SLC9A2 (solute carrier family 9 member A2)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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6549 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Solute carrier family 9 member A2 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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SLC9A2 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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NHE2 |
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Chromosome
Chromosome number
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2 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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2q12.1 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the sodium-hydrogen exchanger (NHE) protein family. These proteins are involved in sodium-ion transport by exchanging intracellular hydrogen ions to external sodium ions and help in the regulation of cell pH and volume. The e |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||
| UniProt ID | Q9UBY0 | |||||||||||||||
| Protein name | Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2) | |||||||||||||||
| Protein function | Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:10444453). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic crypt i | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine (PubMed:10444453, PubMed:8843774). In the distal colon, expressed along the cryptal axis (PubMed:8843774). {ECO:0000269|Pu | |||||||||||||||
| Sequence |
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| Sequence length | 812 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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