Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	65003
Gene name	Mitochondrial ribosomal protein L11
Gene symbol	MRPL11
Synonyms (NCBI Gene)	CGI-113L11MTMRP-L11uL11m
Chromosome	11
Chromosome location	11q13.2
Summary	This nuclear gene encodes a 39S subunit component of the mitochondial ribosome. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene are found on chromosomes 5 and 12. [provided by RefSeq, May 2014]

Show/Hide all (18)

miRTarBase ID	miRNA	Experiments	Reference
MIRT037696	hsa-miR-744-5p	CLASH	23622248
MIRT1158415	hsa-miR-1225-5p	CLIP-seq
MIRT1158416	hsa-miR-1265	CLIP-seq
MIRT1158417	hsa-miR-1972	CLIP-seq
MIRT1158418	hsa-miR-331-3p	CLIP-seq
MIRT1158419	hsa-miR-3943	CLIP-seq
MIRT1158420	hsa-miR-4292	CLIP-seq
MIRT1158421	hsa-miR-4323	CLIP-seq
MIRT1158422	hsa-miR-450b-3p	CLIP-seq
MIRT1158423	hsa-miR-4650-5p	CLIP-seq
MIRT1158424	hsa-miR-4713-3p	CLIP-seq
MIRT1158425	hsa-miR-562	CLIP-seq
MIRT1158426	hsa-miR-638	CLIP-seq
MIRT1158427	hsa-miR-769-3p	CLIP-seq
MIRT2045359	hsa-miR-3973	CLIP-seq
MIRT2045360	hsa-miR-520g	CLIP-seq
MIRT2045361	hsa-miR-520h	CLIP-seq
MIRT2045362	hsa-miR-576-3p	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	NAS	11543634
GO:0005515	Function	Protein binding	IPI	22190034, 25416956, 27107012, 31515488, 32296183
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	28892042
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	27023846
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005761	Component	Mitochondrial ribosome	NAS	11543634
GO:0005762	Component	Mitochondrial large ribosomal subunit	IBA
GO:0005762	Component	Mitochondrial large ribosomal subunit	IDA	25278503, 28892042
GO:0005762	Component	Mitochondrial large ribosomal subunit	NAS	25278503
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IBA
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	11543634
GO:0032543	Process	Mitochondrial translation	NAS	27023846
GO:0070180	Function	Large ribosomal subunit rRNA binding	IBA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
611826	14042	ENSG00000174547

Q9Y3B7

Protein name

Large ribosomal subunit protein uL11m (39S ribosomal protein L11, mitochondrial) (L11mt) (MRP-L11)

PDB

3J7Y , 3J9M , 5OOL , 5OOM , 6I9R , 6NU2 , 6NU3 , 6VLZ , 6VMI , 6ZM5 , 6ZM6 , 6ZS9 , 6ZSA , 6ZSB , 6ZSC , 6ZSD , 6ZSE , 6ZSG , 7A5F , 7A5G , 7A5H , 7A5I , 7A5J , 7A5K , 7L08 , 7L20 , 7O9K , 7O9M , 7ODR , 7ODS , 7ODT , 7OF0 , 7OF2 , 7OF3 , 7OF4 , 7OF5 , 7OF6 , 7OF7 , 7OG4 , 7OI6 , 7OI7 , 7OI8 , 7OI9 , 7OIA , 7OIB , 7OIC , 7OID , 7OIE , 7PD3 , 7PO4 , 7QI4

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03946	Ribosomal_L11_N	12 → 78	Ribosomal protein L11, N-terminal domain	Domain
PF00298	Ribosomal_L11	83 → 155	Ribosomal protein L11, RNA binding domain	Domain

Sequence

MSKLGRAARGLRKPEVGGVIRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDI
KEGIPLPTKILVKPDRTFEIKIGQPTVSYFLKAAAGIEKGARQTGKEVAGLVTLKHVYEI
ARIKAQDEAFALQDVPLSSVVRSIIGSARSLGIRVVKDLSSEELAAFQKERAIFLAAQKE
ADLAAQEEAAKK

Sequence length

192

Interactions

View interactions

	KEGG		Reactome
	Ribosome		Mitochondrial translation elongation Mitochondrial translation termination

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CORNEAL ASTIGMATISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Calcinosis Cutis	Associate	17054779	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Associate	35841118	★★★★★ ★☆☆☆☆ Found in Text Mining only
COVID 19	Associate	38259479	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Associate	36585417	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Associate	32707690	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pre Eclampsia	Associate	38259479	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Associate	17054779	★★★★★ ★☆☆☆☆ Found in Text Mining only

MRPL11 (mitochondrial ribosomal protein L11)