Gene Gene information from NCBI Gene database.
Entrez ID 64895
Gene name Poly(A) polymerase gamma
Gene symbol PAPOLG
Synonyms (NCBI Gene)
-
Chromosome 2
Chromosome location 2p16.1
Summary This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3` end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level.
miRNA miRNA information provided by mirtarbase database.
743
miRTarBase ID miRNA Experiments Reference
MIRT028237 hsa-miR-33a-5p Sequencing 20371350
MIRT031918 hsa-miR-16-5p Sequencing 20371350
MIRT701097 hsa-miR-4768-3p HITS-CLIP 23313552
MIRT701096 hsa-miR-4459 HITS-CLIP 23313552
MIRT701095 hsa-miR-4433a-3p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003723 Function RNA binding IEA
GO:0005524 Function ATP binding IEA
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 11463842
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616865 14982 ENSG00000115421
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BWT3
Protein name Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme)
Protein function Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. {ECO:0000269|PubMed:1
PDB 4LT6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04928 PAP_central 20 363 Poly(A) polymerase central domain Domain
PF01909 NTP_transf_2 82 174 Nucleotidyltransferase domain Family
PF04926 PAP_RNA-bind 365 432 Poly(A) polymerase predicted RNA binding domain Domain
PF04926 PAP_RNA-bind 421 506 Poly(A) polymerase predicted RNA binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed predominantly in testis, and weakly in other tissues. Overexpressed in several tumors. {ECO:0000269|PubMed:11463842}.
Sequence
MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHR
LVVLGKLNNLVKEWISDVSES
KNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAP
RHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAI
QTISDN
LDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNML
GFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWD
PRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKL
LEP
PNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSF
PGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGM
KIEATHVKKKQLHHYLPAEILQKKKK
QSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNG
TPFNSPASKSDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSP
PTVCTIPTVVGRNVIPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKD
VEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPA
NNIRVIKNSIRLTLNR
Sequence length 736
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  mRNA surveillance pathway