Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	64924
Gene name	Solute carrier family 30 member 5
Gene symbol	SLC30A5
Synonyms (NCBI Gene)	ZNT5ZNTL1ZTL1ZnT-5
Chromosome	5
Chromosome location	5q13.1-q13.2
Summary	This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a he

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miRTarBase ID	miRNA	Experiments	Reference
MIRT044053	hsa-miR-361-5p	CLASH	23622248
MIRT699395	hsa-miR-33a-3p	HITS-CLIP	23313552
MIRT699394	hsa-miR-6841-5p	HITS-CLIP	23313552
MIRT699393	hsa-miR-6755-5p	HITS-CLIP	23313552
MIRT699392	hsa-miR-135a-3p	HITS-CLIP	23313552
MIRT699391	hsa-miR-105-5p	HITS-CLIP	23313552
MIRT699390	hsa-miR-7853-5p	HITS-CLIP	23313552
MIRT699389	hsa-miR-7158-5p	HITS-CLIP	23313552
MIRT699388	hsa-miR-503-3p	HITS-CLIP	23313552
MIRT699387	hsa-miR-3907	HITS-CLIP	23313552
MIRT699386	hsa-miR-4735-3p	HITS-CLIP	23313552
MIRT632420	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT666284	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT632419	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT632418	hsa-miR-4532	HITS-CLIP	23824327
MIRT632417	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT632413	hsa-miR-1281	HITS-CLIP	23824327
MIRT632410	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT632409	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT632408	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT632420	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT632419	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT632418	hsa-miR-4532	HITS-CLIP	23824327
MIRT632417	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT632416	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT632415	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT632414	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT632413	hsa-miR-1281	HITS-CLIP	23824327
MIRT632412	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT632411	hsa-miR-1976	HITS-CLIP	23824327
MIRT632410	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT632409	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT632408	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT632407	hsa-miR-4279	HITS-CLIP	23824327
MIRT539952	hsa-miR-4781-3p	PAR-CLIP	21572407
MIRT539951	hsa-miR-1273f	PAR-CLIP	21572407
MIRT539950	hsa-miR-31-3p	PAR-CLIP	21572407
MIRT539949	hsa-miR-3934-3p	PAR-CLIP	21572407
MIRT539947	hsa-miR-6832-5p	PAR-CLIP	21572407
MIRT539948	hsa-miR-4732-5p	PAR-CLIP	21572407
MIRT539946	hsa-miR-1178-3p	PAR-CLIP	21572407
MIRT539945	hsa-miR-3674	PAR-CLIP	21572407
MIRT521032	hsa-miR-4459	PAR-CLIP	23446348
MIRT521033	hsa-miR-665	PAR-CLIP	23446348
MIRT521031	hsa-miR-6840-3p	PAR-CLIP	23446348
MIRT521030	hsa-miR-6134	PAR-CLIP	23446348
MIRT521029	hsa-miR-655-5p	PAR-CLIP	23446348
MIRT521028	hsa-miR-3689d	PAR-CLIP	23446348
MIRT521027	hsa-miR-6851-5p	PAR-CLIP	23446348
MIRT521026	hsa-miR-6880-5p	PAR-CLIP	23446348
MIRT521025	hsa-miR-7847-3p	PAR-CLIP	23446348
MIRT521024	hsa-miR-101-3p	PAR-CLIP	23446348
MIRT521023	hsa-miR-582-5p	PAR-CLIP	23446348
MIRT521021	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT521022	hsa-miR-1273e	PAR-CLIP	23446348
MIRT439610	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439610	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT699395	hsa-miR-33a-3p	HITS-CLIP	23313552
MIRT699394	hsa-miR-6841-5p	HITS-CLIP	23313552
MIRT699393	hsa-miR-6755-5p	HITS-CLIP	23313552
MIRT699392	hsa-miR-135a-3p	HITS-CLIP	23313552
MIRT699391	hsa-miR-105-5p	HITS-CLIP	23313552
MIRT699390	hsa-miR-7853-5p	HITS-CLIP	23313552
MIRT699389	hsa-miR-7158-5p	HITS-CLIP	23313552
MIRT699388	hsa-miR-503-3p	HITS-CLIP	23313552
MIRT699387	hsa-miR-3907	HITS-CLIP	23313552
MIRT699386	hsa-miR-4735-3p	HITS-CLIP	23313552
MIRT632420	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT666284	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT632419	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT632418	hsa-miR-4532	HITS-CLIP	23824327
MIRT632417	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT632413	hsa-miR-1281	HITS-CLIP	23824327
MIRT632410	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT632409	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT632408	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT632420	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT632419	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT632418	hsa-miR-4532	HITS-CLIP	23824327
MIRT632417	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT632416	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT632415	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT632414	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT632413	hsa-miR-1281	HITS-CLIP	23824327
MIRT632412	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT632411	hsa-miR-1976	HITS-CLIP	23824327
MIRT632410	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT632409	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT632408	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT632407	hsa-miR-4279	HITS-CLIP	23824327
MIRT539952	hsa-miR-4781-3p	PAR-CLIP	21572407
MIRT539951	hsa-miR-1273f	PAR-CLIP	21572407
MIRT539950	hsa-miR-31-3p	PAR-CLIP	21572407
MIRT539949	hsa-miR-3934-3p	PAR-CLIP	21572407
MIRT539947	hsa-miR-6832-5p	PAR-CLIP	21572407
MIRT539948	hsa-miR-4732-5p	PAR-CLIP	21572407
MIRT539946	hsa-miR-1178-3p	PAR-CLIP	21572407
MIRT539945	hsa-miR-3674	PAR-CLIP	21572407
MIRT521032	hsa-miR-4459	PAR-CLIP	23446348
MIRT521033	hsa-miR-665	PAR-CLIP	23446348
MIRT521031	hsa-miR-6840-3p	PAR-CLIP	23446348
MIRT521030	hsa-miR-6134	PAR-CLIP	23446348
MIRT521029	hsa-miR-655-5p	PAR-CLIP	23446348
MIRT521028	hsa-miR-3689d	PAR-CLIP	23446348
MIRT521027	hsa-miR-6851-5p	PAR-CLIP	23446348
MIRT521026	hsa-miR-6880-5p	PAR-CLIP	23446348
MIRT521025	hsa-miR-7847-3p	PAR-CLIP	23446348
MIRT521024	hsa-miR-101-3p	PAR-CLIP	23446348
MIRT521023	hsa-miR-582-5p	PAR-CLIP	23446348
MIRT521021	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT521022	hsa-miR-1273e	PAR-CLIP	23446348
MIRT1359209	hsa-miR-1237	CLIP-seq
MIRT1359210	hsa-miR-1248	CLIP-seq
MIRT1359211	hsa-miR-1273g	CLIP-seq
MIRT1359212	hsa-miR-1298	CLIP-seq
MIRT1359213	hsa-miR-140-5p	CLIP-seq
MIRT1359214	hsa-miR-150	CLIP-seq
MIRT1359215	hsa-miR-199a-3p	CLIP-seq
MIRT1359216	hsa-miR-199b-3p	CLIP-seq
MIRT1359217	hsa-miR-205	CLIP-seq
MIRT1359218	hsa-miR-219-1-3p	CLIP-seq
MIRT1359219	hsa-miR-3128	CLIP-seq
MIRT1359220	hsa-miR-3129-5p	CLIP-seq
MIRT1359221	hsa-miR-3616-5p	CLIP-seq
MIRT1359222	hsa-miR-362-5p	CLIP-seq
MIRT1359223	hsa-miR-3647-5p	CLIP-seq
MIRT1359224	hsa-miR-3664-5p	CLIP-seq
MIRT1359225	hsa-miR-3686	CLIP-seq
MIRT1359226	hsa-miR-374a	CLIP-seq
MIRT1359227	hsa-miR-374b	CLIP-seq
MIRT1359228	hsa-miR-4328	CLIP-seq
MIRT1359229	hsa-miR-4471	CLIP-seq
MIRT1359230	hsa-miR-4495	CLIP-seq
MIRT1359231	hsa-miR-4652-3p	CLIP-seq
MIRT1359232	hsa-miR-4670-3p	CLIP-seq
MIRT1359233	hsa-miR-4677-3p	CLIP-seq
MIRT1359234	hsa-miR-4680-5p	CLIP-seq
MIRT1359235	hsa-miR-4698	CLIP-seq
MIRT1359236	hsa-miR-4699-3p	CLIP-seq
MIRT1359237	hsa-miR-4712-5p	CLIP-seq
MIRT1359238	hsa-miR-4713-5p	CLIP-seq
MIRT1359239	hsa-miR-4720-5p	CLIP-seq
MIRT1359240	hsa-miR-4742-3p	CLIP-seq
MIRT1359241	hsa-miR-4775	CLIP-seq
MIRT1359242	hsa-miR-4778-5p	CLIP-seq
MIRT1359243	hsa-miR-4799-3p	CLIP-seq
MIRT1359244	hsa-miR-500b	CLIP-seq
MIRT1359245	hsa-miR-501-5p	CLIP-seq
MIRT1359246	hsa-miR-502-5p	CLIP-seq
MIRT1359247	hsa-miR-513a-3p	CLIP-seq
MIRT1359248	hsa-miR-532-3p	CLIP-seq
MIRT1359249	hsa-miR-563	CLIP-seq
MIRT1359250	hsa-miR-569	CLIP-seq
MIRT1359251	hsa-miR-571	CLIP-seq
MIRT1359252	hsa-miR-573	CLIP-seq
MIRT1359253	hsa-miR-590-3p	CLIP-seq
MIRT1359254	hsa-miR-640	CLIP-seq
MIRT1359255	hsa-miR-770-5p	CLIP-seq
MIRT1359256	hsa-miR-889	CLIP-seq
MIRT1359257	hsa-miR-944	CLIP-seq
MIRT1359258	hsa-miR-1294	CLIP-seq
MIRT1359259	hsa-miR-1827	CLIP-seq
MIRT1359260	hsa-miR-2467-3p	CLIP-seq
MIRT1359261	hsa-miR-3612	CLIP-seq
MIRT1359262	hsa-miR-3622a-3p	CLIP-seq
MIRT1359263	hsa-miR-3622b-3p	CLIP-seq
MIRT1359264	hsa-miR-3929	CLIP-seq
MIRT1359265	hsa-miR-4257	CLIP-seq
MIRT1359266	hsa-miR-4316	CLIP-seq
MIRT1359267	hsa-miR-4419b	CLIP-seq
MIRT1359268	hsa-miR-4433	CLIP-seq
MIRT1359269	hsa-miR-4478	CLIP-seq
MIRT1359270	hsa-miR-4514	CLIP-seq
MIRT1359271	hsa-miR-4649-3p	CLIP-seq
MIRT1359272	hsa-miR-4692	CLIP-seq
MIRT1359273	hsa-miR-4695-5p	CLIP-seq
MIRT1359274	hsa-miR-4722-5p	CLIP-seq
MIRT1359275	hsa-miR-4768-3p	CLIP-seq
MIRT1359276	hsa-miR-485-5p	CLIP-seq
MIRT1359277	hsa-miR-500a	CLIP-seq
MIRT1359278	hsa-miR-544b	CLIP-seq
MIRT1359279	hsa-miR-650	CLIP-seq
MIRT1359280	hsa-miR-758	CLIP-seq
MIRT1359281	hsa-miR-940	CLIP-seq
MIRT2106367	hsa-miR-3613-3p	CLIP-seq
MIRT2106368	hsa-miR-410	CLIP-seq
MIRT2106369	hsa-miR-4289	CLIP-seq
MIRT2106370	hsa-miR-450b-5p	CLIP-seq
MIRT2106371	hsa-miR-4536	CLIP-seq
MIRT2106372	hsa-miR-4659a-5p	CLIP-seq
MIRT2106373	hsa-miR-4659b-5p	CLIP-seq
MIRT2106374	hsa-miR-4776-3p	CLIP-seq
MIRT2106375	hsa-miR-4789-5p	CLIP-seq
MIRT2106376	hsa-miR-518a-5p	CLIP-seq
MIRT2106377	hsa-miR-527	CLIP-seq
MIRT2106378	hsa-miR-548a-3p	CLIP-seq
MIRT2106379	hsa-miR-548ae	CLIP-seq
MIRT2106380	hsa-miR-548aj	CLIP-seq
MIRT2106381	hsa-miR-548am	CLIP-seq
MIRT2106382	hsa-miR-548e	CLIP-seq
MIRT2106383	hsa-miR-548f	CLIP-seq
MIRT2106384	hsa-miR-548g	CLIP-seq
MIRT2106385	hsa-miR-548x	CLIP-seq
MIRT2106386	hsa-miR-579	CLIP-seq
MIRT2106387	hsa-miR-664	CLIP-seq
MIRT1359257	hsa-miR-944	CLIP-seq
MIRT1359217	hsa-miR-205	CLIP-seq
MIRT1359247	hsa-miR-513a-3p	CLIP-seq
MIRT1359258	hsa-miR-1294	CLIP-seq
MIRT1359259	hsa-miR-1827	CLIP-seq
MIRT1359262	hsa-miR-3622a-3p	CLIP-seq
MIRT1359263	hsa-miR-3622b-3p	CLIP-seq
MIRT1359266	hsa-miR-4316	CLIP-seq
MIRT1359268	hsa-miR-4433	CLIP-seq
MIRT1359270	hsa-miR-4514	CLIP-seq
MIRT1359272	hsa-miR-4692	CLIP-seq
MIRT1359275	hsa-miR-4768-3p	CLIP-seq
MIRT1359278	hsa-miR-544b	CLIP-seq
MIRT1359280	hsa-miR-758	CLIP-seq
MIRT1359281	hsa-miR-940	CLIP-seq
MIRT1359259	hsa-miR-1827	CLIP-seq
MIRT1359261	hsa-miR-3612	CLIP-seq
MIRT2459677	hsa-miR-3664-3p	CLIP-seq
MIRT1359264	hsa-miR-3929	CLIP-seq
MIRT2459678	hsa-miR-4267	CLIP-seq
MIRT1359267	hsa-miR-4419b	CLIP-seq
MIRT1359268	hsa-miR-4433	CLIP-seq
MIRT1359269	hsa-miR-4478	CLIP-seq
MIRT1359273	hsa-miR-4695-5p	CLIP-seq
MIRT1359274	hsa-miR-4722-5p	CLIP-seq
MIRT1359275	hsa-miR-4768-3p	CLIP-seq
MIRT1359276	hsa-miR-485-5p	CLIP-seq
MIRT2459679	hsa-miR-510	CLIP-seq
MIRT2459680	hsa-miR-512-5p	CLIP-seq
MIRT2459681	hsa-miR-541	CLIP-seq
MIRT2459682	hsa-miR-550a	CLIP-seq
MIRT1359279	hsa-miR-650	CLIP-seq
MIRT2459683	hsa-miR-654-5p	CLIP-seq
MIRT1359281	hsa-miR-940	CLIP-seq
MIRT1359258	hsa-miR-1294	CLIP-seq
MIRT1359259	hsa-miR-1827	CLIP-seq
MIRT1359260	hsa-miR-2467-3p	CLIP-seq
MIRT2624702	hsa-miR-3160-3p	CLIP-seq
MIRT2624703	hsa-miR-323-5p	CLIP-seq
MIRT1359261	hsa-miR-3612	CLIP-seq
MIRT2624704	hsa-miR-3662	CLIP-seq
MIRT2459677	hsa-miR-3664-3p	CLIP-seq
MIRT1359264	hsa-miR-3929	CLIP-seq
MIRT1359265	hsa-miR-4257	CLIP-seq
MIRT2459678	hsa-miR-4267	CLIP-seq
MIRT1359266	hsa-miR-4316	CLIP-seq
MIRT1359267	hsa-miR-4419b	CLIP-seq
MIRT1359268	hsa-miR-4433	CLIP-seq
MIRT2624705	hsa-miR-4455	CLIP-seq
MIRT1359269	hsa-miR-4478	CLIP-seq
MIRT2624706	hsa-miR-4487	CLIP-seq
MIRT1359271	hsa-miR-4649-3p	CLIP-seq
MIRT2624707	hsa-miR-4684-5p	CLIP-seq
MIRT1359273	hsa-miR-4695-5p	CLIP-seq
MIRT1359274	hsa-miR-4722-5p	CLIP-seq
MIRT1359275	hsa-miR-4768-3p	CLIP-seq
MIRT2624708	hsa-miR-4786-3p	CLIP-seq
MIRT1359276	hsa-miR-485-5p	CLIP-seq
MIRT1359277	hsa-miR-500a	CLIP-seq
MIRT2459679	hsa-miR-510	CLIP-seq
MIRT2459680	hsa-miR-512-5p	CLIP-seq
MIRT2459681	hsa-miR-541	CLIP-seq
MIRT2624709	hsa-miR-548c-3p	CLIP-seq
MIRT2459682	hsa-miR-550a	CLIP-seq
MIRT2624710	hsa-miR-556-5p	CLIP-seq
MIRT2624711	hsa-miR-558	CLIP-seq
MIRT2624712	hsa-miR-609	CLIP-seq
MIRT1359279	hsa-miR-650	CLIP-seq
MIRT2459683	hsa-miR-654-5p	CLIP-seq
MIRT1359280	hsa-miR-758	CLIP-seq
MIRT2624713	hsa-miR-876-3p	CLIP-seq
MIRT1359281	hsa-miR-940	CLIP-seq
MIRT1359259	hsa-miR-1827	CLIP-seq
MIRT1359260	hsa-miR-2467-3p	CLIP-seq
MIRT2624702	hsa-miR-3160-3p	CLIP-seq
MIRT1359261	hsa-miR-3612	CLIP-seq
MIRT2624704	hsa-miR-3662	CLIP-seq
MIRT2459677	hsa-miR-3664-3p	CLIP-seq
MIRT1359264	hsa-miR-3929	CLIP-seq
MIRT1359265	hsa-miR-4257	CLIP-seq
MIRT2459678	hsa-miR-4267	CLIP-seq
MIRT1359267	hsa-miR-4419b	CLIP-seq
MIRT1359268	hsa-miR-4433	CLIP-seq
MIRT2624705	hsa-miR-4455	CLIP-seq
MIRT1359269	hsa-miR-4478	CLIP-seq
MIRT2624706	hsa-miR-4487	CLIP-seq
MIRT1359271	hsa-miR-4649-3p	CLIP-seq
MIRT2624707	hsa-miR-4684-5p	CLIP-seq
MIRT1359273	hsa-miR-4695-5p	CLIP-seq
MIRT1359274	hsa-miR-4722-5p	CLIP-seq
MIRT1359275	hsa-miR-4768-3p	CLIP-seq
MIRT2624708	hsa-miR-4786-3p	CLIP-seq
MIRT1359276	hsa-miR-485-5p	CLIP-seq
MIRT2459679	hsa-miR-510	CLIP-seq
MIRT2459680	hsa-miR-512-5p	CLIP-seq
MIRT2459681	hsa-miR-541	CLIP-seq
MIRT2624709	hsa-miR-548c-3p	CLIP-seq
MIRT2459682	hsa-miR-550a	CLIP-seq
MIRT2624710	hsa-miR-556-5p	CLIP-seq
MIRT2624711	hsa-miR-558	CLIP-seq
MIRT2624712	hsa-miR-609	CLIP-seq
MIRT1359279	hsa-miR-650	CLIP-seq
MIRT2459683	hsa-miR-654-5p	CLIP-seq
MIRT1359281	hsa-miR-940	CLIP-seq

Show/Hide all (58)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	21887337
GO:0000139	Component	Golgi membrane	TAS
GO:0005385	Function	Zinc ion transmembrane transporter activity	IBA
GO:0005385	Function	Zinc ion transmembrane transporter activity	IDA	11904301, 11937503, 15525635, 15994300, 17355957, 22529353
GO:0005385	Function	Zinc ion transmembrane transporter activity	IEA
GO:0005385	Function	Zinc ion transmembrane transporter activity	TAS
GO:0005515	Function	Protein binding	IPI	15994300, 19759014, 25657003, 35271311
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	21887337
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA	17349999, 22529353
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IDA	17355957
GO:0005886	Component	Plasma membrane	IEA
GO:0006506	Process	GPI anchor biosynthetic process	IMP	35525268
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006812	Process	Monoatomic cation transport	IEA
GO:0006824	Process	Cobalt ion transport	IDA	11937503
GO:0006829	Process	Zinc ion transport	IDA
GO:0006829	Process	Zinc ion transport	IDA	11937503
GO:0006829	Process	Zinc ion transport	IEA
GO:0006882	Process	Intracellular zinc ion homeostasis	IBA
GO:0006882	Process	Intracellular zinc ion homeostasis	IDA	11937503
GO:0006882	Process	Intracellular zinc ion homeostasis	IEA
GO:0008324	Function	Monoatomic cation transmembrane transporter activity	IEA
GO:0010043	Process	Response to zinc ion	IDA	11937503
GO:0012507	Component	ER to Golgi transport vesicle membrane	IDA	15525635
GO:0012507	Component	ER to Golgi transport vesicle membrane	IEA
GO:0015086	Function	Cadmium ion transmembrane transporter activity	IDA	22529353
GO:0015297	Function	Antiporter activity	IEA
GO:0016020	Component	Membrane	IDA	11904301
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IDA	11937503
GO:0016324	Component	Apical plasma membrane	IEA
GO:0022883	Function	Zinc efflux transmembrane transporter activity	IDA	17355957
GO:0030070	Process	Insulin processing	TAS
GO:0030141	Component	Secretory granule	IDA
GO:0030658	Component	Transport vesicle membrane	IEA
GO:0030667	Component	Secretory granule membrane	IDA	11904301
GO:0030667	Component	Secretory granule membrane	TAS
GO:0031410	Component	Cytoplasmic vesicle	IBA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032580	Component	Golgi cisterna membrane	IEA
GO:0032588	Component	Trans-Golgi network membrane	IDA	19366695
GO:0046872	Function	Metal ion binding	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0062111	Process	Zinc ion import into organelle	IDA	11904301, 22529353
GO:0062111	Process	Zinc ion import into organelle	IMP	35525268
GO:0071577	Process	Zinc ion transmembrane transport	IEA
GO:0071577	Process	Zinc ion transmembrane transport	TAS
GO:0071578	Process	Zinc ion import across plasma membrane	IDA	17355957
GO:0140826	Function	Zinc:proton antiporter activity	IDA	19366695
GO:1904257	Process	Zinc ion import into Golgi lumen	IBA
GO:1904257	Process	Zinc ion import into Golgi lumen	IDA	15525635, 15994300, 19366695
GO:1990674	Component	Golgi cis cisterna membrane	IDA	11904301, 15525635

MIM	HGNC	e!Ensembl
607819	19089	ENSG00000145740

Q8TAD4

Protein name

Proton-coupled zinc antiporter SLC30A5 (Solute carrier family 30 member 5) (Zinc transporter 5) (ZnT-5) (ZnT-like transporter 1) (hZTL1)

Protein function

Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:11904301, PubMed:15525635, PubMed:15994300, PubMed:19366695, PubMed:22529353). By c

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01545	Cation_efflux	419 → 649	Cation efflux family	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed (PubMed:11904301, PubMed:12095919). Highly expressed in pancreas, liver and kidney (PubMed:11904301). Expressed abundantly in insulin-containing beta cells, undetectable in other endocrine cell types including gl

Sequence

MEEKYGGDVLAGPGGGGGLGPVDVPSARLTKYIVLLCFTKFLKAVGLFESYDLLKAVHIV
QFIFILKLGTAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLR
TLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPE
GHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAKRLQAL
SHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFATVIFFVMILDFYVDSICSVKMEVSK
CARYGSFPIFISALLFGNFWTHPITDQLRAMNKAAHQESTEHVLSGGVVVSAIFFILSAN
ILSSPSKRGQKGTLIGYSPEGTPLYNFMGDAFQHSSQSIPRFIKESLKQILEESDSRQIF
YFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYG
YGRIEILSGFINGLFLIVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAF
SHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMRGVFLHVLADT
LGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKEL
HIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRIVQQVTGILKDAGVN
NLTIQVEKEAYFQHMSGLSTGFHDVLAMTKQMESMKYCKDGTYIM

Sequence length

765

Interactions

View interactions

	Reactome
			Insulin processing Zinc efflux and compartmentalization by the SLC30 family

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Concentric hypertrophic cardiomyopathy	Likely pathogenic	rs1746359403, rs1746589361	RCV001270627 RCV001270628	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Hydrops fetalis	Likely pathogenic	rs1746359403, rs1746589361	RCV001270627 RCV001270628	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Hypertrophic cardiomyopathy	Likely pathogenic	rs1746359403, rs1746589361	RCV001270627 RCV001270628	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Noncompaction cardiomyopathy	Likely pathogenic	rs1746359403, rs1746589361	RCV001270627 RCV001270628	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Severe hydrops fetalis	Likely pathogenic	rs1746359403, rs1746589361	RCV001270627 RCV001270628	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (15)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHY	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHY, DILATED	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DILATED CARDIOMYOPATHY	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Cardiomyopathies	Associate	33547425	★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive Disorder Major	Stimulate	27661418	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Associate	23595627	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Diseases	Associate	33547425	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Associate	27833104	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Associate	33110097	★★★★★ ★☆☆☆☆ Found in Text Mining only

SLC30A5 (solute carrier family 30 member 5)