SLC6A12 (solute carrier family 6 member 12)

Gene

• Entrez ID: 6539
• Gene name: Solute carrier family 6 member 12
• Gene symbol: SLC6A12
• Synonyms (NCBI Gene): BGT-1, BGT1, GAT2
• Chromosome: 12
• Chromosome location: 12p13.33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017112	hsa-miR-335-5p	Microarray	18185580
MIRT043673	hsa-miR-342-3p	CLASH	23622248
MIRT1365858	hsa-miR-150	CLIP-seq
MIRT1365859	hsa-miR-3127-3p	CLIP-seq
MIRT1365860	hsa-miR-4713-5p	CLIP-seq
MIRT1365861	hsa-miR-532-3p	CLIP-seq
MIRT2459826	hsa-miR-342-5p	CLIP-seq
MIRT2459827	hsa-miR-3925-3p	CLIP-seq
MIRT2459828	hsa-miR-4257	CLIP-seq
MIRT2459829	hsa-miR-4474-3p	CLIP-seq
MIRT2459830	hsa-miR-4664-5p	CLIP-seq
MIRT2459831	hsa-miR-520a-5p	CLIP-seq
MIRT2459832	hsa-miR-525-5p	CLIP-seq
MIRT2459833	hsa-miR-550a	CLIP-seq
MIRT2459834	hsa-miR-760	CLIP-seq
MIRT2459835	hsa-miR-766	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003333	Process	Amino acid transmembrane transport	IEA
GO:0005332	Function	Gamma-aminobutyric acid:sodium:chloride symporter activity	IBA
GO:0005332	Function	Gamma-aminobutyric acid:sodium:chloride symporter activity	IDA	7589472, 7861179
GO:0005332	Function	Gamma-aminobutyric acid:sodium:chloride symporter activity	IEA
GO:0005515	Function	Protein binding	IPI	21525870, 24550280, 25416956, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006836	Process	Neurotransmitter transport	IEA
GO:0006865	Process	Amino acid transport	IBA
GO:0006865	Process	Amino acid transport	TAS
GO:0008028	Function	Monocarboxylic acid transmembrane transporter activity	IDA	29175673
GO:0015171	Function	Amino acid transmembrane transporter activity	TAS
GO:0015293	Function	Symporter activity	IEA
GO:0015718	Process	Monocarboxylic acid transport	IDA	29175673
GO:0015812	Process	Gamma-aminobutyric acid transport	IDA	7589472, 7861179
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	7861179
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	ISS
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0031460	Process	Glycine betaine transport	ISS
GO:0035725	Process	Sodium ion transmembrane transport	IBA
GO:0042995	Component	Cell projection	IBA
GO:0051936	Process	Gamma-aminobutyric acid reuptake	TAS
GO:0098793	Component	Presynapse	IEA

Other IDs

• MIM: 603080
• HGNC: 11045
• e!Ensembl: ENSG00000111181

Protein

• UniProt ID: P48065
• Protein name: Sodium- and chloride-dependent betaine transporter (BGT-1) (Na(+)/Cl(-) betaine/GABA transporter) (Solute carrier family 6 member 12)
• Protein function: Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process (PubMed:7589472). May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic termin
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00209	SNF	36 → 561	Sodium:neurotransmitter symporter family	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in kidney, liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain. {ECO:0000269|PubMed:7589472}.
• Sequence:

  MDGKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVW
  RFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGL
  ASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTP
  FENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVY
  FTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQG
  CLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGP
  GLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGR
  RELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADR
  FYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGW
  FLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSP
  TREGLIAGEKETHL

• Sequence length: 614

Pathways

KEGG:

Synaptic vesicle cycle
GABAergic synapse

Reactome:

Amino acid transport across the plasma membrane
Na+/Cl- dependent neurotransmitter transporters
Creatine metabolism
Reuptake of GABA