Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	65268
Gene name Gene Name - the full gene name approved by the HGNC.	WNK lysine deficient protein kinase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	WNK2
Synonyms (NCBI Gene) Gene synonyms aliases	NY-CO-43, P/OKcl.13, PRKWNK2, SDCCAG43
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9q22.31
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alterna

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SNP ID	Visualize variation	Clinical significance	Consequence
rs757473977	->G	Likely-pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant, intron variant

Show/Hide all(54)

miRTarBase ID	miRNA	Experiments	Reference
MIRT713201	hsa-miR-4267	HITS-CLIP	19536157
MIRT713200	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT713199	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT713198	hsa-miR-3194-3p	HITS-CLIP	19536157
MIRT713197	hsa-miR-3160-5p	HITS-CLIP	19536157
MIRT713196	hsa-miR-760	HITS-CLIP	19536157
MIRT713195	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT713194	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT713193	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT491929	hsa-miR-936	PAR-CLIP	23592263
MIRT491927	hsa-miR-199a-3p	PAR-CLIP	23592263
MIRT491926	hsa-miR-199b-3p	PAR-CLIP	23592263
MIRT491925	hsa-miR-3129-5p	PAR-CLIP	23592263
MIRT491924	hsa-miR-7114-5p	PAR-CLIP	23592263
MIRT491923	hsa-miR-134-3p	PAR-CLIP	23592263
MIRT491921	hsa-miR-4493	PAR-CLIP	23592263
MIRT491922	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT491920	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT491919	hsa-miR-4648	PAR-CLIP	23592263
MIRT491918	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT491917	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT491915	hsa-miR-4654	PAR-CLIP	23592263
MIRT491916	hsa-miR-4769-5p	PAR-CLIP	23592263
MIRT491914	hsa-miR-222-5p	PAR-CLIP	23592263
MIRT713201	hsa-miR-4267	HITS-CLIP	19536157
MIRT713200	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT713199	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT713198	hsa-miR-3194-3p	HITS-CLIP	19536157
MIRT713197	hsa-miR-3160-5p	HITS-CLIP	19536157
MIRT713196	hsa-miR-760	HITS-CLIP	19536157
MIRT713195	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT713194	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT713193	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT491929	hsa-miR-936	PAR-CLIP	23592263
MIRT491927	hsa-miR-199a-3p	PAR-CLIP	23592263
MIRT491926	hsa-miR-199b-3p	PAR-CLIP	23592263
MIRT491925	hsa-miR-3129-5p	PAR-CLIP	23592263
MIRT491924	hsa-miR-7114-5p	PAR-CLIP	23592263
MIRT491923	hsa-miR-134-3p	PAR-CLIP	23592263
MIRT491921	hsa-miR-4493	PAR-CLIP	23592263
MIRT491922	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT491920	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT491919	hsa-miR-4648	PAR-CLIP	23592263
MIRT491918	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT491917	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT491915	hsa-miR-4654	PAR-CLIP	23592263
MIRT491916	hsa-miR-4769-5p	PAR-CLIP	23592263
MIRT491914	hsa-miR-222-5p	PAR-CLIP	23592263
MIRT1493442	hsa-miR-3616-5p	CLIP-seq
MIRT1493443	hsa-miR-3647-5p	CLIP-seq
MIRT1493444	hsa-miR-4436b-5p	CLIP-seq
MIRT1493445	hsa-miR-4795-5p	CLIP-seq
MIRT1493446	hsa-miR-483-5p	CLIP-seq
MIRT1493447	hsa-miR-573	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	ISS
GO:0005524	Function	ATP binding	ISS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	17667937
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0006468	Process	Protein phosphorylation	IBA	21873635
GO:0006468	Process	Protein phosphorylation	IDA	21733846
GO:0008285	Process	Negative regulation of cell population proliferation	IMP	17667937
GO:0010766	Process	Negative regulation of sodium ion transport	IBA	21873635
GO:0019869	Function	Chloride channel inhibitor activity	IBA	21873635
GO:0019870	Function	Potassium channel inhibitor activity	IBA	21873635
GO:0035556	Process	Intracellular signal transduction	IBA	21873635
GO:0035556	Process	Intracellular signal transduction	ISS
GO:0046777	Process	Protein autophosphorylation	IDA	17667937
GO:0050801	Process	Ion homeostasis	IBA	21873635
GO:0050801	Process	Ion homeostasis	IMP	21733846
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IMP	17667937
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IMP	23797875
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA
GO:1903288	Process	Positive regulation of potassium ion import across plasma membrane	IBA	21873635
GO:2000651	Process	Positive regulation of sodium ion transmembrane transporter activity	IBA	21873635
GO:2000651	Process	Positive regulation of sodium ion transmembrane transporter activity	IMP	21733846

MIM	HGNC	e!Ensembl
606249	14542	ENSG00000165238

Protein

UniProt ID

Q9Y3S1

Protein name

Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43)

Protein function

Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation (PubMed:17667937, PubMed:18593598, PubMed:217

PDB

6ELM , 6FBK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	195 → 453	Protein kinase domain	Domain
PF12202	OSR1_C	474 → 537	Oxidative-stress-responsive kinase 1 C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in various cancer cell lines (at protein level). Predominantly expressed in heart, brain, skeletal muscle and colon. {ECO:0000269|PubMed:11571656, ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:21733846}.

Sequence

MDGDGGRRDVPGTLMEPGRGAGPAGMAEPRAKAARPGPQRFLRRSVVESDQEEPPGLEAA
EAPGPQPPQPLQRRVLLLCKTRRLIAERARGRPAAPAPAALVAQPGAPGAPADAGPEPVG
TQEPGPDPIAAAVETAPAPDGGPREEAAATVRKEDEGAAEAKPEPGRTRRDEPEEEEDDE
DDLKAVATSLDGRFLKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKLERQRFK
EEAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTSGTLKTYLKRFKVMKPKVLRS
WCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGT
PEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTCGIKPASFEK
VHDPEIKEIIGECICKNKEERYEIKDLLSHAFFAEDTGVRVELAEEDHGRKSTIALRLWV
EDPKKLKGKPKDNGAIEFTFDLEKETPDEVAQEMIESGFFHESDVKIVAKSIRDRVALIQ
WRRERIWPALQPKEQQDVGSPDKARGPPVPLQVQVTYHAQAGQPGPPEPEEPEADQHLLP
PTLPTSATSLASDSTFDSGQGSTVYSDSQSSQQSVMLGSLADAAPSPAQCVCSPPVSEGP
VLPQSLPSLGAYQQPTAAPGLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTG
PGQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQM
PQAPLQPLAQVPPQMPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVIL
PSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIH
SAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQP
TLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPG
SQILLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASV
QSVPTQTATLLPPANPPLPGGPGIASPCPTVQLTVEPVQEEQASQDKPPGLPQSCESYGG
SDVTSGKELSDSCEGAFGGGRLEGRAARKHHRRSTRARSRQERASRPRLTILNVCNTGDK
MVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILQAERETFIEQMKDVMDKAEDM
LSEDTDADRGSDPGTSPPHLSTCGLGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAE
HPAPEAPESSPPLPLSSLPPEASQGPCRGLTLPCLPWRRAACGAVFLSLFSAESAQSKQP
PDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAPSSPPVTALPQDGAAPAT
STMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAA
STRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQLPSPPLGPTV
PPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSASAGTPVEVGDRDF
TLEPLRGDQPRSEVCGGDLALPPVPKEAVSGRVQLPQPLVEKSELAPTRGAVMEQGTSSS
MTAESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAFVRPARVEPTDRDGGEAGESSAEP
PPSDMGTVGGQASHPQTLGARALGSPRKRPEQQDVSSPAKTVGRFSVVSTQDEWTLASPH
SLRYSAPPDVYLDEAPSSPDVKLAVRRAQTASSIEVGVGEPVSSDSGDEGPRARPPVQKQ
ASLPVSGSVAGDFVKKATAFLQRPSRAGSLGPETPSRVGMKVPTISVTSFHSQSSYISSD
NDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPT
GRRRKTSKSKLKAGKLLNPLVRQLKVVASSTGHLADSSRGPPAKDPAQASVGLTADSTGL
SGKAVQTQQPCSVRASLSSDICSGLASDGGGARGQGWTVYHPTSERVTYKSSSKPRARFL
SGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPGPQPALHVQAQVNNSNNKKGTFTD
DLHKLVDEWTSKTVGAAQLKPTLNQLKQTQKLQDMEAQAGWAAPGEARAMTAPRAGVGMP
RLPPAPGPLSTTVIPGAAPTLSVPTPDGALGTARRNQVWFGLRVPPTACCGHSTQPRGGQ
RVGSKTASFAASDPVRS

Sequence length

2297

Interactions

View interactions

	KEGG		Reactome
	Parathyroid hormone synthesis, secretion and action		Stimuli-sensing channels

Show/Hide Unknown Diseases (6)

Disease term	Disease name	References	Source
Unknown
Myocardial infarction	Myocardial Infarction	21211798	ClinVar
Bipolar Disorder	Bipolar Disorder		GWAS
Gout	Gout		GWAS
Alzheimer disease	Alzheimer disease		GWAS
Tremor	Tremor		GWAS
Coronary artery disease	Coronary artery disease		GWAS

Show/Hide Text Mining Associations (17)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenomatous Polyposis Coli	Associate	36270769
Alzheimer Disease	Associate	36035305
Carcinoma Hepatocellular	Associate	31349001
Carcinoma Pancreatic Ductal	Associate	31046874
Cerebral Hemorrhage	Associate	39433142
Esophageal Squamous Cell Carcinoma	Associate	26857264
Glioblastoma	Associate	32093151
Glioma	Associate	17578925, 25596741, 32093151
Hyperlipidemias	Associate	39433142
Hypertension	Associate	39433142
Melanoma	Associate	22589389
Meningioma	Associate	19001526
Neoplasm Metastasis	Associate	31349001
Neoplasms	Associate	17578925, 26857264, 33428330
Neoplasms	Inhibit	19001526, 25596741, 31349001, 32093151
Ovarian Neoplasms	Associate	35549643
Stomach Neoplasms	Associate	26857264

WNK2 (WNK lysine deficient protein kinase 2)