Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	65009
Gene name	NDRG family member 4
Gene symbol	NDRG4
Synonyms (NCBI Gene)	BDM1SMAP-8SMAP8
Chromosome	16
Chromosome location	16q21
Summary	This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes an

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miRTarBase ID	miRNA	Experiments	Reference
MIRT612052	hsa-miR-8485	HITS-CLIP	23313552
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT519152	hsa-miR-3145-3p	PAR-CLIP	23446348
MIRT519152	hsa-miR-3145-3p	HITS-CLIP	27418678
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT612052	hsa-miR-8485	HITS-CLIP	23313552
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612052	hsa-miR-8485	HITS-CLIP	23824327
MIRT612051	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT612050	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT612049	hsa-miR-603	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT612048	hsa-miR-3941	HITS-CLIP	23824327
MIRT519153	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT519152	hsa-miR-3145-3p	PAR-CLIP	23446348
MIRT1178278	hsa-miR-1285	CLIP-seq
MIRT1178279	hsa-miR-3132	CLIP-seq
MIRT1178280	hsa-miR-3187-5p	CLIP-seq
MIRT1178281	hsa-miR-329	CLIP-seq
MIRT1178282	hsa-miR-4311	CLIP-seq
MIRT1178283	hsa-miR-4650-3p	CLIP-seq
MIRT1178284	hsa-miR-548n	CLIP-seq
MIRT1178285	hsa-miR-548t	CLIP-seq
MIRT1178286	hsa-miR-612	CLIP-seq
MIRT1178281	hsa-miR-329	CLIP-seq
MIRT1178287	hsa-miR-1302	CLIP-seq
MIRT1178288	hsa-miR-3122	CLIP-seq
MIRT1178289	hsa-miR-3689d	CLIP-seq
MIRT1178290	hsa-miR-3913-5p	CLIP-seq
MIRT1178291	hsa-miR-3918	CLIP-seq
MIRT1178292	hsa-miR-4298	CLIP-seq
MIRT1178293	hsa-miR-4459	CLIP-seq
MIRT1178294	hsa-miR-4640-5p	CLIP-seq
MIRT1178295	hsa-miR-4726-5p	CLIP-seq
MIRT1178296	hsa-miR-665	CLIP-seq
MIRT1178278	hsa-miR-1285	CLIP-seq
MIRT1178280	hsa-miR-3187-5p	CLIP-seq
MIRT1178286	hsa-miR-612	CLIP-seq
MIRT2579154	hsa-miR-4323	CLIP-seq
MIRT2686033	hsa-miR-1193	CLIP-seq
MIRT2686034	hsa-miR-1206	CLIP-seq
MIRT1178278	hsa-miR-1285	CLIP-seq
MIRT2686035	hsa-miR-1343	CLIP-seq
MIRT2686036	hsa-miR-18a	CLIP-seq
MIRT2686037	hsa-miR-18b	CLIP-seq
MIRT2686038	hsa-miR-1910	CLIP-seq
MIRT2686039	hsa-miR-198	CLIP-seq
MIRT2686040	hsa-miR-3127-5p	CLIP-seq
MIRT2686041	hsa-miR-3157-3p	CLIP-seq
MIRT2686042	hsa-miR-3157-5p	CLIP-seq
MIRT1178280	hsa-miR-3187-5p	CLIP-seq
MIRT2686043	hsa-miR-326	CLIP-seq
MIRT2686044	hsa-miR-330-5p	CLIP-seq
MIRT2686045	hsa-miR-3591-3p	CLIP-seq
MIRT2686046	hsa-miR-3675-5p	CLIP-seq
MIRT2686047	hsa-miR-3681	CLIP-seq
MIRT2686048	hsa-miR-3688-3p	CLIP-seq
MIRT2686049	hsa-miR-3691-5p	CLIP-seq
MIRT2686050	hsa-miR-378g	CLIP-seq
MIRT2686051	hsa-miR-3978	CLIP-seq
MIRT2686052	hsa-miR-4290	CLIP-seq
MIRT2686053	hsa-miR-4314	CLIP-seq
MIRT2686054	hsa-miR-4422	CLIP-seq
MIRT2686055	hsa-miR-4481	CLIP-seq
MIRT2686056	hsa-miR-4486	CLIP-seq
MIRT2686057	hsa-miR-4667-5p	CLIP-seq
MIRT2686058	hsa-miR-4690-3p	CLIP-seq
MIRT2686059	hsa-miR-4700-5p	CLIP-seq
MIRT2686060	hsa-miR-4725-5p	CLIP-seq
MIRT2686061	hsa-miR-4735-3p	CLIP-seq
MIRT2686062	hsa-miR-4745-5p	CLIP-seq
MIRT2686063	hsa-miR-4758-5p	CLIP-seq
MIRT2686064	hsa-miR-504	CLIP-seq
MIRT2686065	hsa-miR-555	CLIP-seq
MIRT1178286	hsa-miR-612	CLIP-seq
MIRT2686066	hsa-miR-637	CLIP-seq
MIRT2686067	hsa-miR-760	CLIP-seq
MIRT2686068	hsa-miR-874	CLIP-seq

Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001947	Process	Heart looping	ISS
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	25416956, 26871637, 32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	12755708
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	11352569
GO:0005789	Component	Endoplasmic reticulum membrane	ISS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0007165	Process	Signal transduction	IBA
GO:0008542	Process	Visual learning	IEA
GO:0010642	Process	Negative regulation of platelet-derived growth factor receptor signaling pathway	IDA	12755708
GO:0010976	Process	Positive regulation of neuron projection development	ISS
GO:0014912	Process	Negative regulation of smooth muscle cell migration	IDA	12755708
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IDA	19535783
GO:0030154	Process	Cell differentiation	NAS	11352569, 11978393
GO:0031253	Component	Cell projection membrane	IEA
GO:0035050	Process	Embryonic heart tube development	ISS
GO:0048278	Process	Vesicle docking	IEA
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	IDA	12755708
GO:0060038	Process	Cardiac muscle cell proliferation	ISS
GO:0060973	Process	Cell migration involved in heart development	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IBA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	12755708
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	ISS
GO:2001135	Process	Regulation of endocytic recycling	IEA

MIM	HGNC	e!Ensembl
614463	14466	ENSG00000103034

Q9ULP0

Protein name

Protein NDRG4 (Brain development-related molecule 1) (N-myc downstream-regulated gene 4 protein) (Vascular smooth muscle cell-associated protein 8) (SMAP-8)

Protein function

Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance gro

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03096	Ndr	8 → 290	Ndr family	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma mult

Sequence

MPECWDGEHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEIT
KHFVVCHVDAPGQQVGASQFPQGYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVL
AKFALIFPDLVEGLVLVNIDPNGKGWIDWAATKLSGLTSTLPDTVLSHLFSQEELVNNTE
LVQSYRQQIGNVVNQANLQLFWNMYNSRRDLDINRPGTVPNAKTLRCPVMLVVGDNAPAE
DGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYIAYLKDRRLSGG
AVPSASMTRLARSRTASLTSASSVDGSRPQACTHSESSEGLGQVNHTMEVSC

Sequence length

352

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ACHROMATOPSIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatoblastoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NDRG4-related disorder	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (29)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenoma	Associate	23450047	★★★★★ ★☆☆☆☆ Found in Text Mining only
Adrenocortical Carcinoma	Associate	33667214	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Inhibit	25749388	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Associate	26515606	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Inhibit	33298240	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis	Inhibit	25749388	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Inhibit	25749388	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	24993691, 25538088, 26515606, 27114416, 29775793, 30263958, 32467348, 33504902, 33858496, 33890711, 34621892, 35477541, 35963995, 38224931	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Inhibit	25749388	★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibromatosis Congenital Generalized	Associate	25241110	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Inhibit	22489821	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperplasia	Inhibit	25749388	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Associate	23347191	★★★★★ ★☆☆☆☆ Found in Text Mining only
Influenza Human	Associate	35893690	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intestinal Diseases	Inhibit	33890711	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Promyelocytic Acute	Associate	32467348	★★★★★ ★☆☆☆☆ Found in Text Mining only
Long QT Syndrome	Associate	22912591	★★★★★ ★☆☆☆☆ Found in Text Mining only
Meningioma	Associate	26053091	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Stimulate	39245738	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	26515606	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Inhibit	33298240	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	22489821, 25241110, 25749388, 26515606	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	23347191, 27114416, 28044229	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Stimulate	28042954	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Associate	26515606	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Associate	26023084	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Atresia With Ventricular Septal Defect	Associate	33211401	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Associate	28042954	★★★★★ ★☆☆☆☆ Found in Text Mining only
Tetralogy of Fallot	Associate	33211401	★★★★★ ★☆☆☆☆ Found in Text Mining only

NDRG4 (NDRG family member 4)