Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	64857
Gene name Gene Name - the full gene name approved by the HGNC.	Pleckstrin homology and RhoGEF domain containing G2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PLEKHG2
Synonyms (NCBI Gene) Gene synonyms aliases	ARHGEF42, CLG, CTB-60E11.4, LDAMD
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a RhoGTPase that can activate CDC42 by promoting exchange of GDP for GTP on CDC42. The encoded protein is activated by binding to the beta and gamma subunits of heterotrimeric guanine nucleotide-binding protein. Defects

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SNP ID	Visualize variation	Clinical significance	Consequence
rs201201843	C>T	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs370673772	G>A	Likely-pathogenic, uncertain-significance	Missense variant, coding sequence variant, non coding transcript variant, intron variant
rs571854709	C>-	Conflicting-interpretations-of-pathogenicity	Intron variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT002749	hsa-miR-1-3p	Microarray	15685193
MIRT026245	hsa-miR-192-5p	Microarray	19074876
MIRT048117	hsa-miR-197-3p	CLASH	23622248
MIRT042993	hsa-miR-324-3p	CLASH	23622248
MIRT037583	hsa-miR-744-5p	CLASH	23622248
MIRT690877	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT690876	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT690875	hsa-miR-940	HITS-CLIP	23313552
MIRT690874	hsa-miR-3929	HITS-CLIP	23313552
MIRT690873	hsa-miR-4419b	HITS-CLIP	23313552
MIRT690872	hsa-miR-4478	HITS-CLIP	23313552
MIRT690871	hsa-miR-5690	HITS-CLIP	23313552
MIRT690870	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT690869	hsa-miR-1247-3p	HITS-CLIP	23313552
MIRT690868	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT690867	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT690866	hsa-miR-1827	HITS-CLIP	23313552
MIRT690865	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT690864	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT690863	hsa-miR-6804-3p	HITS-CLIP	23313552
MIRT690862	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT690861	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT690860	hsa-miR-4281	HITS-CLIP	23313552
MIRT690859	hsa-miR-7977	HITS-CLIP	23313552
MIRT690858	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT690857	hsa-miR-133a-3p	HITS-CLIP	23313552
MIRT690856	hsa-miR-665	HITS-CLIP	23313552
MIRT526890	hsa-miR-548u	PAR-CLIP	22012620
MIRT526889	hsa-miR-7161-5p	PAR-CLIP	22012620
MIRT526888	hsa-miR-483-5p	PAR-CLIP	22012620
MIRT526887	hsa-miR-3167	PAR-CLIP	22012620
MIRT526886	hsa-miR-876-5p	PAR-CLIP	22012620
MIRT048117	hsa-miR-197-3p	PAR-CLIP	22012620
MIRT526885	hsa-miR-5096	PAR-CLIP	22012620
MIRT496211	hsa-miR-941	PAR-CLIP	22291592
MIRT496210	hsa-miR-6871-3p	PAR-CLIP	22291592
MIRT496209	hsa-miR-5582-5p	PAR-CLIP	22291592
MIRT496208	hsa-miR-3622a-5p	PAR-CLIP	22291592
MIRT496207	hsa-miR-5191	PAR-CLIP	22291592
MIRT496206	hsa-miR-4423-3p	PAR-CLIP	22291592
MIRT453351	hsa-miR-6757-5p	PAR-CLIP	23592263
MIRT453350	hsa-miR-6890-5p	PAR-CLIP	23592263
MIRT453349	hsa-miR-1825	PAR-CLIP	23592263
MIRT453348	hsa-miR-199a-5p	PAR-CLIP	23592263
MIRT453347	hsa-miR-199b-5p	PAR-CLIP	23592263
MIRT453346	hsa-miR-3126-5p	PAR-CLIP	23592263
MIRT453345	hsa-miR-6875-5p	PAR-CLIP	23592263
MIRT453344	hsa-miR-4419a	PAR-CLIP	23592263
MIRT453343	hsa-miR-4510	PAR-CLIP	23592263
MIRT453342	hsa-miR-6127	PAR-CLIP	23592263
MIRT453341	hsa-miR-6129	PAR-CLIP	23592263
MIRT453340	hsa-miR-6130	PAR-CLIP	23592263
MIRT453339	hsa-miR-6133	PAR-CLIP	23592263
MIRT453338	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT453337	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT453336	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT453335	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT453334	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT453333	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT453331	hsa-miR-6881-5p	PAR-CLIP	23592263
MIRT453332	hsa-miR-6834-5p	PAR-CLIP	23592263
MIRT690870	hsa-miR-4768-3p	PAR-CLIP	27292025
MIRT690877	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT690876	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT690875	hsa-miR-940	HITS-CLIP	23313552
MIRT690874	hsa-miR-3929	HITS-CLIP	23313552
MIRT690873	hsa-miR-4419b	HITS-CLIP	23313552
MIRT690872	hsa-miR-4478	HITS-CLIP	23313552
MIRT690871	hsa-miR-5690	HITS-CLIP	23313552
MIRT690870	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT690869	hsa-miR-1247-3p	HITS-CLIP	23313552
MIRT690868	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT690867	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT690866	hsa-miR-1827	HITS-CLIP	23313552
MIRT690865	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT690864	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT690863	hsa-miR-6804-3p	HITS-CLIP	23313552
MIRT690862	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT690861	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT690860	hsa-miR-4281	HITS-CLIP	23313552
MIRT690859	hsa-miR-7977	HITS-CLIP	23313552
MIRT690858	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT690857	hsa-miR-133a-3p	HITS-CLIP	23313552
MIRT690856	hsa-miR-665	HITS-CLIP	23313552
MIRT526890	hsa-miR-548u	PAR-CLIP	22012620
MIRT526889	hsa-miR-7161-5p	PAR-CLIP	22012620
MIRT526888	hsa-miR-483-5p	PAR-CLIP	22012620
MIRT526887	hsa-miR-3167	PAR-CLIP	22012620
MIRT526886	hsa-miR-876-5p	PAR-CLIP	22012620
MIRT048117	hsa-miR-197-3p	PAR-CLIP	22012620
MIRT526885	hsa-miR-5096	PAR-CLIP	22012620
MIRT496211	hsa-miR-941	PAR-CLIP	22291592
MIRT496210	hsa-miR-6871-3p	PAR-CLIP	22291592
MIRT496209	hsa-miR-5582-5p	PAR-CLIP	22291592
MIRT496208	hsa-miR-3622a-5p	PAR-CLIP	22291592
MIRT496207	hsa-miR-5191	PAR-CLIP	22291592
MIRT496206	hsa-miR-4423-3p	PAR-CLIP	22291592
MIRT453351	hsa-miR-6757-5p	PAR-CLIP	23592263
MIRT453350	hsa-miR-6890-5p	PAR-CLIP	23592263
MIRT453349	hsa-miR-1825	PAR-CLIP	23592263
MIRT453348	hsa-miR-199a-5p	PAR-CLIP	23592263
MIRT453347	hsa-miR-199b-5p	PAR-CLIP	23592263
MIRT453346	hsa-miR-3126-5p	PAR-CLIP	23592263
MIRT453345	hsa-miR-6875-5p	PAR-CLIP	23592263
MIRT453344	hsa-miR-4419a	PAR-CLIP	23592263
MIRT453343	hsa-miR-4510	PAR-CLIP	23592263
MIRT453342	hsa-miR-6127	PAR-CLIP	23592263
MIRT453341	hsa-miR-6129	PAR-CLIP	23592263
MIRT453340	hsa-miR-6130	PAR-CLIP	23592263
MIRT453339	hsa-miR-6133	PAR-CLIP	23592263
MIRT453338	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT453337	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT453336	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT453335	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT453334	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT453333	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT453331	hsa-miR-6881-5p	PAR-CLIP	23592263
MIRT453332	hsa-miR-6834-5p	PAR-CLIP	23592263
MIRT1241783	hsa-miR-1200	CLIP-seq
MIRT1241784	hsa-miR-1202	CLIP-seq
MIRT1241785	hsa-miR-1207-5p	CLIP-seq
MIRT1241786	hsa-miR-1262	CLIP-seq
MIRT1241787	hsa-miR-1268	CLIP-seq
MIRT1241788	hsa-miR-1268b	CLIP-seq
MIRT1241789	hsa-miR-1273e	CLIP-seq
MIRT1241790	hsa-miR-1273f	CLIP-seq
MIRT1241791	hsa-miR-1297	CLIP-seq
MIRT1241792	hsa-miR-1302	CLIP-seq
MIRT1241793	hsa-miR-138	CLIP-seq
MIRT1241794	hsa-miR-143	CLIP-seq
MIRT1241795	hsa-miR-185	CLIP-seq
MIRT1241796	hsa-miR-186	CLIP-seq
MIRT1241797	hsa-miR-1908	CLIP-seq
MIRT1241798	hsa-miR-1915	CLIP-seq
MIRT1241799	hsa-miR-197	CLIP-seq
MIRT1241800	hsa-miR-1976	CLIP-seq
MIRT1241801	hsa-miR-2467-3p	CLIP-seq
MIRT1241802	hsa-miR-26a	CLIP-seq
MIRT1241803	hsa-miR-26b	CLIP-seq
MIRT1241804	hsa-miR-2964a-3p	CLIP-seq
MIRT1241805	hsa-miR-302f	CLIP-seq
MIRT1241806	hsa-miR-30a	CLIP-seq
MIRT1241807	hsa-miR-30b	CLIP-seq
MIRT1241808	hsa-miR-30c	CLIP-seq
MIRT1241809	hsa-miR-30d	CLIP-seq
MIRT1241810	hsa-miR-30e	CLIP-seq
MIRT1241811	hsa-miR-3122	CLIP-seq
MIRT1241812	hsa-miR-3153	CLIP-seq
MIRT1241813	hsa-miR-3159	CLIP-seq
MIRT1241814	hsa-miR-3187-3p	CLIP-seq
MIRT1241815	hsa-miR-3192	CLIP-seq
MIRT1241816	hsa-miR-3194-5p	CLIP-seq
MIRT1241817	hsa-miR-3199	CLIP-seq
MIRT1241818	hsa-miR-34b	CLIP-seq
MIRT1241819	hsa-miR-3607-3p	CLIP-seq
MIRT1241820	hsa-miR-3612	CLIP-seq
MIRT1241821	hsa-miR-3614-5p	CLIP-seq
MIRT1241822	hsa-miR-365	CLIP-seq
MIRT1241823	hsa-miR-3650	CLIP-seq
MIRT1241824	hsa-miR-3667-3p	CLIP-seq
MIRT1241825	hsa-miR-3672	CLIP-seq
MIRT1241826	hsa-miR-3689a-3p	CLIP-seq
MIRT1241827	hsa-miR-3689c	CLIP-seq
MIRT1241828	hsa-miR-3689d	CLIP-seq
MIRT1241829	hsa-miR-3913-5p	CLIP-seq
MIRT1241830	hsa-miR-3972	CLIP-seq
MIRT1241831	hsa-miR-4257	CLIP-seq
MIRT1241832	hsa-miR-4268	CLIP-seq
MIRT1241833	hsa-miR-4279	CLIP-seq
MIRT1241834	hsa-miR-4292	CLIP-seq
MIRT1241835	hsa-miR-4298	CLIP-seq
MIRT1241836	hsa-miR-4306	CLIP-seq
MIRT1241837	hsa-miR-4308	CLIP-seq
MIRT1241838	hsa-miR-4317	CLIP-seq
MIRT1241839	hsa-miR-4324	CLIP-seq
MIRT1241840	hsa-miR-4327	CLIP-seq
MIRT1241841	hsa-miR-4420	CLIP-seq
MIRT1241842	hsa-miR-4425	CLIP-seq
MIRT1241843	hsa-miR-4435	CLIP-seq
MIRT1241844	hsa-miR-4450	CLIP-seq
MIRT1241845	hsa-miR-4461	CLIP-seq
MIRT1241846	hsa-miR-4465	CLIP-seq
MIRT1241847	hsa-miR-4530	CLIP-seq
MIRT1241848	hsa-miR-4537	CLIP-seq
MIRT1241849	hsa-miR-4644	CLIP-seq
MIRT1241850	hsa-miR-4667-5p	CLIP-seq
MIRT1241851	hsa-miR-4668-5p	CLIP-seq
MIRT1241852	hsa-miR-4684-5p	CLIP-seq
MIRT1241853	hsa-miR-4700-5p	CLIP-seq
MIRT1241854	hsa-miR-4701-3p	CLIP-seq
MIRT1241855	hsa-miR-4701-5p	CLIP-seq
MIRT1241856	hsa-miR-4708-5p	CLIP-seq
MIRT1241857	hsa-miR-4713-3p	CLIP-seq
MIRT1241858	hsa-miR-4722-3p	CLIP-seq
MIRT1241859	hsa-miR-4726-3p	CLIP-seq
MIRT1241860	hsa-miR-4736	CLIP-seq
MIRT1241861	hsa-miR-4755-3p	CLIP-seq
MIRT1241862	hsa-miR-4763-3p	CLIP-seq
MIRT1241863	hsa-miR-4770	CLIP-seq
MIRT1241864	hsa-miR-4772-3p	CLIP-seq
MIRT1241865	hsa-miR-4797-5p	CLIP-seq
MIRT1241866	hsa-miR-490-3p	CLIP-seq
MIRT1241867	hsa-miR-495	CLIP-seq
MIRT1241868	hsa-miR-542-3p	CLIP-seq
MIRT1241869	hsa-miR-544b	CLIP-seq
MIRT1241870	hsa-miR-548aa	CLIP-seq
MIRT1241871	hsa-miR-548c-3p	CLIP-seq
MIRT1241872	hsa-miR-548s	CLIP-seq
MIRT1241873	hsa-miR-580	CLIP-seq
MIRT1241874	hsa-miR-588	CLIP-seq
MIRT1241875	hsa-miR-646	CLIP-seq
MIRT1241876	hsa-miR-650	CLIP-seq
MIRT1241877	hsa-miR-663	CLIP-seq
MIRT1241878	hsa-miR-670	CLIP-seq
MIRT1241879	hsa-miR-759	CLIP-seq
MIRT1552356	hsa-miR-4481	CLIP-seq
MIRT1552357	hsa-miR-4745-5p	CLIP-seq
MIRT1552358	hsa-miR-4758-5p	CLIP-seq
MIRT2071183	hsa-miR-1193	CLIP-seq
MIRT2071184	hsa-miR-1197	CLIP-seq
MIRT1241783	hsa-miR-1200	CLIP-seq
MIRT2071185	hsa-miR-1227	CLIP-seq
MIRT2071186	hsa-miR-1231	CLIP-seq
MIRT2071187	hsa-miR-1246	CLIP-seq
MIRT2071188	hsa-miR-1255a	CLIP-seq
MIRT2071189	hsa-miR-1255b	CLIP-seq
MIRT1241786	hsa-miR-1262	CLIP-seq
MIRT1241790	hsa-miR-1273f	CLIP-seq
MIRT2071190	hsa-miR-1285	CLIP-seq
MIRT2071191	hsa-miR-1289	CLIP-seq
MIRT1241791	hsa-miR-1297	CLIP-seq
MIRT1241797	hsa-miR-1908	CLIP-seq
MIRT1241798	hsa-miR-1915	CLIP-seq
MIRT1241800	hsa-miR-1976	CLIP-seq
MIRT1241801	hsa-miR-2467-3p	CLIP-seq
MIRT1241802	hsa-miR-26a	CLIP-seq
MIRT1241803	hsa-miR-26b	CLIP-seq
MIRT2071192	hsa-miR-27a	CLIP-seq
MIRT2071193	hsa-miR-27b	CLIP-seq
MIRT1241804	hsa-miR-2964a-3p	CLIP-seq
MIRT2071194	hsa-miR-3120-5p	CLIP-seq
MIRT2071195	hsa-miR-3123	CLIP-seq
MIRT2071196	hsa-miR-3135b	CLIP-seq
MIRT2071197	hsa-miR-3145-5p	CLIP-seq
MIRT1241813	hsa-miR-3159	CLIP-seq
MIRT2071198	hsa-miR-3187-5p	CLIP-seq
MIRT1241815	hsa-miR-3192	CLIP-seq
MIRT2071199	hsa-miR-3198	CLIP-seq
MIRT2071200	hsa-miR-3202	CLIP-seq
MIRT1241818	hsa-miR-34b	CLIP-seq
MIRT1241820	hsa-miR-3612	CLIP-seq
MIRT1241821	hsa-miR-3614-5p	CLIP-seq
MIRT2071201	hsa-miR-3652	CLIP-seq
MIRT2071202	hsa-miR-3662	CLIP-seq
MIRT2071203	hsa-miR-3664-5p	CLIP-seq
MIRT2071204	hsa-miR-3674	CLIP-seq
MIRT2071205	hsa-miR-3677-5p	CLIP-seq
MIRT2071206	hsa-miR-3681	CLIP-seq
MIRT2071207	hsa-miR-3688-3p	CLIP-seq
MIRT1241826	hsa-miR-3689a-3p	CLIP-seq
MIRT1241827	hsa-miR-3689c	CLIP-seq
MIRT2071208	hsa-miR-3691-5p	CLIP-seq
MIRT2071209	hsa-miR-378	CLIP-seq
MIRT2071210	hsa-miR-378b	CLIP-seq
MIRT2071211	hsa-miR-378c	CLIP-seq
MIRT2071212	hsa-miR-378d	CLIP-seq
MIRT2071213	hsa-miR-378e	CLIP-seq
MIRT2071214	hsa-miR-378f	CLIP-seq
MIRT2071215	hsa-miR-378h	CLIP-seq
MIRT2071216	hsa-miR-378i	CLIP-seq
MIRT2071217	hsa-miR-3919	CLIP-seq
MIRT2071218	hsa-miR-3977	CLIP-seq
MIRT2071219	hsa-miR-422a	CLIP-seq
MIRT1241831	hsa-miR-4257	CLIP-seq
MIRT2071220	hsa-miR-4276	CLIP-seq
MIRT1241833	hsa-miR-4279	CLIP-seq
MIRT2071221	hsa-miR-4294	CLIP-seq
MIRT2071222	hsa-miR-4300	CLIP-seq
MIRT2071223	hsa-miR-4302	CLIP-seq
MIRT2071224	hsa-miR-4309	CLIP-seq
MIRT1241839	hsa-miR-4324	CLIP-seq
MIRT1241840	hsa-miR-4327	CLIP-seq
MIRT1241841	hsa-miR-4420	CLIP-seq
MIRT2071225	hsa-miR-4430	CLIP-seq
MIRT2071226	hsa-miR-4433	CLIP-seq
MIRT2071227	hsa-miR-4436a	CLIP-seq
MIRT1241846	hsa-miR-4465	CLIP-seq
MIRT2071228	hsa-miR-4470	CLIP-seq
MIRT1552356	hsa-miR-4481	CLIP-seq
MIRT2071229	hsa-miR-4520a-3p	CLIP-seq
MIRT2071230	hsa-miR-4522	CLIP-seq
MIRT2071231	hsa-miR-4533	CLIP-seq
MIRT1241848	hsa-miR-4537	CLIP-seq
MIRT2071232	hsa-miR-4638-3p	CLIP-seq
MIRT2071233	hsa-miR-4698	CLIP-seq
MIRT1241854	hsa-miR-4701-3p	CLIP-seq
MIRT1241858	hsa-miR-4722-3p	CLIP-seq
MIRT1241859	hsa-miR-4726-3p	CLIP-seq
MIRT2071234	hsa-miR-4733-3p	CLIP-seq
MIRT1552357	hsa-miR-4745-5p	CLIP-seq
MIRT2071235	hsa-miR-4752	CLIP-seq
MIRT2071236	hsa-miR-4756-3p	CLIP-seq
MIRT1552358	hsa-miR-4758-5p	CLIP-seq
MIRT1241864	hsa-miR-4772-3p	CLIP-seq
MIRT2071237	hsa-miR-4790-3p	CLIP-seq
MIRT1241866	hsa-miR-490-3p	CLIP-seq
MIRT2071238	hsa-miR-513a-5p	CLIP-seq
MIRT1241869	hsa-miR-544b	CLIP-seq
MIRT2071239	hsa-miR-612	CLIP-seq
MIRT2071240	hsa-miR-617	CLIP-seq
MIRT1241876	hsa-miR-650	CLIP-seq
MIRT1241877	hsa-miR-663	CLIP-seq
MIRT2071241	hsa-miR-766	CLIP-seq
MIRT2071242	hsa-miR-920	CLIP-seq
MIRT2071243	hsa-miR-939	CLIP-seq
MIRT1241783	hsa-miR-1200	CLIP-seq
MIRT1241784	hsa-miR-1202	CLIP-seq
MIRT2071185	hsa-miR-1227	CLIP-seq
MIRT2298419	hsa-miR-1245	CLIP-seq
MIRT2071188	hsa-miR-1255a	CLIP-seq
MIRT2071189	hsa-miR-1255b	CLIP-seq
MIRT2071190	hsa-miR-1285	CLIP-seq
MIRT2071191	hsa-miR-1289	CLIP-seq
MIRT1241791	hsa-miR-1297	CLIP-seq
MIRT2298420	hsa-miR-150	CLIP-seq
MIRT1241797	hsa-miR-1908	CLIP-seq
MIRT1241798	hsa-miR-1915	CLIP-seq
MIRT1241800	hsa-miR-1976	CLIP-seq
MIRT2298421	hsa-miR-219-2-3p	CLIP-seq
MIRT1241801	hsa-miR-2467-3p	CLIP-seq
MIRT1241802	hsa-miR-26a	CLIP-seq
MIRT1241803	hsa-miR-26b	CLIP-seq
MIRT1241804	hsa-miR-2964a-3p	CLIP-seq
MIRT1241811	hsa-miR-3122	CLIP-seq
MIRT2071196	hsa-miR-3135b	CLIP-seq
MIRT2071197	hsa-miR-3145-5p	CLIP-seq
MIRT2071198	hsa-miR-3187-5p	CLIP-seq
MIRT1241815	hsa-miR-3192	CLIP-seq
MIRT1241816	hsa-miR-3194-5p	CLIP-seq
MIRT2071199	hsa-miR-3198	CLIP-seq
MIRT2298422	hsa-miR-323b-3p	CLIP-seq
MIRT1241818	hsa-miR-34b	CLIP-seq
MIRT2298423	hsa-miR-3545-3p	CLIP-seq
MIRT1241820	hsa-miR-3612	CLIP-seq
MIRT1241821	hsa-miR-3614-5p	CLIP-seq
MIRT1241822	hsa-miR-365	CLIP-seq
MIRT2071201	hsa-miR-3652	CLIP-seq
MIRT2071204	hsa-miR-3674	CLIP-seq
MIRT2071205	hsa-miR-3677-5p	CLIP-seq
MIRT1241826	hsa-miR-3689a-3p	CLIP-seq
MIRT1241827	hsa-miR-3689c	CLIP-seq
MIRT1241828	hsa-miR-3689d	CLIP-seq
MIRT2071208	hsa-miR-3691-5p	CLIP-seq
MIRT2298424	hsa-miR-3714	CLIP-seq
MIRT2298425	hsa-miR-371-5p	CLIP-seq
MIRT2298426	hsa-miR-371b-5p	CLIP-seq
MIRT1241829	hsa-miR-3913-5p	CLIP-seq
MIRT2298427	hsa-miR-3945	CLIP-seq
MIRT1241830	hsa-miR-3972	CLIP-seq
MIRT2298428	hsa-miR-4253	CLIP-seq
MIRT1241831	hsa-miR-4257	CLIP-seq
MIRT1241833	hsa-miR-4279	CLIP-seq
MIRT2071221	hsa-miR-4294	CLIP-seq
MIRT2071224	hsa-miR-4309	CLIP-seq
MIRT1241839	hsa-miR-4324	CLIP-seq
MIRT1241841	hsa-miR-4420	CLIP-seq
MIRT2071225	hsa-miR-4430	CLIP-seq
MIRT2071226	hsa-miR-4433	CLIP-seq
MIRT1241843	hsa-miR-4435	CLIP-seq
MIRT1241846	hsa-miR-4465	CLIP-seq
MIRT2298429	hsa-miR-4491	CLIP-seq
MIRT1241848	hsa-miR-4537	CLIP-seq
MIRT2298430	hsa-miR-4657	CLIP-seq
MIRT2298431	hsa-miR-4713-5p	CLIP-seq
MIRT1241858	hsa-miR-4722-3p	CLIP-seq
MIRT1241859	hsa-miR-4726-3p	CLIP-seq
MIRT2298432	hsa-miR-4732-5p	CLIP-seq
MIRT2071235	hsa-miR-4752	CLIP-seq
MIRT1241864	hsa-miR-4772-3p	CLIP-seq
MIRT1241866	hsa-miR-490-3p	CLIP-seq
MIRT2298433	hsa-miR-500a	CLIP-seq
MIRT2298434	hsa-miR-532-3p	CLIP-seq
MIRT1241869	hsa-miR-544b	CLIP-seq
MIRT1241871	hsa-miR-548c-3p	CLIP-seq
MIRT2298435	hsa-miR-550a	CLIP-seq
MIRT2071239	hsa-miR-612	CLIP-seq
MIRT2298436	hsa-miR-640	CLIP-seq
MIRT1241876	hsa-miR-650	CLIP-seq
MIRT1241877	hsa-miR-663	CLIP-seq
MIRT2071241	hsa-miR-766	CLIP-seq
MIRT2392662	hsa-miR-1287	CLIP-seq
MIRT1241801	hsa-miR-2467-3p	CLIP-seq
MIRT2071196	hsa-miR-3135b	CLIP-seq
MIRT1241815	hsa-miR-3192	CLIP-seq
MIRT1241818	hsa-miR-34b	CLIP-seq
MIRT1241820	hsa-miR-3612	CLIP-seq
MIRT1241821	hsa-miR-3614-5p	CLIP-seq
MIRT1241826	hsa-miR-3689a-3p	CLIP-seq
MIRT1241827	hsa-miR-3689c	CLIP-seq
MIRT1241831	hsa-miR-4257	CLIP-seq
MIRT1241866	hsa-miR-490-3p	CLIP-seq
MIRT1241876	hsa-miR-650	CLIP-seq
MIRT1241783	hsa-miR-1200	CLIP-seq
MIRT2456660	hsa-miR-1247	CLIP-seq
MIRT1241787	hsa-miR-1268	CLIP-seq
MIRT1241788	hsa-miR-1268b	CLIP-seq
MIRT2456661	hsa-miR-1283	CLIP-seq
MIRT1241791	hsa-miR-1297	CLIP-seq
MIRT1241798	hsa-miR-1915	CLIP-seq
MIRT1241800	hsa-miR-1976	CLIP-seq
MIRT1241801	hsa-miR-2467-3p	CLIP-seq
MIRT1241802	hsa-miR-26a	CLIP-seq
MIRT1241803	hsa-miR-26b	CLIP-seq
MIRT1241806	hsa-miR-30a	CLIP-seq
MIRT1241807	hsa-miR-30b	CLIP-seq
MIRT1241808	hsa-miR-30c	CLIP-seq
MIRT1241809	hsa-miR-30d	CLIP-seq
MIRT1241810	hsa-miR-30e	CLIP-seq
MIRT2071194	hsa-miR-3120-5p	CLIP-seq
MIRT1241811	hsa-miR-3122	CLIP-seq
MIRT1241815	hsa-miR-3192	CLIP-seq
MIRT1241818	hsa-miR-34b	CLIP-seq
MIRT1241819	hsa-miR-3607-3p	CLIP-seq
MIRT1241820	hsa-miR-3612	CLIP-seq
MIRT2456662	hsa-miR-3613-3p	CLIP-seq
MIRT1241821	hsa-miR-3614-5p	CLIP-seq
MIRT2071203	hsa-miR-3664-5p	CLIP-seq
MIRT1241826	hsa-miR-3689a-3p	CLIP-seq
MIRT1241827	hsa-miR-3689c	CLIP-seq
MIRT2298425	hsa-miR-371-5p	CLIP-seq
MIRT2298426	hsa-miR-371b-5p	CLIP-seq
MIRT1241829	hsa-miR-3913-5p	CLIP-seq
MIRT1241831	hsa-miR-4257	CLIP-seq
MIRT1241833	hsa-miR-4279	CLIP-seq
MIRT1241839	hsa-miR-4324	CLIP-seq
MIRT1241846	hsa-miR-4465	CLIP-seq
MIRT2456663	hsa-miR-4486	CLIP-seq
MIRT2071230	hsa-miR-4522	CLIP-seq
MIRT1241848	hsa-miR-4537	CLIP-seq
MIRT1241852	hsa-miR-4684-5p	CLIP-seq
MIRT1241858	hsa-miR-4722-3p	CLIP-seq
MIRT1241859	hsa-miR-4726-3p	CLIP-seq
MIRT1241866	hsa-miR-490-3p	CLIP-seq
MIRT1241869	hsa-miR-544b	CLIP-seq
MIRT1241870	hsa-miR-548aa	CLIP-seq
MIRT1241871	hsa-miR-548c-3p	CLIP-seq
MIRT2456664	hsa-miR-585	CLIP-seq
MIRT2456665	hsa-miR-605	CLIP-seq
MIRT1241876	hsa-miR-650	CLIP-seq
MIRT1241791	hsa-miR-1297	CLIP-seq
MIRT1241798	hsa-miR-1915	CLIP-seq
MIRT1241800	hsa-miR-1976	CLIP-seq
MIRT1241802	hsa-miR-26a	CLIP-seq
MIRT1241803	hsa-miR-26b	CLIP-seq
MIRT2456662	hsa-miR-3613-3p	CLIP-seq
MIRT1241833	hsa-miR-4279	CLIP-seq
MIRT1241846	hsa-miR-4465	CLIP-seq
MIRT1241852	hsa-miR-4684-5p	CLIP-seq
MIRT1241858	hsa-miR-4722-3p	CLIP-seq
MIRT1241859	hsa-miR-4726-3p	CLIP-seq
MIRT1241870	hsa-miR-548aa	CLIP-seq
MIRT1241871	hsa-miR-548c-3p	CLIP-seq
MIRT1241783	hsa-miR-1200	CLIP-seq
MIRT1241784	hsa-miR-1202	CLIP-seq
MIRT1241787	hsa-miR-1268	CLIP-seq
MIRT1241788	hsa-miR-1268b	CLIP-seq
MIRT1241789	hsa-miR-1273e	CLIP-seq
MIRT2071190	hsa-miR-1285	CLIP-seq
MIRT1241791	hsa-miR-1297	CLIP-seq
MIRT1241797	hsa-miR-1908	CLIP-seq
MIRT1241798	hsa-miR-1915	CLIP-seq
MIRT1241800	hsa-miR-1976	CLIP-seq
MIRT1241801	hsa-miR-2467-3p	CLIP-seq
MIRT1241802	hsa-miR-26a	CLIP-seq
MIRT1241803	hsa-miR-26b	CLIP-seq
MIRT1241804	hsa-miR-2964a-3p	CLIP-seq
MIRT1241805	hsa-miR-302f	CLIP-seq
MIRT1241806	hsa-miR-30a	CLIP-seq
MIRT1241807	hsa-miR-30b	CLIP-seq
MIRT1241808	hsa-miR-30c	CLIP-seq
MIRT1241809	hsa-miR-30d	CLIP-seq
MIRT1241810	hsa-miR-30e	CLIP-seq
MIRT2071194	hsa-miR-3120-5p	CLIP-seq
MIRT1241811	hsa-miR-3122	CLIP-seq
MIRT2071197	hsa-miR-3145-5p	CLIP-seq
MIRT2071198	hsa-miR-3187-5p	CLIP-seq
MIRT1241815	hsa-miR-3192	CLIP-seq
MIRT1241816	hsa-miR-3194-5p	CLIP-seq
MIRT1241818	hsa-miR-34b	CLIP-seq
MIRT1241819	hsa-miR-3607-3p	CLIP-seq
MIRT1241820	hsa-miR-3612	CLIP-seq
MIRT2456662	hsa-miR-3613-3p	CLIP-seq
MIRT1241821	hsa-miR-3614-5p	CLIP-seq
MIRT1241822	hsa-miR-365	CLIP-seq
MIRT2071203	hsa-miR-3664-5p	CLIP-seq
MIRT1241826	hsa-miR-3689a-3p	CLIP-seq
MIRT1241827	hsa-miR-3689c	CLIP-seq
MIRT1241828	hsa-miR-3689d	CLIP-seq
MIRT2298425	hsa-miR-371-5p	CLIP-seq
MIRT2298426	hsa-miR-371b-5p	CLIP-seq
MIRT1241829	hsa-miR-3913-5p	CLIP-seq
MIRT1241830	hsa-miR-3972	CLIP-seq
MIRT1241831	hsa-miR-4257	CLIP-seq
MIRT1241833	hsa-miR-4279	CLIP-seq
MIRT1241839	hsa-miR-4324	CLIP-seq
MIRT1241846	hsa-miR-4465	CLIP-seq
MIRT2071230	hsa-miR-4522	CLIP-seq
MIRT1241848	hsa-miR-4537	CLIP-seq
MIRT1241852	hsa-miR-4684-5p	CLIP-seq
MIRT1241858	hsa-miR-4722-3p	CLIP-seq
MIRT1241859	hsa-miR-4726-3p	CLIP-seq
MIRT1241866	hsa-miR-490-3p	CLIP-seq
MIRT1241869	hsa-miR-544b	CLIP-seq
MIRT1241870	hsa-miR-548aa	CLIP-seq
MIRT1241871	hsa-miR-548c-3p	CLIP-seq
MIRT1241873	hsa-miR-580	CLIP-seq
MIRT2071239	hsa-miR-612	CLIP-seq
MIRT1241876	hsa-miR-650	CLIP-seq
MIRT1241877	hsa-miR-663	CLIP-seq
MIRT2071241	hsa-miR-766	CLIP-seq
MIRT1241783	hsa-miR-1200	CLIP-seq
MIRT1241784	hsa-miR-1202	CLIP-seq
MIRT2456660	hsa-miR-1247	CLIP-seq
MIRT1241787	hsa-miR-1268	CLIP-seq
MIRT1241788	hsa-miR-1268b	CLIP-seq
MIRT1241789	hsa-miR-1273e	CLIP-seq
MIRT2456661	hsa-miR-1283	CLIP-seq
MIRT2071190	hsa-miR-1285	CLIP-seq
MIRT1241791	hsa-miR-1297	CLIP-seq
MIRT1241797	hsa-miR-1908	CLIP-seq
MIRT1241798	hsa-miR-1915	CLIP-seq
MIRT1241800	hsa-miR-1976	CLIP-seq
MIRT1241801	hsa-miR-2467-3p	CLIP-seq
MIRT1241802	hsa-miR-26a	CLIP-seq
MIRT1241803	hsa-miR-26b	CLIP-seq
MIRT1241804	hsa-miR-2964a-3p	CLIP-seq
MIRT1241805	hsa-miR-302f	CLIP-seq
MIRT2071194	hsa-miR-3120-5p	CLIP-seq
MIRT1241811	hsa-miR-3122	CLIP-seq
MIRT2071197	hsa-miR-3145-5p	CLIP-seq
MIRT2071198	hsa-miR-3187-5p	CLIP-seq
MIRT1241815	hsa-miR-3192	CLIP-seq
MIRT1241816	hsa-miR-3194-5p	CLIP-seq
MIRT1241818	hsa-miR-34b	CLIP-seq
MIRT1241820	hsa-miR-3612	CLIP-seq
MIRT2456662	hsa-miR-3613-3p	CLIP-seq
MIRT1241821	hsa-miR-3614-5p	CLIP-seq
MIRT1241822	hsa-miR-365	CLIP-seq
MIRT2071203	hsa-miR-3664-5p	CLIP-seq
MIRT1241826	hsa-miR-3689a-3p	CLIP-seq
MIRT1241827	hsa-miR-3689c	CLIP-seq
MIRT2298425	hsa-miR-371-5p	CLIP-seq
MIRT2298426	hsa-miR-371b-5p	CLIP-seq
MIRT1241829	hsa-miR-3913-5p	CLIP-seq
MIRT1241830	hsa-miR-3972	CLIP-seq
MIRT1241831	hsa-miR-4257	CLIP-seq
MIRT1241833	hsa-miR-4279	CLIP-seq
MIRT1241839	hsa-miR-4324	CLIP-seq
MIRT1241846	hsa-miR-4465	CLIP-seq
MIRT2071230	hsa-miR-4522	CLIP-seq
MIRT1241848	hsa-miR-4537	CLIP-seq
MIRT1241852	hsa-miR-4684-5p	CLIP-seq
MIRT1241858	hsa-miR-4722-3p	CLIP-seq
MIRT1241859	hsa-miR-4726-3p	CLIP-seq
MIRT1241866	hsa-miR-490-3p	CLIP-seq
MIRT1241869	hsa-miR-544b	CLIP-seq
MIRT1241870	hsa-miR-548aa	CLIP-seq
MIRT1241871	hsa-miR-548c-3p	CLIP-seq
MIRT1241873	hsa-miR-580	CLIP-seq
MIRT2456665	hsa-miR-605	CLIP-seq
MIRT2071239	hsa-miR-612	CLIP-seq
MIRT1241876	hsa-miR-650	CLIP-seq
MIRT1241877	hsa-miR-663	CLIP-seq
MIRT2071241	hsa-miR-766	CLIP-seq

Show/Hide all(8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0030833	Process	Regulation of actin filament polymerization	IBA
GO:0030833	Process	Regulation of actin filament polymerization	IMP	26573021
GO:0031267	Function	Small GTPase binding	IBA

MIM	HGNC	e!Ensembl
611893	29515	ENSG00000090924

Protein

UniProt ID

Q9H7P9

Protein name

Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2)

Protein function

May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-b

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00621	RhoGEF	106 → 281	RhoGEF domain	Domain
PF00169	PH	315 → 410	PH domain	Domain

Sequence

MPEGAQGLSLSKPSPSLGCGRRGEVCDCGTVCETRTAPAAPTMASPRGSGSSTSLSTVGS
EGDPAPGPTPACSASRPEPLPGPPIRLHLSPVGIPGSARPSRLERVAREIVETERAYVRD
LRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLENSSSAGGIAECFV
QRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLRHSLPLQSFLLKPVQRI
LKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRL
GGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGLEYTYKGHI
FCCNLSVSESPRDPLGFKVSDLTIPKHRHLLQAKNQEEKRLWIHCLQRLFFENHPASIPA
KAKQVLLENSLHCAPKSKPVLEPLTPPLGSPRPRDARSFTPGRRNTAPSPGPSVIRRGRR
QSEPVKDPYVMFPQNAKPGFKHAGSEGELYPPESQPPVSGSAPPEDLEDAGPPTLDPSGT
SITEEILELLNQRGLRDPGPSTHDIPKFPGDSQVPGDSETLTFQALPSRDSSEEEEEEEE
GLEMDERGPSPLHVLEGLESSIAAEMPSIPCLTKIPDVPNLPEIPSRCEIPEGSRLPSLS
DISDVFEMPCLPAIPSVPNTPSLSSTPTLSCDSWLQGPLQEPAEAPATRRELFSGSNPGK
LGEPPSGGKAGPEEDEEGVSFTDFQPQDVTQHQGFPDELAFRSCSEIRSAWQALEQGQLA
RPGFPEPLLILEDSDLGGDSGSGKAGAPSSERTASRVRELARLYSERIQQMQRAETRASA
NAPRRRPRVLAQPQPSPCLPQEQAEPGLLPAFGHVLVCELAFPLTCAQESVPLGPAVWVQ
AAIPLSKQGGSPDGQGLHVSNLPKQDLPGIHVSAATLLPEQGGSRHVQAPAATPLPKQEG
PLHLQVPALTTFSDQGHPEIQVPATTPLPEHRSHMVIPAPSTAFCPEQGHCADIHVPTTP
ALPKEICSDFTVSVTTPVPKQEGHLDSESPTNIPLTKQGGSRDVQGPDPVCSQPIQPLSW
HGSSLDPQGPGDTLPPLPCHLPDLQIPGTSPLPAHGSHLDHRIPANAPLSLSQELPDTQV
PATTPLPLPQVLTDIWVQALPTSPKQGSLPDIQGPAAAPPLPEPSLTDTQVQKLTPSLEQ
KSLIDAHVPAATPLPERGGSLDIQGLSPTPVQTTMVLSKPGGSLASHVARLESSDLTPPH
SPPPSSRQLLGPNAAALSRYLAASYISQSLARRQGPGGGAPAASRGSWSSAPTSRASSPP
PQPQPPPPPARRLSYATTVNIHVGGGGRLRPAKAQVRLNHPALLASTQESMGLHRAQGAP
DAPFHM

Sequence length

1386

Interactions

View interactions

	Reactome
			NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Epilepsy	epilepsy	N/A	N/A	GenCC
Leukodystrophy And Acquired Microcephaly With Or Without Dystonia	leukodystrophy and acquired microcephaly with or without dystonia;	N/A	N/A	GenCC
Microcephaly	microcephaly	N/A	N/A	ClinVar

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Cardiac Output Low	Associate	34788622
Leukemia	Associate	24001768
Neoplasms	Associate	34788622
Pancreatic Neoplasms	Associate	24041470
Squamous Cell Carcinoma of Head and Neck	Associate	35361159

PLEKHG2 (pleckstrin homology and RhoGEF domain containing G2)