Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
64854
Gene name Gene Name - the full gene name approved by the HGNC.
Ubiquitin specific peptidase 46
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
USP46
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q12
Summary Summary of gene provided in NCBI Entrez Gene.
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019851 hsa-miR-375 Microarray 20215506
MIRT020484 hsa-miR-106b-5p Microarray 17242205
MIRT038649 hsa-miR-140-3p CLASH 23622248
MIRT553000 hsa-miR-338-5p PAR-CLIP 21572407
MIRT552999 hsa-miR-3065-5p PAR-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001662 Process Behavioral fear response IEA
GO:0004197 Function Cysteine-type endopeptidase activity IBA 21873635
GO:0004843 Function Thiol-dependent ubiquitin-specific protease activity IBA 21873635
GO:0004843 Function Thiol-dependent ubiquitin-specific protease activity IDA 14715245, 19075014
GO:0005515 Function Protein binding IPI 19075014, 19615732, 20147737, 32296183, 32814053
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612849 20075 ENSG00000109189
Protein
UniProt ID P62068
Protein name Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46)
Protein function Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction wi
PDB 5CVM , 5CVN , 5CVO , 5L8H , 6JLQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00443 UCH 35 362 Ubiquitin carboxyl-terminal hydrolase Family
Tissue specificity TISSUE SPECIFICITY: Broadly expressed. {ECO:0000269|PubMed:14715245}.
Sequence
Sequence length 366
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Mental depression Major Depressive Disorder 21663972 ClinVar
Dementia Dementia GWAS
Oligodendroglioma Oligodendroglioma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 38176460
Carcinogenesis Inhibit 31542232
Carcinoma Renal Cell Inhibit 31542232
Carcinoma Renal Cell Associate 33029497
Colorectal Neoplasms Inhibit 33029497
Lung Neoplasms Inhibit 33029497
Neoplasm Metastasis Associate 31542232
Neoplasms Associate 31542232, 33576437
Ovarian Neoplasms Inhibit 33576437
Retinoblastoma Associate 37603355