Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6549
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 9 member A2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC9A2
Synonyms (NCBI Gene) Gene synonyms aliases
NHE2
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q12.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the sodium-hydrogen exchanger (NHE) protein family. These proteins are involved in sodium-ion transport by exchanging intracellular hydrogen ions to external sodium ions and help in the regulation of cell pH and volume. The e
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT051193 hsa-miR-16-5p CLASH 23622248
MIRT1368586 hsa-miR-1183 CLIP-seq
MIRT1368587 hsa-miR-1226 CLIP-seq
MIRT1368588 hsa-miR-125a-3p CLIP-seq
MIRT1368589 hsa-miR-1271 CLIP-seq
Transcription factors
Transcription factor Regulation Reference
CDX2 Unknown 11254504
EP300 Unknown 11254504
MYOD1 Unknown 11254504
NFKB1 Unknown 11254504
RELA Unknown 11254504
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005886 Component Plasma membrane IBA 21873635
GO:0005886 Component Plasma membrane TAS
GO:0006811 Process Ion transport TAS
GO:0008104 Process Protein localization IEA
GO:0015385 Function Sodium:proton antiporter activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600530 11072 ENSG00000115616
Protein
UniProt ID Q9UBY0
Protein name Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2)
Protein function Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:10444453). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic crypt i
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00999 Na_H_Exchanger 84 485 Sodium/hydrogen exchanger family Family
PF16644 NEXCaM_BD 575 684 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine (PubMed:10444453, PubMed:8843774). In the distal colon, expressed along the cryptal axis (PubMed:8843774). {ECO:0000269|Pu
Sequence
MEPLGNWRSLRAPLPPMLLLLLLQVAGPVGALAETLLNAPRAMGTSSSPPSPASVVAPGT
TLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLL
LGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWN
SIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVF
GESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTT
RFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIK
YFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFR
TIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIR
PLVEF
LDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRK
LLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDE
IRELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRA
STSTSRYLSLPKNTKLPEKLQKRR
TISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFS
KKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDS
LTEGIPPKPPPRLVWRASEPGSRKARFGSEKP
Sequence length 812
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Sodium/Proton exchangers
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma GWAS
Crohn Disease Crohn Disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acidosis Stimulate 24376510
Barrett Esophagus Associate 18845559, 21969813
Melanoma Associate 32241263
Neoplasms Associate 25423035
Ovarian Neoplasms Associate 36978087
Short Bowel Syndrome Associate 19389806
Trichohepatoenteric Syndrome Associate 20176027