Gene Gene information from NCBI Gene database.
Entrez ID 6517
Gene name Solute carrier family 2 member 4
Gene symbol SLC2A4
Synonyms (NCBI Gene)
GLUT4
Chromosome 17
Chromosome location 17p13.1
Summary This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is seque
miRNA miRNA information provided by mirtarbase database.
337
miRTarBase ID miRNA Experiments Reference
MIRT006559 hsa-miR-223-3p FlowImmunoblotImmunofluorescenceImmunohistochemistryImmunoprecipitaionIn situ hybridizationLuciferase reporter assayNorthern blotqRT-PCR 20080987
MIRT019111 hsa-miR-335-5p Microarray 18185580
MIRT038921 hsa-miR-92a-1-5p CLASH 23622248
MIRT053085 hsa-miR-93-5p Luciferase reporter assayqRT-PCRWestern blot 23493574
MIRT611339 hsa-miR-548ac HITS-CLIP 23824327
Transcription factors Transcription factors information provided by TRRUST V2 database.
7
Transcription factor Regulation Reference
HDAC4 Unknown 23899560
HDAC5 Repression 22991226
HDAC5 Unknown 23899560
MEF2A Activation 14630949;18198354
MEF2A Unknown 15294043
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
83
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 19478182, 25910212, 33961781
GO:0005737 Component Cytoplasm IEA
GO:0005768 Component Endosome IEA
GO:0005771 Component Multivesicular body IEA
GO:0005802 Component Trans-Golgi network IDA 12467732
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
138190 11009 ENSG00000181856
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P14672
Protein name Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4)
Protein function Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracel
PDB 7WSM , 7WSN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00083 Sugar_tr 27 483 Sugar (and other) transporter Family
Tissue specificity TISSUE SPECIFICITY: Skeletal and cardiac muscles; brown and white fat.
Sequence
Sequence length 509
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  FoxO signaling pathway
AMPK signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Insulin resistance
Diabetic cardiomyopathy
  Cellular hexose transport
Transcriptional regulation of white adipocyte differentiation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
19
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ALZHEIMERS DISEASE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARDIOMEGALY CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cervical cancer Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Breast Neoplasms Associate 10950817, 34488531, 34525987
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 33570246
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Associate 31180527, 37549925
★☆☆☆☆
Found in Text Mining only
Cardiomegaly Stimulate 22028857
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cardiomyopathy Hypertrophic Associate 32455814
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Associate 29504525
★☆☆☆☆
Found in Text Mining only
Coronary Disease Associate 35468725
★☆☆☆☆
Found in Text Mining only
Dental Caries Associate 31261961
★☆☆☆☆
Found in Text Mining only
Diabetes Gestational Stimulate 27981520
★☆☆☆☆
Found in Text Mining only
Diabetes Gestational Associate 30805369, 35532201, 35712865
★☆☆☆☆
Found in Text Mining only