Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	65251
Gene name	Zinc finger protein 649
Gene symbol	ZNF649
Synonyms (NCBI Gene)	-
Chromosome	19
Chromosome location	19q13.41

Show/Hide all (75)

miRTarBase ID	miRNA	Experiments	Reference
MIRT529334	hsa-miR-618	PAR-CLIP	22012620
MIRT529333	hsa-miR-6887-3p	PAR-CLIP	22012620
MIRT529332	hsa-miR-1913	PAR-CLIP	22012620
MIRT529331	hsa-miR-324-3p	PAR-CLIP	22012620
MIRT529330	hsa-miR-4313	PAR-CLIP	22012620
MIRT529329	hsa-miR-2355-5p	PAR-CLIP	22012620
MIRT529334	hsa-miR-618	PAR-CLIP	22012620
MIRT529333	hsa-miR-6887-3p	PAR-CLIP	22012620
MIRT529332	hsa-miR-1913	PAR-CLIP	22012620
MIRT529331	hsa-miR-324-3p	PAR-CLIP	22012620
MIRT529330	hsa-miR-4313	PAR-CLIP	22012620
MIRT529329	hsa-miR-2355-5p	PAR-CLIP	22012620
MIRT1533422	hsa-miR-105	CLIP-seq
MIRT1533423	hsa-miR-1236	CLIP-seq
MIRT1533424	hsa-miR-151-3p	CLIP-seq
MIRT1533425	hsa-miR-1825	CLIP-seq
MIRT1533426	hsa-miR-198	CLIP-seq
MIRT1533427	hsa-miR-199a-5p	CLIP-seq
MIRT1533428	hsa-miR-199b-5p	CLIP-seq
MIRT1533429	hsa-miR-297	CLIP-seq
MIRT1533430	hsa-miR-3136-3p	CLIP-seq
MIRT1533431	hsa-miR-3136-5p	CLIP-seq
MIRT1533432	hsa-miR-338-5p	CLIP-seq
MIRT1533433	hsa-miR-3689a-3p	CLIP-seq
MIRT1533434	hsa-miR-3689c	CLIP-seq
MIRT1533435	hsa-miR-3919	CLIP-seq
MIRT1533436	hsa-miR-4265	CLIP-seq
MIRT1533437	hsa-miR-4296	CLIP-seq
MIRT1533438	hsa-miR-4301	CLIP-seq
MIRT1533439	hsa-miR-4311	CLIP-seq
MIRT1533440	hsa-miR-4322	CLIP-seq
MIRT1533441	hsa-miR-4423-5p	CLIP-seq
MIRT1533442	hsa-miR-4439	CLIP-seq
MIRT1533443	hsa-miR-4463	CLIP-seq
MIRT1533444	hsa-miR-4493	CLIP-seq
MIRT1533445	hsa-miR-4499	CLIP-seq
MIRT1533446	hsa-miR-4513	CLIP-seq
MIRT1533447	hsa-miR-4648	CLIP-seq
MIRT1533448	hsa-miR-4654	CLIP-seq
MIRT1533449	hsa-miR-4693-3p	CLIP-seq
MIRT1533450	hsa-miR-4728-5p	CLIP-seq
MIRT1533451	hsa-miR-4769-5p	CLIP-seq
MIRT1533452	hsa-miR-4781-3p	CLIP-seq
MIRT1533453	hsa-miR-495	CLIP-seq
MIRT1533454	hsa-miR-513c	CLIP-seq
MIRT1533455	hsa-miR-514b-5p	CLIP-seq
MIRT1533456	hsa-miR-567	CLIP-seq
MIRT1533457	hsa-miR-570	CLIP-seq
MIRT2161390	hsa-miR-3135b	CLIP-seq
MIRT2161391	hsa-miR-3612	CLIP-seq
MIRT2161392	hsa-miR-3975	CLIP-seq
MIRT2161393	hsa-miR-4443	CLIP-seq
MIRT2161394	hsa-miR-650	CLIP-seq
MIRT2380264	hsa-miR-1179	CLIP-seq
MIRT2380265	hsa-miR-3120-3p	CLIP-seq
MIRT2161390	hsa-miR-3135b	CLIP-seq
MIRT2161391	hsa-miR-3612	CLIP-seq
MIRT2161392	hsa-miR-3975	CLIP-seq
MIRT2380266	hsa-miR-4310	CLIP-seq
MIRT2161393	hsa-miR-4443	CLIP-seq
MIRT2380267	hsa-miR-4789-5p	CLIP-seq
MIRT2380268	hsa-miR-512-5p	CLIP-seq
MIRT2380269	hsa-miR-545	CLIP-seq
MIRT2380270	hsa-miR-548g	CLIP-seq
MIRT2380271	hsa-miR-572	CLIP-seq
MIRT2161394	hsa-miR-650	CLIP-seq
MIRT2380264	hsa-miR-1179	CLIP-seq
MIRT2161390	hsa-miR-3135b	CLIP-seq
MIRT2161391	hsa-miR-3612	CLIP-seq
MIRT2161392	hsa-miR-3975	CLIP-seq
MIRT2380266	hsa-miR-4310	CLIP-seq
MIRT2161393	hsa-miR-4443	CLIP-seq
MIRT2380268	hsa-miR-512-5p	CLIP-seq
MIRT2380271	hsa-miR-572	CLIP-seq
MIRT2161394	hsa-miR-650	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IBA
GO:0005515	Function	Protein binding	IPI	23455924, 31403225, 32814053, 33961781, 35271311
GO:0005615	Component	Extracellular space	HDA	23580065
GO:0005634	Component	Nucleus	IDA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
611903	25741	ENSG00000198093

Q9BS31

Protein name

Zinc finger protein 649

Protein function

Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	7 → 48	KRAB box	Family
PF00096	zf-C2H2	178 → 200	Zinc finger, C2H2 type	Domain
PF13912	zf-C2H2_6	206 → 231		Domain
PF00096	zf-C2H2	262 → 284	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	290 → 312	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	318 → 340	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	346 → 368	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	374 → 396	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	402 → 424	Zinc finger, C2H2 type	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, and brain. Lower expression in liver, lung, kidney, pancreas and placenta. {ECO:0000269|PubMed:15950191}.

Sequence

MTKAQESLTLEDVAVDFTWEEWQFLSPAQKDLYRDVMLENYSNLVSVGYQAGKPDALTKL
EQGEPLWTLEDEIHSPAHPEIEKADDHLQQPLQNQKILKRTGQRYEHGRTLKSYLGLTNQ
SRRYNRKEPAEFNGDGAFLHDNHEQMPTEIEFPESRKPISTKSQFLKHQQTHNIEKAHEC
TDCGKAFLKKSQLTEHKRIHTGKKPHVCSLCGKAFYKKYRLTEHERAHRGEKPHGCSLCG
KAFYKRYRLTEHERAHKGEKPYGCSECGKAFPRKSELTEHQRIHTGIKPHQCSECGRAFS
RKSLLVVHQRTHTGEKPHTCSECGKGFIQKGNLNIHQRTHTGEKPYGCIDCGKAFSQKSC
LVAHQRYHTGKTPFVCPECGQPCSQKSGLIRHQKIHSGEKPYKCSDCGKAFLTKTMLIVH
HRTHTGERPYGCDECEKAYFYMSCLVKHKRIHSREKRGDSVKVENPSTASHSLSPSEHVQ
GKSPVNMVTVAMVAGQCEFAHILHS

Sequence length

505

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BRAIN INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	31994347	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	32735773	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	35379199	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Associate	27454520	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	31994347	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZNF649 (zinc finger protein 649)