Gene Gene information from NCBI Gene database.
Entrez ID 64853
Gene name Axin interactor, dorsalization associated
Gene symbol AIDA
Synonyms (NCBI Gene)
C1orf80
Chromosome 1
Chromosome location 1q41
miRNA miRNA information provided by mirtarbase database.
466
miRTarBase ID miRNA Experiments Reference
MIRT052535 hsa-let-7a-5p CLASH 23622248
MIRT052314 hsa-let-7b-5p CLASH 23622248
MIRT051868 hsa-let-7c-5p CLASH 23622248
MIRT049134 hsa-miR-92a-3p CLASH 23622248
MIRT488961 hsa-miR-3121-3p PAR-CLIP 23592263
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21900206, 25416956, 32296183
GO:0005737 Component Cytoplasm IEA
GO:0009953 Process Dorsal/ventral pattern formation ISS
GO:0016020 Component Membrane IBA
GO:0019904 Function Protein domain specific binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612375 25761 ENSG00000186063
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96BJ3
Protein name Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist)
Protein function Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-s
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08910 Aida_N 9 112 Aida N-terminus Family
PF14186 Aida_C2 156 301 Cytoskeletal adhesion Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle. {ECO:0000269|PubMed:17681137}.
Sequence
Sequence length 306
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CORONARY ATHEROSCLEROSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EYE DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Coronary Artery Disease Associate 31287004
★☆☆☆☆
Found in Text Mining only
Inflammation Associate 36184552
★☆☆☆☆
Found in Text Mining only
Vascular Diseases Associate 36928188
★☆☆☆☆
Found in Text Mining only
Vascular System Injuries Associate 36184552
★☆☆☆☆
Found in Text Mining only