PAPOLG (poly(A) polymerase gamma)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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64895 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Poly(A) polymerase gamma |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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PAPOLG |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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- |
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Chromosome
Chromosome number
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2 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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2p16.1 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3` end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||||||||||||
| UniProt ID | Q9BWT3 | |||||||||||||||||||||||||
| Protein name | Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme) | |||||||||||||||||||||||||
| Protein function | Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:1 | |||||||||||||||||||||||||
| PDB | 4LT6 | |||||||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed predominantly in testis, and weakly in other tissues. Overexpressed in several tumors. {ECO:0000269|PubMed:11463842}. | |||||||||||||||||||||||||
| Sequence | ||||||||||||||||||||||||||
| Sequence length | 736 | |||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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