Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6533
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 6 member 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC6A6
Synonyms (NCBI Gene) Gene synonyms aliases
HTRDC, TAUT
Disease Acronyms (UniProt) Disease acronyms from UniProt database
HTRDC
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p25.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a multi-pass membrane protein that is a member of a family of sodium and chloride-ion dependent transporters. The encoded protein transports taurine and beta-alanine. There is a pseudogene for this gene on chromosome 21. Alternative spli
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019132 hsa-miR-335-5p Microarray 18185580
MIRT020030 hsa-miR-375 Microarray 20215506
MIRT050435 hsa-miR-23a-3p CLASH 23622248
MIRT045237 hsa-miR-186-5p CLASH 23622248
MIRT038054 hsa-miR-423-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
TP53 Repression 16734743
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005368 Function Taurine transmembrane transporter activity IDA 19074966, 31903486
GO:0005368 Function Taurine transmembrane transporter activity IMP 23519128
GO:0005368 Function Taurine transmembrane transporter activity ISS
GO:0005369 Function Taurine:sodium symporter activity IBA 21873635
GO:0005369 Function Taurine:sodium symporter activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
186854 11052 ENSG00000131389
Protein
UniProt ID P31641
Protein name Sodium- and chloride-dependent taurine transporter (Solute carrier family 6 member 6)
Protein function Mediates sodium- and chloride-dependent transport of taurine (PubMed:31345061, PubMed:31903486, PubMed:8010975, PubMed:8382624, PubMed:8654117). Mediates transport of beta-alanine (PubMed:8010975). Can also mediate transport of hypotaurine and g
PDB 9K7B , 9K7N
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00209 SNF 41 568 Sodium:neurotransmitter symporter family Family
Tissue specificity TISSUE SPECIFICITY: Expressed abundantly in placenta and skeletal muscle, at intermediate levels in heart, brain, lung, kidney and pancreas and at low levels in liver. {ECO:0000269|PubMed:8010975, ECO:0000269|PubMed:8382624}.
Sequence
Sequence length 620
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Amino acid transport across the plasma membrane
Na+/Cl- dependent neurotransmitter transporters
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Myopathy hypotaurinemic retinal degeneration and cardiomyopathy GenCC
Associations from Text Mining
Disease Name Relationship Type References
Cardiomyopathies Associate 31903486
Colonic Neoplasms Associate 29562499
Diabetes Mellitus Type 1 Stimulate 26955642
Diabetic Neuropathies Associate 19602579
Fetal Growth Retardation Associate 15166008, 23392873, 23519128
Hepatoblastoma Associate 12871209
Hyperglycemia Associate 26955642
Hypertensive Retinopathy Associate 26955642
Inflammation Associate 27322952
Muscular Disorders Atrophic Associate 27322952