Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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6489
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Gene name
Gene Name - the full gene name approved by the HGNC.
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ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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ST8SIA1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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GD3S, SIAT8, SIAT8-A, SIAT8A, ST8SiaI |
Chromosome
Chromosome number
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12 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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12p12.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the |
UniProt ID |
Q92185
|
Protein name |
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (EC 2.4.3.8) (Alpha-2,8-sialyltransferase 8A) (Ganglioside GD3 synthase) (Ganglioside GT3 synthase) (Sialyltransferase 8A) (SIAT8-A) (Sialyltransferase St8Sia I) (ST8SiaI) |
Protein function |
Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphingolipds that contain one or more residues of sialic acid (PubM |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00777
|
Glyco_transf_29 |
91 → 344 |
Glycosyltransferase family 29 (sialyltransferase) |
Family |
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Tissue specificity |
TISSUE SPECIFICITY: Strongly expressed in melanoma cell lines, adult and fetal brain and to a lesser extent in adult and fetal lung. {ECO:0000269|PubMed:7937974, ECO:0000269|PubMed:8631981}. |
Sequence |
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Sequence length |
356 |
Interactions |
View interactions
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