Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	64943
Gene name Gene Name - the full gene name approved by the HGNC.	5'-nucleotidase domain containing 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NT5DC2
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p21.1

Show/Hide all(11)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030270	hsa-miR-26b-5p	Microarray	19088304
MIRT052241	hsa-let-7b-5p	CLASH	23622248
MIRT051686	hsa-let-7e-5p	CLASH	23622248
MIRT051291	hsa-miR-16-5p	CLASH	23622248
MIRT046905	hsa-miR-221-3p	CLASH	23622248
MIRT042644	hsa-miR-423-3p	CLASH	23622248
MIRT042173	hsa-miR-484	CLASH	23622248
MIRT037848	hsa-miR-455-3p	CLASH	23622248
MIRT036776	hsa-miR-760	CLASH	23622248
MIRT2056814	hsa-miR-3675-5p	CLIP-seq
MIRT2056815	hsa-miR-486-3p	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0008253	Function	5'-nucleotidase activity	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0033137	Process	Negative regulation of peptidyl-serine phosphorylation	ISS
GO:0045914	Process	Negative regulation of catecholamine metabolic process	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0051354	Process	Negative regulation of oxidoreductase activity	ISS
GO:1903180	Process	Negative regulation of dopamine biosynthetic process	ISS

MIM	HGNC	e!Ensembl
621077	25717	ENSG00000168268

Protein

UniProt ID

Q9H857

Protein name

5'-nucleotidase domain-containing protein 2 (EC 3.1.3.-)

Protein function

Promotes dephosphorylation of tyrosine 3-monooxygenase TH which decreases TH catalytic activity and leads to reduced synthesis of catecholamines including dopamine, noradrenaline and adrenaline. The exact mechanism of activity is unknown but may

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05761	5_nucleotid	56 → 497		Family

Sequence

MRVESGSAQERGILLESLSTLLEKTTASHEGRAPGNRELTDLLPPEVCSLLNPAAIYANN
EISLRDVEVYGFDYDYTLAQYADALHPEIFSTARDILIEHYKYPEGIRKYDYNPSFAIRG
LHYDIQKSLLMKIDAFHYVQLGTAYRGLQPVPDEEVIELYGGTQHIPLYQMSGFYGKGPS
IKQFMDIFSLPEMALLSCVVDYFLGHSLEFDQAHLYKDVTDAIRDVHVKGLMYQWIEQDM
EKYILRGDETFAVLSRLVAHGKQLFLITNSPFSFVDKGMRHMVGPDWRQLFDVVIVQADK
PSFFTDRRKPFRKLDEKGSLQWDRITRLEKGKIYRQGNLFDFLRLTEWRGPRVLYFGDHL
YSDLADLMLRHGWRTGAIIPELEREIRIINTEQYMHSLTWQQALTGLLERMQTYQDAESR
QVLAAWMKERQELRCITKALFNAQFGSIFRTFHNPTYFSRRLVRFSDLYMASLSCLLNYR
VDFTFYPRRTPLQHEAPLWMDQLCTGCMKTPFLGDMAHIR

Sequence length

520

Interactions

View interactions

NT5DC2 (5'-nucleotidase domain containing 2)