USP46 (ubiquitin specific peptidase 46)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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64854 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Ubiquitin specific peptidase 46 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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USP46 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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Chromosome
Chromosome number
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4 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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4q12 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | P62068 | ||||||||||
Protein name | Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46) | ||||||||||
Protein function | Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction wi | ||||||||||
PDB | 5CVM , 5CVN , 5CVO , 5L8H , 6JLQ | ||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Broadly expressed. {ECO:0000269|PubMed:14715245}. | ||||||||||
Sequence | |||||||||||
Sequence length | 366 | ||||||||||
Interactions | View interactions |
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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