Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6511
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 1 member 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC1A6
Synonyms (NCBI Gene) Gene synonyms aliases
EAAT4
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.12
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT028877 hsa-miR-26b-5p Microarray 19088304
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001504 Process Neurotransmitter uptake IMP 7791878
GO:0005314 Function High-affinity glutamate transmembrane transporter activity ISS
GO:0005794 Component Golgi apparatus IEA
GO:0005886 Component Plasma membrane IDA
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600637 10944 ENSG00000105143
Protein
UniProt ID P48664
Protein name Excitatory amino acid transporter 4 (Sodium-dependent glutamate/aspartate transporter) (Solute carrier family 1 member 6)
Protein function Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:26690923, PubMed:7791878). Functions as a symporter that transports one amino acid molecule together with
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00375 SDF 58 522 Sodium:dicarboxylate symporter family Family
Tissue specificity TISSUE SPECIFICITY: Brain, mainly in the cerebellum (PubMed:7791878). Expressed densely and selectively in cell bodies of Purkinje cells. {ECO:0000269|PubMed:7791878}.
Sequence
Sequence length 564
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Synaptic vesicle cycle
Glutamatergic synapse
Spinocerebellar ataxia
  Glutamate Neurotransmitter Release Cycle
Transport of inorganic cations/anions and amino acids/oligopeptides
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
17221839
Unknown
Disease term Disease name Evidence References Source
Mental depression Unipolar Depression, Major Depressive Disorder 11850151 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Epilepsy Inhibit 17868051
Lymphoma Non Hodgkin Associate 37543576
Urinary Bladder Neoplasms Associate 34905506, 35462469