance	IBA
GO:0007411	Process	Axon guidance	IDA	11748139
GO:0007411	Process	Axon guidance	IEA
GO:0008045	Process	Motor neuron axon guidance	IEA
GO:0008045	Process	Motor neuron axon guidance	IMP	16162649
GO:0008201	Function	Heparin binding	IBA
GO:0021510	Process	Spinal cord development	IEA
GO:0021772	Process	Olfactory bulb development	IEA
GO:0021834	Process	Chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration	IDA	11748139
GO:0022028	Process	Tangential migration from the subventricular zone to the olfactory bulb	IEA
GO:0022029	Process	Telencephalon cell migration	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0031290	Process	Retinal ganglion cell axon guidance	IEA
GO:0033563	Process	Dorsal/ventral axon guidance	IEA
GO:0043395	Function	Heparan sulfate proteoglycan binding	IEA
GO:0048495	Function	Roundabout binding	IBA
GO:0048495	Function	Roundabout binding	IEA
GO:0048495	Function	Roundabout binding	IPI	15207848
GO:0048812	Process	Neuron projection morphogenesis	IEA
GO:0048843	Process	Negative regulation of axon extension involved in axon guidance	IEA
GO:0048846	Process	Axon extension involved in axon guidance	IDA	16840550
GO:0048846	Process	Axon extension involved in axon guidance	IEA
GO:0048853	Process	Forebrain morphogenesis	NAS	9813312
GO:0050919	Process	Negative chemotaxis	IBA
GO:0050919	Process	Negative chemotaxis	IDA	11748139
GO:0050919	Process	Negative chemotaxis	IEA
GO:0050919	Process	Negative chemotaxis	IEA
GO:0051964	Process	Negative regulation of synapse assembly	ISS

MIM	HGNC	e!Ensembl
603742	11085	ENSG00000187122

O75093

Protein name

Slit homolog 1 protein (Slit-1) (Multiple epidermal growth factor-like domains protein 4) (Multiple EGF-like domains protein 4)

Protein function

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tu

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01462	LRRNT	33 → 60	Leucine rich repeat N-terminal domain	Family
PF13855	LRR_8	61 → 121	Leucine rich repeat	Repeat
PF13855	LRR_8	109 → 169	Leucine rich repeat	Repeat
PF13855	LRR_8	157 → 217	Leucine rich repeat	Repeat
PF01463	LRRCT	239 → 264	Leucine rich repeat C-terminal domain	Family
PF01462	LRRNT	281 → 308	Leucine rich repeat N-terminal domain	Family
PF13855	LRR_8	309 → 369	Leucine rich repeat	Repeat
PF13855	LRR_8	357 → 412	Leucine rich repeat	Repeat
PF13855	LRR_8	381 → 441	Leucine rich repeat	Repeat
PF01463	LRRCT	463 → 488	Leucine rich repeat C-terminal domain	Family
PF13855	LRR_8	589 → 649	Leucine rich repeat	Repeat
PF13855	LRR_8	613 → 673	Leucine rich repeat	Repeat
PF01463	LRRCT	695 → 720	Leucine rich repeat C-terminal domain	Family
PF01462	LRRNT	733 → 760	Leucine rich repeat N-terminal domain	Family
PF13855	LRR_8	761 → 820	Leucine rich repeat	Repeat
PF13855	LRR_8	808 → 868	Leucine rich repeat	Repeat
PF01463	LRRCT	890 → 915	Leucine rich repeat C-terminal domain	Family
PF00008	EGF	929 → 960	EGF-like domain	Domain
PF00008	EGF	968 → 1001	EGF-like domain	Domain
PF00008	EGF	1009 → 1039	EGF-like domain	Domain
PF00008	EGF	1047 → 1079	EGF-like domain	Domain
PF00008	EGF	1087 → 1117	EGF-like domain	Domain
PF12661	hEGF	1136 → 1157	Human growth factor-like EGF	Domain
PF02210	Laminin_G_2	1194 → 1322	Laminin G domain	Domain
PF12661	hEGF	1347 → 1368	Human growth factor-like EGF	Domain

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney. {ECO:0000269|PubMed:9813312}.

Sequence

MALTPGWGSSAGPVRPELWLLLWAAAWRLGASACPALCTCTGTTVDCHGTGLQAIPKNIP
RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ
LHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRAL
RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFT
QCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGL
TAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLN
SLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSL
AKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQI
KSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQ
STAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQ
LESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTL
QSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCE
EGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQL
STFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLH
GNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDME
GKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRD
CEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVC
VDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNC
SENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGA
NCVDQGNRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDN
GILLYNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNL
SIDGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNLYIN
NELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGP
CHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGA
HCVCDPGFSGELCEQESECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPGQGCCQG
LRLKRRKFTFECSDGTSFAEEVEKPTKCGCALCA

Sequence length

1534

Interactions

View interactions

	KEGG
	Axon guidance

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Monomelic amyotrophy	Likely pathogenic	rs2493101808	RCV003224774

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Carcinoma Hepatocellular	Associate	19114000
Coronary Artery Disease	Associate	35793981
Developmental Disabilities	Associate	32973238
Glioma	Associate	35996510
Leukemia Myeloid Acute	Associate	30820596
Neoplasms	Associate	15534609
Parkinson Disease	Associate	26961748
Pituitary Neoplasms	Associate	33168897

SLIT1 (slit guidance ligand 1)