SLA (Src like adaptor)

Gene

• Entrez ID: 6503
• Gene name: Src like adaptor
• Gene symbol: SLA
• Synonyms (NCBI Gene): SLA1, SLAP
• Chromosome: 8
• Chromosome location: 8q24.22

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1351345	hsa-miR-1193	CLIP-seq
MIRT1351346	hsa-miR-3064-3p	CLIP-seq
MIRT1351347	hsa-miR-3159	CLIP-seq
MIRT1351348	hsa-miR-325	CLIP-seq
MIRT1351349	hsa-miR-383	CLIP-seq
MIRT1351350	hsa-miR-4300	CLIP-seq
MIRT1351351	hsa-miR-4772-5p	CLIP-seq
MIRT1351352	hsa-miR-920	CLIP-seq
MIRT1351353	hsa-miR-1258	CLIP-seq
MIRT1351354	hsa-miR-1267	CLIP-seq
MIRT1351355	hsa-miR-1275	CLIP-seq
MIRT1351356	hsa-miR-188-5p	CLIP-seq
MIRT1351357	hsa-miR-1915	CLIP-seq
MIRT1351358	hsa-miR-204	CLIP-seq
MIRT1351359	hsa-miR-211	CLIP-seq
MIRT1351360	hsa-miR-2355-5p	CLIP-seq
MIRT1351361	hsa-miR-3117-3p	CLIP-seq
MIRT1351362	hsa-miR-3147	CLIP-seq
MIRT1351363	hsa-miR-3150a-5p	CLIP-seq
MIRT1351364	hsa-miR-3150b-5p	CLIP-seq
MIRT1351365	hsa-miR-3169	CLIP-seq
MIRT1351366	hsa-miR-3182	CLIP-seq
MIRT1351367	hsa-miR-3945	CLIP-seq
MIRT1351368	hsa-miR-4253	CLIP-seq
MIRT1351369	hsa-miR-4270	CLIP-seq
MIRT1351370	hsa-miR-4326	CLIP-seq
MIRT1351371	hsa-miR-4425	CLIP-seq
MIRT1351372	hsa-miR-4441	CLIP-seq
MIRT1351373	hsa-miR-4652-3p	CLIP-seq
MIRT1351374	hsa-miR-4661-3p	CLIP-seq
MIRT1351375	hsa-miR-4665-5p	CLIP-seq
MIRT1351376	hsa-miR-4726-3p	CLIP-seq
MIRT1351377	hsa-miR-4759	CLIP-seq
MIRT1351351	hsa-miR-4772-5p	CLIP-seq
MIRT1351378	hsa-miR-494	CLIP-seq
MIRT1351379	hsa-miR-548a-3p	CLIP-seq
MIRT1351380	hsa-miR-548e	CLIP-seq
MIRT1351381	hsa-miR-548f	CLIP-seq
MIRT1351382	hsa-miR-548g	CLIP-seq
MIRT1351383	hsa-miR-892a	CLIP-seq
MIRT2104120	hsa-miR-1237	CLIP-seq
MIRT2104121	hsa-miR-1248	CLIP-seq
MIRT2104122	hsa-miR-1270	CLIP-seq
MIRT2104123	hsa-miR-1284	CLIP-seq
MIRT2104124	hsa-miR-145	CLIP-seq
MIRT2104125	hsa-miR-149	CLIP-seq
MIRT2104126	hsa-miR-185	CLIP-seq
MIRT2104127	hsa-miR-1910	CLIP-seq
MIRT2104128	hsa-miR-2278	CLIP-seq
MIRT2104129	hsa-miR-3064-5p	CLIP-seq
MIRT2104130	hsa-miR-3189-3p	CLIP-seq
MIRT2104131	hsa-miR-326	CLIP-seq
MIRT2104132	hsa-miR-330-5p	CLIP-seq
MIRT2104133	hsa-miR-4274	CLIP-seq
MIRT2104134	hsa-miR-4279	CLIP-seq
MIRT2104135	hsa-miR-4306	CLIP-seq
MIRT2104136	hsa-miR-432	CLIP-seq
MIRT2104137	hsa-miR-4474-3p	CLIP-seq
MIRT2104138	hsa-miR-4531	CLIP-seq
MIRT2104139	hsa-miR-4644	CLIP-seq
MIRT2104140	hsa-miR-4753-3p	CLIP-seq
MIRT2104141	hsa-miR-4794	CLIP-seq
MIRT2104142	hsa-miR-4799-5p	CLIP-seq
MIRT2104143	hsa-miR-502-5p	CLIP-seq
MIRT2104144	hsa-miR-620	CLIP-seq
MIRT2104145	hsa-miR-942	CLIP-seq
MIRT2328239	hsa-miR-3713	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001784	Function	Phosphotyrosine residue binding	IBA
GO:0005154	Function	Epidermal growth factor receptor binding	IBA
GO:0005515	Function	Protein binding	IPI	9742401, 16273093, 24658140, 28514442, 31980649, 32296183, 33961781
GO:0005654	Component	Nucleoplasm	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0007165	Process	Signal transduction	IBA
GO:0008180	Component	COP9 signalosome	IBA
GO:0043408	Process	Regulation of MAPK cascade	IBA

Other IDs

• MIM: 601099
• HGNC: 10902
• e!Ensembl: ENSG00000155926

Protein

• UniProt ID: Q13239
• Protein name: Src-like-adapter (Src-like-adapter protein 1) (SLAP-1) (hSLAP)
• Protein function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-c
• PDB: 2CUD
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00018	SH3_1	29 → 74	SH3 domain	Domain
  PF00017	SH2	84 → 160	SH2 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:9660183}.
• Sequence:

  MGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISDEGGWWK
  AISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFY
  SLSVRHRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTPCLTQST
  AAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDESLFSYGLRESIASYLSLT
  SEDNTSFDRKKKSISLMYGGSKRKSSFFSSPPYFED

• Sequence length: 276