Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	64848
Gene name	YTH N6-methyladenosine RNA binding protein C2
Gene symbol	YTHDC2
Synonyms (NCBI Gene)	CAHLhYTHDC2
Chromosome	5
Chromosome location	5q22.2
Summary	This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop

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miRTarBase ID	miRNA	Experiments	Reference
MIRT048734	hsa-miR-96-5p	CLASH	23622248
MIRT047966	hsa-miR-30c-5p	CLASH	23622248
MIRT041048	hsa-miR-505-3p	CLASH	23622248
MIRT1499757	hsa-miR-1297	CLIP-seq
MIRT1499758	hsa-miR-1321	CLIP-seq
MIRT1499759	hsa-miR-155	CLIP-seq
MIRT1499760	hsa-miR-181a	CLIP-seq
MIRT1499761	hsa-miR-181b	CLIP-seq
MIRT1499762	hsa-miR-181c	CLIP-seq
MIRT1499763	hsa-miR-181d	CLIP-seq
MIRT1499764	hsa-miR-26a	CLIP-seq
MIRT1499765	hsa-miR-26b	CLIP-seq
MIRT1499766	hsa-miR-3120-3p	CLIP-seq
MIRT1499767	hsa-miR-3160-5p	CLIP-seq
MIRT1499768	hsa-miR-3617	CLIP-seq
MIRT1499769	hsa-miR-3646	CLIP-seq
MIRT1499770	hsa-miR-3662	CLIP-seq
MIRT1499771	hsa-miR-382	CLIP-seq
MIRT1499772	hsa-miR-383	CLIP-seq
MIRT1499773	hsa-miR-3919	CLIP-seq
MIRT1499774	hsa-miR-3974	CLIP-seq
MIRT1499775	hsa-miR-4262	CLIP-seq
MIRT1499776	hsa-miR-4276	CLIP-seq
MIRT1499777	hsa-miR-4302	CLIP-seq
MIRT1499778	hsa-miR-4419a	CLIP-seq
MIRT1499779	hsa-miR-4446-5p	CLIP-seq
MIRT1499780	hsa-miR-4465	CLIP-seq
MIRT1499781	hsa-miR-4510	CLIP-seq
MIRT1499782	hsa-miR-4643	CLIP-seq
MIRT1499783	hsa-miR-466	CLIP-seq
MIRT1499784	hsa-miR-4739	CLIP-seq
MIRT1499785	hsa-miR-4755-5p	CLIP-seq
MIRT1499786	hsa-miR-4756-5p	CLIP-seq
MIRT1499787	hsa-miR-4760-3p	CLIP-seq
MIRT1499788	hsa-miR-4772-5p	CLIP-seq
MIRT1499789	hsa-miR-4789-3p	CLIP-seq
MIRT1499790	hsa-miR-5095	CLIP-seq
MIRT1499791	hsa-miR-548a-3p	CLIP-seq
MIRT1499792	hsa-miR-548a-5p	CLIP-seq
MIRT1499793	hsa-miR-548ab	CLIP-seq
MIRT1499794	hsa-miR-548ag	CLIP-seq
MIRT1499795	hsa-miR-548ai	CLIP-seq
MIRT1499796	hsa-miR-548ak	CLIP-seq
MIRT1499797	hsa-miR-548b-5p	CLIP-seq
MIRT1499798	hsa-miR-548c-3p	CLIP-seq
MIRT1499799	hsa-miR-548c-5p	CLIP-seq
MIRT1499800	hsa-miR-548d-5p	CLIP-seq
MIRT1499801	hsa-miR-548e	CLIP-seq
MIRT1499802	hsa-miR-548f	CLIP-seq
MIRT1499803	hsa-miR-548h	CLIP-seq
MIRT1499804	hsa-miR-548i	CLIP-seq
MIRT1499805	hsa-miR-548j	CLIP-seq
MIRT1499806	hsa-miR-548k	CLIP-seq
MIRT1499807	hsa-miR-548l	CLIP-seq
MIRT1499808	hsa-miR-548w	CLIP-seq
MIRT1499809	hsa-miR-548y	CLIP-seq
MIRT1499810	hsa-miR-552	CLIP-seq
MIRT1499811	hsa-miR-559	CLIP-seq
MIRT1499812	hsa-miR-579	CLIP-seq
MIRT1499813	hsa-miR-580	CLIP-seq
MIRT1499814	hsa-miR-630	CLIP-seq
MIRT1499815	hsa-miR-641	CLIP-seq
MIRT1499816	hsa-miR-654-3p	CLIP-seq
MIRT1499817	hsa-miR-664	CLIP-seq
MIRT1499818	hsa-miR-873	CLIP-seq
MIRT1555672	hsa-miR-2116	CLIP-seq
MIRT1555673	hsa-miR-3692	CLIP-seq
MIRT1555674	hsa-miR-4303	CLIP-seq
MIRT1555675	hsa-miR-4677-5p	CLIP-seq
MIRT1499771	hsa-miR-382	CLIP-seq
MIRT1499812	hsa-miR-579	CLIP-seq
MIRT1499814	hsa-miR-630	CLIP-seq
MIRT1499817	hsa-miR-664	CLIP-seq
MIRT1499759	hsa-miR-155	CLIP-seq
MIRT1555672	hsa-miR-2116	CLIP-seq
MIRT1499767	hsa-miR-3160-5p	CLIP-seq
MIRT2370981	hsa-miR-3667-3p	CLIP-seq
MIRT1555673	hsa-miR-3692	CLIP-seq
MIRT2370982	hsa-miR-369-3p	CLIP-seq
MIRT2370983	hsa-miR-374c	CLIP-seq
MIRT1499773	hsa-miR-3919	CLIP-seq
MIRT1499782	hsa-miR-4643	CLIP-seq
MIRT1499783	hsa-miR-466	CLIP-seq
MIRT1555675	hsa-miR-4677-5p	CLIP-seq
MIRT1499789	hsa-miR-4789-3p	CLIP-seq
MIRT2370984	hsa-miR-513c	CLIP-seq
MIRT2370985	hsa-miR-514b-5p	CLIP-seq
MIRT2370986	hsa-miR-655	CLIP-seq
MIRT1499787	hsa-miR-4760-3p	CLIP-seq
MIRT2664501	hsa-miR-2117	CLIP-seq
MIRT2664502	hsa-miR-219-2-3p	CLIP-seq
MIRT2664503	hsa-miR-3163	CLIP-seq
MIRT2664504	hsa-miR-3202	CLIP-seq
MIRT1499770	hsa-miR-3662	CLIP-seq
MIRT2664505	hsa-miR-3664-5p	CLIP-seq
MIRT2664506	hsa-miR-3671	CLIP-seq
MIRT2664507	hsa-miR-371-5p	CLIP-seq
MIRT2664508	hsa-miR-371b-5p	CLIP-seq
MIRT2664509	hsa-miR-4273	CLIP-seq
MIRT1499776	hsa-miR-4276	CLIP-seq
MIRT1499777	hsa-miR-4302	CLIP-seq
MIRT2664510	hsa-miR-4327	CLIP-seq
MIRT2664511	hsa-miR-4474-3p	CLIP-seq
MIRT2664512	hsa-miR-4511	CLIP-seq
MIRT2664513	hsa-miR-4533	CLIP-seq
MIRT2664514	hsa-miR-4694-3p	CLIP-seq
MIRT2664515	hsa-miR-4714-5p	CLIP-seq
MIRT1499787	hsa-miR-4760-3p	CLIP-seq
MIRT2664516	hsa-miR-5096	CLIP-seq
MIRT2370984	hsa-miR-513c	CLIP-seq
MIRT2370985	hsa-miR-514b-5p	CLIP-seq
MIRT2664517	hsa-miR-548aa	CLIP-seq
MIRT2664518	hsa-miR-548b-3p	CLIP-seq
MIRT1499798	hsa-miR-548c-3p	CLIP-seq
MIRT2664502	hsa-miR-219-2-3p	CLIP-seq
MIRT1499766	hsa-miR-3120-3p	CLIP-seq
MIRT2695436	hsa-miR-3140-3p	CLIP-seq
MIRT2695437	hsa-miR-3152-5p	CLIP-seq
MIRT2664504	hsa-miR-3202	CLIP-seq
MIRT2664510	hsa-miR-4327	CLIP-seq
MIRT2664511	hsa-miR-4474-3p	CLIP-seq
MIRT2664513	hsa-miR-4533	CLIP-seq
MIRT2664514	hsa-miR-4694-3p	CLIP-seq
MIRT2695438	hsa-miR-4774-3p	CLIP-seq
MIRT1499813	hsa-miR-580	CLIP-seq
MIRT2695439	hsa-miR-7	CLIP-seq

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0003724	Function	RNA helicase activity	IEA
GO:0004386	Function	Helicase activity	IBA
GO:0004386	Function	Helicase activity	IEA
GO:0005515	Function	Protein binding	IPI	21903422, 26742488, 29033321
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	21559518
GO:0007283	Process	Spermatogenesis	IEA
GO:0007286	Process	Spermatid development	IEA
GO:0007286	Process	Spermatid development	ISS
GO:0008186	Function	ATP-dependent activity, acting on RNA	IDA	21559518
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0034458	Function	3'-5' RNA helicase activity	IDA	29033321
GO:0034458	Function	3'-5' RNA helicase activity	IEA
GO:0034612	Process	Response to tumor necrosis factor	IDA	21559518
GO:0035770	Component	Ribonucleoprotein granule	IEA
GO:0035770	Component	Ribonucleoprotein granule	ISS
GO:0044829	Process	Host-mediated activation of viral genome replication	IMP	21559518
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0048477	Process	Oogenesis	IEA
GO:0048599	Process	Oocyte development	IEA
GO:0048599	Process	Oocyte development	ISS
GO:0051321	Process	Meiotic cell cycle	IEA
GO:0051729	Process	Germline cell cycle switching, mitotic to meiotic cell cycle	IEA
GO:0051729	Process	Germline cell cycle switching, mitotic to meiotic cell cycle	ISS
GO:0070063	Function	RNA polymerase binding	IEA
GO:0070063	Function	RNA polymerase binding	IPI	21559518
GO:0070555	Process	Response to interleukin-1	IDA	21559518
GO:1990247	Function	N6-methyladenosine-containing RNA reader activity	IDA	26318451, 28809393, 29033321
GO:1990247	Function	N6-methyladenosine-containing RNA reader activity	IEA

MIM	HGNC	e!Ensembl
616530	24721	ENSG00000047188

Q9H6S0

Protein name

3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2)

Protein function

3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596). Specifically recognizes and binds N6-methyladen

PDB

2YU6 , 6K6U , 6LR2 , 9H35 , 9H36

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01424	R3H	45 → 104	R3H domain	Domain
PF00270	DEAD	196 → 355	DEAD/DEAH box helicase	Domain
PF00271	Helicase_C	607 → 744	Helicase conserved C-terminal domain	Family
PF04408	HA2	809 → 928	Helicase associated domain (HA2)	Domain
PF07717	OB_NTP_bind	971 → 1067	Oligonucleotide/oligosaccharide-binding (OB)-fold	Domain
PF04146	YTH	1288 → 1362	YT521-B-like domain	Domain
PF04146	YTH	1351 → 1419	YT521-B-like domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in testis (PubMed:29087293). Not detected in spermatogonia next to the tubule wall but is strongly expressed in spermatocytes, suggesting that it is up-regulated in germ cells upon entry into meiosis (PubMed:29087293). {ECO:0

Sequence

MSRPSSVSPRQPAPGGGGGGGPSPCGPGGGGRAKGLKDIRIDEEVKIAVNIALERFRYGD
QREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKKDGSETAHAMMTCNLT
HNTKHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEAENREMSKTSGRLNNGIPQIPVK
RGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIP
CRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTL
MAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYF
GSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQEEKQQTTLTEWYSAQEN
SFKPESQRQRTVLNVTDEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHK
DIDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNG
WMALDWAKHFGQTEIVDLLESYSATLEFGNLDESSLVQTNGSDLSAEDRELLKAYHHSFD
DEKVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFADSTHRYQVFM
LHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFV
TMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHT
KLLAPVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPH
LGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMAL
LRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRD
VNTNSENWAVVKAALVAGMYPNLVHVDRENLVLTGPKEKKVRFHPASVLSQPQYKKIPPA
NGQAAAIKALPTDWLIYDEMTRAHRIANIRCCSAVTPVTILVFCGPARLASNALQEPSSF
RVDGIPNDSSDSEMEDKTTANLAALKLDEWLHFTLEPEAASLLLQLRQKWHSLFLRRMRA
PSKPWSQVDEATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMSSEELPLASSWRSNNSRK
SSADTEFSDECTTAERVLMKSPSPALHPPQKYKDRGILHPKRGTEDRSDQSSLKSTDSSS
YPSPCASPSPPSSGKGSKSPSPRPNMPVRYFIMKSSNLRNLEISQQKGIWSTTPSNERKL
NRAFWESSIVYLVFSVQGSGHFQGFSRMSSEIGREKSQDWGSAGLGGVFKVEWIRKESLP
FQFAHHLLNPWNDNKKVQISRDGQELEPLVGEQLLQLWERLPLGEKNTTD

Sequence length

1430

Interactions

View interactions

Show/Hide Unknown Diseases (15)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cholangiocarcinoma	Benign	rs1035409	RCV005936998
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign	rs72805421	RCV005937265
Colorectal cancer	Benign	rs72805422, rs72805421	RCV005937142 RCV005937261
Familial cancer of breast	Benign	rs10077431	RCV005937345
Familial pancreatic carcinoma	Benign	rs72805421	RCV005937259
Gastric cancer	Benign; Likely benign	rs72805421, rs374503453	RCV005937262 RCV005871453
Hepatocellular carcinoma	Benign	rs10077431, rs72805421	RCV005937346 RCV005937257
Lymphoma	Benign	rs72805421	RCV005937263
Malignant lymphoma, large B-cell, diffuse	Benign	rs72805422, rs10077431, rs72805421	RCV005937141 RCV005937347 RCV005937260
Ovarian cancer	Benign	rs72805421	RCV005937258
Prostate cancer	Uncertain significance	rs193921121	RCV000149300
Thymoma	Benign	rs1035409	RCV005936997
Uterine carcinosarcoma	Benign	rs72805422, rs1035409, rs72805421	RCV005937143 RCV005936996 RCV005937264
Uveal melanoma	Benign	rs1035409	RCV005936995
YTHDC2-related disorder	Likely benign; Benign; Uncertain significance	rs138392928, rs145439600, rs183270517, rs139910362, rs1289395774, rs6594732, rs72805422, rs2303718, rs10071816, rs6867579, rs10077431, rs1035409, rs72805421, rs11748794, rs75714066 View all (29 more)	RCV003907096 RCV003929622 RCV003929796 RCV003931888 RCV003964589 RCV003974345 RCV003974420 RCV003974102 RCV003979798 RCV003982424 RCV003982464 RCV003916947 RCV003982295 RCV003977396 RCV003984533 RCV003984540 RCV003941803 RCV003942086 RCV003944164 RCV003952220 RCV003944594 RCV003964052 RCV003919543 RCV003924334 RCV003937021 RCV003921979 RCV003922228 RCV003932152 RCV003934113 RCV003942135 RCV003942328 RCV003937388 RCV003964359 RCV003982048 RCV003982217 RCV003957312 RCV003978914 RCV003978936 RCV003972137 RCV003915911 RCV003915912 RCV003975508 RCV003955843 RCV003912976 RCV003915913 RCV003981458

Show/Hide Text Mining Associations (37)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	34312987
Adenocarcinoma of Lung	Associate	32258108
Adenocarcinoma of Lung	Inhibit	32956555, 34497675
Adrenocortical Carcinoma	Associate	34312987
Aortic Dissection	Associate	36819785
Arthritis Rheumatoid	Associate	36582238, 38432455
Carcinogenesis	Associate	32956555
Carcinoma Endometrioid	Associate	33692441
Carcinoma Hepatocellular	Stimulate	32631107, 34221187
Carcinoma Hepatocellular	Associate	34234878
Carcinoma Non Small Cell Lung	Inhibit	32956555
Carcinoma Non Small Cell Lung	Associate	34367534, 34812534
Carcinoma Renal Cell	Associate	38164857
Carcinoma Squamous Cell	Associate	32956555, 34312987
Chemical and Drug Induced Liver Injury	Associate	36072379
Colonic Neoplasms	Associate	31823961, 32596399
Colorectal Neoplasms	Associate	33415160, 37194014
Diabetes Mellitus Type 1	Associate	35784577
Diabetic Nephropathies	Associate	36585417
Endometrial Neoplasms	Associate	34312987
Fever	Associate	36072379
Glaucoma Open Angle	Associate	40128732
Glioma	Associate	34312987
Lymphatic Metastasis	Inhibit	32956555
Melanoma Cutaneous Malignant	Associate	34312987
Myocardial Infarction	Associate	36061306
Neoplasms	Associate	31823961, 32398949, 32596399, 32956555, 34312987, 36416324
Osteoporosis	Associate	36967763
Parkinson Disease	Associate	39533574
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	36567510
Primary Ovarian Insufficiency	Associate	35138268
Pulmonary Disease Chronic Obstructive	Associate	32961012
Rectal Neoplasms	Associate	34312987
Sarcoma	Associate	33370249
Squamous Cell Carcinoma of Head and Neck	Associate	34207099, 36416324
Tuberculosis Pulmonary	Associate	36072379
Uterine Cervical Neoplasms	Associate	37474926

YTHDC2 (YTH N6-methyladenosine RNA binding protein C2)