Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
6489
Gene name Gene Name - the full gene name approved by the HGNC.
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ST8SIA1
Synonyms (NCBI Gene) Gene synonyms aliases
GD3S, SIAT8, SIAT8-A, SIAT8A, ST8SiaI
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12p12.1
Summary Summary of gene provided in NCBI Entrez Gene.
Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT1393850 hsa-miR-1226 CLIP-seq
MIRT1393851 hsa-miR-1252 CLIP-seq
MIRT1393852 hsa-miR-125a-3p CLIP-seq
MIRT1393853 hsa-miR-1263 CLIP-seq
MIRT1393854 hsa-miR-1285 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane TAS
GO:0003828 Function Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA 21873635
GO:0003828 Function Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA 8706663, 18348864, 22885356
GO:0005515 Function Protein binding IPI 32814053
GO:0005975 Process Carbohydrate metabolic process TAS 8195250
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601123 10869 ENSG00000111728
Protein
UniProt ID Q92185
Protein name Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (EC 2.4.3.8) (Alpha-2,8-sialyltransferase 8A) (Ganglioside GD3 synthase) (Ganglioside GT3 synthase) (Sialyltransferase 8A) (SIAT8-A) (Sialyltransferase St8Sia I) (ST8SiaI)
Protein function Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphingolipds that contain one or more residues of sialic acid (PubM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00777 Glyco_transf_29 91 344 Glycosyltransferase family 29 (sialyltransferase) Family
Tissue specificity TISSUE SPECIFICITY: Strongly expressed in melanoma cell lines, adult and fetal brain and to a lesser extent in adult and fetal lung. {ECO:0000269|PubMed:7937974, ECO:0000269|PubMed:8631981}.
Sequence
Sequence length 356
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycosphingolipid biosynthesis - lacto and neolacto series
Glycosphingolipid biosynthesis - globo and isoglobo series
Glycosphingolipid biosynthesis - ganglio series
Metabolic pathways
  Sialic acid metabolism
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Dementia Dementia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 19125296, 22885356, 23626833, 28367091, 29698439, 33260650
Carcinogenesis Associate 30237308
Colorectal Neoplasms Associate 24485021
Esophageal Neoplasms Associate 31527170
Glioblastoma Stimulate 22885356
Graves Disease Inhibit 29047240
Graves Ophthalmopathy Associate 29047240
Hereditary Breast and Ovarian Cancer Syndrome Associate 23479608
Melanoma Stimulate 22885356
Melanoma Associate 31611597