Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6578
Gene name	Solute carrier organic anion transporter family member 2A1
Gene symbol	SLCO2A1
Synonyms (NCBI Gene)	MATR1OATP2A1PGTPHOADPHOAR2SLC21A2
Chromosome	3
Chromosome location	3q22.1-q22.2
Summary	This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, D

Show/Hide all (14)

SNP ID	Visualize variation	Clinical significance	Consequence
rs387906806	C>T	Pathogenic	Missense variant, coding sequence variant
rs387907295	C>A	Pathogenic	Missense variant, coding sequence variant
rs387907296	T>A,C	Pathogenic	Missense variant, coding sequence variant, 5 prime UTR variant
rs387907297	C>A,T	Pathogenic	Missense variant, coding sequence variant, stop gained, 5 prime UTR variant
rs751192029	A>-,AA	Pathogenic	Frameshift variant, coding sequence variant
rs765249238	C>T	Pathogenic	Splice donor variant
rs774795340	C>T	Pathogenic	Coding sequence variant, missense variant
rs776813259	G>A	Pathogenic	Genic downstream transcript variant, downstream transcript variant, coding sequence variant, stop gained
rs1085307096	GGTAGACTTCGG>-	Likely-pathogenic	Inframe deletion, coding sequence variant
rs1381150705	G>C	Pathogenic	Coding sequence variant, 5 prime UTR variant, stop gained
rs1559927542	T>-	Pathogenic	Frameshift variant, coding sequence variant
rs1559943990	C>T	Pathogenic	Splice acceptor variant
rs1576428882	C>G	Likely-pathogenic	Splice acceptor variant
rs1576467025	C>-	Likely-pathogenic	Frameshift variant, 5 prime UTR variant, coding sequence variant

Show/Hide all (67)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025150	hsa-miR-181a-5p	Microarray	17612493
MIRT1369319	hsa-miR-1182	CLIP-seq
MIRT1369320	hsa-miR-1224-3p	CLIP-seq
MIRT1369321	hsa-miR-1229	CLIP-seq
MIRT1369322	hsa-miR-1236	CLIP-seq
MIRT1369323	hsa-miR-1976	CLIP-seq
MIRT1369324	hsa-miR-2467-5p	CLIP-seq
MIRT1369325	hsa-miR-3119	CLIP-seq
MIRT1369326	hsa-miR-3188	CLIP-seq
MIRT1369327	hsa-miR-370	CLIP-seq
MIRT1369328	hsa-miR-3975	CLIP-seq
MIRT1369329	hsa-miR-4279	CLIP-seq
MIRT1369330	hsa-miR-4286	CLIP-seq
MIRT1369331	hsa-miR-4488	CLIP-seq
MIRT1369332	hsa-miR-4667-5p	CLIP-seq
MIRT1369333	hsa-miR-4697-5p	CLIP-seq
MIRT1369334	hsa-miR-4700-3p	CLIP-seq
MIRT1369335	hsa-miR-4700-5p	CLIP-seq
MIRT1369336	hsa-miR-4757-5p	CLIP-seq
MIRT1369337	hsa-miR-4768-5p	CLIP-seq
MIRT1369338	hsa-miR-485-5p	CLIP-seq
MIRT1369339	hsa-miR-637	CLIP-seq
MIRT2332910	hsa-miR-130a	CLIP-seq
MIRT2332911	hsa-miR-130b	CLIP-seq
MIRT2332912	hsa-miR-2682	CLIP-seq
MIRT2332913	hsa-miR-299-3p	CLIP-seq
MIRT2332914	hsa-miR-301a	CLIP-seq
MIRT2332915	hsa-miR-301b	CLIP-seq
MIRT2332916	hsa-miR-3122	CLIP-seq
MIRT2332917	hsa-miR-34a	CLIP-seq
MIRT2332918	hsa-miR-34c-5p	CLIP-seq
MIRT2332919	hsa-miR-3666	CLIP-seq
MIRT2332920	hsa-miR-3689a-3p	CLIP-seq
MIRT2332921	hsa-miR-3689c	CLIP-seq
MIRT2332922	hsa-miR-3714	CLIP-seq
MIRT2332923	hsa-miR-3913-5p	CLIP-seq
MIRT2332924	hsa-miR-4270	CLIP-seq
MIRT2332925	hsa-miR-4295	CLIP-seq
MIRT2332926	hsa-miR-4297	CLIP-seq
MIRT2332927	hsa-miR-4441	CLIP-seq
MIRT2332928	hsa-miR-4464	CLIP-seq
MIRT2332929	hsa-miR-4493	CLIP-seq
MIRT2332930	hsa-miR-449a	CLIP-seq
MIRT2332931	hsa-miR-449b	CLIP-seq
MIRT2332932	hsa-miR-449c	CLIP-seq
MIRT2332933	hsa-miR-454	CLIP-seq
MIRT2332934	hsa-miR-4648	CLIP-seq
MIRT2332935	hsa-miR-4654	CLIP-seq
MIRT2332936	hsa-miR-4710	CLIP-seq
MIRT2332937	hsa-miR-4748	CLIP-seq
MIRT2332938	hsa-miR-4755-3p	CLIP-seq
MIRT1369336	hsa-miR-4757-5p	CLIP-seq
MIRT2332939	hsa-miR-4769-5p	CLIP-seq
MIRT2332940	hsa-miR-515-3p	CLIP-seq
MIRT2332941	hsa-miR-519e	CLIP-seq
MIRT2332942	hsa-miR-548m	CLIP-seq
MIRT2332943	hsa-miR-576-3p	CLIP-seq
MIRT2394833	hsa-miR-1179	CLIP-seq
MIRT1369319	hsa-miR-1182	CLIP-seq
MIRT2394834	hsa-miR-3184	CLIP-seq
MIRT2394835	hsa-miR-423-5p	CLIP-seq
MIRT2394836	hsa-miR-4649-3p	CLIP-seq
MIRT2394837	hsa-miR-4716-3p	CLIP-seq
MIRT2394838	hsa-miR-4723-5p	CLIP-seq
MIRT2394839	hsa-miR-4728-5p	CLIP-seq
MIRT2394840	hsa-miR-507	CLIP-seq
MIRT2394841	hsa-miR-557	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005319	Function	Lipid transporter activity	IEA
GO:0005319	Function	Lipid transporter activity	TAS	8787677
GO:0005737	Component	Cytoplasm	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8787677
GO:0006869	Process	Lipid transport	IEA
GO:0006869	Process	Lipid transport	TAS	8787677
GO:0009925	Component	Basal plasma membrane	IDA	35307651
GO:0009925	Component	Basal plasma membrane	IEA
GO:0015132	Function	Prostaglandin transmembrane transporter activity	IBA
GO:0015132	Function	Prostaglandin transmembrane transporter activity	IEA
GO:0015132	Function	Prostaglandin transmembrane transporter activity	TAS
GO:0015347	Function	Sodium-independent organic anion transmembrane transporter activity	IBA
GO:0015732	Process	Prostaglandin transport	IBA
GO:0015732	Process	Prostaglandin transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	8787677
GO:0016323	Component	Basolateral plasma membrane	IBA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0043252	Process	Sodium-independent organic anion transport	IBA
GO:0043252	Process	Sodium-independent organic anion transport	TAS
GO:0055085	Process	Transmembrane transport	IEA

MIM	HGNC	e!Ensembl
601460	10955	ENSG00000174640

Q92959

Protein name

Solute carrier organic anion transporter family member 2A1 (SLCO2A1) (OATP2A1) (PHOAR2) (Prostaglandin transporter) (PGT) (Solute carrier family 21 member 2) (SLC21A2)

Protein function

Mediates the transport of prostaglandins (PGs, mainly PGE2, PGE1, PGE3, PGF2alpha, PGD2, PGH2) and thromboxanes (thromboxane B2) across the cell membrane (PubMed:11997326, PubMed:26692285, PubMed:8787677). PGs and thromboxanes play fundamental r

PDB

3MRR , 8KGI , 8KGV , 8KGW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03137	OATP	33 → 602	Organic Anion Transporter Polypeptide (OATP) family	Family
PF07648	Kazal_2	445 → 494	Kazal-type serine protease inhibitor domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous (PubMed:22331663, PubMed:8787677). Significant expression observed in lung, kidney, spleen, and heart (PubMed:22331663). Expressed in the endometrium (at both mRNA and protein levels) (PubMed:15657371, PubMed:16339169). Expr

Sequence

MGLLPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIE
KRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHF
LSEPYQYTLASTGNNSRLQAELCQKHWQDLPPSKCHSTTQNPQKETSSMWGLMVVAQLLA
GIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVN
TAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLE
EAKSRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTS
AAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGC
STPTVAEVYPPSTSSSIHPQSPACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMS
SATSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLPAIFLISFVSLIACISHNPLYMMV
LRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDND
ALRDRYLGLQMGYKALGMLLLCFISWRVKKNKEYNVQKAAGLI

Sequence length

643

Interactions

View interactions

	Reactome
			Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) Transport of organic anions

Show/Hide Causal Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Cervical cancer	Pathogenic	rs774795340	RCV005900928
Hepatocellular carcinoma	Pathogenic	rs765249238	RCV005893890
Hypertrophic osteoarthropathy, primary, autosomal dominant	Pathogenic; Likely pathogenic	rs2108043577, rs765824772, rs1177054873, rs776813259, rs774795340, rs387907297	RCV001527660 RCV001527662 RCV001527665 RCV001527663 RCV001527659 RCV001527661
Hypertrophic osteoarthropathy, primary, autosomal recessive, 2	Pathogenic; Likely pathogenic	rs2108043577, rs778081416, rs1177054873, rs2108035368, rs765698717, rs2108045784, rs2108045848, rs200316980, rs387907297, rs1576444504, rs768030732, rs758054913, rs776813259, rs1085307096, rs765249238 View all (25 more)	RCV003642961 RCV001527664 RCV001527666 RCV001527667 RCV001533517 RCV001533515 RCV001533516 RCV003642983 RCV003642981 RCV002052072 RCV006257371 RCV003776900 RCV000490280 RCV000490458 RCV000490351 RCV003389097 RCV003447855 RCV003643500 RCV003643501 RCV003643502 RCV003643503 RCV003643504 RCV003643505 RCV003643507 RCV003643508 RCV003643509 RCV003643510 RCV003643511 RCV000023104 RCV000023105 RCV000023106 RCV000505666 RCV000030778 RCV003642868 RCV000030780 RCV000030781 RCV000030782 RCV001029822 RCV001029816 RCV001198034 RCV001255883 RCV001255885 RCV001255886
Pachydermoperiostosis syndrome	Pathogenic	rs2472498909	RCV003994633

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Adrenocortical carcinoma, hereditary	Benign	rs10935090	RCV005921192
Clear cell carcinoma of kidney	Uncertain significance	rs140206661	RCV005926580
Colorectal cancer	Benign	rs10935090	RCV005921195
Familial pancreatic carcinoma	Benign	rs10935090	RCV005921193
Gastric cancer	Benign	rs149443780	RCV005912095
Malignant lymphoma, large B-cell, diffuse	Benign	rs10935090	RCV005921194
Malignant tumor of esophagus	Benign	rs149443780	RCV005912094
SLCO2A1-related disorder	Likely benign; Benign; Conflicting classifications of pathogenicity	rs556416557, rs79619371, rs556819076, rs561841509, rs377718592, rs746875740, rs146970901, rs146195307, rs201797879, rs145832999, rs141676845, rs142920472, rs530021473	RCV004731218 RCV003903349 RCV003973788 RCV003911936 RCV003961429 RCV003954371 RCV003903257 RCV003955851 RCV003910626 RCV003932931 RCV003923100 RCV003923197 RCV003960553
Thymoma	Conflicting classifications of pathogenicity	rs149946676	RCV005917445
Thyroid cancer, nonmedullary, 1	Likely benign	rs527244554	RCV005903068

Show/Hide Text Mining Associations (53)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
3C syndrome	Stimulate	21383546
Adenoma	Associate	24099521
Alzheimer Disease	Associate	18353443
Anemia	Associate	29313109, 33328413, 33852188, 35611666
Aortic Dissection	Associate	36818541
Arthralgia	Associate	33852188, 37226222
Atresia of small intestine	Associate	26539716, 30400730, 37077520
Autoimmune enteropathy	Associate	30065566
Behcet Syndrome	Associate	32092751
Breast Neoplasms	Associate	35617355
Carcinoma Hepatocellular	Associate	21383546, 33988674
Chronic Disease	Associate	26539716, 29313109, 30400730, 31011259, 31611528, 32092751, 32943023, 33166338, 33328413, 35185052, 35611666, 36480694, 36907595, 37077520
Clubfoot	Associate	24838973
Colitis Ulcerative	Associate	30065566, 32943023, 36480694
Colonic Diseases	Associate	24838973
Colonic Neoplasms	Associate	21383546
Colorectal Neoplasms	Associate	24694755, 24838973, 35416128
Congenital Hereditary and Neonatal Diseases and Abnormalities	Associate	36480694
Constriction Pathologic	Associate	36480694, 36907595
Crohn Disease	Associate	26539716, 29313109, 36480694
Drug Related Side Effects and Adverse Reactions	Associate	32278009
Ductus Arteriosus Patent	Associate	26265282
Eosinophilic enteropathy	Associate	37077520
Fanconi Syndrome	Associate	32278009
Fibrosis	Associate	40160813
Gastroesophageal Reflux	Associate	32784296
Gastrointestinal Hemorrhage	Stimulate	28425581
Gastrointestinal Hemorrhage	Associate	32943023
Hyponatremia	Associate	28783044
Hypoproteinemia	Associate	35185052
Idiopathic Pulmonary Fibrosis	Associate	12100034
Ileal Diseases	Associate	33328413
Inflammation	Associate	40160813
Intestinal Diseases	Associate	30065566, 32092751, 35611666
Intestinal Polyposis	Associate	32092751
Joint Diseases	Associate	28425581
Lung Neoplasms	Associate	26464663
Nail dysplasia isolated congenital	Associate	36833358
Neoplasms	Associate	21383546, 24838973, 26464663, 32103057, 33081378
Neoplasms	Inhibit	33619025
Neoplastic Syndromes Hereditary	Associate	26539716, 31011259
Optic Nerve Diseases	Associate	40160813
Osteoarthropathy Primary Hypertrophic	Associate	22197487, 24838973, 27134495, 28425581, 28851954, 29313109, 31611528, 33328413, 33852188, 34027406, 35611666, 35813463, 37226222, 39607761
Osteoarthropathy Secondary Hypertrophic	Associate	28425581
Pancreatic Neoplasms	Stimulate	23307416
Pre Eclampsia	Associate	36982197
Prostate Cancer Hereditary 7	Associate	33619025
Prostatic Neoplasms	Associate	33619025
Squamous Cell Carcinoma of Head and Neck	Associate	23137910
Stomach Neoplasms	Associate	30702489, 33081378, 33440718, 36044785
Thyroid cancer follicular	Associate	24099521
Tooth Loss	Associate	26539716
Ulcer	Associate	31611528, 32943023, 33166338

SLCO2A1 (solute carrier organic anion transporter family member 2A1)