Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
64895
Gene name Gene Name - the full gene name approved by the HGNC.
Poly(A) polymerase gamma
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PAPOLG
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p16.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3` end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level.
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT028237 hsa-miR-33a-5p Sequencing 20371350
MIRT031918 hsa-miR-16-5p Sequencing 20371350
MIRT701097 hsa-miR-4768-3p HITS-CLIP 23313552
MIRT701096 hsa-miR-4459 HITS-CLIP 23313552
MIRT701095 hsa-miR-4433a-3p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding IEA
GO:0004652 Function Polynucleotide adenylyltransferase activity IBA 21873635
GO:0004652 Function Polynucleotide adenylyltransferase activity IDA 11463842
GO:0005524 Function ATP binding IEA
GO:0005634 Component Nucleus IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
616865 14982 ENSG00000115421
Protein
UniProt ID Q9BWT3
Protein name Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme)
Protein function Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:1
PDB 4LT6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04928 PAP_central 20 363 Poly(A) polymerase central domain Domain
PF01909 NTP_transf_2 82 174 Nucleotidyltransferase domain Family
PF04926 PAP_RNA-bind 365 432 Poly(A) polymerase predicted RNA binding domain Domain
PF04926 PAP_RNA-bind 421 506 Poly(A) polymerase predicted RNA binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed predominantly in testis, and weakly in other tissues. Overexpressed in several tumors. {ECO:0000269|PubMed:11463842}.
Sequence
MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHR
LVVLGKLNNLVKEWISDVSES
KNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAP
RHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAI
QTISDN
LDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNML
GFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWD
PRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKL
LEP
PNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSF
PGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGM
KIEATHVKKKQLHHYLPAEILQKKKK
QSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNG
TPFNSPASKSDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSP
PTVCTIPTVVGRNVIPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKD
VEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPA
NNIRVIKNSIRLTLNR
Sequence length 736
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  mRNA surveillance pathway  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Systemic lupus erythematosus Systemic lupus erythematosus GWAS
Sarcoidosis Sarcoidosis GWAS
Pelvic Organ Prolapse Pelvic Organ Prolapse GWAS
Psoriasis Psoriasis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 35482720
Carcinoma Ovarian Epithelial Associate 23551967
Genetic Diseases Inborn Associate 30122582
Neoplasms Associate 11463842