Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	6518
Gene name	Solute carrier family 2 member 5
Gene symbol	SLC2A5
Synonyms (NCBI Gene)	GLUT-5GLUT5
Chromosome	1
Chromosome location	1p36.23
Summary	The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021373	hsa-miR-9-5p	Microarray	17612493
MIRT692267	hsa-miR-6815-5p	HITS-CLIP	23313552
MIRT692266	hsa-miR-6865-5p	HITS-CLIP	23313552
MIRT692265	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT692264	hsa-miR-3184-5p	HITS-CLIP	23313552
MIRT692263	hsa-miR-423-5p	HITS-CLIP	23313552
MIRT692262	hsa-miR-1914-3p	HITS-CLIP	23313552
MIRT692261	hsa-miR-5194	HITS-CLIP	23313552
MIRT692260	hsa-miR-6738-5p	HITS-CLIP	23313552
MIRT692259	hsa-miR-3135a	HITS-CLIP	23313552
MIRT692258	hsa-miR-6802-5p	HITS-CLIP	23313552
MIRT692257	hsa-miR-7977	HITS-CLIP	23313552
MIRT692256	hsa-miR-6834-5p	HITS-CLIP	23313552
MIRT692255	hsa-miR-1226-5p	HITS-CLIP	23313552
MIRT692254	hsa-miR-6734-5p	HITS-CLIP	23313552
MIRT692253	hsa-miR-1304-5p	HITS-CLIP	23313552
MIRT550589	hsa-miR-512-5p	PAR-CLIP	21572407
MIRT550588	hsa-miR-510-5p	PAR-CLIP	21572407
MIRT550587	hsa-miR-4695-5p	PAR-CLIP	21572407
MIRT550586	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT550585	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT550584	hsa-miR-940	PAR-CLIP	21572407
MIRT550583	hsa-miR-3929	PAR-CLIP	21572407
MIRT550582	hsa-miR-4419b	PAR-CLIP	21572407
MIRT550581	hsa-miR-4478	PAR-CLIP	21572407
MIRT550580	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT550579	hsa-miR-4459	PAR-CLIP	21572407
MIRT550578	hsa-miR-4433a-3p	PAR-CLIP	21572407
MIRT550577	hsa-miR-3664-3p	PAR-CLIP	21572407
MIRT550576	hsa-miR-4649-3p	PAR-CLIP	21572407
MIRT550575	hsa-miR-4790-3p	PAR-CLIP	21572407
MIRT550574	hsa-miR-1827	PAR-CLIP	21572407
MIRT550573	hsa-miR-485-5p	PAR-CLIP	21572407
MIRT550572	hsa-miR-6884-5p	PAR-CLIP	21572407
MIRT550571	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT550569	hsa-miR-7160-5p	PAR-CLIP	21572407
MIRT550570	hsa-miR-3650	PAR-CLIP	21572407
MIRT550568	hsa-miR-665	PAR-CLIP	21572407
MIRT550574	hsa-miR-1827	PAR-CLIP	27292025
MIRT550570	hsa-miR-3650	PAR-CLIP	27292025
MIRT550576	hsa-miR-4649-3p	PAR-CLIP	27292025
MIRT550571	hsa-miR-4722-5p	PAR-CLIP	27292025
MIRT550580	hsa-miR-4768-3p	PAR-CLIP	27292025
MIRT550575	hsa-miR-4790-3p	PAR-CLIP	27292025
MIRT550568	hsa-miR-665	PAR-CLIP	27292025
MIRT550586	hsa-miR-6808-5p	PAR-CLIP	27292025
MIRT550585	hsa-miR-6893-5p	PAR-CLIP	27292025
MIRT550569	hsa-miR-7160-5p	PAR-CLIP	27292025
MIRT550584	hsa-miR-940	PAR-CLIP	27292025
MIRT692267	hsa-miR-6815-5p	HITS-CLIP	23313552
MIRT692266	hsa-miR-6865-5p	HITS-CLIP	23313552
MIRT692265	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT692264	hsa-miR-3184-5p	HITS-CLIP	23313552
MIRT692263	hsa-miR-423-5p	HITS-CLIP	23313552
MIRT692262	hsa-miR-1914-3p	HITS-CLIP	23313552
MIRT692261	hsa-miR-5194	HITS-CLIP	23313552
MIRT692260	hsa-miR-6738-5p	HITS-CLIP	23313552
MIRT692259	hsa-miR-3135a	HITS-CLIP	23313552
MIRT692258	hsa-miR-6802-5p	HITS-CLIP	23313552
MIRT692257	hsa-miR-7977	HITS-CLIP	23313552
MIRT692256	hsa-miR-6834-5p	HITS-CLIP	23313552
MIRT692255	hsa-miR-1226-5p	HITS-CLIP	23313552
MIRT692254	hsa-miR-6734-5p	HITS-CLIP	23313552
MIRT692253	hsa-miR-1304-5p	HITS-CLIP	23313552
MIRT550589	hsa-miR-512-5p	PAR-CLIP	21572407
MIRT550588	hsa-miR-510-5p	PAR-CLIP	21572407
MIRT550587	hsa-miR-4695-5p	PAR-CLIP	21572407
MIRT550586	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT550585	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT550584	hsa-miR-940	PAR-CLIP	21572407
MIRT550583	hsa-miR-3929	PAR-CLIP	21572407
MIRT550582	hsa-miR-4419b	PAR-CLIP	21572407
MIRT550581	hsa-miR-4478	PAR-CLIP	21572407
MIRT550580	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT550579	hsa-miR-4459	PAR-CLIP	21572407
MIRT550578	hsa-miR-4433a-3p	PAR-CLIP	21572407
MIRT550577	hsa-miR-3664-3p	PAR-CLIP	21572407
MIRT550576	hsa-miR-4649-3p	PAR-CLIP	21572407
MIRT550575	hsa-miR-4790-3p	PAR-CLIP	21572407
MIRT550574	hsa-miR-1827	PAR-CLIP	21572407
MIRT550573	hsa-miR-485-5p	PAR-CLIP	21572407
MIRT550572	hsa-miR-6884-5p	PAR-CLIP	21572407
MIRT550571	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT550569	hsa-miR-7160-5p	PAR-CLIP	21572407
MIRT550570	hsa-miR-3650	PAR-CLIP	21572407
MIRT550568	hsa-miR-665	PAR-CLIP	21572407
MIRT755815	hsa-miR-92a-1-5p	Luciferase reporter assayWestern blottingqRT-PCR	35734423
MIRT1359008	hsa-miR-185	CLIP-seq
MIRT1359009	hsa-miR-4306	CLIP-seq
MIRT1359010	hsa-miR-4644	CLIP-seq
MIRT1359011	hsa-miR-4690-3p	CLIP-seq

Show/Hide all (38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003044	Process	Regulation of systemic arterial blood pressure mediated by a chemical signal	IEA
GO:0003044	Process	Regulation of systemic arterial blood pressure mediated by a chemical signal	ISS
GO:0005353	Function	Fructose transmembrane transporter activity	IBA
GO:0005353	Function	Fructose transmembrane transporter activity	IDA	8333543, 28083649, 29548810
GO:0005353	Function	Fructose transmembrane transporter activity	IEA
GO:0005353	Function	Fructose transmembrane transporter activity	TAS	1634504
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	8333543, 28083649
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	1634504
GO:0005975	Process	Carbohydrate metabolic process	TAS	1634504
GO:0009750	Process	Response to fructose	IEA
GO:0009750	Process	Response to fructose	ISS
GO:0015755	Process	Fructose transmembrane transport	IBA
GO:0015755	Process	Fructose transmembrane transport	IDA	28083649, 29548810
GO:0015755	Process	Fructose transmembrane transport	IEA
GO:0015755	Process	Fructose transmembrane transport	TAS	1634504
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	ISS
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0035579	Component	Specific granule membrane	TAS
GO:0042383	Component	Sarcolemma	IEA
GO:0042383	Component	Sarcolemma	ISS
GO:0046323	Process	D-glucose import	IBA
GO:0055056	Function	D-glucose transmembrane transporter activity	IBA
GO:0055056	Function	D-glucose transmembrane transporter activity	TAS	1695905
GO:0055085	Process	Transmembrane transport	IEA
GO:0070061	Function	Fructose binding	ISS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0070837	Process	Dehydroascorbic acid transport	IBA
GO:0071332	Process	Cellular response to fructose stimulus	IEA
GO:0071332	Process	Cellular response to fructose stimulus	ISS
GO:0106001	Process	Intestinal hexose absorption	TAS
GO:1904659	Process	D-glucose transmembrane transport	TAS	1695905
GO:1990539	Process	Fructose import across plasma membrane	IDA	8333543
GO:1990539	Process	Fructose import across plasma membrane	IEA

MIM	HGNC	e!Ensembl
138230	11010	ENSG00000142583

P22732

Protein name

Solute carrier family 2, facilitated glucose transporter member 5 (Fructose transporter) (Glucose transporter type 5, small intestine) (GLUT-5)

Protein function

Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:16186102, PubMed:17710649, PubMed:28083649, PubMed:29548810, PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (Pu

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00083	Sugar_tr	20 → 475	Sugar (and other) transporter	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in skeletal muscle, and in jejunum brush border membrane and basolateral membrane (at protein level) (PubMed:7619085). Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue. {ECO

Sequence

MEQQDQSMKEGRLTLVLALATLIAAFGSSFQYGYNVAAVNSPALLMQQFYNETYYGRTGE
FMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSR
VATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIF
GLRNLLANVDGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQKKDEAAAKKALQTLRGW
DSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYA
DQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLT
AALALQDTVSWMPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHW
LSNFTVGLIFPFIQEGLGPYSFIVFAVICLLTTIYIFLIVPETKAKTFIEINQIFTKMNK
VSEVYPEKEELKELPPVTSEQ

Sequence length

501

Interactions

View interactions

	KEGG		Reactome
	Carbohydrate digestion and absorption		Neutrophil degranulation Intestinal hexose absorption

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Long QT syndrome	association	rs779760381	RCV000190149

Show/Hide Text Mining Associations (27)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	29642606
Adenocarcinoma of Lung	Associate	34604392
Alcoholism	Associate	18190912
Breast Neoplasms	Associate	27074918, 29642606, 34064801, 38019251, 8700847
Calcinosis Cutis	Stimulate	10622535
Carcinogenesis	Associate	35813468
Carcinoma Pancreatic Ductal	Associate	37738413
Cardiovascular Diseases	Associate	23341889
Colorectal Neoplasms	Associate	34052986
Dermatofibrosarcoma	Associate	35441365
Diabetes Mellitus	Stimulate	11804845
Diabetes Mellitus	Associate	27074918, 28740135, 37062501
Diabetes Mellitus Type 2	Associate	11804845
Glioblastoma	Associate	36245009
Hypoxia	Stimulate	17658463
Hypoxia	Associate	33679749
Inflammatory Bowel Diseases	Associate	33159578
Leukemia Biphenotypic Acute	Associate	30272826
Leukemia Myeloid Acute	Associate	31918632
Metabolic Syndrome	Associate	28740135
Neoplasms	Associate	27074918, 28740135, 29642606, 34052986, 34064801, 34604392, 35813468, 37062501, 38019251
Obesity	Associate	37062501
Ovarian Neoplasms	Associate	37087023
Philadelphia Chromosome	Stimulate	30272826
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	30272826
Prostatic Neoplasms	Associate	34001952
Sleep Deprivation	Associate	23440187

SLC2A5 (solute carrier family 2 member 5)