Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6515
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 2 member 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC2A3
Synonyms (NCBI Gene) Gene synonyms aliases
GLUT3
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12p13.31
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006235 hsa-miR-195-5p Luciferase reporter assay, Western blot 22265971
MIRT006235 hsa-miR-195-5p Luciferase reporter assay, Western blot 22265971
MIRT006235 hsa-miR-195-5p Luciferase reporter assay, Western blot 22265971
MIRT006235 hsa-miR-195-5p Luciferase reporter assay, Western blot 22265971
MIRT006235 hsa-miR-195-5p Luciferase reporter assay, Western blot 22265971
Transcription factors
Transcription factor Regulation Reference
HMGA1 Activation 22706202
ZBTB7A Repression 25184678
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005353 Function Fructose transmembrane transporter activity IDA 8457197
GO:0005354 Function Galactose transmembrane transporter activity IDA 8457197
GO:0005515 Function Protein binding IPI 32296183, 35810171
GO:0005536 Function D-glucose binding IDA 26176916
GO:0005886 Component Plasma membrane IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
138170 11007 ENSG00000059804
Protein
UniProt ID P11169
Protein name Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3)
Protein function Facilitative glucose transporter (PubMed:26176916, PubMed:32860739, PubMed:9477959). Can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:26176916, PubMed:9477959). Mediates the uptake of glucose, 2-deoxy
PDB 4ZW9 , 4ZWB , 4ZWC , 5C65 , 7CRZ , 7SPS , 7SPT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00083 Sugar_tr 13 465 Sugar (and other) transporter Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in brain (PubMed:8457197). Expressed in many tissues. {ECO:0000269|PubMed:3170580, ECO:0000269|PubMed:8457197}.
Sequence
Sequence length 496
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Cellular hexose transport
Vitamin C (ascorbate) metabolism
Neutrophil degranulation
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Alzheimer disease Alzheimer's disease or family history of Alzheimer's disease N/A N/A GWAS
Anxiety Disorder Anxiety N/A N/A GWAS
Dementia Dementia N/A N/A GWAS
Huntington Disease Huntington disease N/A N/A GenCC
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
22q11 Deletion Syndrome Associate 27604636
Adenocarcinoma Associate 26410497, 34814273
Adenocarcinoma of Lung Associate 24928511
Alzheimer Disease Associate 23341039, 29055815
Arthritis Rheumatoid Associate 24178905
Attention Deficit Disorder with Hyperactivity Associate 29477591
Autistic Disorder Associate 35466476
Blood Platelet Disorders Associate 26367242
Brain Edema Associate 32908869
Breast Neoplasms Associate 22270867, 34525987, 35178446, 35501580, 37222403