Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	64928
Gene name	Mitochondrial ribosomal protein L14
Gene symbol	MRPL14
Synonyms (NCBI Gene)	L14mtL32mtMRP-L14MRP-L32MRPL32RMPL32RPML32uL14m
Chromosome	6
Chromosome location	6p21.1
Summary	This nuclear gene encodes a protein component of the 39S subunit of the mitochondrial ribosome. A pseudogene of this gene is found on chromosome 17. [provided by RefSeq, Jan 2016]

Show/Hide all (76)

miRTarBase ID	miRNA	Experiments	Reference
MIRT043247	hsa-miR-324-5p	CLASH	23622248
MIRT2045372	hsa-miR-1293	CLIP-seq
MIRT2045373	hsa-miR-136	CLIP-seq
MIRT2045374	hsa-miR-4330	CLIP-seq
MIRT2045375	hsa-miR-4483	CLIP-seq
MIRT2045376	hsa-miR-4766-3p	CLIP-seq
MIRT2045377	hsa-miR-4772-3p	CLIP-seq
MIRT2045378	hsa-miR-548p	CLIP-seq
MIRT2045379	hsa-miR-876-3p	CLIP-seq
MIRT2045372	hsa-miR-1293	CLIP-seq
MIRT2045373	hsa-miR-136	CLIP-seq
MIRT2274406	hsa-miR-150	CLIP-seq
MIRT2274407	hsa-miR-1912	CLIP-seq
MIRT2274408	hsa-miR-199a-5p	CLIP-seq
MIRT2274409	hsa-miR-199b-5p	CLIP-seq
MIRT2274410	hsa-miR-3130-5p	CLIP-seq
MIRT2274411	hsa-miR-3179	CLIP-seq
MIRT2274412	hsa-miR-3611	CLIP-seq
MIRT2274413	hsa-miR-4287	CLIP-seq
MIRT2274414	hsa-miR-4302	CLIP-seq
MIRT2045374	hsa-miR-4330	CLIP-seq
MIRT2274415	hsa-miR-4482	CLIP-seq
MIRT2045375	hsa-miR-4483	CLIP-seq
MIRT2274416	hsa-miR-4685-3p	CLIP-seq
MIRT2045376	hsa-miR-4766-3p	CLIP-seq
MIRT2045378	hsa-miR-548p	CLIP-seq
MIRT2045379	hsa-miR-876-3p	CLIP-seq
MIRT2274406	hsa-miR-150	CLIP-seq
MIRT2045372	hsa-miR-1293	CLIP-seq
MIRT2045373	hsa-miR-136	CLIP-seq
MIRT2274406	hsa-miR-150	CLIP-seq
MIRT2274407	hsa-miR-1912	CLIP-seq
MIRT2274408	hsa-miR-199a-5p	CLIP-seq
MIRT2274409	hsa-miR-199b-5p	CLIP-seq
MIRT2274410	hsa-miR-3130-5p	CLIP-seq
MIRT2274411	hsa-miR-3179	CLIP-seq
MIRT2274412	hsa-miR-3611	CLIP-seq
MIRT2573288	hsa-miR-378g	CLIP-seq
MIRT2274413	hsa-miR-4287	CLIP-seq
MIRT2274414	hsa-miR-4302	CLIP-seq
MIRT2045374	hsa-miR-4330	CLIP-seq
MIRT2573289	hsa-miR-4437	CLIP-seq
MIRT2573290	hsa-miR-4474-3p	CLIP-seq
MIRT2274415	hsa-miR-4482	CLIP-seq
MIRT2045375	hsa-miR-4483	CLIP-seq
MIRT2573291	hsa-miR-4674	CLIP-seq
MIRT2274416	hsa-miR-4685-3p	CLIP-seq
MIRT2045376	hsa-miR-4766-3p	CLIP-seq
MIRT2045377	hsa-miR-4772-3p	CLIP-seq
MIRT2045378	hsa-miR-548p	CLIP-seq
MIRT2573292	hsa-miR-661	CLIP-seq
MIRT2045379	hsa-miR-876-3p	CLIP-seq
MIRT2045372	hsa-miR-1293	CLIP-seq
MIRT2045373	hsa-miR-136	CLIP-seq
MIRT2274406	hsa-miR-150	CLIP-seq
MIRT2274407	hsa-miR-1912	CLIP-seq
MIRT2274408	hsa-miR-199a-5p	CLIP-seq
MIRT2274409	hsa-miR-199b-5p	CLIP-seq
MIRT2274410	hsa-miR-3130-5p	CLIP-seq
MIRT2274411	hsa-miR-3179	CLIP-seq
MIRT2274412	hsa-miR-3611	CLIP-seq
MIRT2573288	hsa-miR-378g	CLIP-seq
MIRT2274413	hsa-miR-4287	CLIP-seq
MIRT2274414	hsa-miR-4302	CLIP-seq
MIRT2045374	hsa-miR-4330	CLIP-seq
MIRT2573289	hsa-miR-4437	CLIP-seq
MIRT2573290	hsa-miR-4474-3p	CLIP-seq
MIRT2274415	hsa-miR-4482	CLIP-seq
MIRT2045375	hsa-miR-4483	CLIP-seq
MIRT2573291	hsa-miR-4674	CLIP-seq
MIRT2274416	hsa-miR-4685-3p	CLIP-seq
MIRT2045376	hsa-miR-4766-3p	CLIP-seq
MIRT2045377	hsa-miR-4772-3p	CLIP-seq
MIRT2045378	hsa-miR-548p	CLIP-seq
MIRT2573292	hsa-miR-661	CLIP-seq
MIRT2045379	hsa-miR-876-3p	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	28892042
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	27023846
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005762	Component	Mitochondrial large ribosomal subunit	IDA	25278503, 28892042
GO:0005762	Component	Mitochondrial large ribosomal subunit	NAS	25278503
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0032543	Process	Mitochondrial translation	NAS	27023846
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
611827	14279	ENSG00000180992

Q6P1L8

Protein name

Large ribosomal subunit protein uL14m (39S ribosomal protein L14, mitochondrial) (L14mt) (MRP-L14) (39S ribosomal protein L32, mitochondrial) (L32mt) (MRP-L32)

Protein function

Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).

PDB

3J7Y , 3J9M , 5OOL , 5OOM , 6I9R , 6NU2 , 6NU3 , 6VLZ , 6VMI , 6ZM5 , 6ZM6 , 6ZS9 , 6ZSA , 6ZSB , 6ZSC , 6ZSD , 6ZSE , 6ZSG , 7A5F , 7A5G , 7A5H , 7A5I , 7A5J , 7A5K , 7L08 , 7L20 , 7O9K , 7O9M , 7ODR , 7ODS , 7ODT , 7OF0 , 7OF2 , 7OF3 , 7OF4 , 7OF5 , 7OF6 , 7OF7 , 7OG4 , 7OI6 , 7OI7 , 7OI8 , 7OI9 , 7OIA , 7OIB , 7OIC , 7OID , 7OIE , 7PD3 , 7PO4 , 7QH6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00238	Ribosomal_L14	31 → 145	Ribosomal protein L14p/L23e	Domain

Sequence

MAFFTGLWGPFTCVSRVLSHHCFSTTGSLSAIQKMTRVRVVDNSALGNSPYHRAPRCIHV
YKKNGVGKVGDQILLAIKGQKKKALIVGHCMPGPRMTPRFDSNNVVLIEDNGNPVGTRIK
TPIPTSLRKREGEYSKVLAIAQNFV

Sequence length

145

Interactions

View interactions

	KEGG		Reactome
	Ribosome		Mitochondrial translation elongation Mitochondrial translation termination

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma Follicular	Associate	23569218	★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Associate	36835202	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Associate	23569218	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Diseases	Associate	39754905	★★★★★ ★☆☆☆☆ Found in Text Mining only

MRPL14 (mitochondrial ribosomal protein L14)