Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	64843
Gene name Gene Name - the full gene name approved by the HGNC.	ISL LIM homeobox 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ISL2
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q24.3

Show/Hide all(60)

miRTarBase ID	miRNA	Experiments	Reference
MIRT490294	hsa-miR-7160-3p	PAR-CLIP	23592263
MIRT490293	hsa-miR-7706	PAR-CLIP	23592263
MIRT490292	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT490291	hsa-miR-3195	PAR-CLIP	23592263
MIRT490289	hsa-miR-4533	PAR-CLIP	23592263
MIRT490290	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT490288	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT490287	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT490286	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT490285	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT490284	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT490283	hsa-miR-4271	PAR-CLIP	23592263
MIRT490282	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT490281	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT490280	hsa-miR-6724-5p	PAR-CLIP	23592263
MIRT490294	hsa-miR-7160-3p	PAR-CLIP	23592263
MIRT490293	hsa-miR-7706	PAR-CLIP	23592263
MIRT490292	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT490291	hsa-miR-3195	PAR-CLIP	23592263
MIRT490289	hsa-miR-4533	PAR-CLIP	23592263
MIRT490290	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT490288	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT490287	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT490286	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT490285	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT490284	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT490283	hsa-miR-4271	PAR-CLIP	23592263
MIRT490282	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT490281	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT490280	hsa-miR-6724-5p	PAR-CLIP	23592263
MIRT1072715	hsa-miR-1277	CLIP-seq
MIRT1072716	hsa-miR-3150b-3p	CLIP-seq
MIRT1072717	hsa-miR-3659	CLIP-seq
MIRT1072718	hsa-miR-3921	CLIP-seq
MIRT1072719	hsa-miR-3960	CLIP-seq
MIRT1072720	hsa-miR-4270	CLIP-seq
MIRT1072721	hsa-miR-4326	CLIP-seq
MIRT1072722	hsa-miR-4424	CLIP-seq
MIRT1072723	hsa-miR-4441	CLIP-seq
MIRT1072724	hsa-miR-4653-5p	CLIP-seq
MIRT1072725	hsa-miR-4658	CLIP-seq
MIRT1072726	hsa-miR-4663	CLIP-seq
MIRT1072727	hsa-miR-4682	CLIP-seq
MIRT1072728	hsa-miR-4758-5p	CLIP-seq
MIRT1072729	hsa-miR-4784	CLIP-seq
MIRT1072730	hsa-miR-574-5p	CLIP-seq
MIRT2017903	hsa-miR-1273f	CLIP-seq
MIRT2017904	hsa-miR-3127-3p	CLIP-seq
MIRT2017905	hsa-miR-3667-3p	CLIP-seq
MIRT2017906	hsa-miR-3679-3p	CLIP-seq
MIRT1072722	hsa-miR-4424	CLIP-seq
MIRT2017907	hsa-miR-4446-5p	CLIP-seq
MIRT1072727	hsa-miR-4682	CLIP-seq
MIRT2249702	hsa-miR-375	CLIP-seq
MIRT1072720	hsa-miR-4270	CLIP-seq
MIRT2249703	hsa-miR-4284	CLIP-seq
MIRT1072723	hsa-miR-4441	CLIP-seq
MIRT2249704	hsa-miR-4492	CLIP-seq
MIRT2249705	hsa-miR-4498	CLIP-seq
MIRT2249706	hsa-miR-762	CLIP-seq

Show/Hide all(19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0000987	Function	Cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0003677	Function	DNA binding	ISS	17091338
GO:0005515	Function	Protein binding	IPI	27820671, 28514442, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IC	17091338
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0007409	Process	Axonogenesis	IBA	21873635
GO:0021520	Process	Spinal cord motor neuron cell fate specification	IEA
GO:0021524	Process	Visceral motor neuron differentiation	IEA
GO:0031290	Process	Retinal ganglion cell axon guidance	IEA
GO:0045665	Process	Negative regulation of neuron differentiation	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048665	Process	Neuron fate specification	IBA	21873635
GO:0048666	Process	Neuron development	TAS	9452425
GO:0048935	Process	Peripheral nervous system neuron development	TAS	20096094
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
609481	18524	ENSG00000159556

Protein

UniProt ID

Q96A47

Protein name

Insulin gene enhancer protein ISL-2 (Islet-2)

Protein function

Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00412	LIM	27 → 85	LIM domain	Domain
PF00412	LIM	89 → 145	LIM domain	Domain
PF00046	Homeodomain	192 → 248	Homeodomain	Domain

Sequence

MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQ
YLDETCTCFVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVC
SRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPAL
RPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQ
NKRCKDKKKSILMKQLQQQQHSDKTSLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPP
WKALSEFALQSDLDQPAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVET

Sequence length

359

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Alzheimer disease	Alzheimer disease			GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Pancreatic Ductal	Associate	35508175
Pancreatic Neoplasms	Associate	35508175

ISL2 (ISL LIM homeobox 2)