Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	64901
Gene name	RAN binding protein 17
Gene symbol	RANBP17
Synonyms (NCBI Gene)	-
Chromosome	5
Chromosome location	5q35.1
Summary	The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic

Show/Hide all (56)

miRTarBase ID	miRNA	Experiments	Reference
MIRT044077	hsa-miR-361-5p	CLASH	23622248
MIRT1289482	hsa-miR-1207-5p	CLIP-seq
MIRT1289483	hsa-miR-1301	CLIP-seq
MIRT1289484	hsa-miR-1321	CLIP-seq
MIRT1289485	hsa-miR-1827	CLIP-seq
MIRT1289486	hsa-miR-1914	CLIP-seq
MIRT1289487	hsa-miR-299-5p	CLIP-seq
MIRT1289488	hsa-miR-3193	CLIP-seq
MIRT1289489	hsa-miR-374a	CLIP-seq
MIRT1289490	hsa-miR-374b	CLIP-seq
MIRT1289491	hsa-miR-3942-3p	CLIP-seq
MIRT1289492	hsa-miR-4266	CLIP-seq
MIRT1289493	hsa-miR-4270	CLIP-seq
MIRT1289494	hsa-miR-4441	CLIP-seq
MIRT1289495	hsa-miR-4499	CLIP-seq
MIRT1289496	hsa-miR-4520a-5p	CLIP-seq
MIRT1289497	hsa-miR-4520b-5p	CLIP-seq
MIRT1289498	hsa-miR-4648	CLIP-seq
MIRT1289499	hsa-miR-4649-3p	CLIP-seq
MIRT1289500	hsa-miR-4654	CLIP-seq
MIRT1289501	hsa-miR-4660	CLIP-seq
MIRT1289502	hsa-miR-4739	CLIP-seq
MIRT1289503	hsa-miR-4756-5p	CLIP-seq
MIRT1289504	hsa-miR-4763-3p	CLIP-seq
MIRT1289505	hsa-miR-4769-5p	CLIP-seq
MIRT1289506	hsa-miR-490-3p	CLIP-seq
MIRT1289507	hsa-miR-501-5p	CLIP-seq
MIRT1289508	hsa-miR-5047	CLIP-seq
MIRT1289509	hsa-miR-548u	CLIP-seq
MIRT1289510	hsa-miR-556-3p	CLIP-seq
MIRT1289511	hsa-miR-570	CLIP-seq
MIRT1289512	hsa-miR-659	CLIP-seq
MIRT1289513	hsa-miR-9	CLIP-seq
MIRT1289514	hsa-miR-940	CLIP-seq
MIRT2086011	hsa-miR-1208	CLIP-seq
MIRT2086012	hsa-miR-1912	CLIP-seq
MIRT2086013	hsa-miR-4662a-5p	CLIP-seq
MIRT2086014	hsa-miR-4729	CLIP-seq
MIRT2086015	hsa-miR-4789-3p	CLIP-seq
MIRT2086016	hsa-miR-495	CLIP-seq
MIRT2086017	hsa-miR-499-3p	CLIP-seq
MIRT2086018	hsa-miR-499a-3p	CLIP-seq
MIRT2086019	hsa-miR-606	CLIP-seq
MIRT2086020	hsa-miR-642b	CLIP-seq
MIRT2393460	hsa-miR-1200	CLIP-seq
MIRT2086011	hsa-miR-1208	CLIP-seq
MIRT2393461	hsa-miR-4324	CLIP-seq
MIRT2393462	hsa-miR-4329	CLIP-seq
MIRT2086013	hsa-miR-4662a-5p	CLIP-seq
MIRT2393463	hsa-miR-4786-5p	CLIP-seq
MIRT2086015	hsa-miR-4789-3p	CLIP-seq
MIRT2086017	hsa-miR-499-3p	CLIP-seq
MIRT2086018	hsa-miR-499a-3p	CLIP-seq
MIRT2393464	hsa-miR-544b	CLIP-seq
MIRT2086020	hsa-miR-642b	CLIP-seq
MIRT2393465	hsa-miR-769-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005049	Function	Nuclear export signal receptor activity	IBA
GO:0005049	Function	Nuclear export signal receptor activity	IEA
GO:0005525	Function	GTP binding	NAS	11024021
GO:0005634	Component	Nucleus	IEA
GO:0005643	Component	Nuclear pore	IBA
GO:0005643	Component	Nuclear pore	IEA
GO:0005643	Component	Nuclear pore	NAS	11024021
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0006606	Process	Protein import into nucleus	NAS	11024021
GO:0006611	Process	Protein export from nucleus	IBA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006913	Process	Nucleocytoplasmic transport	IEA
GO:0015031	Process	Protein transport	IEA
GO:0031267	Function	Small GTPase binding	IEA
GO:0051028	Process	MRNA transport	IEA
GO:0051169	Process	Nuclear transport	IEA

MIM	HGNC	e!Ensembl
606141	14428	ENSG00000204764

Q9H2T7

Protein name

Ran-binding protein 17

Protein function

May function as a nuclear transport receptor.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03810	IBN_N	30 → 95	Importin-beta N-terminal domain	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in testis, moderately in pancreas and weakly in other tissues studied. {ECO:0000269|PubMed:11071879}.

Sequence

MALHFQSLAELEVLCTHLYIGTDLTQRIEAEKALLELIDSPECLSKCQLLLEQGTTSYAQ
LLAATCLSKLVSRVSPLPVEQRMDIRNYILNYVASQPKLAPFVIQALIQVIAKITKLGWF
EVQKDQFVFREIIADVKKFLQGTVEHCIIGVIILSELTQEMNLVDYSRPSAKHRKIATSF
RDTSLKDVLVLACSLLKEVFAKPLNLQDQCQQNLVMQVLKLVLNCLNFDFIGSSADESAD
DLCTVQIPTTWRTIFLEPETLDLFFNLYHSLPPLLSQLALSCLVQFASTRRSLFNSPERA
KYLGNLIKGVKRILENPQGLSDPGNYHEFCRFLARLKTNYQLGELVMVKEYPEVIRLIAN
FTITSLQHWEFAPNSVHYLLTLWQRMVASVPFVKSTEPHLLDTYAPEITKAFITSRLDSV
AIVVRDHLDDPLDDTATVFQQLEQLCTVSRCEYEKTCALLVQLFDQNAQNYQKLLHPYSG
VTVDITIQEGRLAWLVYLVGTVVGGRLTYTSTDEHDAMDGELSCRVFQLISLMDTGLPRC
CNEKIELAILWFLDQFRKTYVGDQLQRTSKVYARMSEVLGITDDNHVLETFMTKIVTNLK
YWGRYEPVISRTLQFLNDLSVGYILLKKLVKIDAVKFMLKNHTSEHFPFLGISDNHSLSD
FRCRTTFYTALTRLLMVDLGEDEDEFENFMLPLTVAFETVLQIFNNNFKQEDVKRMLIGL
ARDLRGIAFALNTKTSYTMLFDWMYPTYLPLLQNAVERWYGEPTCTTPILKLMAELMQNR
SQRLNFDVSSPNGILLFREASKMVCTYGNQILSLGSLSKDQIYPMKLKGISICYSALKSA
LCGNYVSFGVFKLYGDNHFDNVLQAFVKMLLSVSHSDLLQYRKLSQSYYPLLECLTQDHM
SFIINLEPPVLMYVLTSISEGLTTLDTVVSSSCCTSLDYIVTYLFKHIAKEGKKPLRCRE
ATQAGQRLLHFMQQNPDVLQQMMSVLMNTIVFEDCRNQWSVSRPLLGLILLNEKYFSELR
ASLINSQPLPKQEVLAQCFRNLMEGVEQNLSVKNRDRFTQNLSVFRRDVAEALRSDGNTE
PCSLDMMS

Sequence length

1088

Interactions

View interactions

	KEGG
	Nucleocytoplasmic transport

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (14)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autism spectrum disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL HYDROCEPHALUS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESSENTIAL TREMOR	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHIATRIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RANBP17-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESTLESS LEGS SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Neoplasms	Associate	37086484	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Associate	35850701	★★★★★ ★☆☆☆☆ Found in Text Mining only

RANBP17 (RAN binding protein 17)