Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	6548
Gene name Gene Name - the full gene name approved by the HGNC.	Solute carrier family 9 member A1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SLC9A1
Synonyms (NCBI Gene) Gene synonyms aliases	APNH, LIKNS, NHE-1, NHE1, PPP1R143
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p36.11
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell

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SNP ID	Visualize variation	Clinical significance	Consequence
rs786204831	C>T	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs1553175089	T>G	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023332	hsa-miR-122-5p	Microarray	17612493
MIRT044326	hsa-miR-106b-5p	CLASH	23622248
MIRT043512	hsa-miR-331-3p	CLASH	23622248
MIRT484494	hsa-miR-4433b-3p	PAR-CLIP	23592263
MIRT484493	hsa-miR-7845-5p	PAR-CLIP	23592263
MIRT484492	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT484491	hsa-miR-574-5p	PAR-CLIP	23592263
MIRT484490	hsa-miR-4533	PAR-CLIP	23592263
MIRT023332	hsa-miR-122-5p	PAR-CLIP	23592263
MIRT484489	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT484488	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT484487	hsa-miR-4271	PAR-CLIP	23592263
MIRT484485	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT484486	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT484484	hsa-miR-4417	PAR-CLIP	23592263
MIRT484483	hsa-miR-3911	PAR-CLIP	23592263
MIRT484482	hsa-miR-644a	PAR-CLIP	23592263
MIRT484481	hsa-miR-6867-5p	PAR-CLIP	23592263
MIRT484480	hsa-miR-4265	PAR-CLIP	23592263
MIRT484479	hsa-miR-4296	PAR-CLIP	23592263
MIRT484478	hsa-miR-4322	PAR-CLIP	23592263
MIRT484477	hsa-miR-147a	PAR-CLIP	23592263
MIRT726507	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT726505	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT726506	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT726504	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT066935	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT066936	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT726503	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT726502	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT726501	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT484494	hsa-miR-4433b-3p	PAR-CLIP	23592263
MIRT484493	hsa-miR-7845-5p	PAR-CLIP	23592263
MIRT484492	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT484491	hsa-miR-574-5p	PAR-CLIP	23592263
MIRT484490	hsa-miR-4533	PAR-CLIP	23592263
MIRT023332	hsa-miR-122-5p	PAR-CLIP	23592263
MIRT484489	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT484488	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT484487	hsa-miR-4271	PAR-CLIP	23592263
MIRT484485	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT484486	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT484484	hsa-miR-4417	PAR-CLIP	23592263
MIRT484483	hsa-miR-3911	PAR-CLIP	23592263
MIRT484482	hsa-miR-644a	PAR-CLIP	23592263
MIRT484481	hsa-miR-6867-5p	PAR-CLIP	23592263
MIRT484480	hsa-miR-4265	PAR-CLIP	23592263
MIRT484479	hsa-miR-4296	PAR-CLIP	23592263
MIRT484478	hsa-miR-4322	PAR-CLIP	23592263
MIRT484477	hsa-miR-147a	PAR-CLIP	23592263
MIRT1368491	hsa-miR-1207-5p	CLIP-seq
MIRT1368492	hsa-miR-122	CLIP-seq
MIRT1368493	hsa-miR-1245b-5p	CLIP-seq
MIRT1368494	hsa-miR-1263	CLIP-seq
MIRT1368495	hsa-miR-1273g	CLIP-seq
MIRT1368496	hsa-miR-1275	CLIP-seq
MIRT1368497	hsa-miR-1280	CLIP-seq
MIRT1368498	hsa-miR-1281	CLIP-seq
MIRT1368499	hsa-miR-1286	CLIP-seq
MIRT1368500	hsa-miR-1294	CLIP-seq
MIRT1368501	hsa-miR-1324	CLIP-seq
MIRT1368502	hsa-miR-1343	CLIP-seq
MIRT1368503	hsa-miR-1827	CLIP-seq
MIRT1368504	hsa-miR-1915	CLIP-seq
MIRT1368505	hsa-miR-1972	CLIP-seq
MIRT1368506	hsa-miR-214	CLIP-seq
MIRT1368507	hsa-miR-2278	CLIP-seq
MIRT1368508	hsa-miR-25	CLIP-seq
MIRT1368509	hsa-miR-3136-3p	CLIP-seq
MIRT1368510	hsa-miR-3142	CLIP-seq
MIRT1368511	hsa-miR-3150b-3p	CLIP-seq
MIRT1368512	hsa-miR-3153	CLIP-seq
MIRT1368513	hsa-miR-3169	CLIP-seq
MIRT1368514	hsa-miR-3182	CLIP-seq
MIRT1368515	hsa-miR-3189-5p	CLIP-seq
MIRT1368516	hsa-miR-32	CLIP-seq
MIRT1368517	hsa-miR-323b-5p	CLIP-seq
MIRT1368518	hsa-miR-335	CLIP-seq
MIRT1368519	hsa-miR-345	CLIP-seq
MIRT1368520	hsa-miR-3619-5p	CLIP-seq
MIRT1368521	hsa-miR-3620	CLIP-seq
MIRT1368522	hsa-miR-363	CLIP-seq
MIRT1368523	hsa-miR-367	CLIP-seq
MIRT1368524	hsa-miR-3686	CLIP-seq
MIRT1368525	hsa-miR-3689d	CLIP-seq
MIRT1368526	hsa-miR-371b-3p	CLIP-seq
MIRT1368527	hsa-miR-3926	CLIP-seq
MIRT1368528	hsa-miR-4269	CLIP-seq
MIRT1368529	hsa-miR-4316	CLIP-seq
MIRT1368530	hsa-miR-4328	CLIP-seq
MIRT1368531	hsa-miR-4419a	CLIP-seq
MIRT1368532	hsa-miR-4437	CLIP-seq
MIRT1368533	hsa-miR-4438	CLIP-seq
MIRT1368534	hsa-miR-4447	CLIP-seq
MIRT1368535	hsa-miR-4455	CLIP-seq
MIRT1368536	hsa-miR-4457	CLIP-seq
MIRT1368537	hsa-miR-4459	CLIP-seq
MIRT1368538	hsa-miR-4472	CLIP-seq
MIRT1368539	hsa-miR-4475	CLIP-seq
MIRT1368540	hsa-miR-4487	CLIP-seq
MIRT1368541	hsa-miR-4510	CLIP-seq
MIRT1368542	hsa-miR-4514	CLIP-seq
MIRT1368543	hsa-miR-4515	CLIP-seq
MIRT1368544	hsa-miR-4520a-3p	CLIP-seq
MIRT1368545	hsa-miR-4520b-3p	CLIP-seq
MIRT1368546	hsa-miR-4525	CLIP-seq
MIRT1368547	hsa-miR-4530	CLIP-seq
MIRT1368548	hsa-miR-4536	CLIP-seq
MIRT1368549	hsa-miR-4650-5p	CLIP-seq
MIRT1368550	hsa-miR-4653-3p	CLIP-seq
MIRT1368551	hsa-miR-4659a-3p	CLIP-seq
MIRT1368552	hsa-miR-4659b-3p	CLIP-seq
MIRT1368553	hsa-miR-4665-5p	CLIP-seq
MIRT1368554	hsa-miR-4674	CLIP-seq
MIRT1368555	hsa-miR-4685-5p	CLIP-seq
MIRT1368556	hsa-miR-4689	CLIP-seq
MIRT1368557	hsa-miR-4690-5p	CLIP-seq
MIRT1368558	hsa-miR-4692	CLIP-seq
MIRT1368559	hsa-miR-4709-5p	CLIP-seq
MIRT1368560	hsa-miR-4713-5p	CLIP-seq
MIRT1368561	hsa-miR-4714-5p	CLIP-seq
MIRT1368562	hsa-miR-4722-5p	CLIP-seq
MIRT1368563	hsa-miR-4723-5p	CLIP-seq
MIRT1368564	hsa-miR-4728-5p	CLIP-seq
MIRT1368565	hsa-miR-4736	CLIP-seq
MIRT1368566	hsa-miR-4746-3p	CLIP-seq
MIRT1368567	hsa-miR-4758-3p	CLIP-seq
MIRT1368568	hsa-miR-4763-3p	CLIP-seq
MIRT1368569	hsa-miR-4779	CLIP-seq
MIRT1368570	hsa-miR-4784	CLIP-seq
MIRT1368571	hsa-miR-4786-5p	CLIP-seq
MIRT1368572	hsa-miR-5095	CLIP-seq
MIRT1368573	hsa-miR-625	CLIP-seq
MIRT1368574	hsa-miR-637	CLIP-seq
MIRT1368575	hsa-miR-646	CLIP-seq
MIRT1368576	hsa-miR-759	CLIP-seq
MIRT1368577	hsa-miR-761	CLIP-seq
MIRT1368578	hsa-miR-765	CLIP-seq
MIRT1368579	hsa-miR-769-5p	CLIP-seq
MIRT1368580	hsa-miR-877	CLIP-seq
MIRT1368581	hsa-miR-885-3p	CLIP-seq
MIRT1368582	hsa-miR-922	CLIP-seq
MIRT1368583	hsa-miR-92a	CLIP-seq
MIRT1368584	hsa-miR-92b	CLIP-seq
MIRT1368585	hsa-miR-940	CLIP-seq
MIRT1368542	hsa-miR-4514	CLIP-seq
MIRT1368558	hsa-miR-4692	CLIP-seq
MIRT2109521	hsa-miR-1208	CLIP-seq
MIRT1368492	hsa-miR-122	CLIP-seq
MIRT2109522	hsa-miR-1245b-3p	CLIP-seq
MIRT1368496	hsa-miR-1275	CLIP-seq
MIRT1368499	hsa-miR-1286	CLIP-seq
MIRT1368500	hsa-miR-1294	CLIP-seq
MIRT2109523	hsa-miR-1299	CLIP-seq
MIRT1368501	hsa-miR-1324	CLIP-seq
MIRT1368502	hsa-miR-1343	CLIP-seq
MIRT2109524	hsa-miR-140-3p	CLIP-seq
MIRT1368503	hsa-miR-1827	CLIP-seq
MIRT2109525	hsa-miR-185	CLIP-seq
MIRT1368504	hsa-miR-1915	CLIP-seq
MIRT1368505	hsa-miR-1972	CLIP-seq
MIRT2109526	hsa-miR-1976	CLIP-seq
MIRT1368506	hsa-miR-214	CLIP-seq
MIRT2109527	hsa-miR-2392	CLIP-seq
MIRT2109528	hsa-miR-2467-5p	CLIP-seq
MIRT1368508	hsa-miR-25	CLIP-seq
MIRT2109529	hsa-miR-2682	CLIP-seq
MIRT2109530	hsa-miR-2964a-5p	CLIP-seq
MIRT2109531	hsa-miR-3135b	CLIP-seq
MIRT1368509	hsa-miR-3136-3p	CLIP-seq
MIRT1368511	hsa-miR-3150b-3p	CLIP-seq
MIRT1368513	hsa-miR-3169	CLIP-seq
MIRT1368514	hsa-miR-3182	CLIP-seq
MIRT2109532	hsa-miR-3188	CLIP-seq
MIRT1368515	hsa-miR-3189-5p	CLIP-seq
MIRT1368516	hsa-miR-32	CLIP-seq
MIRT2109533	hsa-miR-3202	CLIP-seq
MIRT1368518	hsa-miR-335	CLIP-seq
MIRT2109534	hsa-miR-338-3p	CLIP-seq
MIRT2109535	hsa-miR-3605-5p	CLIP-seq
MIRT1368520	hsa-miR-3619-5p	CLIP-seq
MIRT1368522	hsa-miR-363	CLIP-seq
MIRT2109536	hsa-miR-3652	CLIP-seq
MIRT2109537	hsa-miR-3665	CLIP-seq
MIRT1368523	hsa-miR-367	CLIP-seq
MIRT2109538	hsa-miR-3682-5p	CLIP-seq
MIRT1368524	hsa-miR-3686	CLIP-seq
MIRT1368525	hsa-miR-3689d	CLIP-seq
MIRT1368526	hsa-miR-371b-3p	CLIP-seq
MIRT2109539	hsa-miR-3915	CLIP-seq
MIRT2109540	hsa-miR-3919	CLIP-seq
MIRT2109541	hsa-miR-3921	CLIP-seq
MIRT2109542	hsa-miR-3928	CLIP-seq
MIRT2109543	hsa-miR-3975	CLIP-seq
MIRT2109544	hsa-miR-4266	CLIP-seq
MIRT1368528	hsa-miR-4269	CLIP-seq
MIRT2109545	hsa-miR-4290	CLIP-seq
MIRT2109546	hsa-miR-4306	CLIP-seq
MIRT1368529	hsa-miR-4316	CLIP-seq
MIRT1368530	hsa-miR-4328	CLIP-seq
MIRT1368531	hsa-miR-4419a	CLIP-seq
MIRT2109547	hsa-miR-4430	CLIP-seq
MIRT1368533	hsa-miR-4438	CLIP-seq
MIRT1368534	hsa-miR-4447	CLIP-seq
MIRT1368538	hsa-miR-4472	CLIP-seq
MIRT2109548	hsa-miR-4476	CLIP-seq
MIRT2109549	hsa-miR-4481	CLIP-seq
MIRT2109550	hsa-miR-449c	CLIP-seq
MIRT2109551	hsa-miR-4502	CLIP-seq
MIRT1368541	hsa-miR-4510	CLIP-seq
MIRT1368542	hsa-miR-4514	CLIP-seq
MIRT1368543	hsa-miR-4515	CLIP-seq
MIRT1368544	hsa-miR-4520a-3p	CLIP-seq
MIRT1368545	hsa-miR-4520b-3p	CLIP-seq
MIRT1368546	hsa-miR-4525	CLIP-seq
MIRT1368547	hsa-miR-4530	CLIP-seq
MIRT2109552	hsa-miR-4644	CLIP-seq
MIRT2109553	hsa-miR-4645-5p	CLIP-seq
MIRT1368549	hsa-miR-4650-5p	CLIP-seq
MIRT1368550	hsa-miR-4653-3p	CLIP-seq
MIRT2109554	hsa-miR-4653-5p	CLIP-seq
MIRT1368551	hsa-miR-4659a-3p	CLIP-seq
MIRT1368552	hsa-miR-4659b-3p	CLIP-seq
MIRT2109555	hsa-miR-4660	CLIP-seq
MIRT2109556	hsa-miR-4663	CLIP-seq
MIRT1368553	hsa-miR-4665-5p	CLIP-seq
MIRT2109557	hsa-miR-4673	CLIP-seq
MIRT2109558	hsa-miR-4677-3p	CLIP-seq
MIRT2109559	hsa-miR-4679	CLIP-seq
MIRT2109560	hsa-miR-4682	CLIP-seq
MIRT1368556	hsa-miR-4689	CLIP-seq
MIRT2109561	hsa-miR-4690-3p	CLIP-seq
MIRT1368557	hsa-miR-4690-5p	CLIP-seq
MIRT1368558	hsa-miR-4692	CLIP-seq
MIRT2109562	hsa-miR-4694-3p	CLIP-seq
MIRT2109563	hsa-miR-4708-5p	CLIP-seq
MIRT1368559	hsa-miR-4709-5p	CLIP-seq
MIRT2109564	hsa-miR-4722-3p	CLIP-seq
MIRT1368563	hsa-miR-4723-5p	CLIP-seq
MIRT1368564	hsa-miR-4728-5p	CLIP-seq
MIRT1368565	hsa-miR-4736	CLIP-seq
MIRT2109565	hsa-miR-4745-5p	CLIP-seq
MIRT2109566	hsa-miR-4756-3p	CLIP-seq
MIRT1368567	hsa-miR-4758-3p	CLIP-seq
MIRT2109567	hsa-miR-4762-3p	CLIP-seq
MIRT1368569	hsa-miR-4779	CLIP-seq
MIRT2109568	hsa-miR-4782-5p	CLIP-seq
MIRT1368570	hsa-miR-4784	CLIP-seq
MIRT2109569	hsa-miR-485-5p	CLIP-seq
MIRT1368572	hsa-miR-5095	CLIP-seq
MIRT2109570	hsa-miR-516b	CLIP-seq
MIRT1368573	hsa-miR-625	CLIP-seq
MIRT1368574	hsa-miR-637	CLIP-seq
MIRT1368576	hsa-miR-759	CLIP-seq
MIRT1368577	hsa-miR-761	CLIP-seq
MIRT2109571	hsa-miR-764	CLIP-seq
MIRT1368580	hsa-miR-877	CLIP-seq
MIRT1368582	hsa-miR-922	CLIP-seq
MIRT1368583	hsa-miR-92a	CLIP-seq
MIRT1368584	hsa-miR-92b	CLIP-seq
MIRT1368585	hsa-miR-940	CLIP-seq
MIRT1368491	hsa-miR-1207-5p	CLIP-seq
MIRT2109521	hsa-miR-1208	CLIP-seq
MIRT1368492	hsa-miR-122	CLIP-seq
MIRT2109522	hsa-miR-1245b-3p	CLIP-seq
MIRT1368493	hsa-miR-1245b-5p	CLIP-seq
MIRT2332656	hsa-miR-1262	CLIP-seq
MIRT1368494	hsa-miR-1263	CLIP-seq
MIRT2332657	hsa-miR-1266	CLIP-seq
MIRT1368495	hsa-miR-1273g	CLIP-seq
MIRT1368496	hsa-miR-1275	CLIP-seq
MIRT1368497	hsa-miR-1280	CLIP-seq
MIRT1368498	hsa-miR-1281	CLIP-seq
MIRT1368499	hsa-miR-1286	CLIP-seq
MIRT2332658	hsa-miR-1293	CLIP-seq
MIRT1368500	hsa-miR-1294	CLIP-seq
MIRT2109523	hsa-miR-1299	CLIP-seq
MIRT1368501	hsa-miR-1324	CLIP-seq
MIRT1368502	hsa-miR-1343	CLIP-seq
MIRT2332659	hsa-miR-1470	CLIP-seq
MIRT1368503	hsa-miR-1827	CLIP-seq
MIRT2109525	hsa-miR-185	CLIP-seq
MIRT1368504	hsa-miR-1915	CLIP-seq
MIRT1368505	hsa-miR-1972	CLIP-seq
MIRT2109526	hsa-miR-1976	CLIP-seq
MIRT2332660	hsa-miR-19a	CLIP-seq
MIRT2332661	hsa-miR-19b	CLIP-seq
MIRT1368506	hsa-miR-214	CLIP-seq
MIRT1368507	hsa-miR-2278	CLIP-seq
MIRT2109527	hsa-miR-2392	CLIP-seq
MIRT1368508	hsa-miR-25	CLIP-seq
MIRT2332662	hsa-miR-296-5p	CLIP-seq
MIRT2332663	hsa-miR-3131	CLIP-seq
MIRT1368510	hsa-miR-3142	CLIP-seq
MIRT1368511	hsa-miR-3150b-3p	CLIP-seq
MIRT1368512	hsa-miR-3153	CLIP-seq
MIRT2332664	hsa-miR-3157-5p	CLIP-seq
MIRT1368513	hsa-miR-3169	CLIP-seq
MIRT1368514	hsa-miR-3182	CLIP-seq
MIRT1368516	hsa-miR-32	CLIP-seq
MIRT2109533	hsa-miR-3202	CLIP-seq
MIRT1368517	hsa-miR-323b-5p	CLIP-seq
MIRT2332665	hsa-miR-329	CLIP-seq
MIRT2332666	hsa-miR-342-5p	CLIP-seq
MIRT1368519	hsa-miR-345	CLIP-seq
MIRT2109535	hsa-miR-3605-5p	CLIP-seq
MIRT2332667	hsa-miR-361-3p	CLIP-seq
MIRT1368520	hsa-miR-3619-5p	CLIP-seq
MIRT1368521	hsa-miR-3620	CLIP-seq
MIRT2332668	hsa-miR-362-3p	CLIP-seq
MIRT1368522	hsa-miR-363	CLIP-seq
MIRT1368523	hsa-miR-367	CLIP-seq
MIRT1368524	hsa-miR-3686	CLIP-seq
MIRT2109539	hsa-miR-3915	CLIP-seq
MIRT1368527	hsa-miR-3926	CLIP-seq
MIRT2109542	hsa-miR-3928	CLIP-seq
MIRT2332669	hsa-miR-3941	CLIP-seq
MIRT1368528	hsa-miR-4269	CLIP-seq
MIRT2332670	hsa-miR-4274	CLIP-seq
MIRT2332671	hsa-miR-4278	CLIP-seq
MIRT2332672	hsa-miR-4291	CLIP-seq
MIRT2109546	hsa-miR-4306	CLIP-seq
MIRT2332673	hsa-miR-4307	CLIP-seq
MIRT1368529	hsa-miR-4316	CLIP-seq
MIRT1368530	hsa-miR-4328	CLIP-seq
MIRT1368531	hsa-miR-4419a	CLIP-seq
MIRT2332674	hsa-miR-4435	CLIP-seq
MIRT1368532	hsa-miR-4437	CLIP-seq
MIRT1368533	hsa-miR-4438	CLIP-seq
MIRT1368534	hsa-miR-4447	CLIP-seq
MIRT1368535	hsa-miR-4455	CLIP-seq
MIRT1368536	hsa-miR-4457	CLIP-seq
MIRT1368537	hsa-miR-4459	CLIP-seq
MIRT1368538	hsa-miR-4472	CLIP-seq
MIRT2109548	hsa-miR-4476	CLIP-seq
MIRT2332675	hsa-miR-4483	CLIP-seq
MIRT1368540	hsa-miR-4487	CLIP-seq
MIRT2332676	hsa-miR-4488	CLIP-seq
MIRT1368541	hsa-miR-4510	CLIP-seq
MIRT1368542	hsa-miR-4514	CLIP-seq
MIRT2332677	hsa-miR-4518	CLIP-seq
MIRT1368544	hsa-miR-4520a-3p	CLIP-seq
MIRT1368545	hsa-miR-4520b-3p	CLIP-seq
MIRT1368546	hsa-miR-4525	CLIP-seq
MIRT1368547	hsa-miR-4530	CLIP-seq
MIRT1368548	hsa-miR-4536	CLIP-seq
MIRT2332678	hsa-miR-455-5p	CLIP-seq
MIRT2109552	hsa-miR-4644	CLIP-seq
MIRT2332679	hsa-miR-4651	CLIP-seq
MIRT1368550	hsa-miR-4653-3p	CLIP-seq
MIRT1368551	hsa-miR-4659a-3p	CLIP-seq
MIRT1368552	hsa-miR-4659b-3p	CLIP-seq
MIRT2332680	hsa-miR-4664-5p	CLIP-seq
MIRT1368553	hsa-miR-4665-5p	CLIP-seq
MIRT2332681	hsa-miR-4667-3p	CLIP-seq
MIRT1368554	hsa-miR-4674	CLIP-seq
MIRT2332682	hsa-miR-4675	CLIP-seq
MIRT1368555	hsa-miR-4685-5p	CLIP-seq
MIRT1368556	hsa-miR-4689	CLIP-seq
MIRT1368557	hsa-miR-4690-5p	CLIP-seq
MIRT2332683	hsa-miR-4691-3p	CLIP-seq
MIRT1368558	hsa-miR-4692	CLIP-seq
MIRT2332684	hsa-miR-4697-5p	CLIP-seq
MIRT2332685	hsa-miR-4701-3p	CLIP-seq
MIRT1368559	hsa-miR-4709-5p	CLIP-seq
MIRT1368560	hsa-miR-4713-5p	CLIP-seq
MIRT1368561	hsa-miR-4714-5p	CLIP-seq
MIRT2332686	hsa-miR-4716-3p	CLIP-seq
MIRT2109564	hsa-miR-4722-3p	CLIP-seq
MIRT1368562	hsa-miR-4722-5p	CLIP-seq
MIRT1368563	hsa-miR-4723-5p	CLIP-seq
MIRT1368564	hsa-miR-4728-5p	CLIP-seq
MIRT2332687	hsa-miR-4731-3p	CLIP-seq
MIRT2332688	hsa-miR-4731-5p	CLIP-seq
MIRT1368565	hsa-miR-4736	CLIP-seq
MIRT2332689	hsa-miR-4741	CLIP-seq
MIRT1368566	hsa-miR-4746-3p	CLIP-seq
MIRT2332690	hsa-miR-4751	CLIP-seq
MIRT1368568	hsa-miR-4763-3p	CLIP-seq
MIRT1368569	hsa-miR-4779	CLIP-seq
MIRT2109568	hsa-miR-4782-5p	CLIP-seq
MIRT1368570	hsa-miR-4784	CLIP-seq
MIRT1368571	hsa-miR-4786-5p	CLIP-seq
MIRT2332691	hsa-miR-4801	CLIP-seq
MIRT2332692	hsa-miR-495	CLIP-seq
MIRT1368572	hsa-miR-5095	CLIP-seq
MIRT2109570	hsa-miR-516b	CLIP-seq
MIRT2332693	hsa-miR-541	CLIP-seq
MIRT2332694	hsa-miR-542-3p	CLIP-seq
MIRT2332695	hsa-miR-550a	CLIP-seq
MIRT2332696	hsa-miR-603	CLIP-seq
MIRT2332697	hsa-miR-608	CLIP-seq
MIRT2332698	hsa-miR-611	CLIP-seq
MIRT1368573	hsa-miR-625	CLIP-seq
MIRT1368575	hsa-miR-646	CLIP-seq
MIRT2332699	hsa-miR-654-5p	CLIP-seq
MIRT2332700	hsa-miR-711	CLIP-seq
MIRT1368576	hsa-miR-759	CLIP-seq
MIRT1368577	hsa-miR-761	CLIP-seq
MIRT1368578	hsa-miR-765	CLIP-seq
MIRT1368579	hsa-miR-769-5p	CLIP-seq
MIRT1368580	hsa-miR-877	CLIP-seq
MIRT1368581	hsa-miR-885-3p	CLIP-seq
MIRT1368582	hsa-miR-922	CLIP-seq
MIRT1368583	hsa-miR-92a	CLIP-seq
MIRT1368584	hsa-miR-92b	CLIP-seq
MIRT1368585	hsa-miR-940	CLIP-seq
MIRT1368500	hsa-miR-1294	CLIP-seq
MIRT2109523	hsa-miR-1299	CLIP-seq
MIRT1368503	hsa-miR-1827	CLIP-seq
MIRT1368506	hsa-miR-214	CLIP-seq
MIRT2109529	hsa-miR-2682	CLIP-seq
MIRT1368511	hsa-miR-3150b-3p	CLIP-seq
MIRT1368514	hsa-miR-3182	CLIP-seq
MIRT1368518	hsa-miR-335	CLIP-seq
MIRT1368520	hsa-miR-3619-5p	CLIP-seq
MIRT2109537	hsa-miR-3665	CLIP-seq
MIRT1368524	hsa-miR-3686	CLIP-seq
MIRT1368529	hsa-miR-4316	CLIP-seq
MIRT1368530	hsa-miR-4328	CLIP-seq
MIRT1368531	hsa-miR-4419a	CLIP-seq
MIRT1368533	hsa-miR-4438	CLIP-seq
MIRT2394823	hsa-miR-4480	CLIP-seq
MIRT2109550	hsa-miR-449c	CLIP-seq
MIRT1368541	hsa-miR-4510	CLIP-seq
MIRT1368542	hsa-miR-4514	CLIP-seq
MIRT1368551	hsa-miR-4659a-3p	CLIP-seq
MIRT1368552	hsa-miR-4659b-3p	CLIP-seq
MIRT1368556	hsa-miR-4689	CLIP-seq
MIRT1368558	hsa-miR-4692	CLIP-seq
MIRT1368565	hsa-miR-4736	CLIP-seq
MIRT2109568	hsa-miR-4782-5p	CLIP-seq
MIRT1368570	hsa-miR-4784	CLIP-seq
MIRT1368572	hsa-miR-5095	CLIP-seq
MIRT2109570	hsa-miR-516b	CLIP-seq
MIRT2332693	hsa-miR-541	CLIP-seq
MIRT1368575	hsa-miR-646	CLIP-seq
MIRT2332699	hsa-miR-654-5p	CLIP-seq
MIRT1368576	hsa-miR-759	CLIP-seq
MIRT1368577	hsa-miR-761	CLIP-seq
MIRT2109571	hsa-miR-764	CLIP-seq
MIRT1368581	hsa-miR-885-3p	CLIP-seq
MIRT1368582	hsa-miR-922	CLIP-seq
MIRT1368585	hsa-miR-940	CLIP-seq
MIRT2109522	hsa-miR-1245b-3p	CLIP-seq
MIRT2109533	hsa-miR-3202	CLIP-seq
MIRT2109539	hsa-miR-3915	CLIP-seq
MIRT2109542	hsa-miR-3928	CLIP-seq
MIRT2109548	hsa-miR-4476	CLIP-seq
MIRT2459930	hsa-miR-1225-3p	CLIP-seq
MIRT1368497	hsa-miR-1280	CLIP-seq
MIRT1368498	hsa-miR-1281	CLIP-seq
MIRT2109533	hsa-miR-3202	CLIP-seq
MIRT2109548	hsa-miR-4476	CLIP-seq
MIRT1368560	hsa-miR-4713-5p	CLIP-seq
MIRT2459931	hsa-miR-873	CLIP-seq
MIRT2459932	hsa-miR-939	CLIP-seq
MIRT2109521	hsa-miR-1208	CLIP-seq
MIRT1368492	hsa-miR-122	CLIP-seq
MIRT2459930	hsa-miR-1225-3p	CLIP-seq
MIRT2109522	hsa-miR-1245b-3p	CLIP-seq
MIRT1368500	hsa-miR-1294	CLIP-seq
MIRT2109523	hsa-miR-1299	CLIP-seq
MIRT1368503	hsa-miR-1827	CLIP-seq
MIRT1368511	hsa-miR-3150b-3p	CLIP-seq
MIRT2332664	hsa-miR-3157-5p	CLIP-seq
MIRT2109533	hsa-miR-3202	CLIP-seq
MIRT2109539	hsa-miR-3915	CLIP-seq
MIRT2109542	hsa-miR-3928	CLIP-seq
MIRT2627156	hsa-miR-3943	CLIP-seq
MIRT1368529	hsa-miR-4316	CLIP-seq
MIRT1368531	hsa-miR-4419a	CLIP-seq
MIRT2109548	hsa-miR-4476	CLIP-seq
MIRT1368541	hsa-miR-4510	CLIP-seq
MIRT1368550	hsa-miR-4653-3p	CLIP-seq
MIRT1368556	hsa-miR-4689	CLIP-seq
MIRT2332683	hsa-miR-4691-3p	CLIP-seq
MIRT1368569	hsa-miR-4779	CLIP-seq
MIRT2109568	hsa-miR-4782-5p	CLIP-seq
MIRT1368570	hsa-miR-4784	CLIP-seq
MIRT2109570	hsa-miR-516b	CLIP-seq
MIRT2459931	hsa-miR-873	CLIP-seq
MIRT1368580	hsa-miR-877	CLIP-seq
MIRT2459932	hsa-miR-939	CLIP-seq
MIRT1368492	hsa-miR-122	CLIP-seq
MIRT2459930	hsa-miR-1225-3p	CLIP-seq
MIRT1368500	hsa-miR-1294	CLIP-seq
MIRT2109523	hsa-miR-1299	CLIP-seq
MIRT1368504	hsa-miR-1915	CLIP-seq
MIRT1368511	hsa-miR-3150b-3p	CLIP-seq
MIRT2109533	hsa-miR-3202	CLIP-seq
MIRT1368529	hsa-miR-4316	CLIP-seq
MIRT2691309	hsa-miR-4323	CLIP-seq
MIRT1368531	hsa-miR-4419a	CLIP-seq
MIRT2109548	hsa-miR-4476	CLIP-seq
MIRT1368541	hsa-miR-4510	CLIP-seq
MIRT1368550	hsa-miR-4653-3p	CLIP-seq
MIRT1368556	hsa-miR-4689	CLIP-seq
MIRT2691310	hsa-miR-4713-3p	CLIP-seq
MIRT1368569	hsa-miR-4779	CLIP-seq
MIRT2109568	hsa-miR-4782-5p	CLIP-seq
MIRT1368570	hsa-miR-4784	CLIP-seq
MIRT2109570	hsa-miR-516b	CLIP-seq
MIRT2459931	hsa-miR-873	CLIP-seq
MIRT2459932	hsa-miR-939	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
PPARA	Unknown	19958503
PPARG	Repression	19887620

Show/Hide all(96)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002026	Process	Regulation of the force of heart contraction	IEA
GO:0005515	Function	Protein binding	IPI	8901634, 11350981, 11696366, 12809501, 15035633, 16710297, 21392185, 30287853, 31912575, 33961781
GO:0005516	Function	Calmodulin binding	IEA
GO:0005543	Function	Phospholipid binding	IDA	22020933
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	TAS	17565280
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	21553168
GO:0005739	Component	Mitochondrion	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	15035633, 21553168, 24840010
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006811	Process	Monoatomic ion transport	TAS
GO:0006812	Process	Monoatomic cation transport	IEA
GO:0006814	Process	Sodium ion transport	IEA
GO:0006814	Process	Sodium ion transport	IEA
GO:0006883	Process	Intracellular sodium ion homeostasis	IDA	24840010
GO:0006885	Process	Regulation of pH	IDA	8901634
GO:0006885	Process	Regulation of pH	IEA
GO:0006885	Process	Regulation of pH	IEA
GO:0006885	Process	Regulation of pH	TAS	8283968
GO:0009986	Component	Cell surface	IEA
GO:0010447	Process	Response to acidic pH	IDA	8901634
GO:0010447	Process	Response to acidic pH	IEA
GO:0010447	Process	Response to acidic pH	IEA
GO:0010613	Process	Positive regulation of cardiac muscle hypertrophy	IMP	21359875
GO:0010882	Process	Regulation of cardiac muscle contraction by calcium ion signaling	IMP	15105296
GO:0014704	Component	Intercalated disc	IEA
GO:0015297	Function	Antiporter activity	IEA
GO:0015385	Function	Sodium:proton antiporter activity	IBA
GO:0015385	Function	Sodium:proton antiporter activity	IDA	2536298, 8901634, 11350981, 24840010
GO:0015385	Function	Sodium:proton antiporter activity	IEA
GO:0015385	Function	Sodium:proton antiporter activity	ISS
GO:0015385	Function	Sodium:proton antiporter activity	TAS	24840010
GO:0015386	Function	Potassium:proton antiporter activity	IBA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	8283968
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	ISS
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016477	Process	Cell migration	TAS	17565280
GO:0030011	Process	Maintenance of cell polarity	TAS	17565280
GO:0030027	Component	Lamellipodium	TAS	17565280
GO:0030154	Process	Cell differentiation	IEA
GO:0030307	Process	Positive regulation of cell growth	IEA
GO:0030315	Component	T-tubule	IEA
GO:0030346	Function	Protein phosphatase 2B binding	IDA	22688515
GO:0030346	Function	Protein phosphatase 2B binding	IPI	22688515
GO:0030674	Function	Protein-macromolecule adaptor activity	TAS	17565280
GO:0032869	Process	Cellular response to insulin stimulus	IEA
GO:0035794	Process	Positive regulation of mitochondrial membrane permeability	IEA
GO:0035994	Process	Response to muscle stretch	IMP	15105296
GO:0036376	Process	Sodium ion export across plasma membrane	ISS
GO:0042383	Component	Sarcolemma	IEA
GO:0042802	Function	Identical protein binding	IDA	17073455, 34108458
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0045121	Component	Membrane raft	IDA	22688515
GO:0045760	Process	Positive regulation of action potential	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	22688515
GO:0048306	Function	Calcium-dependent protein binding	IDA	15035633
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0048863	Process	Stem cell differentiation	IEA
GO:0051259	Process	Protein complex oligomerization	ISS
GO:0051453	Process	Regulation of intracellular pH	IBA
GO:0051453	Process	Regulation of intracellular pH	IDA	15035633, 24840010
GO:0051453	Process	Regulation of intracellular pH	IEA
GO:0051492	Process	Regulation of stress fiber assembly	TAS	17565280
GO:0051893	Process	Regulation of focal adhesion assembly	TAS	17565280
GO:0055007	Process	Cardiac muscle cell differentiation	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0060090	Function	Molecular adaptor activity	TAS	17565280
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0070417	Process	Cellular response to cold	IEA
GO:0070886	Process	Positive regulation of calcineurin-NFAT signaling cascade	IDA	22688515
GO:0071236	Process	Cellular response to antibiotic	IEA
GO:0071257	Process	Cellular response to electrical stimulus	IEA
GO:0071260	Process	Cellular response to mechanical stimulus	TAS	17565280
GO:0071456	Process	Cellular response to hypoxia	IEA
GO:0071468	Process	Cellular response to acidic pH	IDA	24840010
GO:0071468	Process	Cellular response to acidic pH	ISS
GO:0071805	Process	Potassium ion transmembrane transport	IBA
GO:0071872	Process	Cellular response to epinephrine stimulus	IMP	21359875
GO:0086003	Process	Cardiac muscle cell contraction	IEA
GO:0086036	Process	Regulation of cardiac muscle cell membrane potential	TAS	24840010
GO:0086092	Process	Regulation of the force of heart contraction by cardiac conduction	IMP	21359875
GO:0090533	Component	Cation-transporting ATPase complex	IDA	24840010
GO:0098719	Process	Sodium ion import across plasma membrane	IBA
GO:0098719	Process	Sodium ion import across plasma membrane	IDA	2536298, 24840010
GO:0098735	Process	Positive regulation of the force of heart contraction	IMP	15105296
GO:1902533	Process	Positive regulation of intracellular signal transduction	IEA
GO:1902600	Process	Proton transmembrane transport	IDA	24840010
GO:1902600	Process	Proton transmembrane transport	IEA
GO:1990351	Component	Transporter complex	IEA

MIM	HGNC	e!Ensembl
107310	11071	ENSG00000090020

Protein

UniProt ID

P19634

Protein name

Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1)

Protein function

Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (PubMed:11350981, PubMed:11532004, PubM

PDB

1Y4E , 2BEC , 2E30 , 2HTG , 2KBV , 2L0E , 2MDF , 2YGG , 6BJF , 6NUC , 6NUF , 6NUU , 6ZBI , 7DSV , 7DSW , 7DSX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00999	Na_H_Exchanger	105 → 505	Sodium/hydrogen exchanger family	Family
PF16644	NEXCaM_BD	599 → 700	Regulatory region of Na+/H+ exchanger NHE binds to calmodulin	Domain

Tissue specificity

TISSUE SPECIFICITY: Kidney and intestine.

Sequence

MVLRSGICGLSPHRIFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDV
TTAPPEVTPESRPVNHSVTDHGMKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFH
VIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLR
QFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPV
AVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEHVGIVDIFLGFLSFFV
VALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASG
VVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLF
CLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLF
LTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGH
YGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSA
VSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYE
EAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITID
PASPQSPESVDLVNEELKGKVLGLSRDPAKVAEEDEDDDGGIMMRSKETSSPGTDDVFTP
APSDSPSSQRIQRCLSDPGPHPEPGEGEPFFPKGQ

Sequence length

815

Interactions

View interactions

	KEGG		Reactome
	cAMP signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Apelin signaling pathway Regulation of actin cytoskeleton Thyroid hormone signaling pathway Salivary secretion Gastric acid secretion Pancreatic secretion Bile secretion Proteoglycans in cancer		Hyaluronan uptake and degradation Sodium/Proton exchangers

Show/Hide Causal Diseases (1)

Disease merge term	Disease name	dbSNP ID	References
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Lichtenstein-knorr syndrome	lichtenstein-knorr syndrome	rs786204831	N/A

Show/Hide Text Mining Associations (40)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Acidosis	Stimulate	17209041, 24376510
Aortic Dissection	Associate	37684281
Barrett Esophagus	Associate	20876775
Breast Neoplasms	Associate	15843433, 17332506, 26646587, 27266704, 29895196
Calcinosis	Associate	35339998
Cardiomegaly	Associate	35334035
COVID 19	Associate	33215884
Diabetes Mellitus Type 2	Associate	33426802
Diabetic Nephropathies	Associate	10886567
Diabetic Nephropathies	Stimulate	37916327
Drug Related Side Effects and Adverse Reactions	Associate	36380966
Esophageal Squamous Cell Carcinoma	Associate	27902974
Essential Hypertension	Stimulate	7875760
Glioblastoma	Associate	28732990
Glioma	Associate	10751317, 12693711, 27287871, 40459830
Heart Diseases	Associate	17981808, 18077454
Hypertension	Stimulate	7875760
Hypertension Pulmonary	Associate	21454803
Hypertrophy	Associate	21454803, 35334035
Hypoxia	Associate	21454803
Hypoxia	Stimulate	22216126
Hypoxia	Inhibit	28806945
Hypoxia Brain	Stimulate	28476026
Irritable Bowel Syndrome	Stimulate	33843785
Kidney Diseases	Associate	8201013
Leukemia	Associate	35624145
Leukemia Lymphoma Adult T Cell	Associate	35041720
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	25802333
Leukemia Myeloid Acute	Associate	35624145
Lung Diseases	Associate	21454803
Lung Neoplasms	Associate	37921568
Melanoma	Associate	11248216, 17916606, 29558744
Muscular Dystrophy Duchenne	Associate	36814107
Neoplasm Metastasis	Associate	27049728
Neoplasms	Associate	10751317, 24481225, 25372487, 27434882, 27902974, 28806945, 34038242
Neurologic Manifestations	Associate	34108458
Ovarian Neoplasms	Associate	27773735
Pancreatic Neoplasms	Associate	19393580
Triple Negative Breast Neoplasms	Associate	27049728
Wounds and Injuries	Associate	24883122

SLC9A1 (solute carrier family 9 member A1)