MRPS11 (mitochondrial ribosomal protein S11)

Gene

• Entrez ID: 64963
• Gene name: Mitochondrial ribosomal protein S11
• Gene symbol: MRPS11
• Synonyms (NCBI Gene): HCC-2, MRP-S11, S11mt, uS11m
• Chromosome: 15
• Chromosome location: 15q25.3
• Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022877	hsa-miR-124-3p	Microarray	18668037
MIRT051908	hsa-let-7b-5p	CLASH	23622248
MIRT046384	hsa-miR-15b-5p	CLASH	23622248
MIRT038922	hsa-miR-92a-1-5p	CLASH	23622248
MIRT1159711	hsa-miR-2278	CLIP-seq
MIRT1159712	hsa-miR-2467-5p	CLIP-seq
MIRT1159713	hsa-miR-2861	CLIP-seq
MIRT1159714	hsa-miR-3156-3p	CLIP-seq
MIRT1159715	hsa-miR-3160-3p	CLIP-seq
MIRT1159716	hsa-miR-3188	CLIP-seq
MIRT1159717	hsa-miR-3691-3p	CLIP-seq
MIRT1159718	hsa-miR-3975	CLIP-seq
MIRT1159719	hsa-miR-4301	CLIP-seq
MIRT1159720	hsa-miR-4330	CLIP-seq
MIRT1159721	hsa-miR-4468	CLIP-seq
MIRT1159722	hsa-miR-4633-3p	CLIP-seq
MIRT1159723	hsa-miR-4649-3p	CLIP-seq
MIRT1159724	hsa-miR-485-5p	CLIP-seq
MIRT1159725	hsa-miR-519a	CLIP-seq
MIRT1159726	hsa-miR-519b-3p	CLIP-seq
MIRT1159727	hsa-miR-519c-3p	CLIP-seq
MIRT1159728	hsa-miR-624	CLIP-seq
MIRT1159711	hsa-miR-2278	CLIP-seq
MIRT1159729	hsa-miR-3145-3p	CLIP-seq
MIRT1159720	hsa-miR-4330	CLIP-seq
MIRT1159721	hsa-miR-4468	CLIP-seq
MIRT1159730	hsa-miR-552	CLIP-seq
MIRT2045849	hsa-miR-1296	CLIP-seq
MIRT2045850	hsa-miR-1914	CLIP-seq
MIRT2045851	hsa-miR-2909	CLIP-seq
MIRT2045852	hsa-miR-3136-5p	CLIP-seq
MIRT2045853	hsa-miR-3158-3p	CLIP-seq
MIRT2045854	hsa-miR-3674	CLIP-seq
MIRT2045855	hsa-miR-4436b-5p	CLIP-seq
MIRT2045856	hsa-miR-4439	CLIP-seq
MIRT2045857	hsa-miR-4446-3p	CLIP-seq
MIRT2045858	hsa-miR-4668-3p	CLIP-seq
MIRT2045859	hsa-miR-4717-5p	CLIP-seq
MIRT2045860	hsa-miR-943	CLIP-seq
MIRT2274891	hsa-miR-1207-3p	CLIP-seq
MIRT2274892	hsa-miR-1299	CLIP-seq
MIRT2274893	hsa-miR-185	CLIP-seq
MIRT1159711	hsa-miR-2278	CLIP-seq
MIRT2274894	hsa-miR-3135b	CLIP-seq
MIRT2045852	hsa-miR-3136-5p	CLIP-seq
MIRT2274895	hsa-miR-3660	CLIP-seq
MIRT2274896	hsa-miR-3682-5p	CLIP-seq
MIRT2274897	hsa-miR-3689d	CLIP-seq
MIRT2274898	hsa-miR-4252	CLIP-seq
MIRT2274899	hsa-miR-4267	CLIP-seq
MIRT2274900	hsa-miR-4270	CLIP-seq
MIRT2274901	hsa-miR-4306	CLIP-seq
MIRT2274902	hsa-miR-4314	CLIP-seq
MIRT1159720	hsa-miR-4330	CLIP-seq
MIRT2045855	hsa-miR-4436b-5p	CLIP-seq
MIRT2045856	hsa-miR-4439	CLIP-seq
MIRT2274903	hsa-miR-4441	CLIP-seq
MIRT1159721	hsa-miR-4468	CLIP-seq
MIRT2274904	hsa-miR-4526	CLIP-seq
MIRT2274905	hsa-miR-4644	CLIP-seq
MIRT2274906	hsa-miR-4667-5p	CLIP-seq
MIRT2274907	hsa-miR-4700-5p	CLIP-seq
MIRT2274908	hsa-miR-4753-5p	CLIP-seq
MIRT2274909	hsa-miR-4778-5p	CLIP-seq
MIRT2274910	hsa-miR-4782-5p	CLIP-seq
MIRT2274911	hsa-miR-486-3p	CLIP-seq
MIRT2274912	hsa-miR-516b	CLIP-seq
MIRT1159728	hsa-miR-624	CLIP-seq
MIRT2274913	hsa-miR-637	CLIP-seq
MIRT2274914	hsa-miR-766	CLIP-seq
MIRT2274915	hsa-miR-892a	CLIP-seq
MIRT2045860	hsa-miR-943	CLIP-seq
MIRT1159711	hsa-miR-2278	CLIP-seq
MIRT1159712	hsa-miR-2467-5p	CLIP-seq
MIRT1159713	hsa-miR-2861	CLIP-seq
MIRT1159729	hsa-miR-3145-3p	CLIP-seq
MIRT1159714	hsa-miR-3156-3p	CLIP-seq
MIRT1159715	hsa-miR-3160-3p	CLIP-seq
MIRT1159716	hsa-miR-3188	CLIP-seq
MIRT1159717	hsa-miR-3691-3p	CLIP-seq
MIRT1159718	hsa-miR-3975	CLIP-seq
MIRT2274900	hsa-miR-4270	CLIP-seq
MIRT1159719	hsa-miR-4301	CLIP-seq
MIRT1159720	hsa-miR-4330	CLIP-seq
MIRT2274903	hsa-miR-4441	CLIP-seq
MIRT1159721	hsa-miR-4468	CLIP-seq
MIRT1159722	hsa-miR-4633-3p	CLIP-seq
MIRT1159723	hsa-miR-4649-3p	CLIP-seq
MIRT2573851	hsa-miR-4650-5p	CLIP-seq
MIRT1159724	hsa-miR-485-5p	CLIP-seq
MIRT1159725	hsa-miR-519a	CLIP-seq
MIRT1159726	hsa-miR-519b-3p	CLIP-seq
MIRT1159727	hsa-miR-519c-3p	CLIP-seq
MIRT1159730	hsa-miR-552	CLIP-seq
MIRT1159728	hsa-miR-624	CLIP-seq
MIRT2685326	hsa-miR-1913	CLIP-seq
MIRT1159711	hsa-miR-2278	CLIP-seq
MIRT1159712	hsa-miR-2467-5p	CLIP-seq
MIRT1159713	hsa-miR-2861	CLIP-seq
MIRT2685327	hsa-miR-3135	CLIP-seq
MIRT2045852	hsa-miR-3136-5p	CLIP-seq
MIRT2685328	hsa-miR-3137	CLIP-seq
MIRT1159729	hsa-miR-3145-3p	CLIP-seq
MIRT2685329	hsa-miR-3150a-3p	CLIP-seq
MIRT2685330	hsa-miR-3151	CLIP-seq
MIRT1159714	hsa-miR-3156-3p	CLIP-seq
MIRT1159715	hsa-miR-3160-3p	CLIP-seq
MIRT2685331	hsa-miR-3175	CLIP-seq
MIRT1159716	hsa-miR-3188	CLIP-seq
MIRT2685332	hsa-miR-324-3p	CLIP-seq
MIRT2685333	hsa-miR-3591-5p	CLIP-seq
MIRT2685334	hsa-miR-3667-3p	CLIP-seq
MIRT2045854	hsa-miR-3674	CLIP-seq
MIRT1159717	hsa-miR-3691-3p	CLIP-seq
MIRT1159718	hsa-miR-3975	CLIP-seq
MIRT2274898	hsa-miR-4252	CLIP-seq
MIRT2274900	hsa-miR-4270	CLIP-seq
MIRT1159719	hsa-miR-4301	CLIP-seq
MIRT1159720	hsa-miR-4330	CLIP-seq
MIRT2045855	hsa-miR-4436b-5p	CLIP-seq
MIRT2045856	hsa-miR-4439	CLIP-seq
MIRT2274903	hsa-miR-4441	CLIP-seq
MIRT2685335	hsa-miR-4447	CLIP-seq
MIRT1159721	hsa-miR-4468	CLIP-seq
MIRT2685336	hsa-miR-4472	CLIP-seq
MIRT1159722	hsa-miR-4633-3p	CLIP-seq
MIRT1159723	hsa-miR-4649-3p	CLIP-seq
MIRT2573851	hsa-miR-4650-5p	CLIP-seq
MIRT2045859	hsa-miR-4717-5p	CLIP-seq
MIRT2685337	hsa-miR-4749-3p	CLIP-seq
MIRT1159724	hsa-miR-485-5p	CLIP-seq
MIRT2685338	hsa-miR-491-5p	CLIP-seq
MIRT1159725	hsa-miR-519a	CLIP-seq
MIRT1159726	hsa-miR-519b-3p	CLIP-seq
MIRT1159727	hsa-miR-519c-3p	CLIP-seq
MIRT1159730	hsa-miR-552	CLIP-seq
MIRT1159728	hsa-miR-624	CLIP-seq
MIRT2685339	hsa-miR-643	CLIP-seq
MIRT2685340	hsa-miR-648	CLIP-seq
MIRT2685341	hsa-miR-939	CLIP-seq
MIRT2045860	hsa-miR-943	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000028	Process	Ribosomal small subunit assembly	IBA	21873635
GO:0000462	Process	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA	21873635
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003735	Function	Structural constituent of ribosome	IBA	21873635
GO:0003735	Function	Structural constituent of ribosome	ISS	11402041
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005739	Component	Mitochondrion	IDA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005763	Component	Mitochondrial small ribosomal subunit	IDA	21531335, 25838379
GO:0005763	Component	Mitochondrial small ribosomal subunit	ISS
GO:0006412	Process	Translation	IBA	21873635
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA	21873635
GO:0032543	Process	Mitochondrial translation	ISS	11402041
GO:0042769	Process	DNA damage response, detection of DNA damage	NAS	15300802
GO:0048027	Function	MRNA 5'-UTR binding	IBA	21873635
GO:0070125	Process	Mitochondrial translational elongation	TAS
GO:0070126	Process	Mitochondrial translational termination	TAS
GO:0070181	Function	Small ribosomal subunit rRNA binding	IBA	21873635

Other IDs

• MIM: 611977
• HGNC: 14050
• e!Ensembl: ENSG00000181991

Protein

• UniProt ID: P82912
• Protein name: Small ribosomal subunit protein uS11m (28S ribosomal protein S11, mitochondrial) (MRP-S11) (S11mt) (Cervical cancer proto-oncogene 2 protein) (HCC-2)
• PDB: 3J9M, 6NU2, 6NU3, 6RW4, 6RW5, 6VLZ, 6VMI, 6ZM5, 6ZM6, 6ZS9, 6ZSA, 6ZSB, 6ZSC, 6ZSD, 6ZSE, 6ZSG, 7A5F, 7A5G, 7A5I, 7A5K, 7L08, 7OG4, 7P2E, 7PNX, 7PNY, 7PNZ, 7PO0, 7PO1, 7PO2, 7PO3, 7QI4, 7QI5, 7QI6, 8ANY, 8CSR, 8CSS, 8CST, 8CSU, 8K2A, 8OIR, 8OIS, 8QRK, 8QRL, 8QRM, 8QRN, 8RRI, 8XT0, 8XT2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00411	Ribosomal_S11	84 → 193	Ribosomal protein S11	Family

• Sequence:

  MQAVRNAGSRFLRSWTWPQTAGRVVARTPAGTICTGARQLQDAAAKQKVEQNAAPSHTKF
  SIYPPIPGEESSLRWAGKKFEEIPIAHIKASHNNTQIQVVSASNEPLAFASCGTEGFRNA
  KKGTGIAAQTAGIAAAARAKQKGVIHIRVVVKGLGPGRLSAMHGLIMGGLEVISITDNTP
  IPHNGCRPRKARKL

• Sequence length: 194

Pathways

KEGG:

Ribosome

Reactome:

Mitochondrial translation elongation
Mitochondrial translation termination

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	21364753

Unknown
Disease term	Disease name	Evidence	References	Source
Oligodendroglioma	Oligodendroglioma			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Cerebral Infarction	Inhibit	37418282
Cerebral Infarction	Associate	39290696
Endometrial Neoplasms	Associate	35830453
Polycystic Ovary Syndrome	Associate	35830453
Pulmonary Disease Chronic Obstructive	Associate	37720876