Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	65061
Gene name Gene Name - the full gene name approved by the HGNC.	Cyclin dependent kinase 15
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CDK15
Synonyms (NCBI Gene) Gene synonyms aliases	ALS2CR7, PFTAIRE2, PFTK2
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q33.1

Show/Hide all(86)

miRTarBase ID	miRNA	Experiments	Reference
MIRT606937	hsa-miR-6782-5p	HITS-CLIP	24906430
MIRT606936	hsa-miR-3184-5p	HITS-CLIP	24906430
MIRT606935	hsa-miR-423-5p	HITS-CLIP	24906430
MIRT606934	hsa-miR-1914-3p	HITS-CLIP	24906430
MIRT606933	hsa-miR-5194	HITS-CLIP	24906430
MIRT606932	hsa-miR-6738-5p	HITS-CLIP	24906430
MIRT606931	hsa-miR-6747-5p	HITS-CLIP	24906430
MIRT606930	hsa-miR-4455	HITS-CLIP	24906430
MIRT607557	hsa-miR-323a-5p	HITS-CLIP	24906430
MIRT607556	hsa-miR-876-3p	HITS-CLIP	24906430
MIRT606929	hsa-miR-3650	HITS-CLIP	24906430
MIRT606928	hsa-miR-3911	HITS-CLIP	24906430
MIRT606927	hsa-miR-644a	HITS-CLIP	24906430
MIRT606926	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT606925	hsa-miR-6834-5p	HITS-CLIP	24906430
MIRT606924	hsa-miR-1226-5p	HITS-CLIP	24906430
MIRT606923	hsa-miR-6734-5p	HITS-CLIP	24906430
MIRT606922	hsa-miR-147a	HITS-CLIP	24906430
MIRT606921	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT606937	hsa-miR-6782-5p	HITS-CLIP	24906430
MIRT606936	hsa-miR-3184-5p	HITS-CLIP	24906430
MIRT606935	hsa-miR-423-5p	HITS-CLIP	24906430
MIRT606934	hsa-miR-1914-3p	HITS-CLIP	24906430
MIRT606933	hsa-miR-5194	HITS-CLIP	24906430
MIRT606932	hsa-miR-6738-5p	HITS-CLIP	24906430
MIRT606931	hsa-miR-6747-5p	HITS-CLIP	24906430
MIRT606930	hsa-miR-4455	HITS-CLIP	24906430
MIRT606929	hsa-miR-3650	HITS-CLIP	24906430
MIRT606928	hsa-miR-3911	HITS-CLIP	24906430
MIRT606927	hsa-miR-644a	HITS-CLIP	24906430
MIRT606926	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT606925	hsa-miR-6834-5p	HITS-CLIP	24906430
MIRT606924	hsa-miR-1226-5p	HITS-CLIP	24906430
MIRT606923	hsa-miR-6734-5p	HITS-CLIP	24906430
MIRT606922	hsa-miR-147a	HITS-CLIP	24906430
MIRT606921	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT606924	hsa-miR-1226-5p	HITS-CLIP	27418678
MIRT606924	hsa-miR-1226-5p	HITS-CLIP	27418678
MIRT606922	hsa-miR-147a	HITS-CLIP	27418678
MIRT606922	hsa-miR-147a	HITS-CLIP	27418678
MIRT606922	hsa-miR-147a	HITS-CLIP	27418678
MIRT606922	hsa-miR-147a	HITS-CLIP	27418678
MIRT606934	hsa-miR-1914-3p	HITS-CLIP	27418678
MIRT606934	hsa-miR-1914-3p	HITS-CLIP	27418678
MIRT606936	hsa-miR-3184-5p	HITS-CLIP	27418678
MIRT606936	hsa-miR-3184-5p	HITS-CLIP	27418678
MIRT607557	hsa-miR-323a-5p	HITS-CLIP	27418678
MIRT607557	hsa-miR-323a-5p	HITS-CLIP	27418678
MIRT607557	hsa-miR-323a-5p	HITS-CLIP	27418678
MIRT606929	hsa-miR-3650	HITS-CLIP	27418678
MIRT606929	hsa-miR-3650	HITS-CLIP	27418678
MIRT606928	hsa-miR-3911	HITS-CLIP	27418678
MIRT606928	hsa-miR-3911	HITS-CLIP	27418678
MIRT606928	hsa-miR-3911	HITS-CLIP	27418678
MIRT606928	hsa-miR-3911	HITS-CLIP	27418678
MIRT606935	hsa-miR-423-5p	HITS-CLIP	27418678
MIRT606935	hsa-miR-423-5p	HITS-CLIP	27418678
MIRT606930	hsa-miR-4455	HITS-CLIP	27418678
MIRT606930	hsa-miR-4455	HITS-CLIP	27418678
MIRT606933	hsa-miR-5194	HITS-CLIP	27418678
MIRT606933	hsa-miR-5194	HITS-CLIP	27418678
MIRT606921	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT606921	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT606921	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT606921	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT606927	hsa-miR-644a	HITS-CLIP	27418678
MIRT606927	hsa-miR-644a	HITS-CLIP	27418678
MIRT606927	hsa-miR-644a	HITS-CLIP	27418678
MIRT606927	hsa-miR-644a	HITS-CLIP	27418678
MIRT606923	hsa-miR-6734-5p	HITS-CLIP	27418678
MIRT606923	hsa-miR-6734-5p	HITS-CLIP	27418678
MIRT606932	hsa-miR-6738-5p	HITS-CLIP	27418678
MIRT606932	hsa-miR-6738-5p	HITS-CLIP	27418678
MIRT606931	hsa-miR-6747-5p	HITS-CLIP	27418678
MIRT606931	hsa-miR-6747-5p	HITS-CLIP	27418678
MIRT606937	hsa-miR-6782-5p	HITS-CLIP	27418678
MIRT606937	hsa-miR-6782-5p	HITS-CLIP	27418678
MIRT606925	hsa-miR-6834-5p	HITS-CLIP	27418678
MIRT606925	hsa-miR-6834-5p	HITS-CLIP	27418678
MIRT606926	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT606926	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT606926	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT606926	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT607556	hsa-miR-876-3p	HITS-CLIP	27418678
MIRT607556	hsa-miR-876-3p	HITS-CLIP	27418678
MIRT607556	hsa-miR-876-3p	HITS-CLIP	27418678

Show/Hide all(12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000083	Process	Regulation of transcription involved in G1/S transition of mitotic cell cycle	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	24866247
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	22939624, 23602568, 25036637
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	IBA	21873635
GO:0006468	Process	Protein phosphorylation	IBA	21873635
GO:0030332	Function	Cyclin binding	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA
GO:0051726	Process	Regulation of cell cycle	IEA

MIM	HGNC	e!Ensembl
616147	14434	ENSG00000138395

Protein

UniProt ID

Q96Q40

Protein name

Cyclin-dependent kinase 15 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein) (Cell division protein kinase 15) (Serine/threonine-protein kinase ALS2CR7) (Serine/threonine-protein kinase PFTAIRE-2)

Protein function

Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	103 → 387	Protein kinase domain	Domain

Sequence

MGQELCAKTVQPGCSCYHCSEGGEAHSCRRSQPETTEAAFKLTDLKEASCSMTSFHPRGL
QAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKG
ISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEY
MHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKL
ADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLF
PGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEA
EDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDEESLFTVSGVRLKPEMCDLLA
SYQKGHHPAQFSKCW

Sequence length

435

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Renal carcinoma	Conventional (Clear Cell) Renal Cell Carcinoma	rs121913668, rs121913670, rs121913243, rs786202724

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	33157918
Breast Neoplasms	Associate	34162268
Carcinoma Intraductal Noninfiltrating	Inhibit	34162268
Inflammation	Associate	30867819
Lymphatic Metastasis	Stimulate	34162268
Neoplasms	Associate	34162268
Niemann Pick Disease Type C	Associate	30867819
Prodromal Symptoms	Stimulate	34162268

CDK15 (cyclin dependent kinase 15)