Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID	6496
Gene name	SIX homeobox 3
Gene symbol	SIX3
Synonyms (NCBI Gene)	HPE2
Chromosome	2
Chromosome location	2p21
Summary	This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. [provided by RefSeq, Oct 2009]

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miRTarBase ID	miRNA	Experiments	Reference
MIRT612491	hsa-miR-339-5p	HITS-CLIP	19536157
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	19536157
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT635884	hsa-miR-10a-3p	HITS-CLIP	23824327
MIRT635883	hsa-miR-495-3p	HITS-CLIP	23824327
MIRT635881	hsa-miR-5688	HITS-CLIP	23824327
MIRT635882	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT635880	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT635879	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT635878	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT621100	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT621100	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT621099	hsa-miR-665	HITS-CLIP	23824327
MIRT621098	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT621097	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT621096	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT621095	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT621094	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT621100	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT621099	hsa-miR-665	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT635884	hsa-miR-10a-3p	HITS-CLIP	23824327
MIRT635883	hsa-miR-495-3p	HITS-CLIP	23824327
MIRT635881	hsa-miR-5688	HITS-CLIP	23824327
MIRT635882	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT635880	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT635879	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT635878	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT621100	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT621099	hsa-miR-665	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT621096	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT621095	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT621100	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT621099	hsa-miR-665	HITS-CLIP	23824327
MIRT621098	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT621097	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT621096	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT621095	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT621094	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT484631	hsa-miR-4428	PAR-CLIP	20371350
MIRT484630	hsa-miR-6873-5p	PAR-CLIP	20371350
MIRT484629	hsa-miR-4779	PAR-CLIP	20371350
MIRT484627	hsa-miR-1321	PAR-CLIP	20371350
MIRT484626	hsa-miR-4739	PAR-CLIP	20371350
MIRT484625	hsa-miR-4756-5p	PAR-CLIP	20371350
MIRT484624	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT484623	hsa-miR-1296-3p	PAR-CLIP	20371350
MIRT484622	hsa-miR-4419a	PAR-CLIP	20371350
MIRT484621	hsa-miR-4510	PAR-CLIP	20371350
MIRT484620	hsa-miR-6127	PAR-CLIP	20371350
MIRT484619	hsa-miR-6129	PAR-CLIP	20371350
MIRT484618	hsa-miR-6130	PAR-CLIP	20371350
MIRT484617	hsa-miR-6133	PAR-CLIP	20371350
MIRT484616	hsa-miR-4481	PAR-CLIP	20371350
MIRT484614	hsa-miR-4745-5p	PAR-CLIP	20371350
MIRT484615	hsa-miR-4533	PAR-CLIP	20371350
MIRT484613	hsa-miR-765	PAR-CLIP	20371350
MIRT484612	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT484611	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT484610	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT484609	hsa-miR-4271	PAR-CLIP	20371350
MIRT484608	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT484607	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT484606	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT484605	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT484604	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT484602	hsa-miR-5698	PAR-CLIP	20371350
MIRT484603	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT484601	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT484600	hsa-miR-4525	PAR-CLIP	20371350
MIRT484599	hsa-miR-5010-5p	PAR-CLIP	20371350
MIRT484598	hsa-miR-4447	PAR-CLIP	20371350
MIRT484597	hsa-miR-4472	PAR-CLIP	20371350
MIRT484596	hsa-miR-1275	PAR-CLIP	20371350
MIRT484595	hsa-miR-4665-5p	PAR-CLIP	20371350
MIRT484594	hsa-miR-6758-5p	PAR-CLIP	20371350
MIRT484631	hsa-miR-4428	PAR-CLIP	24398324
MIRT484594	hsa-miR-6758-5p	PAR-CLIP	24398324
MIRT484629	hsa-miR-4779	PAR-CLIP	24398324
MIRT484627	hsa-miR-1321	PAR-CLIP	24398324
MIRT484626	hsa-miR-4739	PAR-CLIP	24398324
MIRT484625	hsa-miR-4756-5p	PAR-CLIP	24398324
MIRT484624	hsa-miR-6783-5p	PAR-CLIP	24398324
MIRT484623	hsa-miR-1296-3p	PAR-CLIP	24398324
MIRT484622	hsa-miR-4419a	PAR-CLIP	24398324
MIRT484621	hsa-miR-4510	PAR-CLIP	24398324
MIRT484620	hsa-miR-6127	PAR-CLIP	24398324
MIRT484619	hsa-miR-6129	PAR-CLIP	24398324
MIRT484618	hsa-miR-6130	PAR-CLIP	24398324
MIRT484617	hsa-miR-6133	PAR-CLIP	24398324
MIRT484616	hsa-miR-4481	PAR-CLIP	24398324
MIRT484614	hsa-miR-4745-5p	PAR-CLIP	24398324
MIRT484615	hsa-miR-4533	PAR-CLIP	24398324
MIRT484613	hsa-miR-765	PAR-CLIP	24398324
MIRT484612	hsa-miR-4747-5p	PAR-CLIP	24398324
MIRT484611	hsa-miR-5196-5p	PAR-CLIP	24398324
MIRT484610	hsa-miR-7106-5p	PAR-CLIP	24398324
MIRT484609	hsa-miR-4271	PAR-CLIP	24398324
MIRT484608	hsa-miR-4725-3p	PAR-CLIP	24398324
MIRT484607	hsa-miR-6780b-5p	PAR-CLIP	24398324
MIRT484606	hsa-miR-6825-5p	PAR-CLIP	24398324
MIRT484605	hsa-miR-625-5p	PAR-CLIP	24398324
MIRT484604	hsa-miR-4723-5p	PAR-CLIP	24398324
MIRT484602	hsa-miR-5698	PAR-CLIP	24398324
MIRT484603	hsa-miR-6870-5p	PAR-CLIP	24398324
MIRT484601	hsa-miR-7111-5p	PAR-CLIP	24398324
MIRT484600	hsa-miR-4525	PAR-CLIP	24398324
MIRT484599	hsa-miR-5010-5p	PAR-CLIP	24398324
MIRT484598	hsa-miR-4447	PAR-CLIP	24398324
MIRT484597	hsa-miR-4472	PAR-CLIP	24398324
MIRT484596	hsa-miR-1275	PAR-CLIP	24398324
MIRT484595	hsa-miR-4665-5p	PAR-CLIP	24398324
MIRT484629	hsa-miR-4779	PAR-CLIP	23592263
MIRT484628	hsa-miR-4433b-3p	PAR-CLIP	23592263
MIRT484624	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT484623	hsa-miR-1296-3p	PAR-CLIP	23592263
MIRT484616	hsa-miR-4481	PAR-CLIP	23592263
MIRT484614	hsa-miR-4745-5p	PAR-CLIP	23592263
MIRT484615	hsa-miR-4533	PAR-CLIP	23592263
MIRT484613	hsa-miR-765	PAR-CLIP	23592263
MIRT484612	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT484611	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT484610	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT484609	hsa-miR-4271	PAR-CLIP	23592263
MIRT484608	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT484607	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT484606	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT484605	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT484604	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT484602	hsa-miR-5698	PAR-CLIP	23592263
MIRT484603	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT484601	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT484600	hsa-miR-4525	PAR-CLIP	23592263
MIRT484599	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT484598	hsa-miR-4447	PAR-CLIP	23592263
MIRT484597	hsa-miR-4472	PAR-CLIP	23592263
MIRT484596	hsa-miR-1275	PAR-CLIP	23592263
MIRT484595	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT484594	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT484631	hsa-miR-4428	PAR-CLIP	23592263
MIRT484630	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT484629	hsa-miR-4779	PAR-CLIP	23592263
MIRT484628	hsa-miR-4433b-3p	PAR-CLIP	23592263
MIRT484627	hsa-miR-1321	PAR-CLIP	23592263
MIRT484626	hsa-miR-4739	PAR-CLIP	23592263
MIRT484625	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT484624	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT484623	hsa-miR-1296-3p	PAR-CLIP	23592263
MIRT484622	hsa-miR-4419a	PAR-CLIP	23592263
MIRT484621	hsa-miR-4510	PAR-CLIP	23592263
MIRT484620	hsa-miR-6127	PAR-CLIP	23592263
MIRT484619	hsa-miR-6129	PAR-CLIP	23592263
MIRT484618	hsa-miR-6130	PAR-CLIP	23592263
MIRT484617	hsa-miR-6133	PAR-CLIP	23592263
MIRT484616	hsa-miR-4481	PAR-CLIP	23592263
MIRT484614	hsa-miR-4745-5p	PAR-CLIP	23592263
MIRT484615	hsa-miR-4533	PAR-CLIP	23592263
MIRT484613	hsa-miR-765	PAR-CLIP	23592263
MIRT484612	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT484611	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT484610	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT484609	hsa-miR-4271	PAR-CLIP	23592263
MIRT484608	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT484607	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT484606	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT484605	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT484604	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT484602	hsa-miR-5698	PAR-CLIP	23592263
MIRT484603	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT484601	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT484600	hsa-miR-4525	PAR-CLIP	23592263
MIRT484599	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT484598	hsa-miR-4447	PAR-CLIP	23592263
MIRT484597	hsa-miR-4472	PAR-CLIP	23592263
MIRT484596	hsa-miR-1275	PAR-CLIP	23592263
MIRT484595	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT484594	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT635884	hsa-miR-10a-3p	HITS-CLIP	27418678
MIRT635884	hsa-miR-10a-3p	HITS-CLIP	27418678
MIRT635884	hsa-miR-10a-3p	HITS-CLIP	27418678
MIRT635879	hsa-miR-302c-5p	HITS-CLIP	27418678
MIRT635879	hsa-miR-302c-5p	HITS-CLIP	27418678
MIRT635879	hsa-miR-302c-5p	HITS-CLIP	27418678
MIRT635883	hsa-miR-495-3p	HITS-CLIP	27418678
MIRT635883	hsa-miR-495-3p	HITS-CLIP	27418678
MIRT635883	hsa-miR-495-3p	HITS-CLIP	27418678
MIRT635878	hsa-miR-552-5p	HITS-CLIP	27418678
MIRT635878	hsa-miR-552-5p	HITS-CLIP	27418678
MIRT635878	hsa-miR-552-5p	HITS-CLIP	27418678
MIRT635881	hsa-miR-5688	HITS-CLIP	27418678
MIRT635881	hsa-miR-5688	HITS-CLIP	27418678
MIRT635881	hsa-miR-5688	HITS-CLIP	27418678
MIRT635882	hsa-miR-7-1-3p	HITS-CLIP	27418678
MIRT635882	hsa-miR-7-1-3p	HITS-CLIP	27418678
MIRT635882	hsa-miR-7-1-3p	HITS-CLIP	27418678
MIRT635880	hsa-miR-7-2-3p	HITS-CLIP	27418678
MIRT635880	hsa-miR-7-2-3p	HITS-CLIP	27418678
MIRT635880	hsa-miR-7-2-3p	HITS-CLIP	27418678
MIRT612491	hsa-miR-339-5p	HITS-CLIP	19536157
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	19536157
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	19536157
MIRT635884	hsa-miR-10a-3p	HITS-CLIP	23824327
MIRT635883	hsa-miR-495-3p	HITS-CLIP	23824327
MIRT635881	hsa-miR-5688	HITS-CLIP	23824327
MIRT635882	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT635880	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT635879	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT635878	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT621100	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT621100	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT621099	hsa-miR-665	HITS-CLIP	23824327
MIRT621098	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT621097	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT621096	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT621095	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT621094	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT621100	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT621099	hsa-miR-665	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT635884	hsa-miR-10a-3p	HITS-CLIP	23824327
MIRT635883	hsa-miR-495-3p	HITS-CLIP	23824327
MIRT635881	hsa-miR-5688	HITS-CLIP	23824327
MIRT635882	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT635880	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT635879	hsa-miR-302c-5p	HITS-CLIP	23824327
MIRT635878	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT621100	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT621099	hsa-miR-665	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT621096	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT621095	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT621100	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT621099	hsa-miR-665	HITS-CLIP	23824327
MIRT621098	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT621097	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT621096	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT621095	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT621094	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT612492	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT612491	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT612490	hsa-miR-6748-3p	HITS-CLIP	23824327
MIRT612489	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT612488	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT484631	hsa-miR-4428	PAR-CLIP	20371350
MIRT484630	hsa-miR-6873-5p	PAR-CLIP	20371350
MIRT484629	hsa-miR-4779	PAR-CLIP	20371350
MIRT484627	hsa-miR-1321	PAR-CLIP	20371350
MIRT484626	hsa-miR-4739	PAR-CLIP	20371350
MIRT484625	hsa-miR-4756-5p	PAR-CLIP	20371350
MIRT484624	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT484623	hsa-miR-1296-3p	PAR-CLIP	20371350
MIRT484622	hsa-miR-4419a	PAR-CLIP	20371350
MIRT484621	hsa-miR-4510	PAR-CLIP	20371350
MIRT484620	hsa-miR-6127	PAR-CLIP	20371350
MIRT484619	hsa-miR-6129	PAR-CLIP	20371350
MIRT484618	hsa-miR-6130	PAR-CLIP	20371350
MIRT484617	hsa-miR-6133	PAR-CLIP	20371350
MIRT484616	hsa-miR-4481	PAR-CLIP	20371350
MIRT484614	hsa-miR-4745-5p	PAR-CLIP	20371350
MIRT484615	hsa-miR-4533	PAR-CLIP	20371350
MIRT484613	hsa-miR-765	PAR-CLIP	20371350
MIRT484612	hsa-miR-4747-5p	PAR-CLIP	20371350
MIRT484611	hsa-miR-5196-5p	PAR-CLIP	20371350
MIRT484610	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT484609	hsa-miR-4271	PAR-CLIP	20371350
MIRT484608	hsa-miR-4725-3p	PAR-CLIP	20371350
MIRT484607	hsa-miR-6780b-5p	PAR-CLIP	20371350
MIRT484606	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT484605	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT484604	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT484602	hsa-miR-5698	PAR-CLIP	20371350
MIRT484603	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT484601	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT484600	hsa-miR-4525	PAR-CLIP	20371350
MIRT484599	hsa-miR-5010-5p	PAR-CLIP	20371350
MIRT484598	hsa-miR-4447	PAR-CLIP	20371350
MIRT484597	hsa-miR-4472	PAR-CLIP	20371350
MIRT484596	hsa-miR-1275	PAR-CLIP	20371350
MIRT484595	hsa-miR-4665-5p	PAR-CLIP	20371350
MIRT484594	hsa-miR-6758-5p	PAR-CLIP	20371350
MIRT484631	hsa-miR-4428	PAR-CLIP	24398324
MIRT484594	hsa-miR-6758-5p	PAR-CLIP	24398324
MIRT484629	hsa-miR-4779	PAR-CLIP	24398324
MIRT484627	hsa-miR-1321	PAR-CLIP	24398324
MIRT484626	hsa-miR-4739	PAR-CLIP	24398324
MIRT484625	hsa-miR-4756-5p	PAR-CLIP	24398324
MIRT484624	hsa-miR-6783-5p	PAR-CLIP	24398324
MIRT484623	hsa-miR-1296-3p	PAR-CLIP	24398324
MIRT484622	hsa-miR-4419a	PAR-CLIP	24398324
MIRT484621	hsa-miR-4510	PAR-CLIP	24398324
MIRT484620	hsa-miR-6127	PAR-CLIP	24398324
MIRT484619	hsa-miR-6129	PAR-CLIP	24398324
MIRT484618	hsa-miR-6130	PAR-CLIP	24398324
MIRT484617	hsa-miR-6133	PAR-CLIP	24398324
MIRT484616	hsa-miR-4481	PAR-CLIP	24398324
MIRT484614	hsa-miR-4745-5p	PAR-CLIP	24398324
MIRT484615	hsa-miR-4533	PAR-CLIP	24398324
MIRT484613	hsa-miR-765	PAR-CLIP	24398324
MIRT484612	hsa-miR-4747-5p	PAR-CLIP	24398324
MIRT484611	hsa-miR-5196-5p	PAR-CLIP	24398324
MIRT484610	hsa-miR-7106-5p	PAR-CLIP	24398324
MIRT484609	hsa-miR-4271	PAR-CLIP	24398324
MIRT484608	hsa-miR-4725-3p	PAR-CLIP	24398324
MIRT484607	hsa-miR-6780b-5p	PAR-CLIP	24398324
MIRT484606	hsa-miR-6825-5p	PAR-CLIP	24398324
MIRT484605	hsa-miR-625-5p	PAR-CLIP	24398324
MIRT484604	hsa-miR-4723-5p	PAR-CLIP	24398324
MIRT484602	hsa-miR-5698	PAR-CLIP	24398324
MIRT484603	hsa-miR-6870-5p	PAR-CLIP	24398324
MIRT484601	hsa-miR-7111-5p	PAR-CLIP	24398324
MIRT484600	hsa-miR-4525	PAR-CLIP	24398324
MIRT484599	hsa-miR-5010-5p	PAR-CLIP	24398324
MIRT484598	hsa-miR-4447	PAR-CLIP	24398324
MIRT484597	hsa-miR-4472	PAR-CLIP	24398324
MIRT484596	hsa-miR-1275	PAR-CLIP	24398324
MIRT484595	hsa-miR-4665-5p	PAR-CLIP	24398324
MIRT484629	hsa-miR-4779	PAR-CLIP	23592263
MIRT484628	hsa-miR-4433b-3p	PAR-CLIP	23592263
MIRT484624	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT484623	hsa-miR-1296-3p	PAR-CLIP	23592263
MIRT484616	hsa-miR-4481	PAR-CLIP	23592263
MIRT484614	hsa-miR-4745-5p	PAR-CLIP	23592263
MIRT484615	hsa-miR-4533	PAR-CLIP	23592263
MIRT484613	hsa-miR-765	PAR-CLIP	23592263
MIRT484612	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT484611	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT484610	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT484609	hsa-miR-4271	PAR-CLIP	23592263
MIRT484608	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT484607	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT484606	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT484605	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT484604	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT484602	hsa-miR-5698	PAR-CLIP	23592263
MIRT484603	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT484601	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT484600	hsa-miR-4525	PAR-CLIP	23592263
MIRT484599	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT484598	hsa-miR-4447	PAR-CLIP	23592263
MIRT484597	hsa-miR-4472	PAR-CLIP	23592263
MIRT484596	hsa-miR-1275	PAR-CLIP	23592263
MIRT484595	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT484594	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT484631	hsa-miR-4428	PAR-CLIP	23592263
MIRT484630	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT484629	hsa-miR-4779	PAR-CLIP	23592263
MIRT484628	hsa-miR-4433b-3p	PAR-CLIP	23592263
MIRT484627	hsa-miR-1321	PAR-CLIP	23592263
MIRT484626	hsa-miR-4739	PAR-CLIP	23592263
MIRT484625	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT484624	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT484623	hsa-miR-1296-3p	PAR-CLIP	23592263
MIRT484622	hsa-miR-4419a	PAR-CLIP	23592263
MIRT484621	hsa-miR-4510	PAR-CLIP	23592263
MIRT484620	hsa-miR-6127	PAR-CLIP	23592263
MIRT484619	hsa-miR-6129	PAR-CLIP	23592263
MIRT484618	hsa-miR-6130	PAR-CLIP	23592263
MIRT484617	hsa-miR-6133	PAR-CLIP	23592263
MIRT484616	hsa-miR-4481	PAR-CLIP	23592263
MIRT484614	hsa-miR-4745-5p	PAR-CLIP	23592263
MIRT484615	hsa-miR-4533	PAR-CLIP	23592263
MIRT484613	hsa-miR-765	PAR-CLIP	23592263
MIRT484612	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT484611	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT484610	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT484609	hsa-miR-4271	PAR-CLIP	23592263
MIRT484608	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT484607	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT484606	hsa-miR-6825-5p	PAR-CLIP	23592263
MIRT484605	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT484604	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT484602	hsa-miR-5698	PAR-CLIP	23592263
MIRT484603	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT484601	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT484600	hsa-miR-4525	PAR-CLIP	23592263
MIRT484599	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT484598	hsa-miR-4447	PAR-CLIP	23592263
MIRT484597	hsa-miR-4472	PAR-CLIP	23592263
MIRT484596	hsa-miR-1275	PAR-CLIP	23592263
MIRT484595	hsa-miR-4665-5p	PAR-CLIP	23592263
MIRT484594	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT1350384	hsa-miR-122	CLIP-seq
MIRT1350385	hsa-miR-1243	CLIP-seq
MIRT1350386	hsa-miR-1252	CLIP-seq
MIRT1350387	hsa-miR-1273d	CLIP-seq
MIRT1350388	hsa-miR-147	CLIP-seq
MIRT1350389	hsa-miR-1972	CLIP-seq
MIRT1350390	hsa-miR-200b	CLIP-seq
MIRT1350391	hsa-miR-200c	CLIP-seq
MIRT1350392	hsa-miR-3138	CLIP-seq
MIRT1350393	hsa-miR-3150b-3p	CLIP-seq
MIRT1350394	hsa-miR-3153	CLIP-seq
MIRT1350395	hsa-miR-342-5p	CLIP-seq
MIRT1350396	hsa-miR-3654	CLIP-seq
MIRT1350397	hsa-miR-3662	CLIP-seq
MIRT1350398	hsa-miR-3911	CLIP-seq
MIRT1350399	hsa-miR-429	CLIP-seq
MIRT1350400	hsa-miR-4311	CLIP-seq
MIRT1350401	hsa-miR-4505	CLIP-seq
MIRT1350402	hsa-miR-4639-5p	CLIP-seq
MIRT1350403	hsa-miR-4646-5p	CLIP-seq
MIRT1350404	hsa-miR-4651	CLIP-seq
MIRT1350405	hsa-miR-4664-5p	CLIP-seq
MIRT1350406	hsa-miR-4668-5p	CLIP-seq
MIRT1350407	hsa-miR-4717-5p	CLIP-seq
MIRT1350408	hsa-miR-4721	CLIP-seq
MIRT1350409	hsa-miR-4731-5p	CLIP-seq
MIRT1350410	hsa-miR-4784	CLIP-seq
MIRT1350411	hsa-miR-4800-5p	CLIP-seq
MIRT1350412	hsa-miR-495	CLIP-seq
MIRT1350413	hsa-miR-520d-5p	CLIP-seq
MIRT1350414	hsa-miR-524-5p	CLIP-seq
MIRT1350415	hsa-miR-574-5p	CLIP-seq
MIRT1350416	hsa-miR-608	CLIP-seq
MIRT1350417	hsa-miR-644	CLIP-seq
MIRT1350418	hsa-miR-656	CLIP-seq
MIRT1350419	hsa-miR-875-3p	CLIP-seq
MIRT1350412	hsa-miR-495	CLIP-seq
MIRT1350412	hsa-miR-495	CLIP-seq
MIRT1350412	hsa-miR-495	CLIP-seq
MIRT2103838	hsa-miR-548c-3p	CLIP-seq
MIRT2394566	hsa-miR-561	CLIP-seq
MIRT1350412	hsa-miR-495	CLIP-seq
MIRT2459424	hsa-miR-4755-5p	CLIP-seq
MIRT2459425	hsa-miR-642a	CLIP-seq
MIRT2459426	hsa-miR-642b	CLIP-seq
MIRT2459427	hsa-miR-766	CLIP-seq

Show/Hide all (2)

Transcription factor	Regulation	Reference
PAX6	Activation	11554737
PROX1	Activation	11554737

Show/Hide all (80)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	18836447
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001222	Function	Transcription corepressor binding	IEA
GO:0001222	Function	Transcription corepressor binding	IPI	12441302, 14973488
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	ISS
GO:0001654	Process	Eye development	IBA
GO:0001654	Process	Eye development	IDA	18791198
GO:0001654	Process	Eye development	IEA
GO:0002070	Process	Epithelial cell maturation	IEA
GO:0002070	Process	Epithelial cell maturation	ISS
GO:0002088	Process	Lens development in camera-type eye	IEA
GO:0002088	Process	Lens development in camera-type eye	ISS
GO:0003404	Process	Optic vesicle morphogenesis	IEA
GO:0003404	Process	Optic vesicle morphogenesis	ISS
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	12543801
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005667	Component	Transcription regulator complex	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006606	Process	Protein import into nucleus	IEA
GO:0007420	Process	Brain development	IBA
GO:0007420	Process	Brain development	IEA
GO:0007420	Process	Brain development	TAS	10369266
GO:0007601	Process	Visual perception	IEA
GO:0007601	Process	Visual perception	TAS	10369266
GO:0008406	Process	Gonad development	IEA
GO:0009946	Process	Proximal/distal axis specification	IEA
GO:0009946	Process	Proximal/distal axis specification	ISS
GO:0014016	Process	Neuroblast differentiation	IEA
GO:0014016	Process	Neuroblast differentiation	ISS
GO:0021536	Process	Diencephalon development	IEA
GO:0021537	Process	Telencephalon development	IEA
GO:0021537	Process	Telencephalon development	ISS
GO:0021797	Process	Forebrain anterior/posterior pattern specification	IEA
GO:0021798	Process	Forebrain dorsal/ventral pattern formation	IDA	18791198
GO:0021846	Process	Cell proliferation in forebrain	IEA
GO:0021846	Process	Cell proliferation in forebrain	ISS
GO:0021978	Process	Telencephalon regionalization	IEA
GO:0021978	Process	Telencephalon regionalization	ISS
GO:0021983	Process	Pituitary gland development	IEA
GO:0021983	Process	Pituitary gland development	ISS
GO:0030178	Process	Negative regulation of Wnt signaling pathway	IEA
GO:0030878	Process	Thyroid gland development	IEA
GO:0035264	Process	Multicellular organism growth	IEA
GO:0042127	Process	Regulation of cell population proliferation	IEA
GO:0042127	Process	Regulation of cell population proliferation	ISS
GO:0042826	Function	Histone deacetylase binding	IEA
GO:0043010	Process	Camera-type eye development	IEA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045665	Process	Negative regulation of neuron differentiation	IEA
GO:0045665	Process	Negative regulation of neuron differentiation	ISS
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	18791198
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048512	Process	Circadian behavior	IEA
GO:0060235	Process	Lens induction in camera-type eye	IEA
GO:0061074	Process	Regulation of neural retina development	IEA
GO:0061074	Process	Regulation of neural retina development	ISS
GO:0070306	Process	Lens fiber cell differentiation	IEA
GO:0070306	Process	Lens fiber cell differentiation	ISS
GO:0097402	Process	Neuroblast migration	IEA
GO:0097402	Process	Neuroblast migration	ISS
GO:1901987	Process	Regulation of cell cycle phase transition	IEA
GO:1901987	Process	Regulation of cell cycle phase transition	ISS
GO:1902692	Process	Regulation of neuroblast proliferation	IEA
GO:1902692	Process	Regulation of neuroblast proliferation	ISS
GO:1902742	Process	Apoptotic process involved in development	IEA
GO:1902742	Process	Apoptotic process involved in development	ISS
GO:1990086	Process	Lens fiber cell apoptotic process	IEA
GO:1990086	Process	Lens fiber cell apoptotic process	ISS
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:2000177	Process	Regulation of neural precursor cell proliferation	IEA
GO:2000177	Process	Regulation of neural precursor cell proliferation	ISS

MIM	HGNC	e!Ensembl
603714	10889	ENSG00000138083

O95343

Protein name

Homeobox protein SIX3 (Sine oculis homeobox homolog 3)

Protein function

Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitan

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16878	SIX1_SD	87 → 201	Transcriptional regulator, SIX1, N-terminal SD domain	Domain
PF00046	Homeodomain	207 → 263	Homeodomain	Domain

Sequence

MVFRSPLDLYSSHFLLPNFADSHHRSILLASSGGGNGAGGGGGAGGGSGGGNGAGGGGAG
GAGGGGGGGSRAPPEELSMFQLPTLNFSPEQVASVCETLEETGDIERLGRFLWSLPVAPG
ACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKL
RGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELA
QATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPSTA
ASPTTSVSSLTERADTGTSILSVTSSDSECDV

Sequence length

332

Interactions

View interactions

171

Show/Hide Causal Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Holoprosencephaly 2	Pathogenic; Likely pathogenic	rs2103641880, rs2466514157, rs121917878, rs121917879, rs121917880, rs1572624159, rs137853021, rs1403385518, rs2466513762, rs387906867, rs753473749, rs1553337688, rs1558420022, rs397515502, rs1666605262	RCV001730118 RCV002819396 RCV000006466 RCV000006467 RCV000006468 RCV000006469 RCV000006472 RCV003508710 RCV003508821 RCV000023328 RCV002248753 RCV000656533 RCV000702708 RCV000055688 RCV001270879
Schizencephaly	Pathogenic	rs387906867	RCV000023329
SIX3-related disorder	Likely pathogenic	rs1572624326	RCV003416998

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Intellectual disability	Uncertain significance	rs121917881	RCV005625687
Solitary median maxillary central incisor syndrome	Benign; Likely benign	rs199823175	RCV000171135

Show/Hide Text Mining Associations (29)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma Bronchiolo Alveolar	Associate	23977152
Adenocarcinoma of Lung	Inhibit	23977152
Anophthalmia with pulmonary hypoplasia	Associate	11826019
Astrocytoma	Associate	33051600
Breast Neoplasms	Inhibit	29463994
Carcinogenesis	Associate	23977152
Carcinogenesis	Inhibit	29463994
Carcinoma Non Small Cell Lung	Associate	33264103
Central Nervous System Vascular Malformations	Associate	22310223
Colorectal Neoplasms	Associate	19723660
Combined Pituitary Hormone Deficiency	Associate	35951005
Diabetes Mellitus Type 2	Associate	29621232, 30102368, 33893274
Familial schizencephaly	Associate	20157829
Glioblastoma	Inhibit	32051553
Glioma	Associate	21962230
Holoprosencephaly	Associate	16199538, 19346217, 19353631, 19431187, 20157829, 20531442, 21940735, 21976454, 21995818, 22310223, 23276570, 27363716, 28670735, 29333838, 35951005
Hyperglycemia	Associate	27133132
Hypopituitarism	Associate	35951005
Infections	Associate	22438545
Lung Neoplasms	Associate	23977152, 33264103
Macular Degeneration	Associate	27019633
Neoplasm Metastasis	Stimulate	23977152
Neoplasm Metastasis	Inhibit	29463994
Neoplasm Metastasis	Associate	33264103
Neoplasms	Inhibit	29463994, 32051553, 33264103
Pituitary Diseases	Associate	35951005
Schizophrenia	Associate	28972157
Thinness	Associate	35951005
Wilms Tumor	Associate	26317783

SIX3 (SIX homeobox 3)